FAS

Functionⁱ

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).2 Publications

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding, Receptor
Biological process	Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand R-HSA-3371378 Regulation by c-FLIP R-HSA-5213460 RIPK1-mediated regulated necrosis R-HSA-5218900 CASP8 activity is inhibited R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-69416 Dimerization of procaspase-8 R-HSA-75157 FasL/ CD95L signaling
SIGNORⁱ	P25445

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor receptor superfamily member 6 Alternative name(s): Apo-1 antigen Apoptosis-mediating surface antigen FAS FASLG receptor CD_antigen: CD95
Gene namesⁱ	Name:FAS Synonyms:APT1, FAS1, TNFRSF6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11920 FAS
MIMⁱ	134637 gene
neXtProtⁱ	NX_P25445

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	26 – 173	ExtracellularSequence analysisAdd BLAST	148
Transmembraneⁱ	174 – 190	HelicalSequence analysisAdd BLAST	17
Topological domainⁱ	191 – 335	CytoplasmicSequence analysisAdd BLAST	145

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Autoimmune lymphoproliferative syndrome 1A (ALPS1A)13 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_013417	28	T → A in ALPS1A; associated with autoimmune hepatitis type 2. 1 Publication	1
Natural variantⁱVAR_013418	82	C → R in ALPS1A. 1 Publication	1
Natural variantⁱVAR_013419	121	R → W in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs121913078EnsemblClinVar.	1
Natural variantⁱVAR_013423	232	Y → C in ALPS1A; no effect on interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913079EnsemblClinVar.	1
Natural variantⁱVAR_013424	241	T → K in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs201072885Ensembl.	1
Natural variantⁱVAR_013425	241	T → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913076EnsemblClinVar.	1
Natural variantⁱVAR_065128	249	V → L in ALPS1A. 1 Publication	1
Natural variantⁱVAR_013426	250	R → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913080EnsemblClinVar.	1
Natural variantⁱVAR_013427	250	R → Q in ALPS1A; no effect on interaction with FADD. 2 Publications	1
Natural variantⁱVAR_065129	253	G → D in ALPS1A. 1 Publication	1
Natural variantⁱVAR_065130	253	G → S in ALPS1A. 1 Publication	1
Natural variantⁱVAR_013428	257	A → D in ALPS1A; loss of interaction with FADD. 2 Publications	1
Natural variantⁱVAR_065131	259	I → R in ALPS1A. 1 Publication	1
Natural variantⁱVAR_013429	260	D → G in ALPS1A. 1 Publication	1
Natural variantⁱVAR_013431	260	D → V in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 4 PublicationsCorresponds to variant dbSNP:rs28929498EnsemblClinVar.	1
Natural variantⁱVAR_013430	260	D → Y in ALPS1A; loss of interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913086EnsemblClinVar.	1
Natural variantⁱVAR_058910	262	I → S in ALPS1A. 1 Publication	1
Natural variantⁱVAR_013433	270	T → I in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913081EnsemblClinVar.	1
Natural variantⁱVAR_065132	270	T → K in ALPS1A; loss of interaction with FADD. 2 Publications	1
Natural variantⁱVAR_013434	272	E → G in ALPS1A. 2 Publications	1
Natural variantⁱVAR_013435	272	E → K in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 3 Publications	1
Natural variantⁱVAR_013438	310	I → S in ALPS1A. 1 Publication	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	250	R → E: Strongly decreased interaction with FADD. 1 Publication	1
Mutagenesisⁱ	261	E → K: Loss of interaction with FADD. 1 Publication	1
Mutagenesisⁱ	283	Q → K: Loss of interaction with FADD. 1 Publication	1
Mutagenesisⁱ	287	K → D: Strongly decreased interaction with FADD. 1 Publication	1
Mutagenesisⁱ	291	Y → D: Decreased interaction with FADD. 1 Publication	1
Mutagenesisⁱ	313	I → D: Constitutive activation. Promotes apoptosis, both in the presence and in the absence of stimulation by a ligand. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	355
GeneReviewsⁱ	FAS
MalaCards human disease database More...MalaCardsⁱ	FAS
MIMⁱ	601859 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000026103
Orphanetⁱ	3261 Autoimmune lymphoproliferative syndrome 117 Behcet disease 3437 Vogt-Koyanagi-Harada disease
PharmGKBⁱ	PA36613

Miscellaneous databases

Pharosⁱ	P25445 Tbio

Pharosⁱ

P25445 Tbio

Polymorphism and mutation databases

BioMutaⁱ	FAS
DMDMⁱ	119833

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_0000034563	26 – 335	Tumor necrosis factor receptor superfamily member 6Add BLAST		310

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	28	O-linked (GalNAc...) threonine1 Publication	1
Disulfide bondⁱ	59 ↔ 73	PROSITE-ProRule annotation
Disulfide bondⁱ	63 ↔ 82	PROSITE-ProRule annotation
Disulfide bondⁱ	85 ↔ 101	PROSITE-ProRule annotation
Disulfide bondⁱ	104 ↔ 119	PROSITE-ProRule annotation
Disulfide bondⁱ	107 ↔ 127	PROSITE-ProRule annotation
Glycosylationⁱ	118	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	129 ↔ 143	PROSITE-ProRule annotation
Glycosylationⁱ	136	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	146 ↔ 157	PROSITE-ProRule annotation
Disulfide bondⁱ	149 ↔ 165	PROSITE-ProRule annotation
Modified residueⁱ	209	PhosphoserineCombined sources	1
Modified residueⁱ	214	PhosphothreonineBy similarity	1
Modified residueⁱ	225	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P25445
jPOSTⁱ	P25445
MassIVEⁱ	P25445
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P25445
PaxDbⁱ	P25445
PeptideAtlas More...PeptideAtlasⁱ	P25445
PRIDEⁱ	P25445
ProteomicsDBⁱ	54273 [P25445-1] 54274 [P25445-2] 54275 [P25445-3] 54276 [P25445-4] 54277 [P25445-5] 54278 [P25445-6] 64806
TopDownProteomicsⁱ	P25445-7 [P25445-7]

PTM databases

GlyConnectⁱ	773
iPTMnetⁱ	P25445
PhosphoSitePlusⁱ	P25445
SwissPalmⁱ	P25445
UniCarbKBⁱ	P25445

Expressionⁱ

Tissue specificityⁱ

Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000026103 Expressed in right ovary and 215 other tissues
ExpressionAtlasⁱ	P25445 baseline and differential
Genevisibleⁱ	P25445 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000026103 Low tissue specificity

HPAⁱ

ENSG00000026103 Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Binds DAXX.

Interacts with HIPK3 (By similarity).

Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2 (PubMed:7538908, PubMed:10535980).

Interacts with BABAM2 and FEM1B (PubMed:10542291, PubMed:15465831).

Interacts with FADD (PubMed:21109225, PubMed:19118384).

Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity).

Interacts with CALM (PubMed:24914971). In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B. The interaction with BIRC2 and DDX3X is further enhanced upon receptor stimulation and accompanied by DDX3X and BIRC2 cleavage (PubMed:18846110).

By similarity8 Publications

Binary interactionsⁱ

With	#Exp.	IntAct
itself	3	EBI-494743,EBI-494743
CALM3 [P62158]	4	EBI-494743,EBI-397435
CASP8 [Q14790]	14	EBI-494743,EBI-78060
CAV1 [Q03135]	3	EBI-494743,EBI-603614
DAXX [Q9UER7]	3	EBI-494743,EBI-77321
FADD [Q13158]	21	EBI-494743,EBI-494804
FASLG [P48023]	4	EBI-494743,EBI-495538
MAP3K5 [Q99683]	2	EBI-494743,EBI-476263
Pdcd6 [P12815] from Mus musculus.	2	EBI-494743,EBI-309164
PML [P29590]	4	EBI-494743,EBI-295890
PML-RAR [Q15156]	6	EBI-494743,EBI-867256
PTPN13 [Q12923]	3	EBI-494743,EBI-355227
SRC [P12931]	2	EBI-494743,EBI-621482

With	#Exp.	IntAct
CASP8 [Q14790]	3	EBI-15749113,EBI-78060
CAV1 [Q03135]	3	EBI-15749113,EBI-603614
FADD [Q13158]	17	EBI-15749113,EBI-494804
YES1 [P07947]	2	EBI-15749113,EBI-515331

Show more details

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106851, 108 interactors
CORUMⁱ	P25445
Database of interacting proteins More...DIPⁱ	DIP-924N
IntActⁱ	P25445, 81 interactors
Molecular INTeraction database More...MINTⁱ	P25445
STRINGⁱ	9606.ENSP00000347979

Miscellaneous databases

RNActⁱ	P25445 protein

RNActⁱ

P25445 protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	67 – 71	Combined sources	5
Beta strandⁱ	75 – 77	Combined sources	3
Beta strandⁱ	82 – 84	Combined sources	3
Turnⁱ	87 – 89	Combined sources	3
Helixⁱ	109 – 111	Combined sources	3
Beta strandⁱ	113 – 117	Combined sources	5
Beta strandⁱ	126 – 129	Combined sources	4
Beta strandⁱ	137 – 139	Combined sources	3
Helixⁱ	174 – 181	Combined sources	8
Helixⁱ	184 – 193	Combined sources	10
Helixⁱ	232 – 242	Combined sources	11
Turnⁱ	251 – 253	Combined sources	3
Helixⁱ	256 – 265	Combined sources	10
Helixⁱ	270 – 282	Combined sources	13
Helixⁱ	287 – 319	Combined sources	33
Helixⁱ	327 – 334	Combined sources	8

Show more details

3D structure databases

SMRⁱ	P25445
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P25445

EvolutionaryTraceⁱ

P25445

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	47 – 83	TNFR-Cys 1Add BLAST	37
Repeatⁱ	84 – 127	TNFR-Cys 2Add BLAST	44
Repeatⁱ	128 – 166	TNFR-Cys 3Add BLAST	39
Domainⁱ	230 – 314	DeathPROSITE-ProRule annotationAdd BLAST	85

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	212 – 317	Interaction with HIPK3By similarityAdd BLAST		106
Regionⁱ	230 – 254	Interaction with CALM1 PublicationAdd BLAST		25

Domainⁱ

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J23A Eukaryota ENOG4112ADB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00950000183126
HOGENOMⁱ	CLU_067123_1_0_1
InParanoidⁱ	P25445
KEGG Orthology (KO) More...KOⁱ	K04390
OMAⁱ	DTKCRCK
Database of Orthologous Groups More...OrthoDBⁱ	993446at2759
PhylomeDBⁱ	P25445
TreeFamⁱ	TF333916

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08316 Death_FAS_TNFRSF6, 1 hit cd10579 TNFRSF6, 1 hit
InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR008063 Fas_rcpt IPR001368 TNFR/NGFR_Cys_rich_reg IPR033998 TNFRSF6_death IPR033999 TNFRSF6_N
PANTHERⁱ	PTHR46874 PTHR46874, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF00020 TNFR_c6, 2 hits
PRINTSⁱ	PR01680 TNFACTORR6
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM00208 TNFR, 3 hits
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit PS00652 TNFR_NGFR_1, 2 hits PS50050 TNFR_NGFR_2, 2 hits

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P25445-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE 
        60         70         80         90        100
GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK 
       110        120        130        140        150
CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE 
       160        170        180        190        200
HGIIKECTLT SNTKCKEEGS RSNLGWLCLL LLPIPLIVWV KRKEVQKTCR 
       210        220        230        240        250
KHRKENQGSH ESPTLNPETV AINLSDVDLS KYITTIAGVM TLSQVKGFVR 
       260        270        280        290        300
KNGVNEAKID EIKNDNVQDT AEQKVQLLRN WHQLHGKKEA YDTLIKDLKK 
       310        320        330 
ANLCTLAEKI QTIILKDITS DSENSNFRNE IQSLV

Length:335

Mass (Da):37,732

Last modified:May 1, 1992 - v1

Checksum:ⁱ0139942535111410

GO

Isoform 2 (identifier: P25445-2) [UniParc]FASTA Add to basket

Also known as: del2, D

The sequence of this isoform differs from the canonical sequence as follows:
66-103: GERKARDCTV...KAHFSSKCRR → DVNMESSRNA...GFVFFFCQFH
104-335: Missing.

« Hide

        10         20         30         40         50
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE 
        60         70         80         90        100
GLHHDGQFCH KPCPPDVNME SSRNAHSPAT PSAKRKDPDL TWGGFVFFFC 

QFH

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated

Show »

Length:103

Mass (Da):11,435

Checksum:ⁱF0DEA7F598AFBB00

GO

Isoform 3 (identifier: P25445-3) [UniParc]FASTA Add to basket

Also known as: del3, E

The sequence of this isoform differs from the canonical sequence as follows:
66-86: GERKARDCTVNGDEPDCVPCQ → DVNMESSRNAHSPATPSAKRK
87-335: Missing.

« Hide

        10         20         30         40         50
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE 
        60         70         80 
GLHHDGQFCH KPCPPDVNME SSRNAHSPAT PSAKRK

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated

Show »

Length:86

Mass (Da):9,390

Checksum:ⁱD55B05CA4C2D1D49

GO

Isoform 4 (identifier: P25445-4) [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
112-149: GLEVEINCTR...CEHCDPCTKC → DVNMESSRNA...GFVFFFCQFH
150-335: Missing.

« Hide

        10         20         30         40         50
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE 
        60         70         80         90        100
GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK 
       110        120        130        140 
CRRCRLCDEG HDVNMESSRN AHSPATPSAK RKDPDLTWGG FVFFFCQFH

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated

Show »

Length:149

Mass (Da):16,648

Checksum:ⁱ5061E69484678FC0

GO

Isoform 5 (identifier: P25445-5) [UniParc]FASTA Add to basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
112-132: GLEVEINCTRTQNTKCRCKPN → DVNMESSRNAHSPATPSAKRK
133-335: Missing.

« Hide

        10         20         30         40         50
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE 
        60         70         80         90        100
GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK 
       110        120        130 
CRRCRLCDEG HDVNMESSRN AHSPATPSAK RK

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated

Show »

Length:132

Mass (Da):14,602

Checksum:ⁱB10B6F86DE5E8690

GO

Isoform 6 (identifier: P25445-6) [UniParc]FASTA Add to basket

Also known as: TMdel, A

The sequence of this isoform differs from the canonical sequence as follows:
169-189: Missing.

« Hide

        10         20         30         40         50
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE 
        60         70         80         90        100
GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK 
       110        120        130        140        150
CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE 
       160        170        180        190        200
HGIIKECTLT SNTKCKEEVK RKEVQKTCRK HRKENQGSHE SPTLNPETVA 
       210        220        230        240        250
INLSDVDLSK YITTIAGVMT LSQVKGFVRK NGVNEAKIDE IKNDNVQDTA 
       260        270        280        290        300
EQKVQLLRNW HQLHGKKEAY DTLIKDLKKA NLCTLAEKIQ TIILKDITSD 
       310 
SENSNFRNEI QSLV

Show »

Length:314

Mass (Da):35,386

Checksum:ⁱ83F8FAC62DB8B457

GO

Isoform 7 (identifier: P25445-7) [UniParc]FASTA Add to basket

Also known as: FasExo8Del

The sequence of this isoform differs from the canonical sequence as follows:
218-220: ETV → MLT
221-335: Missing.

« Hide

        10         20         30         40         50
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE 
        60         70         80         90        100
GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK 
       110        120        130        140        150
CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE 
       160        170        180        190        200
HGIIKECTLT SNTKCKEEGS RSNLGWLCLL LLPIPLIVWV KRKEVQKTCR 
       210        220
KHRKENQGSH ESPTLNPMLT

Note: Dominant negative isoform, resistant to Fas-mediated apoptosis.Curated

Show »

Length:220

Mass (Da):24,781

Checksum:ⁱF4CD01DBF0649B39

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7C5Z8	H7C5Z8_HUMAN	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 6	FAS	233	Annotation score:
K9J972	K9J972_HUMAN	FAS receptor variant 9 FAS receptor variant 9 (Tumor necrosis factor receptor superfamily member 6)	FAS	197	Annotation score:
A0A087WTM9	A0A087WTM9_HUMAN	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 6	FAS	244	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	224	L → F in AAR08906 (Ref. 11) Curated		1
Sequence conflictⁱ	242	L → P in CAR92543 (Ref. 9) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_020008	16	A → T1 PublicationCorresponds to variant dbSNP:rs3218619EnsemblClinVar.	1
Natural variantⁱVAR_013416	25	A → T in non-Hodgkin lymphoma; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs606231364EnsemblClinVar.	1
Natural variantⁱVAR_013417	28	T → A in ALPS1A; associated with autoimmune hepatitis type 2. 1 Publication	1
Natural variantⁱVAR_013418	82	C → R in ALPS1A. 1 Publication	1
Natural variantⁱVAR_018321	118	N → S in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913083EnsemblClinVar.	1
Natural variantⁱVAR_013419	121	R → W in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs121913078EnsemblClinVar.	1
Natural variantⁱVAR_020009	122	T → I1 PublicationCorresponds to variant dbSNP:rs3218614EnsemblClinVar.	1
Natural variantⁱVAR_018322	178	C → R in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913084EnsemblClinVar.	1
Natural variantⁱVAR_013420	180	L → F in non-Hodgkin lymphoma; somatic mutation. 1 Publication	1
Natural variantⁱVAR_013421	183	P → L in non-Hodgkin lymphoma; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs758835365Ensembl.	1
Natural variantⁱVAR_052347	184	I → V. Corresponds to variant dbSNP:rs28362322EnsemblClinVar.	1
Natural variantⁱVAR_013422	198	T → I in non-Hodgkin lymphoma; somatic mutation. 1 Publication	1
Natural variantⁱVAR_013423	232	Y → C in ALPS1A; no effect on interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913079EnsemblClinVar.	1
Natural variantⁱVAR_013424	241	T → K in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs201072885Ensembl.	1
Natural variantⁱVAR_013425	241	T → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913076EnsemblClinVar.	1
Natural variantⁱVAR_065128	249	V → L in ALPS1A. 1 Publication	1
Natural variantⁱVAR_013426	250	R → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913080EnsemblClinVar.	1
Natural variantⁱVAR_013427	250	R → Q in ALPS1A; no effect on interaction with FADD. 2 Publications	1
Natural variantⁱVAR_065129	253	G → D in ALPS1A. 1 Publication	1
Natural variantⁱVAR_065130	253	G → S in ALPS1A. 1 Publication	1
Natural variantⁱVAR_018323	255	N → D in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913082EnsemblClinVar.	1
Natural variantⁱVAR_013428	257	A → D in ALPS1A; loss of interaction with FADD. 2 Publications	1
Natural variantⁱVAR_065131	259	I → R in ALPS1A. 1 Publication	1
Natural variantⁱVAR_013429	260	D → G in ALPS1A. 1 Publication	1
Natural variantⁱVAR_013431	260	D → V in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 4 PublicationsCorresponds to variant dbSNP:rs28929498EnsemblClinVar.	1
Natural variantⁱVAR_013430	260	D → Y in ALPS1A; loss of interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913086EnsemblClinVar.	1
Natural variantⁱVAR_058910	262	I → S in ALPS1A. 1 Publication	1
Natural variantⁱVAR_013432	264	N → K in non-Hodgkin lymphoma; somatic mutation. 1 Publication	1
Natural variantⁱVAR_013433	270	T → I in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913081EnsemblClinVar.	1
Natural variantⁱVAR_065132	270	T → K in ALPS1A; loss of interaction with FADD. 2 Publications	1
Natural variantⁱVAR_013434	272	E → G in ALPS1A. 2 Publications	1
Natural variantⁱVAR_013435	272	E → K in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 3 Publications	1
Natural variantⁱVAR_013436	278	L → F in non-Hodgkin lymphoma; somatic mutation. 1 Publication	1
Natural variantⁱVAR_013437	299	K → N in non-Hodgkin lymphoma; somatic mutation. 1 Publication	1
Natural variantⁱVAR_020942	305	T → I1 PublicationCorresponds to variant dbSNP:rs3218611Ensembl.	1
Natural variantⁱVAR_013438	310	I → S in ALPS1A. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_006481	66 – 103	GERKA…SKCRR → DVNMESSRNAHSPATPSAKR KDPDLTWGGFVFFFCQFH in isoform 2. 2 PublicationsAdd BLAST	38
Alternative sequenceⁱVSP_006483	66 – 86	GERKA…CVPCQ → DVNMESSRNAHSPATPSAKR K in isoform 3. 2 PublicationsAdd BLAST	21
Alternative sequenceⁱVSP_006484	87 – 335	Missing in isoform 3. 2 PublicationsAdd BLAST	249
Alternative sequenceⁱVSP_006482	104 – 335	Missing in isoform 2. 2 PublicationsAdd BLAST	232
Alternative sequenceⁱVSP_006485	112 – 149	GLEVE…PCTKC → DVNMESSRNAHSPATPSAKR KDPDLTWGGFVFFFCQFH in isoform 4. 2 PublicationsAdd BLAST	38
Alternative sequenceⁱVSP_006487	112 – 132	GLEVE…RCKPN → DVNMESSRNAHSPATPSAKR K in isoform 5. 2 PublicationsAdd BLAST	21
Alternative sequenceⁱVSP_006488	133 – 335	Missing in isoform 5. 2 PublicationsAdd BLAST	203
Alternative sequenceⁱVSP_006486	150 – 335	Missing in isoform 4. 2 PublicationsAdd BLAST	186
Alternative sequenceⁱVSP_006489	169 – 189	Missing in isoform 6. 2 PublicationsAdd BLAST	21
Alternative sequenceⁱVSP_045235	218 – 220	ETV → MLT in isoform 7. 1 Publication	3
Alternative sequenceⁱVSP_045236	221 – 335	Missing in isoform 7. 1 PublicationAdd BLAST	115

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M67454 mRNA Translation: AAA63174.1 X63717 mRNA Translation: CAA45250.1 X83490 mRNA No translation available. X83491 mRNA No translation available. X83492 mRNA No translation available. X83493 mRNA No translation available. Z47993 mRNA Translation: CAA88031.1 Z47994 mRNA Translation: CAA88032.1 Z47995 mRNA Translation: CAA88033.1 Z66556 mRNA No translation available. Z70519 mRNA Translation: CAA94430.1 Z70520 mRNA Translation: CAA94431.1 AY495076 mRNA Translation: AAS76663.1 X89101 mRNA Translation: CAA61473.1 FM246458 mRNA Translation: CAR92543.1 AK290978 mRNA Translation: BAF83667.1 AY450925 Genomic DNA Translation: AAR08906.1 AL157394 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50151.1 BC012479 mRNA Translation: AAH12479.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7393.1 [P25445-1] CCDS7394.1 [P25445-6] CCDS7395.1 [P25445-7]
PIRⁱ	A40036 I37383 I37384 S58662
NCBI Reference Sequences More...RefSeqⁱ	NP_000034.1, NM_000043.5 [P25445-1] NP_001307548.1, NM_001320619.1 NP_690610.1, NM_152871.3 [P25445-6] NP_690611.1, NM_152872.3 [P25445-7]

Genome annotation databases

Ensemblⁱ	ENST00000355279; ENSP00000347426; ENSG00000026103 [P25445-7] ENST00000357339; ENSP00000349896; ENSG00000026103 [P25445-6] ENST00000479522; ENSP00000424113; ENSG00000026103 [P25445-3] ENST00000484444; ENSP00000420975; ENSG00000026103 [P25445-2] ENST00000488877; ENSP00000425159; ENSG00000026103 [P25445-4] ENST00000492756; ENSP00000422453; ENSG00000026103 [P25445-5] ENST00000494410; ENSP00000423755; ENSG00000026103 [P25445-4] ENST00000652046; ENSP00000498466; ENSG00000026103 [P25445-1]
GeneIDⁱ	355
KEGGⁱ	hsa:355
UCSC genome browser More...UCSCⁱ	uc001kfr.4 human [P25445-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P25445	Mutant tumor necrosis receptor superfamily member 6		HUMAN		228	UniRef100_P25445

Protein	Similar proteins		Species	Score	Length	Source
P25445	Mutant tumor necrosis receptor superfamily member 6		HUMAN		228	UniRef90_P25445
Fas cell surface death receptor		GORGO		340
Fas cell surface death receptor		PANTR		337
Fas cell surface death receptor		PANPA		335
Fas cell surface death receptor		NOMLE		335
+15
P25445-2	Isoform 3 of Tumor necrosis factor receptor superfamily member 6		HUMAN		86	UniRef90_P25445-2
FAS isoform 6		PONAB		104
FAS isoform 6		PANTR		103
FAS isoform 8		PONAB		86
FAS isoform 8		PANTR		86
P25445-4	Isoform 5 of Tumor necrosis factor receptor superfamily member 6		HUMAN		132	UniRef90_P25445-4
FAS isoform 13		PONAB		150
FAS isoform 13		PANTR		149
FAS isoform 10		PONAB		132
FAS isoform 10		PANTR		132
P25445-6	Tumor necrosis factor receptor superfamily, member 6 isoform 1 variant (Fragment)		HUMAN		362	UniRef90_P25445-6
FAS isoform 1		PONAB		336
Fas cell surface death receptor		PANPA		314
Fas cell surface death receptor		NOMLE		314
Fas cell surface death receptor		GORGO		314
+13
P25445-7	FAS variant		HUMAN		255	UniRef90_P25445-7
FAS isoform 5		PONAB		234
FAS isoform 5		PANTR		233
Fas cell surface death receptor		NOMLE		220
Fas cell surface death receptor		PANPA		220
+7

Protein	Similar proteins		Species	Score	Length	Source
P25445	Mutant tumor necrosis receptor superfamily member 6		HUMAN		228	UniRef50_P25445
Fas cell surface death receptor		GORGO		340
Fas cell surface death receptor		PANTR		337
Fas cell surface death receptor		NOMLE		335
Fas cell surface death receptor		PANPA		335
+43
P25445-2	Isoform 3 of Tumor necrosis factor receptor superfamily member 6		HUMAN		86	UniRef50_P25445-2
FAS isoform 6		PONAB		104
FAS isoform 6		PANTR		103
FAS isoform 8		PONAB		86
FAS isoform 8		PANTR		86
P25445-4	Isoform 5 of Tumor necrosis factor receptor superfamily member 6		HUMAN		132	UniRef50_P25445-4
FAS isoform 13		PONAB		150
FAS isoform 13		PANTR		149
FAS isoform 10		PONAB		132
FAS isoform 10		PANTR		132
P25445-7	FAS variant		HUMAN		255	UniRef50_P25445-7
FAS isoform 5		PONAB		234
FAS isoform 5		PANTR		233
Fas cell surface death receptor		NOMLE		220
Fas cell surface death receptor		PANPA		220
+23

Cross-referencesⁱ

Web resourcesⁱ

Autoimmune Lymphoproliferative Syndrome Database (ALPSbase)

Mutations in TNFRSF6 causing ALPS type Ia

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M67454 mRNA Translation: AAA63174.1 X63717 mRNA Translation: CAA45250.1 X83490 mRNA No translation available. X83491 mRNA No translation available. X83492 mRNA No translation available. X83493 mRNA No translation available. Z47993 mRNA Translation: CAA88031.1 Z47994 mRNA Translation: CAA88032.1 Z47995 mRNA Translation: CAA88033.1 Z66556 mRNA No translation available. Z70519 mRNA Translation: CAA94430.1 Z70520 mRNA Translation: CAA94431.1 AY495076 mRNA Translation: AAS76663.1 X89101 mRNA Translation: CAA61473.1 FM246458 mRNA Translation: CAR92543.1 AK290978 mRNA Translation: BAF83667.1 AY450925 Genomic DNA Translation: AAR08906.1 AL157394 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50151.1 BC012479 mRNA Translation: AAH12479.1
CCDSⁱ	CCDS7393.1 [P25445-1] CCDS7394.1 [P25445-6] CCDS7395.1 [P25445-7]
PIRⁱ	A40036 I37383 I37384 S58662
RefSeqⁱ	NP_000034.1, NM_000043.5 [P25445-1] NP_001307548.1, NM_001320619.1 NP_690610.1, NM_152871.3 [P25445-6] NP_690611.1, NM_152872.3 [P25445-7]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BZI	model	-	A	1-335	[»]
	1DDF	NMR	-	A	218-335	[»]
	2NA7	NMR	-	A/B/C	171-198	[»]
	3EWT	X-ray	2.40	E	230-254	[»]
	3EZQ	X-ray	2.73	A/C/E/G/I/K/M/O	223-335	[»]
	3THM	X-ray	2.10	F	17-172	[»]
	3TJE	X-ray	1.93	F	17-172	[»]
SMRⁱ	P25445
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106851, 108 interactors
CORUMⁱ	P25445
DIPⁱ	DIP-924N
IntActⁱ	P25445, 81 interactors
MINTⁱ	P25445
STRINGⁱ	9606.ENSP00000347979

PTM databases

GlyConnectⁱ	773
iPTMnetⁱ	P25445
PhosphoSitePlusⁱ	P25445
SwissPalmⁱ	P25445
UniCarbKBⁱ	P25445

Polymorphism and mutation databases

BioMutaⁱ	FAS
DMDMⁱ	119833

Proteomic databases

EPDⁱ	P25445
jPOSTⁱ	P25445
MassIVEⁱ	P25445
MaxQBⁱ	P25445
PaxDbⁱ	P25445
PeptideAtlasⁱ	P25445
PRIDEⁱ	P25445
ProteomicsDBⁱ	54273 [P25445-1] 54274 [P25445-2] 54275 [P25445-3] 54276 [P25445-4] 54277 [P25445-5] 54278 [P25445-6] 64806
TopDownProteomicsⁱ	P25445-7 [P25445-7]

Protocols and materials databases

ABCDⁱ	P25445
Antibodypediaⁱ	4525 2718 antibodies
The DNASU plasmid repository More...DNASUⁱ	355

Genome annotation databases

Ensemblⁱ	ENST00000355279; ENSP00000347426; ENSG00000026103 [P25445-7] ENST00000357339; ENSP00000349896; ENSG00000026103 [P25445-6] ENST00000479522; ENSP00000424113; ENSG00000026103 [P25445-3] ENST00000484444; ENSP00000420975; ENSG00000026103 [P25445-2] ENST00000488877; ENSP00000425159; ENSG00000026103 [P25445-4] ENST00000492756; ENSP00000422453; ENSG00000026103 [P25445-5] ENST00000494410; ENSP00000423755; ENSG00000026103 [P25445-4] ENST00000652046; ENSP00000498466; ENSG00000026103 [P25445-1]
GeneIDⁱ	355
KEGGⁱ	hsa:355
UCSCⁱ	uc001kfr.4 human [P25445-1]

Organism-specific databases

CTDⁱ	355
DisGeNETⁱ	355
GeneCardsⁱ	FAS
GeneReviewsⁱ	FAS
HGNCⁱ	HGNC:11920 FAS
HPAⁱ	ENSG00000026103 Low tissue specificity
MalaCardsⁱ	FAS
MIMⁱ	134637 gene 601859 phenotype
neXtProtⁱ	NX_P25445
OpenTargetsⁱ	ENSG00000026103
Orphanetⁱ	3261 Autoimmune lymphoproliferative syndrome 117 Behcet disease 3437 Vogt-Koyanagi-Harada disease
PharmGKBⁱ	PA36613
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J23A Eukaryota ENOG4112ADB LUCA
GeneTreeⁱ	ENSGT00950000183126
HOGENOMⁱ	CLU_067123_1_0_1
InParanoidⁱ	P25445
KOⁱ	K04390
OMAⁱ	DTKCRCK
OrthoDBⁱ	993446at2759
PhylomeDBⁱ	P25445
TreeFamⁱ	TF333916

Enzyme and pathway databases

Reactomeⁱ	R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand R-HSA-3371378 Regulation by c-FLIP R-HSA-5213460 RIPK1-mediated regulated necrosis R-HSA-5218900 CASP8 activity is inhibited R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-69416 Dimerization of procaspase-8 R-HSA-75157 FasL/ CD95L signaling
SIGNORⁱ	P25445

Miscellaneous databases

ChiTaRSⁱ	FAS human
EvolutionaryTraceⁱ	P25445
GeneWikiⁱ	Fas_receptor
GenomeRNAiⁱ	355
Pharosⁱ	P25445 Tbio
Protein Ontology More...PROⁱ	PR:P25445
RNActⁱ	P25445 protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000026103 Expressed in right ovary and 215 other tissues
ExpressionAtlasⁱ	P25445 baseline and differential
Genevisibleⁱ	P25445 HS

Family and domain databases

CDDⁱ	cd08316 Death_FAS_TNFRSF6, 1 hit cd10579 TNFRSF6, 1 hit
InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR008063 Fas_rcpt IPR001368 TNFR/NGFR_Cys_rich_reg IPR033998 TNFRSF6_death IPR033999 TNFRSF6_N
PANTHERⁱ	PTHR46874 PTHR46874, 1 hit
Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF00020 TNFR_c6, 2 hits
PRINTSⁱ	PR01680 TNFACTORR6
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM00208 TNFR, 3 hits
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit PS00652 TNFR_NGFR_1, 2 hits PS50050 TNFR_NGFR_2, 2 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNR6_HUMAN
Accessionⁱ	P25445Primary (citable) accession number: P25445 Secondary accession number(s): A9UJX4 Q6SSE9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	May 1, 1992
	Last modified:	April 22, 2020
	This is version 247 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniProtKB - P25445 (TNR6_HUMAN)

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Tumor necrosis factor receptor superfamily member 6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Extracellular region or secreted

Extracellular region or secreted

Extracellular region or secreted

Extracellular region or secreted

Cytosol

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P25445

Isoform 1 [P25445-1]

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

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Proteomic databases

Protocols and materials databases

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Organism-specific databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

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Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

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Keywords - Technical termⁱ