UniProtKB - P25445 (TNR6_HUMAN)
Tumor necrosis factor receptor superfamily member 6
FAS
Functioni
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
2 PublicationsGO - Molecular functioni
- calmodulin binding Source: UniProtKB
- identical protein binding Source: IntAct
- kinase binding Source: BHF-UCL
- signaling receptor activity Source: ProtInc
- tumor necrosis factor-activated receptor activity Source: GO_Central
GO - Biological processi
- activation-induced cell death of T cells Source: GO_Central
- apoptotic process Source: MGI
- cellular response to amino acid starvation Source: CAFA
- cellular response to hyperoxia Source: UniProtKB
- cellular response to mechanical stimulus Source: UniProtKB
- extrinsic apoptotic signaling pathway Source: UniProtKB
- extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
- Fas signaling pathway Source: CAFA
- immune response Source: InterPro
- motor neuron apoptotic process Source: GO_Central
- necroptotic signaling pathway Source: BHF-UCL
- negative regulation of apoptotic process Source: GO_Central
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of apoptotic signaling pathway Source: CAFA
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: CAFA
- positive regulation of protein phosphorylation Source: CAFA
- protein-containing complex assembly Source: ProtInc
- regulation of apoptotic process Source: UniProtKB
- regulation of stress-activated MAPK cascade Source: CAFA
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Calmodulin-binding, Receptor |
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | P25445 |
Reactomei | R-HSA-140534, Caspase activation via Death Receptors in the presence of ligand R-HSA-3371378, Regulation by c-FLIP R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5218900, CASP8 activity is inhibited R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-69416, Dimerization of procaspase-8 R-HSA-75157, FasL/ CD95L signaling |
SignaLinki | P25445 |
SIGNORi | P25445 |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member 6Alternative name(s): Apo-1 antigen Apoptosis-mediating surface antigen FAS FASLG receptor CD_antigen: CD95 |
Gene namesi | Name:FAS Synonyms:APT1, FAS1, TNFRSF6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11920, FAS |
MIMi | 134637, gene |
neXtProti | NX_P25445 |
VEuPathDBi | HostDB:ENSG00000026103 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein Curated
Other locations
- Membrane raft 1 Publication
Extracellular region or secreted
Extracellular region or secreted
Extracellular region or secreted
Extracellular region or secreted
Extracellular region or secreted
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nuclear body Source: HPA
Plasma Membrane
- CD95 death-inducing signaling complex Source: UniProtKB
- death-inducing signaling complex Source: UniProtKB
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: HPA
Other locations
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 173 | ExtracellularSequence analysisAdd BLAST | 148 | |
Transmembranei | 174 – 190 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 191 – 335 | CytoplasmicSequence analysisAdd BLAST | 145 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Autoimmune lymphoproliferative syndrome 1A (ALPS1A)13 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013417 | 28 | T → A in ALPS1A; associated with autoimmune hepatitis type 2. 1 Publication | 1 | |
Natural variantiVAR_013418 | 82 | C → R in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_013419 | 121 | R → W in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs121913078EnsemblClinVar. | 1 | |
Natural variantiVAR_013423 | 232 | Y → C in ALPS1A; no effect on interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913079EnsemblClinVar. | 1 | |
Natural variantiVAR_013424 | 241 | T → K in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs201072885Ensembl. | 1 | |
Natural variantiVAR_013425 | 241 | T → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913076EnsemblClinVar. | 1 | |
Natural variantiVAR_065128 | 249 | V → L in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_013426 | 250 | R → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913080EnsemblClinVar. | 1 | |
Natural variantiVAR_013427 | 250 | R → Q in ALPS1A; no effect on interaction with FADD. 2 Publications | 1 | |
Natural variantiVAR_065129 | 253 | G → D in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_065130 | 253 | G → S in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_013428 | 257 | A → D in ALPS1A; loss of interaction with FADD. 2 Publications | 1 | |
Natural variantiVAR_065131 | 259 | I → R in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_013429 | 260 | D → G in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_013431 | 260 | D → V in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 4 PublicationsCorresponds to variant dbSNP:rs28929498EnsemblClinVar. | 1 | |
Natural variantiVAR_013430 | 260 | D → Y in ALPS1A; loss of interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913086EnsemblClinVar. | 1 | |
Natural variantiVAR_058910 | 262 | I → S in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_013433 | 270 | T → I in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913081EnsemblClinVar. | 1 | |
Natural variantiVAR_065132 | 270 | T → K in ALPS1A; loss of interaction with FADD. 2 Publications | 1 | |
Natural variantiVAR_013434 | 272 | E → G in ALPS1A. 2 Publications | 1 | |
Natural variantiVAR_013435 | 272 | E → K in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 3 Publications | 1 | |
Natural variantiVAR_013438 | 310 | I → S in ALPS1A. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 199 | C → V: Loss of palmitoylation. 1 Publication | 1 | |
Mutagenesisi | 250 | R → A: Abolished GlcNAcylation by E.coli NleB1. 1 Publication | 1 | |
Mutagenesisi | 250 | R → E: Strongly decreased interaction with FADD. 1 Publication | 1 | |
Mutagenesisi | 261 | E → K: Loss of interaction with FADD. 1 Publication | 1 | |
Mutagenesisi | 283 | Q → K: Loss of interaction with FADD. 1 Publication | 1 | |
Mutagenesisi | 287 | K → D: Strongly decreased interaction with FADD. 1 Publication | 1 | |
Mutagenesisi | 291 | Y → D: Decreased interaction with FADD. 1 Publication | 1 | |
Mutagenesisi | 313 | I → D: Constitutive activation. Promotes apoptosis, both in the presence and in the absence of stimulation by a ligand. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 355 |
GeneReviewsi | FAS |
MalaCardsi | FAS |
MIMi | 601859, phenotype |
OpenTargetsi | ENSG00000026103 |
Orphaneti | 3261, Autoimmune lymphoproliferative syndrome 117, Behcet disease 3437, Vogt-Koyanagi-Harada disease |
PharmGKBi | PA36613 |
Miscellaneous databases
Pharosi | P25445, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4523207 |
Genetic variation databases
BioMutai | FAS |
DMDMi | 119833 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000034563 | 26 – 335 | Tumor necrosis factor receptor superfamily member 6Add BLAST | 310 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 28 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 59 ↔ 73 | PROSITE-ProRule annotation | ||
Disulfide bondi | 63 ↔ 82 | PROSITE-ProRule annotation | ||
Disulfide bondi | 85 ↔ 101 | PROSITE-ProRule annotation | ||
Disulfide bondi | 104 ↔ 119 | PROSITE-ProRule annotation | ||
Disulfide bondi | 107 ↔ 127 | PROSITE-ProRule annotation | ||
Glycosylationi | 118 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 129 ↔ 143 | PROSITE-ProRule annotation | ||
Glycosylationi | 136 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 146 ↔ 157 | PROSITE-ProRule annotation | ||
Disulfide bondi | 149 ↔ 165 | PROSITE-ProRule annotation | ||
Lipidationi | 199 | S-palmitoyl cysteine1 Publication | 1 | |
Modified residuei | 209 | PhosphoserineCombined sources | 1 | |
Modified residuei | 214 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 225 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 250 | (Microbial infection) N-beta-linked (GlcNAc) arginine1 Publication1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | P25445 |
jPOSTi | P25445 |
MassIVEi | P25445 |
MaxQBi | P25445 |
PaxDbi | P25445 |
PeptideAtlasi | P25445 |
PRIDEi | P25445 |
ProteomicsDBi | 54273 [P25445-1] 54276 [P25445-4] 54277 [P25445-5] 54278 [P25445-6] 64806 |
TopDownProteomicsi | P25445-7 [P25445-7] |
PTM databases
GlyConnecti | 773, 1 O-Linked glycan (1 site) |
GlyGeni | P25445, 7 sites, 4 O-linked glycans (4 sites) |
iPTMneti | P25445 |
PhosphoSitePlusi | P25445 |
SwissPalmi | P25445 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000026103, Expressed in right ovary and 226 other tissues |
ExpressionAtlasi | P25445, baseline and differential |
Genevisiblei | P25445, HS |
Organism-specific databases
HPAi | ENSG00000026103, Low tissue specificity |
Interactioni
Subunit structurei
Binds DAXX.
Interacts with HIPK3 (By similarity).
Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2 (PubMed:7538908, PubMed:10535980).
Interacts with BABAM2 and FEM1B (PubMed:10542291, PubMed:15465831).
Interacts with FADD (PubMed:21109225, PubMed:19118384).
Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity).
Interacts with CALM (PubMed:24914971). In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B. The interaction with BIRC2 and DDX3X is further enhanced upon receptor stimulation and accompanied by DDX3X and BIRC2 cleavage (PubMed:18846110).
By similarity8 PublicationsBinary interactionsi
P25445
Isoform 1 [P25445-1]
With | #Exp. | IntAct |
---|---|---|
CASP8 [Q14790] | 3 | EBI-15749113,EBI-78060 |
CAV1 [Q03135] | 3 | EBI-15749113,EBI-603614 |
FADD [Q13158] | 17 | EBI-15749113,EBI-494804 |
YES1 [P07947] | 2 | EBI-15749113,EBI-515331 |
GO - Molecular functioni
- calmodulin binding Source: UniProtKB
- identical protein binding Source: IntAct
- kinase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 106851, 140 interactors |
CORUMi | P25445 |
DIPi | DIP-924N |
IntActi | P25445, 84 interactors |
MINTi | P25445 |
STRINGi | 9606.ENSP00000347979 |
Miscellaneous databases
RNActi | P25445, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P25445 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P25445 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 47 – 83 | TNFR-Cys 1Add BLAST | 37 | |
Repeati | 84 – 127 | TNFR-Cys 2Add BLAST | 44 | |
Repeati | 128 – 166 | TNFR-Cys 3Add BLAST | 39 | |
Domaini | 230 – 314 | DeathPROSITE-ProRule annotationAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 212 – 317 | Interaction with HIPK3By similarityAdd BLAST | 106 | |
Regioni | 230 – 254 | Interaction with CALM1 PublicationAdd BLAST | 25 |
Domaini
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S0SV, Eukaryota |
GeneTreei | ENSGT00950000183126 |
HOGENOMi | CLU_067123_1_0_1 |
InParanoidi | P25445 |
OMAi | QDTKCRC |
OrthoDBi | 993446at2759 |
PhylomeDBi | P25445 |
TreeFami | TF333916 |
Family and domain databases
CDDi | cd08316, Death_FAS_TNFRSF6, 1 hit cd10579, TNFRSF6, 1 hit |
Gene3Di | 1.10.533.10, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR008063, Fas_rcpt IPR001368, TNFR/NGFR_Cys_rich_reg IPR033998, TNFRSF6_death IPR033999, TNFRSF6_N |
PANTHERi | PTHR46874, PTHR46874, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00020, TNFR_c6, 2 hits |
PRINTSi | PR01680, TNFACTORR6 |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00208, TNFR, 3 hits |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS00652, TNFR_NGFR_1, 2 hits PS50050, TNFR_NGFR_2, 2 hits |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE
60 70 80 90 100
GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK
110 120 130 140 150
CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE
160 170 180 190 200
HGIIKECTLT SNTKCKEEGS RSNLGWLCLL LLPIPLIVWV KRKEVQKTCR
210 220 230 240 250
KHRKENQGSH ESPTLNPETV AINLSDVDLS KYITTIAGVM TLSQVKGFVR
260 270 280 290 300
KNGVNEAKID EIKNDNVQDT AEQKVQLLRN WHQLHGKKEA YDTLIKDLKK
310 320 330
ANLCTLAEKI QTIILKDITS DSENSNFRNE IQSLV
The sequence of this isoform differs from the canonical sequence as follows:
66-103: GERKARDCTV...KAHFSSKCRR → DVNMESSRNA...GFVFFFCQFH
104-335: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
66-86: GERKARDCTVNGDEPDCVPCQ → DVNMESSRNAHSPATPSAKRK
87-335: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
112-149: GLEVEINCTR...CEHCDPCTKC → DVNMESSRNA...GFVFFFCQFH
150-335: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
112-132: GLEVEINCTRTQNTKCRCKPN → DVNMESSRNAHSPATPSAKRK
133-335: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C5Z8 | H7C5Z8_HUMAN | Tumor necrosis factor receptor supe... | FAS | 233 | Annotation score: | ||
K9J972 | K9J972_HUMAN | FAS receptor variant 9 | FAS | 197 | Annotation score: | ||
A0A087WTM9 | A0A087WTM9_HUMAN | Tumor necrosis factor receptor supe... | FAS | 244 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 224 | L → F in AAR08906 (Ref. 11) Curated | 1 | |
Sequence conflicti | 242 | L → P in CAR92543 (Ref. 9) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020008 | 16 | A → T1 PublicationCorresponds to variant dbSNP:rs3218619EnsemblClinVar. | 1 | |
Natural variantiVAR_013416 | 25 | A → T in non-Hodgkin lymphoma; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs606231364EnsemblClinVar. | 1 | |
Natural variantiVAR_013417 | 28 | T → A in ALPS1A; associated with autoimmune hepatitis type 2. 1 Publication | 1 | |
Natural variantiVAR_013418 | 82 | C → R in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_018321 | 118 | N → S in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913083EnsemblClinVar. | 1 | |
Natural variantiVAR_013419 | 121 | R → W in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs121913078EnsemblClinVar. | 1 | |
Natural variantiVAR_020009 | 122 | T → I1 PublicationCorresponds to variant dbSNP:rs3218614EnsemblClinVar. | 1 | |
Natural variantiVAR_018322 | 178 | C → R in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913084EnsemblClinVar. | 1 | |
Natural variantiVAR_013420 | 180 | L → F in non-Hodgkin lymphoma; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_013421 | 183 | P → L in non-Hodgkin lymphoma; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs758835365Ensembl. | 1 | |
Natural variantiVAR_052347 | 184 | I → V. Corresponds to variant dbSNP:rs28362322EnsemblClinVar. | 1 | |
Natural variantiVAR_013422 | 198 | T → I in non-Hodgkin lymphoma; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_013423 | 232 | Y → C in ALPS1A; no effect on interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913079EnsemblClinVar. | 1 | |
Natural variantiVAR_013424 | 241 | T → K in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs201072885Ensembl. | 1 | |
Natural variantiVAR_013425 | 241 | T → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913076EnsemblClinVar. | 1 | |
Natural variantiVAR_065128 | 249 | V → L in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_013426 | 250 | R → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913080EnsemblClinVar. | 1 | |
Natural variantiVAR_013427 | 250 | R → Q in ALPS1A; no effect on interaction with FADD. 2 Publications | 1 | |
Natural variantiVAR_065129 | 253 | G → D in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_065130 | 253 | G → S in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_018323 | 255 | N → D in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913082EnsemblClinVar. | 1 | |
Natural variantiVAR_013428 | 257 | A → D in ALPS1A; loss of interaction with FADD. 2 Publications | 1 | |
Natural variantiVAR_065131 | 259 | I → R in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_013429 | 260 | D → G in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_013431 | 260 | D → V in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 4 PublicationsCorresponds to variant dbSNP:rs28929498EnsemblClinVar. | 1 | |
Natural variantiVAR_013430 | 260 | D → Y in ALPS1A; loss of interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913086EnsemblClinVar. | 1 | |
Natural variantiVAR_058910 | 262 | I → S in ALPS1A. 1 Publication | 1 | |
Natural variantiVAR_013432 | 264 | N → K in non-Hodgkin lymphoma; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_013433 | 270 | T → I in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913081EnsemblClinVar. | 1 | |
Natural variantiVAR_065132 | 270 | T → K in ALPS1A; loss of interaction with FADD. 2 Publications | 1 | |
Natural variantiVAR_013434 | 272 | E → G in ALPS1A. 2 Publications | 1 | |
Natural variantiVAR_013435 | 272 | E → K in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 3 Publications | 1 | |
Natural variantiVAR_013436 | 278 | L → F in non-Hodgkin lymphoma; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_013437 | 299 | K → N in non-Hodgkin lymphoma; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_020942 | 305 | T → I1 PublicationCorresponds to variant dbSNP:rs3218611EnsemblClinVar. | 1 | |
Natural variantiVAR_013438 | 310 | I → S in ALPS1A. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006481 | 66 – 103 | GERKA…SKCRR → DVNMESSRNAHSPATPSAKR KDPDLTWGGFVFFFCQFH in isoform 2. 2 PublicationsAdd BLAST | 38 | |
Alternative sequenceiVSP_006483 | 66 – 86 | GERKA…CVPCQ → DVNMESSRNAHSPATPSAKR K in isoform 3. 2 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_006484 | 87 – 335 | Missing in isoform 3. 2 PublicationsAdd BLAST | 249 | |
Alternative sequenceiVSP_006482 | 104 – 335 | Missing in isoform 2. 2 PublicationsAdd BLAST | 232 | |
Alternative sequenceiVSP_006485 | 112 – 149 | GLEVE…PCTKC → DVNMESSRNAHSPATPSAKR KDPDLTWGGFVFFFCQFH in isoform 4. 2 PublicationsAdd BLAST | 38 | |
Alternative sequenceiVSP_006487 | 112 – 132 | GLEVE…RCKPN → DVNMESSRNAHSPATPSAKR K in isoform 5. 2 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_006488 | 133 – 335 | Missing in isoform 5. 2 PublicationsAdd BLAST | 203 | |
Alternative sequenceiVSP_006486 | 150 – 335 | Missing in isoform 4. 2 PublicationsAdd BLAST | 186 | |
Alternative sequenceiVSP_006489 | 169 – 189 | Missing in isoform 6. 2 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_045235 | 218 – 220 | ETV → MLT in isoform 7. 1 Publication | 3 | |
Alternative sequenceiVSP_045236 | 221 – 335 | Missing in isoform 7. 1 PublicationAdd BLAST | 115 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M67454 mRNA Translation: AAA63174.1 X63717 mRNA Translation: CAA45250.1 X83490 mRNA No translation available. X83491 mRNA No translation available. X83492 mRNA No translation available. X83493 mRNA No translation available. Z47993 mRNA Translation: CAA88031.1 Z47994 mRNA Translation: CAA88032.1 Z47995 mRNA Translation: CAA88033.1 Z66556 mRNA No translation available. Z70519 mRNA Translation: CAA94430.1 Z70520 mRNA Translation: CAA94431.1 AY495076 mRNA Translation: AAS76663.1 X89101 mRNA Translation: CAA61473.1 FM246458 mRNA Translation: CAR92543.1 AK290978 mRNA Translation: BAF83667.1 AY450925 Genomic DNA Translation: AAR08906.1 AL157394 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50151.1 BC012479 mRNA Translation: AAH12479.1 |
CCDSi | CCDS7393.1 [P25445-1] CCDS7394.1 [P25445-6] CCDS7395.1 [P25445-7] |
PIRi | A40036 I37383 I37384 S58662 |
RefSeqi | NP_000034.1, NM_000043.5 [P25445-1] NP_001307548.1, NM_001320619.1 NP_690610.1, NM_152871.3 [P25445-6] NP_690611.1, NM_152872.3 [P25445-7] |
Genome annotation databases
Ensembli | ENST00000355279; ENSP00000347426; ENSG00000026103 [P25445-7] ENST00000357339; ENSP00000349896; ENSG00000026103 [P25445-6] ENST00000479522; ENSP00000424113; ENSG00000026103 [P25445-3] ENST00000484444; ENSP00000420975; ENSG00000026103 [P25445-2] ENST00000488877; ENSP00000425159; ENSG00000026103 [P25445-4] ENST00000492756; ENSP00000422453; ENSG00000026103 [P25445-5] ENST00000494410; ENSP00000423755; ENSG00000026103 [P25445-4] ENST00000652046; ENSP00000498466; ENSG00000026103 |
GeneIDi | 355 |
KEGGi | hsa:355 |
MANE-Selecti | ENST00000652046.1; ENSP00000498466.1; NM_000043.6; NP_000034.1 |
UCSCi | uc001kfr.4, human [P25445-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Autoimmune Lymphoproliferative Syndrome Database (ALPSbase) Mutations in TNFRSF6 causing ALPS type Ia |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M67454 mRNA Translation: AAA63174.1 X63717 mRNA Translation: CAA45250.1 X83490 mRNA No translation available. X83491 mRNA No translation available. X83492 mRNA No translation available. X83493 mRNA No translation available. Z47993 mRNA Translation: CAA88031.1 Z47994 mRNA Translation: CAA88032.1 Z47995 mRNA Translation: CAA88033.1 Z66556 mRNA No translation available. Z70519 mRNA Translation: CAA94430.1 Z70520 mRNA Translation: CAA94431.1 AY495076 mRNA Translation: AAS76663.1 X89101 mRNA Translation: CAA61473.1 FM246458 mRNA Translation: CAR92543.1 AK290978 mRNA Translation: BAF83667.1 AY450925 Genomic DNA Translation: AAR08906.1 AL157394 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW50151.1 BC012479 mRNA Translation: AAH12479.1 |
CCDSi | CCDS7393.1 [P25445-1] CCDS7394.1 [P25445-6] CCDS7395.1 [P25445-7] |
PIRi | A40036 I37383 I37384 S58662 |
RefSeqi | NP_000034.1, NM_000043.5 [P25445-1] NP_001307548.1, NM_001320619.1 NP_690610.1, NM_152871.3 [P25445-6] NP_690611.1, NM_152872.3 [P25445-7] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DDF | NMR | - | A | 218-335 | [»] | |
2NA7 | NMR | - | A/B/C | 171-198 | [»] | |
3EWT | X-ray | 2.40 | E | 230-254 | [»] | |
3EZQ | X-ray | 2.73 | A/C/E/G/I/K/M/O | 223-335 | [»] | |
3THM | X-ray | 2.10 | F | 17-172 | [»] | |
3TJE | X-ray | 1.93 | F | 17-172 | [»] | |
SMRi | P25445 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106851, 140 interactors |
CORUMi | P25445 |
DIPi | DIP-924N |
IntActi | P25445, 84 interactors |
MINTi | P25445 |
STRINGi | 9606.ENSP00000347979 |
Chemistry databases
ChEMBLi | CHEMBL4523207 |
PTM databases
GlyConnecti | 773, 1 O-Linked glycan (1 site) |
GlyGeni | P25445, 7 sites, 4 O-linked glycans (4 sites) |
iPTMneti | P25445 |
PhosphoSitePlusi | P25445 |
SwissPalmi | P25445 |
Genetic variation databases
BioMutai | FAS |
DMDMi | 119833 |
Proteomic databases
EPDi | P25445 |
jPOSTi | P25445 |
MassIVEi | P25445 |
MaxQBi | P25445 |
PaxDbi | P25445 |
PeptideAtlasi | P25445 |
PRIDEi | P25445 |
ProteomicsDBi | 54273 [P25445-1] 54276 [P25445-4] 54277 [P25445-5] 54278 [P25445-6] 64806 |
TopDownProteomicsi | P25445-7 [P25445-7] |
Protocols and materials databases
ABCDi | P25445, 12 sequenced antibodies |
Antibodypediai | 4525, 2989 antibodies from 54 providers |
CPTCi | P25445, 2 antibodies |
DNASUi | 355 |
Genome annotation databases
Ensembli | ENST00000355279; ENSP00000347426; ENSG00000026103 [P25445-7] ENST00000357339; ENSP00000349896; ENSG00000026103 [P25445-6] ENST00000479522; ENSP00000424113; ENSG00000026103 [P25445-3] ENST00000484444; ENSP00000420975; ENSG00000026103 [P25445-2] ENST00000488877; ENSP00000425159; ENSG00000026103 [P25445-4] ENST00000492756; ENSP00000422453; ENSG00000026103 [P25445-5] ENST00000494410; ENSP00000423755; ENSG00000026103 [P25445-4] ENST00000652046; ENSP00000498466; ENSG00000026103 |
GeneIDi | 355 |
KEGGi | hsa:355 |
MANE-Selecti | ENST00000652046.1; ENSP00000498466.1; NM_000043.6; NP_000034.1 |
UCSCi | uc001kfr.4, human [P25445-1] |
Organism-specific databases
CTDi | 355 |
DisGeNETi | 355 |
GeneCardsi | FAS |
GeneReviewsi | FAS |
HGNCi | HGNC:11920, FAS |
HPAi | ENSG00000026103, Low tissue specificity |
MalaCardsi | FAS |
MIMi | 134637, gene 601859, phenotype |
neXtProti | NX_P25445 |
OpenTargetsi | ENSG00000026103 |
Orphaneti | 3261, Autoimmune lymphoproliferative syndrome 117, Behcet disease 3437, Vogt-Koyanagi-Harada disease |
PharmGKBi | PA36613 |
VEuPathDBi | HostDB:ENSG00000026103 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0SV, Eukaryota |
GeneTreei | ENSGT00950000183126 |
HOGENOMi | CLU_067123_1_0_1 |
InParanoidi | P25445 |
OMAi | QDTKCRC |
OrthoDBi | 993446at2759 |
PhylomeDBi | P25445 |
TreeFami | TF333916 |
Enzyme and pathway databases
PathwayCommonsi | P25445 |
Reactomei | R-HSA-140534, Caspase activation via Death Receptors in the presence of ligand R-HSA-3371378, Regulation by c-FLIP R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5218900, CASP8 activity is inhibited R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-69416, Dimerization of procaspase-8 R-HSA-75157, FasL/ CD95L signaling |
SignaLinki | P25445 |
SIGNORi | P25445 |
Miscellaneous databases
BioGRID-ORCSi | 355, 8 hits in 1038 CRISPR screens |
ChiTaRSi | FAS, human |
EvolutionaryTracei | P25445 |
GeneWikii | Fas_receptor |
GenomeRNAii | 355 |
Pharosi | P25445, Tbio |
PROi | PR:P25445 |
RNActi | P25445, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000026103, Expressed in right ovary and 226 other tissues |
ExpressionAtlasi | P25445, baseline and differential |
Genevisiblei | P25445, HS |
Family and domain databases
CDDi | cd08316, Death_FAS_TNFRSF6, 1 hit cd10579, TNFRSF6, 1 hit |
Gene3Di | 1.10.533.10, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR008063, Fas_rcpt IPR001368, TNFR/NGFR_Cys_rich_reg IPR033998, TNFRSF6_death IPR033999, TNFRSF6_N |
PANTHERi | PTHR46874, PTHR46874, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00020, TNFR_c6, 2 hits |
PRINTSi | PR01680, TNFACTORR6 |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00208, TNFR, 3 hits |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS00652, TNFR_NGFR_1, 2 hits PS50050, TNFR_NGFR_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TNR6_HUMAN | |
Accessioni | P25445Primary (citable) accession number: P25445 Secondary accession number(s): A9UJX4 Q6SSE9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 256 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references