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UniProtKB - P25445 (TNR6_HUMAN)

Entry version 253 (07 Apr 2021)
Sequence version 1 (01 May 1992)
Previous versions | rss
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Protein

Tumor necrosis factor receptor superfamily member 6

Gene

FAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Receptor
Biological processApoptosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P25445

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-140534, Caspase activation via Death Receptors in the presence of ligand
R-HSA-3371378, Regulation by c-FLIP
R-HSA-5213460, RIPK1-mediated regulated necrosis
R-HSA-5218900, CASP8 activity is inhibited
R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-69416, Dimerization of procaspase-8
R-HSA-75157, FasL/ CD95L signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P25445

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen: CD95
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAS
Synonyms:APT1, FAS1, TNFRSF6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11920, FAS

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		134637, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P25445

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000026103.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 173ExtracellularSequence analysisAdd BLAST148
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei174 – 190HelicalSequence analysisAdd BLAST17
Topological domaini191 – 335CytoplasmicSequence analysisAdd BLAST145

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autoimmune lymphoproliferative syndrome 1A (ALPS1A)13 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01341728T → A in ALPS1A; associated with autoimmune hepatitis type 2. 1 Publication1
Natural variantiVAR_01341882C → R in ALPS1A. 1 Publication1
Natural variantiVAR_013419121R → W in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs121913078EnsemblClinVar.1
Natural variantiVAR_013423232Y → C in ALPS1A; no effect on interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913079EnsemblClinVar.1
Natural variantiVAR_013424241T → K in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs201072885Ensembl.1
Natural variantiVAR_013425241T → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913076EnsemblClinVar.1
Natural variantiVAR_065128249V → L in ALPS1A. 1 Publication1
Natural variantiVAR_013426250R → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913080EnsemblClinVar.1
Natural variantiVAR_013427250R → Q in ALPS1A; no effect on interaction with FADD. 2 Publications1
Natural variantiVAR_065129253G → D in ALPS1A. 1 Publication1
Natural variantiVAR_065130253G → S in ALPS1A. 1 Publication1
Natural variantiVAR_013428257A → D in ALPS1A; loss of interaction with FADD. 2 Publications1
Natural variantiVAR_065131259I → R in ALPS1A. 1 Publication1
Natural variantiVAR_013429260D → G in ALPS1A. 1 Publication1
Natural variantiVAR_013431260D → V in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 4 PublicationsCorresponds to variant dbSNP:rs28929498EnsemblClinVar.1
Natural variantiVAR_013430260D → Y in ALPS1A; loss of interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913086EnsemblClinVar.1
Natural variantiVAR_058910262I → S in ALPS1A. 1 Publication1
Natural variantiVAR_013433270T → I in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913081EnsemblClinVar.1
Natural variantiVAR_065132270T → K in ALPS1A; loss of interaction with FADD. 2 Publications1
Natural variantiVAR_013434272E → G in ALPS1A. 2 Publications1
Natural variantiVAR_013435272E → K in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 3 Publications1
Natural variantiVAR_013438310I → S in ALPS1A. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi199C → V: Loss of palmitoylation. 1 Publication1
Mutagenesisi250R → E: Strongly decreased interaction with FADD. 1 Publication1
Mutagenesisi261E → K: Loss of interaction with FADD. 1 Publication1
Mutagenesisi283Q → K: Loss of interaction with FADD. 1 Publication1
Mutagenesisi287K → D: Strongly decreased interaction with FADD. 1 Publication1
Mutagenesisi291Y → D: Decreased interaction with FADD. 1 Publication1
Mutagenesisi313I → D: Constitutive activation. Promotes apoptosis, both in the presence and in the absence of stimulation by a ligand. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		355

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		FAS

MalaCards human disease database

More...MalaCardsi		FAS
MIMi601859, phenotype

Open Targets

More...OpenTargetsi		ENSG00000026103

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		3261, Autoimmune lymphoproliferative syndrome
117, Behcet disease
3437, Vogt-Koyanagi-Harada disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36613

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P25445, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAS

Domain mapping of disease mutations (DMDM)

More...DMDMi		119833

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003456326 – 335Tumor necrosis factor receptor superfamily member 6Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi28O-linked (GalNAc...) threonine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi59 ↔ 73PROSITE-ProRule annotation
Disulfide bondi63 ↔ 82PROSITE-ProRule annotation
Disulfide bondi85 ↔ 101PROSITE-ProRule annotation
Disulfide bondi104 ↔ 119PROSITE-ProRule annotation
Disulfide bondi107 ↔ 127PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi129 ↔ 143PROSITE-ProRule annotation
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 157PROSITE-ProRule annotation
Disulfide bondi149 ↔ 165PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi199S-palmitoyl cysteine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei209PhosphoserineCombined sources1
Modified residuei214PhosphothreonineBy similarity1
Modified residuei225PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated (PubMed:25301068). Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane (PubMed:25301068).1 Publication
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P25445

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P25445

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P25445

MaxQB - The MaxQuant DataBase

More...MaxQBi		P25445

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P25445

PeptideAtlas

More...PeptideAtlasi		P25445

PRoteomics IDEntifications database

More...PRIDEi		P25445

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54273 [P25445-1]
54274 [P25445-2]
54275 [P25445-3]
54276 [P25445-4]
54277 [P25445-5]
54278 [P25445-6]
64806

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P25445-7 [P25445-7]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		773, 1 O-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P25445, 7 sites, 3 O-linked glycans (4 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P25445

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P25445

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P25445

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000026103, Expressed in right ovary and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P25445, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P25445, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000026103, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DAXX.

Interacts with HIPK3 (By similarity).

Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2 (PubMed:7538908, PubMed:10535980).

Interacts with BABAM2 and FEM1B (PubMed:10542291, PubMed:15465831).

Interacts with FADD (PubMed:21109225, PubMed:19118384).

Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity).

Interacts with CALM (PubMed:24914971). In the absence of stimulation, interacts with BIRC2, DDX3X and GSK3B. The interaction with BIRC2 and DDX3X is further enhanced upon receptor stimulation and accompanied by DDX3X and BIRC2 cleavage (PubMed:18846110).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106851, 118 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P25445

Database of interacting proteins

More...DIPi		DIP-924N

Protein interaction database and analysis system

More...IntActi		P25445, 84 interactors

Molecular INTeraction database

More...MINTi		P25445

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347979

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P25445, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P25445

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P25445

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati47 – 83TNFR-Cys 1Add BLAST37
Repeati84 – 127TNFR-Cys 2Add BLAST44
Repeati128 – 166TNFR-Cys 3Add BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini230 – 314DeathPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni212 – 317Interaction with HIPK3By similarityAdd BLAST106
Regioni230 – 254Interaction with CALM1 PublicationAdd BLAST25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S0SV, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183126

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_067123_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P25445

Identification of Orthologs from Complete Genome Data

More...OMAi		QDTKCRC

Database of Orthologous Groups

More...OrthoDBi		993446at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P25445

TreeFam database of animal gene trees

More...TreeFami		TF333916

Family and domain databases

Conserved Domains Database

More...CDDi		cd08316, Death_FAS_TNFRSF6, 1 hit
cd10579, TNFRSF6, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR008063, Fas_rcpt
IPR001368, TNFR/NGFR_Cys_rich_reg
IPR033998, TNFRSF6_death
IPR033999, TNFRSF6_N

The PANTHER Classification System

More...PANTHERi		PTHR46874, PTHR46874, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00531, Death, 1 hit
PF00020, TNFR_c6, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01680, TNFACTORR6

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00005, DEATH, 1 hit
SM00208, TNFR, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS00652, TNFR_NGFR_1, 2 hits
PS50050, TNFR_NGFR_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P25445-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE 
        60         70         80         90        100
GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK 
       110        120        130        140        150
CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE 
       160        170        180        190        200
HGIIKECTLT SNTKCKEEGS RSNLGWLCLL LLPIPLIVWV KRKEVQKTCR 
       210        220        230        240        250
KHRKENQGSH ESPTLNPETV AINLSDVDLS KYITTIAGVM TLSQVKGFVR 
       260        270        280        290        300
KNGVNEAKID EIKNDNVQDT AEQKVQLLRN WHQLHGKKEA YDTLIKDLKK 
       310        320        330 
ANLCTLAEKI QTIILKDITS DSENSNFRNE IQSLV
Length:335
Mass (Da):37,732
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0139942535111410
GO
Isoform 2 (identifier: P25445-2) [UniParc]FASTAAdd to basket
Also known as: del2, D

The sequence of this isoform differs from the canonical sequence as follows:
     66-103: GERKARDCTV...KAHFSSKCRR → DVNMESSRNA...GFVFFFCQFH
     104-335: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:103
Mass (Da):11,435
Checksum:iF0DEA7F598AFBB00
GO
Isoform 3 (identifier: P25445-3) [UniParc]FASTAAdd to basket
Also known as: del3, E

The sequence of this isoform differs from the canonical sequence as follows:
     66-86: GERKARDCTVNGDEPDCVPCQ → DVNMESSRNAHSPATPSAKRK
     87-335: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:86
Mass (Da):9,390
Checksum:iD55B05CA4C2D1D49
GO
Isoform 4 (identifier: P25445-4) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     112-149: GLEVEINCTR...CEHCDPCTKC → DVNMESSRNA...GFVFFFCQFH
     150-335: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:149
Mass (Da):16,648
Checksum:i5061E69484678FC0
GO
Isoform 5 (identifier: P25445-5) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     112-132: GLEVEINCTRTQNTKCRCKPN → DVNMESSRNAHSPATPSAKRK
     133-335: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:132
Mass (Da):14,602
Checksum:iB10B6F86DE5E8690
GO
Isoform 6 (identifier: P25445-6) [UniParc]FASTAAdd to basket
Also known as: TMdel, A

The sequence of this isoform differs from the canonical sequence as follows:
     169-189: Missing.

Show »
Length:314
Mass (Da):35,386
Checksum:i83F8FAC62DB8B457
GO
Isoform 7 (identifier: P25445-7) [UniParc]FASTAAdd to basket
Also known as: FasExo8Del

The sequence of this isoform differs from the canonical sequence as follows:
     218-220: ETV → MLT
     221-335: Missing.

Note: Dominant negative isoform, resistant to Fas-mediated apoptosis.Curated
Show »
Length:220
Mass (Da):24,781
Checksum:iF4CD01DBF0649B39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5Z8H7C5Z8_HUMAN
Tumor necrosis factor receptor supe...
FAS
233Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K9J972K9J972_HUMAN
FAS receptor variant 9
FAS
197Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTM9A0A087WTM9_HUMAN
Tumor necrosis factor receptor supe...
FAS
244Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti224L → F in AAR08906 (Ref. 11) Curated1
Sequence conflicti242L → P in CAR92543 (Ref. 9) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02000816A → T1 PublicationCorresponds to variant dbSNP:rs3218619EnsemblClinVar.1
Natural variantiVAR_01341625A → T in non-Hodgkin lymphoma; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs606231364EnsemblClinVar.1
Natural variantiVAR_01341728T → A in ALPS1A; associated with autoimmune hepatitis type 2. 1 Publication1
Natural variantiVAR_01341882C → R in ALPS1A. 1 Publication1
Natural variantiVAR_018321118N → S in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913083EnsemblClinVar.1
Natural variantiVAR_013419121R → W in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs121913078EnsemblClinVar.1
Natural variantiVAR_020009122T → I1 PublicationCorresponds to variant dbSNP:rs3218614EnsemblClinVar.1
Natural variantiVAR_018322178C → R in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913084EnsemblClinVar.1
Natural variantiVAR_013420180L → F in non-Hodgkin lymphoma; somatic mutation. 1 Publication1
Natural variantiVAR_013421183P → L in non-Hodgkin lymphoma; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs758835365Ensembl.1
Natural variantiVAR_052347184I → V. Corresponds to variant dbSNP:rs28362322EnsemblClinVar.1
Natural variantiVAR_013422198T → I in non-Hodgkin lymphoma; somatic mutation. 1 Publication1
Natural variantiVAR_013423232Y → C in ALPS1A; no effect on interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913079EnsemblClinVar.1
Natural variantiVAR_013424241T → K in ALPS1A. 1 PublicationCorresponds to variant dbSNP:rs201072885Ensembl.1
Natural variantiVAR_013425241T → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913076EnsemblClinVar.1
Natural variantiVAR_065128249V → L in ALPS1A. 1 Publication1
Natural variantiVAR_013426250R → P in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913080EnsemblClinVar.1
Natural variantiVAR_013427250R → Q in ALPS1A; no effect on interaction with FADD. 2 Publications1
Natural variantiVAR_065129253G → D in ALPS1A. 1 Publication1
Natural variantiVAR_065130253G → S in ALPS1A. 1 Publication1
Natural variantiVAR_018323255N → D in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121913082EnsemblClinVar.1
Natural variantiVAR_013428257A → D in ALPS1A; loss of interaction with FADD. 2 Publications1
Natural variantiVAR_065131259I → R in ALPS1A. 1 Publication1
Natural variantiVAR_013429260D → G in ALPS1A. 1 Publication1
Natural variantiVAR_013431260D → V in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 4 PublicationsCorresponds to variant dbSNP:rs28929498EnsemblClinVar.1
Natural variantiVAR_013430260D → Y in ALPS1A; loss of interaction with FADD. 2 PublicationsCorresponds to variant dbSNP:rs121913086EnsemblClinVar.1
Natural variantiVAR_058910262I → S in ALPS1A. 1 Publication1
Natural variantiVAR_013432264N → K in non-Hodgkin lymphoma; somatic mutation. 1 Publication1
Natural variantiVAR_013433270T → I in ALPS1A. 2 PublicationsCorresponds to variant dbSNP:rs121913081EnsemblClinVar.1
Natural variantiVAR_065132270T → K in ALPS1A; loss of interaction with FADD. 2 Publications1
Natural variantiVAR_013434272E → G in ALPS1A. 2 Publications1
Natural variantiVAR_013435272E → K in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 3 Publications1
Natural variantiVAR_013436278L → F in non-Hodgkin lymphoma; somatic mutation. 1 Publication1
Natural variantiVAR_013437299K → N in non-Hodgkin lymphoma; somatic mutation. 1 Publication1
Natural variantiVAR_020942305T → I1 PublicationCorresponds to variant dbSNP:rs3218611EnsemblClinVar.1
Natural variantiVAR_013438310I → S in ALPS1A. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00648166 – 103GERKA…SKCRR → DVNMESSRNAHSPATPSAKR KDPDLTWGGFVFFFCQFH in isoform 2. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_00648366 – 86GERKA…CVPCQ → DVNMESSRNAHSPATPSAKR K in isoform 3. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_00648487 – 335Missing in isoform 3. 2 PublicationsAdd BLAST249
Alternative sequenceiVSP_006482104 – 335Missing in isoform 2. 2 PublicationsAdd BLAST232
Alternative sequenceiVSP_006485112 – 149GLEVE…PCTKC → DVNMESSRNAHSPATPSAKR KDPDLTWGGFVFFFCQFH in isoform 4. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_006487112 – 132GLEVE…RCKPN → DVNMESSRNAHSPATPSAKR K in isoform 5. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_006488133 – 335Missing in isoform 5. 2 PublicationsAdd BLAST203
Alternative sequenceiVSP_006486150 – 335Missing in isoform 4. 2 PublicationsAdd BLAST186
Alternative sequenceiVSP_006489169 – 189Missing in isoform 6. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_045235218 – 220ETV → MLT in isoform 7. 1 Publication3
Alternative sequenceiVSP_045236221 – 335Missing in isoform 7. 1 PublicationAdd BLAST115

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M67454 mRNA Translation: AAA63174.1
X63717 mRNA Translation: CAA45250.1
X83490 mRNA No translation available.
X83491 mRNA No translation available.
X83492 mRNA No translation available.
X83493 mRNA No translation available.
Z47993 mRNA Translation: CAA88031.1
Z47994 mRNA Translation: CAA88032.1
Z47995 mRNA Translation: CAA88033.1
Z66556 mRNA No translation available.
Z70519 mRNA Translation: CAA94430.1
Z70520 mRNA Translation: CAA94431.1
AY495076 mRNA Translation: AAS76663.1
X89101 mRNA Translation: CAA61473.1
FM246458 mRNA Translation: CAR92543.1
AK290978 mRNA Translation: BAF83667.1
AY450925 Genomic DNA Translation: AAR08906.1
AL157394 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50151.1
BC012479 mRNA Translation: AAH12479.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7393.1 [P25445-1]
CCDS7394.1 [P25445-6]
CCDS7395.1 [P25445-7]

Protein sequence database of the Protein Information Resource

More...PIRi		A40036
I37383
I37384
S58662

NCBI Reference Sequences

More...RefSeqi		NP_000034.1, NM_000043.5 [P25445-1]
NP_001307548.1, NM_001320619.1
NP_690610.1, NM_152871.3 [P25445-6]
NP_690611.1, NM_152872.3 [P25445-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355279; ENSP00000347426; ENSG00000026103 [P25445-7]
ENST00000357339; ENSP00000349896; ENSG00000026103 [P25445-6]
ENST00000479522; ENSP00000424113; ENSG00000026103 [P25445-3]
ENST00000484444; ENSP00000420975; ENSG00000026103 [P25445-2]
ENST00000488877; ENSP00000425159; ENSG00000026103 [P25445-4]
ENST00000492756; ENSP00000422453; ENSG00000026103 [P25445-5]
ENST00000494410; ENSP00000423755; ENSG00000026103 [P25445-4]
ENST00000652046; ENSP00000498466; ENSG00000026103 [P25445-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		355

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:355

UCSC genome browser

More...UCSCi		uc001kfr.4, human [P25445-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Autoimmune Lymphoproliferative Syndrome Database (ALPSbase)

Mutations in TNFRSF6 causing ALPS type Ia

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M67454 mRNA Translation: AAA63174.1
X63717 mRNA Translation: CAA45250.1
X83490 mRNA No translation available.
X83491 mRNA No translation available.
X83492 mRNA No translation available.
X83493 mRNA No translation available.
Z47993 mRNA Translation: CAA88031.1
Z47994 mRNA Translation: CAA88032.1
Z47995 mRNA Translation: CAA88033.1
Z66556 mRNA No translation available.
Z70519 mRNA Translation: CAA94430.1
Z70520 mRNA Translation: CAA94431.1
AY495076 mRNA Translation: AAS76663.1
X89101 mRNA Translation: CAA61473.1
FM246458 mRNA Translation: CAR92543.1
AK290978 mRNA Translation: BAF83667.1
AY450925 Genomic DNA Translation: AAR08906.1
AL157394 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50151.1
BC012479 mRNA Translation: AAH12479.1
CCDSiCCDS7393.1 [P25445-1]
CCDS7394.1 [P25445-6]
CCDS7395.1 [P25445-7]
PIRiA40036
I37383
I37384
S58662
RefSeqiNP_000034.1, NM_000043.5 [P25445-1]
NP_001307548.1, NM_001320619.1
NP_690610.1, NM_152871.3 [P25445-6]
NP_690611.1, NM_152872.3 [P25445-7]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BZImodel-A1-335[»]
1DDFNMR-A218-335[»]
2NA7NMR-A/B/C171-198[»]
3EWTX-ray2.40E230-254[»]
3EZQX-ray2.73A/C/E/G/I/K/M/O223-335[»]
3THMX-ray2.10F17-172[»]
3TJEX-ray1.93F17-172[»]
SMRiP25445
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106851, 118 interactors
CORUMiP25445
DIPiDIP-924N
IntActiP25445, 84 interactors
MINTiP25445
STRINGi9606.ENSP00000347979

PTM databases

GlyConnecti773, 1 O-Linked glycan (1 site)
GlyGeniP25445, 7 sites, 3 O-linked glycans (4 sites)
iPTMnetiP25445
PhosphoSitePlusiP25445
SwissPalmiP25445

Genetic variation databases

BioMutaiFAS
DMDMi119833

Proteomic databases

EPDiP25445
jPOSTiP25445
MassIVEiP25445
MaxQBiP25445
PaxDbiP25445
PeptideAtlasiP25445
PRIDEiP25445
ProteomicsDBi54273 [P25445-1]
54274 [P25445-2]
54275 [P25445-3]
54276 [P25445-4]
54277 [P25445-5]
54278 [P25445-6]
64806
TopDownProteomicsiP25445-7 [P25445-7]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P25445, 7 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4525, 2873 antibodies

The CPTC Antibody Portal

More...CPTCi		P25445, 1 antibody

The DNASU plasmid repository

More...DNASUi		355

Genome annotation databases

EnsembliENST00000355279; ENSP00000347426; ENSG00000026103 [P25445-7]
ENST00000357339; ENSP00000349896; ENSG00000026103 [P25445-6]
ENST00000479522; ENSP00000424113; ENSG00000026103 [P25445-3]
ENST00000484444; ENSP00000420975; ENSG00000026103 [P25445-2]
ENST00000488877; ENSP00000425159; ENSG00000026103 [P25445-4]
ENST00000492756; ENSP00000422453; ENSG00000026103 [P25445-5]
ENST00000494410; ENSP00000423755; ENSG00000026103 [P25445-4]
ENST00000652046; ENSP00000498466; ENSG00000026103 [P25445-1]
GeneIDi355
KEGGihsa:355
UCSCiuc001kfr.4, human [P25445-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		355
DisGeNETi355

GeneCards: human genes, protein and diseases

More...GeneCardsi		FAS
GeneReviewsiFAS
HGNCiHGNC:11920, FAS
HPAiENSG00000026103, Low tissue specificity
MalaCardsiFAS
MIMi134637, gene
601859, phenotype
neXtProtiNX_P25445
OpenTargetsiENSG00000026103
Orphaneti3261, Autoimmune lymphoproliferative syndrome
117, Behcet disease
3437, Vogt-Koyanagi-Harada disease
PharmGKBiPA36613
VEuPathDBiHostDB:ENSG00000026103.19

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S0SV, Eukaryota
GeneTreeiENSGT00950000183126
HOGENOMiCLU_067123_1_0_1
InParanoidiP25445
OMAiQDTKCRC
OrthoDBi993446at2759
PhylomeDBiP25445
TreeFamiTF333916

Enzyme and pathway databases

PathwayCommonsiP25445
ReactomeiR-HSA-140534, Caspase activation via Death Receptors in the presence of ligand
R-HSA-3371378, Regulation by c-FLIP
R-HSA-5213460, RIPK1-mediated regulated necrosis
R-HSA-5218900, CASP8 activity is inhibited
R-HSA-6803211, TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-69416, Dimerization of procaspase-8
R-HSA-75157, FasL/ CD95L signaling
SIGNORiP25445

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		355, 8 hits in 987 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAS, human
EvolutionaryTraceiP25445

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Fas_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		355
PharosiP25445, Tbio

Protein Ontology

More...PROi		PR:P25445
RNActiP25445, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000026103, Expressed in right ovary and 225 other tissues
ExpressionAtlasiP25445, baseline and differential
GenevisibleiP25445, HS

Family and domain databases

CDDicd08316, Death_FAS_TNFRSF6, 1 hit
cd10579, TNFRSF6, 1 hit
InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR008063, Fas_rcpt
IPR001368, TNFR/NGFR_Cys_rich_reg
IPR033998, TNFRSF6_death
IPR033999, TNFRSF6_N
PANTHERiPTHR46874, PTHR46874, 1 hit
PfamiView protein in Pfam
PF00531, Death, 1 hit
PF00020, TNFR_c6, 2 hits
PRINTSiPR01680, TNFACTORR6
SMARTiView protein in SMART
SM00005, DEATH, 1 hit
SM00208, TNFR, 3 hits
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS00652, TNFR_NGFR_1, 2 hits
PS50050, TNFR_NGFR_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25445
Secondary accession number(s): A9UJX4
, B6VNV4, Q14292, Q14293, Q14294, Q14295, Q16652, Q5T9P1, Q5T9P2, Q5T9P3, Q6SSE9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 7, 2021
This is version 253 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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