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Entry version 191 (12 Aug 2020)
Sequence version 3 (23 Apr 2003)
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Protein

POU domain, class 2, transcription factor 1

Gene

Pou2f1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi382 – 441HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6807505, RNA polymerase II transcribes snRNA genes
R-MMU-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-MMU-9018519, Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
POU domain, class 2, transcription factor 1
Alternative name(s):
NF-A1
Octamer-binding protein 1
Short name:
Oct-1
Octamer-binding transcription factor 1
Short name:
OTF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pou2f1
Synonyms:Oct-1, Otf-1, Otf1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:101898, Pou2f1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001007081 – 770POU domain, class 2, transcription factor 1Add BLAST770

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei271PhosphothreonineBy similarity1
Modified residuei277PhosphothreonineBy similarity1
Modified residuei284PhosphoserineBy similarity1
Modified residuei388PhosphoserineBy similarity1
Modified residuei451PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PRKDC.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P25425

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P25425

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P25425

PeptideAtlas

More...
PeptideAtlasi
P25425

PRoteomics IDEntifications database

More...
PRIDEi
P25425

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P25425

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P25425

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. However, isoforms 4 and 5 are only expressed in lymphocytes.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026565, Expressed in secondary oocyte and 292 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P25425, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POU2AF1; the interaction increases POU2F1 transactivation activity.

Interacts with NR3C1, AR, PGR and HCFC1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
202301, 16 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000124738

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P25425, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P25425

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini281 – 355POU-specificPROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3802, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157831

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013065_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P25425

KEGG Orthology (KO)

More...
KOi
K09364

Identification of Orthologs from Complete Genome Data

More...
OMAi
IKAIFPC

Database of Orthologous Groups

More...
OrthoDBi
873012at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P25425

TreeFam database of animal gene trees

More...
TreeFami
TF316413

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
IPR013847, POU
IPR000327, POU_dom
IPR000972, TF_octamer

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 1 hit
PF00157, Pou, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00029, OCTAMER
PR00028, POUDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 1 hit
SM00352, POU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00035, POU_1, 1 hit
PS00465, POU_2, 1 hit
PS51179, POU_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P25425-1) [UniParc]FASTAAdd to basket
Also known as: OCT-1A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNNPSETNKS SMESEDASTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH
60 70 80 90 100
LHQVQLAGTS LQAAAQSLNV QSKSSEESGD SQQSSQPSSQ PPSVQSAIPQ
110 120 130 140 150
TQLMLAGGQI TGLTLTPAQQ QLLLQQAQAQ AQLLAAAVQQ HSASQQHSAA
160 170 180 190 200
GATISASAAT PMTQIPLSQP IQIAQDLQQL QQLQQQNLNL QQFVLVHPTT
210 220 230 240 250
NLQPAQFIIS QTPQGQQGLL QAQNLLTQLP QQSQANLLQP QPSITLTSQP
260 270 280 290 300
TTPTRTIAAA SVQTLPQSQS TPKRIDTPSL EEPSDLEELE QFAKTFKQRR
310 320 330 340 350
IKLGFTQGDV GLAMGKLYGN DFSQTTISRF EALNLSFKNM CKLKPLLEKW
360 370 380 390 400
LNDAENLSSD STASSPSALN SPGLGAEGLN RRRKKRTSIE TNIRVALEKS
410 420 430 440 450
FMENQKPTSE DITLIAEQLN MEKEVIRVWF CNRRQKEKRI NPPSSGGTSS
460 470 480 490 500
SPIKAIFPSP ASLVATTPSL VTSSTATTLT VNPVLPLTSA AVTNLSLTDQ
510 520 530 540 550
DLRRGCSWEV LRSLPDRVTT TAGTTDSTSN NNTATVISTA PPASSAVTSP
560 570 580 590 600
SLSPSPSASA STSEASSASE TNTTQTTSTP LPSPLGASQV MVTTPGLQTA
610 620 630 640 650
AAALQGAAQL PANASLAAMA AAAGLSPGLM APSQFAAGGA LLSLSPGTLG
660 670 680 690 700
SALSPALMSN STLATIQALA SSGSLPITSL DATGNLVFAN AGGAPNIVTA
710 720 730 740 750
PLFLNPQNLS LLTSNPVSLV SAAAASTGNS APTASLHASS TSTESIQSSL
760 770
FTVASASGPA STTTAASKAQ
Length:770
Mass (Da):79,547
Last modified:April 23, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB45CDBE632853FE9
GO
Isoform 2 (identifier: P25425-2) [UniParc]FASTAAdd to basket
Also known as: OCT-1B

The sequence of this isoform differs from the canonical sequence as follows:
     499-522: Missing.

Show »
Length:746
Mass (Da):76,790
Checksum:iA19E2D4CB6C147A2
GO
Isoform 3 (identifier: P25425-3) [UniParc]FASTAAdd to basket
Also known as: OCT-1C

The sequence of this isoform differs from the canonical sequence as follows:
     499-522: Missing.
     717-725: VSLVSAAAA → DCFMDWRTF
     726-770: Missing.

Show »
Length:701
Mass (Da):72,983
Checksum:i85CEC91D2241D0D9
GO
Isoform 4 (identifier: P25425-4) [UniParc]FASTAAdd to basket
Also known as: OCT-1R

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLDCSDCVLDSRM
     54-71: Missing.
     499-522: Missing.
     639-770: Missing.

Show »
Length:608
Mass (Da):63,780
Checksum:iED52028C67A99D5C
GO
Isoform 5 (identifier: P25425-5) [UniParc]FASTAAdd to basket
Also known as: OCT-1L

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLDCSDCVLDSRM
     499-522: Missing.

Show »
Length:758
Mass (Da):78,128
Checksum:iEF08D83A224B2418
GO
Isoform 6 (identifier: P25425-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-691: Missing.

Show »
Length:746
Mass (Da):77,274
Checksum:iAEBEE16A471595D4
GO
Isoform 7 (identifier: P25425-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     639-641: GAL → SCF
     642-770: Missing.

Show »
Length:641
Mass (Da):67,317
Checksum:iBD83AEBFA5C51643
GO
Isoform 8 (identifier: P25425-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-691: Missing.
     717-725: VSLVSAAAA → DCFMDWRTF
     726-770: Missing.

Show »
Length:701
Mass (Da):73,467
Checksum:iF1092FC5322C5061
GO
Isoform 9 (identifier: P25425-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     639-647: GALLSLSPG → IASWIGELS
     648-770: Missing.

Show »
Length:647
Mass (Da):67,937
Checksum:iD59952DB1E8D61F0
GO
Isoform 10 (identifier: P25425-10) [UniParc]FASTAAdd to basket
Also known as: OCT-1Z

The sequence of this isoform differs from the canonical sequence as follows:
     499-522: DQDLRRGCSWEVLRSLPDRVTTTA → GKQQPAYRLVSTVPVRFLWRTARS
     523-770: Missing.

Show »
Length:522
Mass (Da):56,193
Checksum:i6ABAAA323C1F873B
GO
Isoform 11 (identifier: P25425-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLDCSDCVLDSRM
     639-770: Missing.

Show »
Length:650
Mass (Da):68,318
Checksum:i649DDF3D7105D736
GO
Isoform 12 (identifier: P25425-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MADGGAASQDESSAAAAAAADSR

Show »
Length:792
Mass (Da):81,479
Checksum:i96B1978640108D06
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1Z4A0A0R4J1Z4_MOUSE
POU domain protein
Pou2f1
793Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQL7F8VQL7_MOUSE
POU domain protein
Pou2f1
782Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q6Z8E9Q6Z8_MOUSE
POU domain protein
Pou2f1
769Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I1E4X2I1E4X2_MOUSE
POU domain protein
Pou2f1
706Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQE0A0A0A0MQE0_MOUSE
POU domain protein
Pou2f1
758Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQM6A0A0A0MQM6_MOUSE
POU domain protein
Pou2f1
580Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKX3H3BKX3_MOUSE
POU domain, class 2, transcription ...
Pou2f1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWN1A0A0A6YWN1_MOUSE
POU domain, class 2, transcription ...
Pou2f1
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXQ7V9GXQ7_MOUSE
POU domain, class 2, transcription ...
Pou2f1
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VFH6A0A1Y7VFH6_MOUSE
POU domain, class 2, transcription ...
Pou2f1
7Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43Q → L in CAA39679 (PubMed:1561098).Curated1
Sequence conflicti70V → I in CAC34943 (PubMed:11683265).Curated1
Sequence conflicti129A → P (PubMed:7711063).Curated1
Sequence conflicti168S → C in CAD35743 (Ref. 6) Curated1
Sequence conflicti188L → H in CAC34943 (PubMed:11683265).Curated1
Sequence conflicti234Q → R in CAC34943 (PubMed:11683265).Curated1
Sequence conflicti333L → W (PubMed:8376772).Curated1
Sequence conflicti360D → G in CAC34943 (PubMed:11683265).Curated1
Sequence conflicti368A → D (PubMed:1970171).Curated1
Sequence conflicti441N → D in CAC34943 (PubMed:11683265).Curated1
Sequence conflicti474S → G in CAC34943 (PubMed:11683265).Curated1
Sequence conflicti596G → D in CAC34943 (PubMed:11683265).Curated1
Sequence conflicti608A → G in CAA48422 (PubMed:8441632).Curated1
Sequence conflicti608A → G in CAA48423 (PubMed:8441632).Curated1
Sequence conflicti608A → G in CAA48424 (PubMed:8441632).Curated1
Sequence conflicti609Q → R in CAC34943 (PubMed:11683265).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0134031M → MADGGAASQDESSAAAAAAA DSR in isoform 12. 1 Publication1
Alternative sequenceiVSP_0072711M → MLDCSDCVLDSRM in isoform 4, isoform 5 and isoform 11. 3 Publications1
Alternative sequenceiVSP_00727254 – 71Missing in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_013404499 – 522DQDLR…VTTTA → GKQQPAYRLVSTVPVRFLWR TARS in isoform 10. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_002321499 – 522Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 5 PublicationsAdd BLAST24
Alternative sequenceiVSP_013405523 – 770Missing in isoform 10. 1 PublicationAdd BLAST248
Alternative sequenceiVSP_007273639 – 770Missing in isoform 4 and isoform 11. 2 PublicationsAdd BLAST132
Alternative sequenceiVSP_007274639 – 647GALLSLSPG → IASWIGELS in isoform 9. 1 Publication9
Alternative sequenceiVSP_007276639 – 641GAL → SCF in isoform 7. 1 Publication3
Alternative sequenceiVSP_007277642 – 770Missing in isoform 7. 1 PublicationAdd BLAST129
Alternative sequenceiVSP_007275648 – 770Missing in isoform 9. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_007278668 – 691Missing in isoform 6 and isoform 8. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_002322717 – 725VSLVSAAAA → DCFMDWRTF in isoform 3 and isoform 8. 2 Publications9
Alternative sequenceiVSP_002323726 – 770Missing in isoform 3 and isoform 8. 2 PublicationsAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X68362 mRNA Translation: CAA48422.1
X68363 mRNA Translation: CAA48423.1
X68364 mRNA Translation: CAA48424.1
X56230 mRNA Translation: CAA39679.1
AJ296212 mRNA Translation: CAC34943.1
AF508939 mRNA Translation: AAM34281.1
AY177625 mRNA Translation: AAO45298.1
AJ489474 mRNA Translation: CAD35743.1
AK028237 mRNA Translation: BAC25832.1
S65461 mRNA Translation: AAB28234.1
X70324 mRNA Translation: CAA49791.1
X70325 mRNA Translation: CAA49792.1
X51958 mRNA Translation: CAA36217.1
AF095458 mRNA Translation: AAD25325.1
AF095459 mRNA Translation: AAD25326.1
AF095460 mRNA Translation: AAD25327.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15444.1 [P25425-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
I56187
S30293

NCBI Reference Sequences

More...
RefSeqi
NP_035267.2, NM_011137.3
NP_945151.2, NM_198933.3 [P25425-5]
XP_006496767.1, XM_006496704.2 [P25425-1]
XP_011237069.1, XM_011238767.2 [P25425-1]
XP_011237071.1, XM_011238769.2
XP_017174849.1, XM_017319360.1 [P25425-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000069609; ENSMUSP00000064000; ENSMUSG00000026565 [P25425-5]
ENSMUST00000111429; ENSMUSP00000107057; ENSMUSG00000026565 [P25425-2]
ENSMUST00000184643; ENSMUSP00000138962; ENSMUSG00000026565 [P25425-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18986

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18986

UCSC genome browser

More...
UCSCi
uc007djv.1, mouse [P25425-6]
uc007djx.2, mouse [P25425-5]
uc007dkb.2, mouse [P25425-4]
uc007dkc.2, mouse [P25425-11]
uc007dke.1, mouse [P25425-10]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68362 mRNA Translation: CAA48422.1
X68363 mRNA Translation: CAA48423.1
X68364 mRNA Translation: CAA48424.1
X56230 mRNA Translation: CAA39679.1
AJ296212 mRNA Translation: CAC34943.1
AF508939 mRNA Translation: AAM34281.1
AY177625 mRNA Translation: AAO45298.1
AJ489474 mRNA Translation: CAD35743.1
AK028237 mRNA Translation: BAC25832.1
S65461 mRNA Translation: AAB28234.1
X70324 mRNA Translation: CAA49791.1
X70325 mRNA Translation: CAA49792.1
X51958 mRNA Translation: CAA36217.1
AF095458 mRNA Translation: AAD25325.1
AF095459 mRNA Translation: AAD25326.1
AF095460 mRNA Translation: AAD25327.1
CCDSiCCDS15444.1 [P25425-5]
PIRiI56187
S30293
RefSeqiNP_035267.2, NM_011137.3
NP_945151.2, NM_198933.3 [P25425-5]
XP_006496767.1, XM_006496704.2 [P25425-1]
XP_011237069.1, XM_011238767.2 [P25425-1]
XP_011237071.1, XM_011238769.2
XP_017174849.1, XM_017319360.1 [P25425-2]

3D structure databases

SMRiP25425
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi202301, 16 interactors
STRINGi10090.ENSMUSP00000124738

PTM databases

iPTMnetiP25425
PhosphoSitePlusiP25425

Proteomic databases

jPOSTiP25425
MaxQBiP25425
PaxDbiP25425
PeptideAtlasiP25425
PRIDEiP25425

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3616, 621 antibodies

The DNASU plasmid repository

More...
DNASUi
18986

Genome annotation databases

EnsembliENSMUST00000069609; ENSMUSP00000064000; ENSMUSG00000026565 [P25425-5]
ENSMUST00000111429; ENSMUSP00000107057; ENSMUSG00000026565 [P25425-2]
ENSMUST00000184643; ENSMUSP00000138962; ENSMUSG00000026565 [P25425-3]
GeneIDi18986
KEGGimmu:18986
UCSCiuc007djv.1, mouse [P25425-6]
uc007djx.2, mouse [P25425-5]
uc007dkb.2, mouse [P25425-4]
uc007dkc.2, mouse [P25425-11]
uc007dke.1, mouse [P25425-10]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5451
MGIiMGI:101898, Pou2f1

Phylogenomic databases

eggNOGiKOG3802, Eukaryota
GeneTreeiENSGT00940000157831
HOGENOMiCLU_013065_4_0_1
InParanoidiP25425
KOiK09364
OMAiIKAIFPC
OrthoDBi873012at2759
PhylomeDBiP25425
TreeFamiTF316413

Enzyme and pathway databases

ReactomeiR-MMU-6807505, RNA polymerase II transcribes snRNA genes
R-MMU-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-MMU-9018519, Estrogen-dependent gene expression

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
18986, 2 hits in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pou2f1, mouse

Protein Ontology

More...
PROi
PR:P25425
RNActiP25425, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026565, Expressed in secondary oocyte and 292 other tissues
GenevisibleiP25425, MM

Family and domain databases

CDDicd00086, homeodomain, 1 hit
Gene3Di1.10.260.40, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
IPR013847, POU
IPR000327, POU_dom
IPR000972, TF_octamer
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF00157, Pou, 1 hit
PRINTSiPR00029, OCTAMER
PR00028, POUDOMAIN
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SM00352, POU, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit
PS00035, POU_1, 1 hit
PS00465, POU_2, 1 hit
PS51179, POU_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPO2F1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25425
Secondary accession number(s): Q61994
, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: April 23, 2003
Last modified: August 12, 2020
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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