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Protein

Alcohol dehydrogenase 1A

Gene
N/A
Organism
Saara hardwickii (Indian spiny-tailed lizard) (Uromastyx hardwickii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

In U.hardwickii there are two isozymes of alcohol dehydrogenase I.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi97Zinc 2By similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi111Zinc 2By similarity1
Metal bindingi174Zinc 1; catalyticBy similarity1
Binding sitei223NADBy similarity1
Binding sitei228NADBy similarity1
Binding sitei370NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 204NADBy similarity6
Nucleotide bindingi293 – 295NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1A (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase I-A
Short name:
ADH IA
OrganismiSaara hardwickii (Indian spiny-tailed lizard) (Uromastyx hardwickii)
Taxonomic identifieri40250 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaAcrodontaAgamidaeUromastycinaeSaara

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606771 – 375Alcohol dehydrogenase 1AAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylglycine1 Publication1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP25405

Interactioni

Subunit structurei

Multimeric (with different ratios of monomers).

Structurei

3D structure databases

ProteinModelPortaliP25405
SMRiP25405
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P25405-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GTAGKVIKCK AAIAWEIKKP LSIEQIEVAP PKAHEVRIKI LATGICRSDD
60 70 80 90 100
HVISGAFKMP LPMVLGHEAA GVVESVGEGV TCVKPGDKVI PLFVPQCGKC
110 120 130 140 150
SSCRSTRGNL CTSNDLSAAT GLMPDGTSRF TCKGKSLHHF ISTSSFTEYT
160 170 180 190 200
VVHENSVVKI DAAAPLEKVC LIGCGFSTGY GAAVETAKVE PGSTCAVFGL
210 220 230 240 250
GGVGLSAVMG CKAAGASRII GVDINKDKFP KAKEMGATEC VNPLDYKKPI
260 270 280 290 300
NEVLFDLTGG EGVDYSFEVI GRTDTMTAAL ASCHMDYGTS IIVGLPPSAS
310 320 330 340 350
EITFSPGLIF TGRTWKGSVF GGWKSKDSVP RLVSDFMQKK FSLDPLITHT
360 370
MPFDKINEGF ELLRAGKSIR SVLLF
Length:375
Mass (Da):39,663
Last modified:February 1, 1996 - v2
Checksum:iF315BB777996D906
GO

Sequence databases

PIRiS62638

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiS62638

3D structure databases

ProteinModelPortaliP25405
SMRiP25405
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP25405

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000195

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1A_SAAHA
AccessioniPrimary (citable) accession number: P25405
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1996
Last modified: November 22, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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