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Protein

40S ribosomal protein S12

Gene

RPS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S12
Alternative name(s):
Small ribosomal subunit protein eS121 Publication
Gene namesi
Name:RPS12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112306.7
HGNCiHGNC:10385 RPS12
MIMi603660 gene
neXtProtiNX_P25398

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6206
OpenTargetsiENSG00000112306
PharmGKBiPA34784

Polymorphism and mutation databases

BioMutaiRPS12
DMDMi224471878

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001223232 – 13240S ribosomal protein S12Add BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei129N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP25398
MaxQBiP25398
PaxDbiP25398
PeptideAtlasiP25398
PRIDEiP25398
ProteomicsDBi54270
TopDownProteomicsiP25398

2D gel databases

UCD-2DPAGEiP25398

PTM databases

iPTMnetiP25398
PhosphoSitePlusiP25398
SwissPalmiP25398

Expressioni

Gene expression databases

BgeeiENSG00000112306
CleanExiHS_RPS12
GenevisibleiP25398 HS

Organism-specific databases

HPAiHPA006124
HPA006365

Interactioni

Protein-protein interaction databases

BioGridi112120, 129 interactors
CORUMiP25398
IntActiP25398, 25 interactors
MINTiP25398
STRINGi9606.ENSP00000230050

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00AM1-132[»]
5A2Qelectron microscopy3.90M1-132[»]
5AJ0electron microscopy3.50BM1-132[»]
5FLXelectron microscopy3.90M1-132[»]
5LKSelectron microscopy3.60SM1-132[»]
5OA3electron microscopy4.30M1-132[»]
5T2Celectron microscopy3.60AM1-132[»]
5VYCX-ray6.00M1/M2/M3/M4/M5/M61-132[»]
6EK0electron microscopy2.90SM1-132[»]
6FECelectron microscopy6.30r9-132[»]
ProteinModelPortaliP25398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3406 Eukaryota
COG1358 LUCA
GeneTreeiENSGT00390000018318
HOGENOMiHOG000210688
HOVERGENiHBG001720
InParanoidiP25398
KOiK02951
OMAiGLRECAK
OrthoDBiEOG091G0UB5
PhylomeDBiP25398
TreeFamiTF300196

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR000530 Ribosomal_S12e
PANTHERiPTHR11843 PTHR11843, 1 hit
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00972 RIBSOMALS12E
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01189 RIBOSOMAL_S12E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEGIAAGG VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC
60 70 80 90 100
VLASNCDEPM YVKLVEALCA EHQINLIKVD DNKKLGEWVG LCKIDREGKP
110 120 130
RKVVGCSCVV VKDYGKESQA KDVIEEYFKC KK
Length:132
Mass (Da):14,515
Last modified:March 3, 2009 - v3
Checksum:i45AD1274D55FFA25
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52L → Q in CAA37582 (PubMed:1861993).Curated1
Sequence conflicti69C → L in CAA37582 (PubMed:1861993).Curated1
Sequence conflicti99K → N in CAA37582 (PubMed:1861993).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53505 mRNA Translation: CAA37582.1
AB061840 Genomic DNA Translation: BAB79478.1
AK311826 mRNA Translation: BAG34768.1
AL137783 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48011.1
BC017321 mRNA Translation: AAH17321.1
BC071930 mRNA Translation: AAH71930.1
BC095424 mRNA Translation: AAH95424.1
AB007153 Genomic DNA Translation: BAA25819.1
CCDSiCCDS5164.1
PIRiS22989 R3HU12
RefSeqiNP_001007.2, NM_001016.3
UniGeneiHs.546289

Genome annotation databases

EnsembliENST00000230050; ENSP00000230050; ENSG00000112306
GeneIDi6206
KEGGihsa:6206
UCSCiuc003qdx.4 human

Similar proteinsi

Entry informationi

Entry nameiRS12_HUMAN
AccessioniPrimary (citable) accession number: P25398
Secondary accession number(s): Q76M58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 3, 2009
Last modified: June 20, 2018
This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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