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Entry version 151 (07 Apr 2021)
Sequence version 1 (01 May 1992)
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Protein

Tellurite resistance protein TehA

Gene

tehA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance (By similarity).

Otherwise, phenotypically silent.

By similarity

Caution

Was originally thought to be plasmid encoded.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei262Important for gating; obstructs channel and prevents ion flux in the closed conformationBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processAntibiotic resistance, Ion transport, Tellurium resistance, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:TEHA-MONOMER
MetaCyc:TEHA-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.16.1.1, the telurite-resistance/dicarboxylate transporter (tdt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tellurite resistance protein TehA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tehA
Ordered Locus Names:b1429, JW1425
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7CytoplasmicBy similarity7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalBy similarityAdd BLAST21
Topological domaini29 – 35PeriplasmicBy similarity7
Transmembranei36 – 59HelicalBy similarityAdd BLAST24
Topological domaini60 – 79CytoplasmicBy similarityAdd BLAST20
Transmembranei80 – 98HelicalBy similarityAdd BLAST19
Topological domaini99 – 101PeriplasmicBy similarity3
Transmembranei102 – 127HelicalBy similarityAdd BLAST26
Topological domaini128 – 138CytoplasmicBy similarityAdd BLAST11
Transmembranei139 – 159HelicalBy similarityAdd BLAST21
Topological domaini160 – 161PeriplasmicBy similarity2
Transmembranei162 – 189HelicalBy similarityAdd BLAST28
Topological domaini190 – 194CytoplasmicBy similarity5
Transmembranei195 – 218HelicalBy similarityAdd BLAST24
Topological domaini219 – 224PeriplasmicBy similarity6
Transmembranei225 – 248HelicalBy similarityAdd BLAST24
Topological domaini249 – 254CytoplasmicBy similarity6
Transmembranei255 – 275HelicalBy similarityAdd BLAST21
Topological domaini276 – 283PeriplasmicBy similarity8
Transmembranei284 – 310HelicalBy similarityAdd BLAST27
Topological domaini311 – 330CytoplasmicBy similarityAdd BLAST20

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724791 – 330Tellurite resistance protein TehAAdd BLAST330

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P25396

PRoteomics IDEntifications database

More...
PRIDEi
P25396

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer. Each subunit forms a channel (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P25396
With#Exp.IntAct
itself2EBI-15888098,EBI-15888098

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4261847, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-10977N

STRING: functional protein association networks

More...
STRINGi
511145.b1429

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P25396

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1275, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_044414_1_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P25396

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P25396

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09324, TDT_TehA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.10.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004695, SLAC1/Mae1/Ssu1/TehA
IPR039264, TehA
IPR011552, TehA/Mae1
IPR038665, Voltage-dep_anion_channel_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03595, SLAC1, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00816, tdt, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P25396-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSDKVLNLP AGYFGIVLGT IGMGFAWRYA SQVWQVSHWL GDGLVILAMI
60 70 80 90 100
IWGLLTSAFI ARLIRFPHSV LAEVRHPVLS SFVSLFPATT MLVAIGFVPW
110 120 130 140 150
FRPLAVCLFS FGVVVQLAYA AWQTAGLWRG SHPEEATTPG LYLPTVANNF
160 170 180 190 200
ISAMACGALG YTDAGLVFLG AGVFSWLSLE PVILQRLRSS GELPTALRTS
210 220 230 240 250
LGIQLAPALV ACSAWLSVNG GEGDTLAKML FGYGLLQLLF MLRLMPWYLS
260 270 280 290 300
QPFNASFWSF SFGVSALATT GLHLGSGSDN GFFHTLAVPL FIFTNFIIAI
310 320 330
LLIRTFALLM QGKLLVRTER AVLMKAEDKE
Length:330
Mass (Da):35,932
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC592152A2D2FFF5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M74072 Unassigned DNA Translation: AAA19563.1
U00096 Genomic DNA Translation: AAC74511.1
AP009048 Genomic DNA Translation: BAA15058.1

Protein sequence database of the Protein Information Resource

More...
PIRi
H64894

NCBI Reference Sequences

More...
RefSeqi
NP_415946.1, NC_000913.3
WP_001301046.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74511; AAC74511; b1429
BAA15058; BAA15058; BAA15058

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945852

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1425
eco:b1429

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.842

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74072 Unassigned DNA Translation: AAA19563.1
U00096 Genomic DNA Translation: AAC74511.1
AP009048 Genomic DNA Translation: BAA15058.1
PIRiH64894
RefSeqiNP_415946.1, NC_000913.3
WP_001301046.1, NZ_LN832404.1

3D structure databases

SMRiP25396
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261847, 4 interactors
DIPiDIP-10977N
STRINGi511145.b1429

Protein family/group databases

TCDBi2.A.16.1.1, the telurite-resistance/dicarboxylate transporter (tdt) family

Proteomic databases

PaxDbiP25396
PRIDEiP25396

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
945852

Genome annotation databases

EnsemblBacteriaiAAC74511; AAC74511; b1429
BAA15058; BAA15058; BAA15058
GeneIDi945852
KEGGiecj:JW1425
eco:b1429
PATRICifig|1411691.4.peg.842

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1829

Phylogenomic databases

eggNOGiCOG1275, Bacteria
HOGENOMiCLU_044414_1_0_6
InParanoidiP25396
PhylomeDBiP25396

Enzyme and pathway databases

BioCyciEcoCyc:TEHA-MONOMER
MetaCyc:TEHA-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P25396

Family and domain databases

CDDicd09324, TDT_TehA, 1 hit
Gene3Di1.50.10.150, 1 hit
InterProiView protein in InterPro
IPR004695, SLAC1/Mae1/Ssu1/TehA
IPR039264, TehA
IPR011552, TehA/Mae1
IPR038665, Voltage-dep_anion_channel_sf
PfamiView protein in Pfam
PF03595, SLAC1, 1 hit
TIGRFAMsiTIGR00816, tdt, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEHA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25396
Secondary accession number(s): P76864
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 7, 2021
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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