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UniProtKB - P25357 (SNT1_YEAST)
Protein
Probable DNA-binding protein SNT1
Gene
SNT1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis.
Miscellaneous
Present with 396 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 911 – 934 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
GO - Biological processi
- histone deacetylation Source: UniProtKB
- negative regulation of meiotic nuclear division Source: UniProtKB
- positive regulation of stress-activated MAPK cascade Source: SGD
- regulation of transcription, DNA-templated Source: SGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
Reactomei | R-SCE-3214815, HDACs deacetylate histones |
Names & Taxonomyi
Protein namesi | Recommended name: Probable DNA-binding protein SNT1Alternative name(s): SANT domain-containing protein 1 |
Gene namesi | Name:SNT1 Ordered Locus Names:YCR033W ORF Names:YCR33W, YCR592 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000629, SNT1 |
VEuPathDBi | FungiDB:YCR033W |
Subcellular locationi
Nucleus
- Nucleus Curated
Cytosol
- cytosol Source: SGD
Nucleus
- histone deacetylase complex Source: UniProtKB
- nucleus Source: SGD
- Rpd3L-Expanded complex Source: SGD
- Set3 complex Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197122 | 1 – 1226 | Probable DNA-binding protein SNT1Add BLAST | 1226 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 187 | PhosphoserineCombined sources | 1 | |
Modified residuei | 395 | PhosphoserineCombined sources | 1 | |
Modified residuei | 796 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1037 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P25357 |
PaxDbi | P25357 |
PRIDEi | P25357 |
PTM databases
iPTMneti | P25357 |
Interactioni
Subunit structurei
Identified in a Set3C complex with SET3, HST1, HOS2, SIF2, CPR1 and HOS4.
1 PublicationProtein-protein interaction databases
BioGRIDi | 31016, 676 interactors |
ComplexPortali | CPX-1342, SET3C histone deacetylase complex |
DIPi | DIP-2082N |
IntActi | P25357, 14 interactors |
MINTi | P25357 |
STRINGi | 4932.YCR033W |
Miscellaneous databases
RNActi | P25357, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 668 – 720 | SANTPROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 884 – 938 | HTH myb-typePROSITE-ProRule annotationAdd BLAST | 55 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 219 | DisorderedSequence analysisAdd BLAST | 219 | |
Regioni | 264 – 331 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 569 – 605 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 732 – 796 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 1172 – 1194 | DisorderedSequence analysisAdd BLAST | 23 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 539 – 591 | Sequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 22 – 69 | Polar residuesSequence analysisAdd BLAST | 48 | |
Compositional biasi | 88 – 168 | Polar residuesSequence analysisAdd BLAST | 81 | |
Compositional biasi | 194 – 219 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 278 – 307 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 569 – 594 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 758 – 775 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG1878, Eukaryota |
GeneTreei | ENSGT00940000175552 |
HOGENOMi | CLU_004864_0_0_1 |
InParanoidi | P25357 |
OMAi | KFMDSNN |
Family and domain databases
CDDi | cd00167, SANT, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 1 hit PS51293, SANT, 1 hit |
i Sequence
Sequence statusi: Complete.
P25357-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGYPPPTRRL GDKKRYHYSN NPNRRHPSAV YSKNSFPKSS NNGFVSSPTA
60 70 80 90 100
DNSTNPSVTP STASVPLPTA APGSTFGIEA PRPSRYDPSS VSRPSSSSYS
110 120 130 140 150
STRKIGSRYN PDVERSSSTT SSTPESMNTS TITHTNTDIG NSRYSRKTMS
160 170 180 190 200
RYNPQSTSST NVTHFPSALS NAPPFYVANG SSRRPRSMDD YSPDVTNKLE
210 220 230 240 250
TNNVSSVNNN SPHSYYSRSN KWRSIGTPSR PPFDNHVGNM TTTSNTNSIH
260 270 280 290 300
QREPFWKANS TTILKSTHSQ SSPSLHTKKF HDANKLDKPE ASVKVETPSK
310 320 330 340 350
DETKAISYHD NNFPPRKSVS KPNAPLEPDN IKVGEEDALG KKEVHKSGRE
360 370 380 390 400
IAKEHPTPVK MKEHDELEAR AKKVSKINID GKQDEIWTTA KTVASAVEVS
410 420 430 440 450
KESQKELTRS VERKESPEIR DYERAYDPKA LKTDVTKLTV DNDNKSYEEP
460 470 480 490 500
LEKVEGCIFP LPKAETRLWE LKNQKRNKII SEQKYLLKKA IRNFSEYPFY
510 520 530 540 550
AQNKLIHQQA TGLILTKIIS KIKKEEHLKK INLKHDYFDL QKKYEKECEI
560 570 580 590 600
LTKLSENLRK EEIENKRKEH ELMEQKRREE GIETEKEKSL RHPSSSSSSR
610 620 630 640 650
RRNRADFVDD AEMENVLLQI DPNYKHYQAA ATIPPLILDP IRKHSYKFCD
660 670 680 690 700
VNNLVTDKKL WASRILKDAS DNFTDHEHSL FLEGYLIHPK KFGKISHYMG
710 720 730 740 750
GLRSPEECVL HYYRTKKTVN YKQLLIDKNK KRKMSAAAKR RKRKERSNDE
760 770 780 790 800
EVEVDESKEE STNTIEKEEK SENNAEENVQ PVLVQGSEVK GDPLGTPEKV
810 820 830 840 850
ENMIEQRGEE FAGELENAER VNDLKRAHDE VGEESNKSSV IETNNGVQIM
860 870 880 890 900
DPKGAVQNGY YPEETKELDF SLENALQRKK HKSAPEHKTS YWSVRESQLF
910 920 930 940 950
PELLKEFGSQ WSLISEKLGT KSTTMVRNYY QRNAARNGWK LLVDETDLKR
960 970 980 990 1000
DGTSSESVQQ SQILIQPERP NINAYSNIPP QQRPALGYFV GQPTHGHNTS
1010 1020 1030 1040 1050
ISSIDGSIRP FGPDFHRDTF SKISAPLTTL PPPRLPSIQF PRSEMAEPTV
1060 1070 1080 1090 1100
TDLRNRPLDH IDTLADAASS VTNNQNFSNE RNAIDIGRKS TTISNLLNNS
1110 1120 1130 1140 1150
DRSMKSSFQS ASRHEAQLED TPSMNNIVVQ EIKPNITTPR SSSISALLNP
1160 1170 1180 1190 1200
VNGNGQSNPD GRPLLPFQHA ISQGTPTFPL PAPRTSPISR APPKFNFSND
1210 1220
PLAALAAVAS APDAMSSFLS KKENNN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 305 | A → T in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 375 | S → N in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 404 | Q → H in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 435 | V → A in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 442 | N → D in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 482 | E → K in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 513 | L → V in AAB21259 (PubMed:1776366).Curated | 1 | |
Sequence conflicti | 644 | H → Y in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 766 | E → D in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 806 | Q → K in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 831 | V → I in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 846 | G → E in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 851 | D → A in CAA41799 (PubMed:1872032).Curated | 1 | |
Sequence conflicti | 855 – 857 | AVQ → GVR in CAA41799 (PubMed:1872032).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S78624 Genomic DNA Translation: AAB21259.1 X59075 Genomic DNA Translation: CAA41799.1 X59720 Genomic DNA Translation: CAC42983.1 BK006937 Genomic DNA Translation: DAA07512.1 |
PIRi | S15053 |
RefSeqi | NP_009962.2, NM_001178747.1 |
Genome annotation databases
EnsemblFungii | YCR033W_mRNA; YCR033W; YCR033W |
GeneIDi | 850399 |
KEGGi | sce:YCR033W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S78624 Genomic DNA Translation: AAB21259.1 X59075 Genomic DNA Translation: CAA41799.1 X59720 Genomic DNA Translation: CAC42983.1 BK006937 Genomic DNA Translation: DAA07512.1 |
PIRi | S15053 |
RefSeqi | NP_009962.2, NM_001178747.1 |
3D structure databases
SMRi | P25357 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31016, 676 interactors |
ComplexPortali | CPX-1342, SET3C histone deacetylase complex |
DIPi | DIP-2082N |
IntActi | P25357, 14 interactors |
MINTi | P25357 |
STRINGi | 4932.YCR033W |
PTM databases
iPTMneti | P25357 |
Proteomic databases
MaxQBi | P25357 |
PaxDbi | P25357 |
PRIDEi | P25357 |
Genome annotation databases
EnsemblFungii | YCR033W_mRNA; YCR033W; YCR033W |
GeneIDi | 850399 |
KEGGi | sce:YCR033W |
Organism-specific databases
SGDi | S000000629, SNT1 |
VEuPathDBi | FungiDB:YCR033W |
Phylogenomic databases
eggNOGi | KOG1878, Eukaryota |
GeneTreei | ENSGT00940000175552 |
HOGENOMi | CLU_004864_0_0_1 |
InParanoidi | P25357 |
OMAi | KFMDSNN |
Enzyme and pathway databases
Reactomei | R-SCE-3214815, HDACs deacetylate histones |
Miscellaneous databases
PROi | PR:P25357 |
RNActi | P25357, protein |
Family and domain databases
CDDi | cd00167, SANT, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 1 hit PS51293, SANT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SNT1_YEAST | |
Accessioni | P25357Primary (citable) accession number: P25357 Secondary accession number(s): D6VR43, Q02397, Q8NIL8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | June 27, 2003 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome III
Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names