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UniProtKB - P25354 (YCP7_YEAST)

Entry version 145 (25 May 2022)
Sequence version 1 (01 May 1992)
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Protein

DUP240 protein YCR007C

Gene

YCR007C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DUP240 protein YCR007C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YCR007C
ORF Names:YCR045, YCR7C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000000600, YCR007C

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YCR007C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 54CytoplasmicSequence analysisAdd BLAST54
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 79ExtracellularSequence analysis4
Transmembranei80 – 104HelicalSequence analysisAdd BLAST25
Topological domaini105 – 239CytoplasmicSequence analysisAdd BLAST135

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002075311 – 239DUP240 protein YCR007CAdd BLAST239

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P25354

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P25354

PRoteomics IDEntifications database

More...PRIDEi		P25354

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts according to large scale protein interaction studies with MEC3 and ULP1.

Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		30985, 62 interactors

Database of interacting proteins

More...DIPi		DIP-4043N

Protein interaction database and analysis system

More...IntActi		P25354, 8 interactors

Molecular INTeraction database

More...MINTi		P25354

STRING: functional protein association networks

More...STRINGi		4932.YCR007C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P25354, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P25354

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SSNW, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000176285

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_081384_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P25354

Identification of Orthologs from Complete Genome Data

More...OMAi		QADICDW

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001142, DUP/COS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00674, DUP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P25354-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPHLDNNSN NDDVKLDTLG EQNVLSSAEN ITLPEDTFKS YMTYLLYEMA 
        60         70         80         90        100
HYKPMIFSFL ALSVSILIVV IFHNVKACDV VFGFSIFVTS ILFLSTLIPF 
       110        120        130        140        150
NVYISDEGFR IKLLLEVITH RPAVKGKEWR AITDNMNQYL LDNGLWSTRY 
       160        170        180        190        200
YFYSSERCYK FFRFLVKEKP PGVNVNSSVK DATSTQIDAP ANEASNEVIK 
       210        220        230 
CFSFSSDPIF EAYFVKAVEV EKQAQQEYWR KQYPDADIP
Length:239
Mass (Da):27,564
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A8586E1AA4E4ED7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti2Q → K in strain: CLIB 219. 1 Publication1
Natural varianti42M → T in strain: CLIB 219, CLIB 410, CLIB 413, CLIB 630 haplotype Ha1, K1, YIIc12 haplotype Ha2 and CLIB 382. 1 Publication1
Natural varianti215V → I in strain: CLIB 630. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ585549 Genomic DNA Translation: CAE52069.1
AJ585550 Genomic DNA Translation: CAE52070.1
AJ585551 Genomic DNA Translation: CAE52071.1
AJ585552 Genomic DNA Translation: CAE52072.1
AJ585553 Genomic DNA Translation: CAE52073.1
AJ585554 Genomic DNA Translation: CAE52074.1
AJ585555 Genomic DNA Translation: CAE52075.1
AJ585556 Genomic DNA Translation: CAE52076.1
AJ585557 Genomic DNA Translation: CAE52077.1
AJ585558 Genomic DNA Translation: CAE52078.1
AJ585559 Genomic DNA Translation: CAE52079.1
AJ585560 Genomic DNA Translation: CAE52080.1
AJ585561 Genomic DNA Translation: CAE52081.1
AJ585562 Genomic DNA Translation: CAE52082.1
AJ585563 Genomic DNA Translation: CAE52083.1
AJ585564 Genomic DNA Translation: CAE52084.1
Z11114 Genomic DNA Translation: CAA77446.1
X59720 Genomic DNA Translation: CAA42324.1
AY558149 Genomic DNA Translation: AAS56475.1
BK006937 Genomic DNA Translation: DAA07485.1

Protein sequence database of the Protein Information Resource

More...PIRi		S20184

NCBI Reference Sequences

More...RefSeqi		NP_009933.1, NM_001178720.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YCR007C_mRNA; YCR007C; YCR007C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		850364

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YCR007C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ585549 Genomic DNA Translation: CAE52069.1
AJ585550 Genomic DNA Translation: CAE52070.1
AJ585551 Genomic DNA Translation: CAE52071.1
AJ585552 Genomic DNA Translation: CAE52072.1
AJ585553 Genomic DNA Translation: CAE52073.1
AJ585554 Genomic DNA Translation: CAE52074.1
AJ585555 Genomic DNA Translation: CAE52075.1
AJ585556 Genomic DNA Translation: CAE52076.1
AJ585557 Genomic DNA Translation: CAE52077.1
AJ585558 Genomic DNA Translation: CAE52078.1
AJ585559 Genomic DNA Translation: CAE52079.1
AJ585560 Genomic DNA Translation: CAE52080.1
AJ585561 Genomic DNA Translation: CAE52081.1
AJ585562 Genomic DNA Translation: CAE52082.1
AJ585563 Genomic DNA Translation: CAE52083.1
AJ585564 Genomic DNA Translation: CAE52084.1
Z11114 Genomic DNA Translation: CAA77446.1
X59720 Genomic DNA Translation: CAA42324.1
AY558149 Genomic DNA Translation: AAS56475.1
BK006937 Genomic DNA Translation: DAA07485.1
PIRiS20184
RefSeqiNP_009933.1, NM_001178720.1

3D structure databases

AlphaFoldDBiP25354
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi30985, 62 interactors
DIPiDIP-4043N
IntActiP25354, 8 interactors
MINTiP25354
STRINGi4932.YCR007C

Proteomic databases

MaxQBiP25354
PaxDbiP25354
PRIDEiP25354

Genome annotation databases

EnsemblFungiiYCR007C_mRNA; YCR007C; YCR007C
GeneIDi850364
KEGGisce:YCR007C

Organism-specific databases

SGDiS000000600, YCR007C
VEuPathDBiFungiDB:YCR007C

Phylogenomic databases

eggNOGiENOG502SSNW, Eukaryota
GeneTreeiENSGT00940000176285
HOGENOMiCLU_081384_0_1_1
InParanoidiP25354
OMAiQADICDW

Miscellaneous databases

Protein Ontology

More...PROi		PR:P25354
RNActiP25354, protein

Family and domain databases

InterProiView protein in InterPro
IPR001142, DUP/COS
PfamiView protein in Pfam
PF00674, DUP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYCP7_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25354
Secondary accession number(s): D6VR16
, Q70DH1, Q70DH4, Q70DH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 25, 2022
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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