G1/S-specific cyclin-D1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cyclin-dependent protein serine/threonine kinase regulator activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Mitotic clonal expansion: a synchronous process required for adipogenesis."
    Tang Q.Q., Otto T.C., Lane M.D.
    Proc. Natl. Acad. Sci. U.S.A. 100:44-49(2003) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: MGI
• histone deacetylase binding Source: MGI
• kinase activity Source: MGIInferred from direct assayⁱ
  • "GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress."
    Vairapandi M., Balliet A.G., Hoffman B., Liebermann D.A.
    J. Cell. Physiol. 192:327-338(2002) [PubMed] [Europe PMC] [Abstract]
• proline-rich region binding Source: MGI
• protein kinase activity Source: MGIInferred from direct assayⁱ
  • "Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase."
    Diehl J.A., Yang W., Rimerman R.A., Xiao H., Emili A.
    Mol. Cell. Biol. 23:1764-1774(2003) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.6

    "Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation."
    Barbash O., Egan E., Pontano L.L., Kosak J., Diehl J.A.
    Oncogene 28:4317-4325(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: UBIQUITINATION AT LYS-269, INTERACTION WITH CDKN1B AND CDK4, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-269 AND THR-286.
• protein-containing complex binding Source: MGI
• transcription corepressor activity Source: UniProtKB
• transcription factor binding Source: MGI

GO - Biological processⁱ

• G1/S transition of mitotic cell cycle Source: MGIInferred from direct assayⁱ
  • "PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway."
    Hamanaka R.B., Bennett B.S., Cullinan S.B., Diehl J.A.
    Mol. Biol. Cell 16:5493-5501(2005) [PubMed] [Europe PMC] [Abstract]
• Leydig cell differentiation Source: MGI
• Wnt signaling pathway Source: MGIInferred from direct assayⁱ
  • "A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors."
    Miranda-Carboni G.A., Krum S.A., Yee K., Nava M., Deng Q.E., Pervin S., Collado-Hidalgo A., Galic Z., Zack J.A., Nakayama K., Nakayama K.I., Lane T.F.
    Genes Dev. 22:3121-3134(2008) [PubMed] [Europe PMC] [Abstract]
• cell division Source: UniProtKB-KW
• cellular response to DNA damage stimulus Source: UniProtKB
• cellular response to organic substance Source: MGIInferred from direct assayⁱ
  • "IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade."
    Nojima H., Adachi M., Matsui T., Okawa K., Tsukita S., Tsukita S.
    Nat. Cell Biol. 10:971-978(2008) [PubMed] [Europe PMC] [Abstract]
• endoplasmic reticulum unfolded protein response Source: MGIInferred from direct assayⁱ
  • "PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway."
    Hamanaka R.B., Bennett B.S., Cullinan S.B., Diehl J.A.
    Mol. Biol. Cell 16:5493-5501(2005) [PubMed] [Europe PMC] [Abstract]
• fat cell differentiation Source: MGIInferred from direct assayⁱ
  • "Mitotic clonal expansion: a synchronous process required for adipogenesis."
    Tang Q.Q., Otto T.C., Lane M.D.
    Proc. Natl. Acad. Sci. U.S.A. 100:44-49(2003) [PubMed] [Europe PMC] [Abstract]
• lactation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Impaired mammary gland development in Cyl-1(-/-) mice during pregnancy and lactation is epithelial cell autonomous."
    Fantl V., Edwards P.A., Steel J.H., Vonderhaar B.K., Dickson C.
    Dev. Biol. 212:1-11(1999) [PubMed] [Europe PMC] [Abstract]
• liver regeneration Source: MGIInferred from direct assayⁱ
  • "Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration."
    Nakamura I., Fernandez-Barrena M.G., Ortiz-Ruiz M.C., Almada L.L., Hu C., Elsawa S.F., Mills L.D., Romecin P.A., Gulaid K.H., Moser C.D., Han J.J., Vrabel A., Hanse E.A., Akogyeram N.A., Albrecht J.H., Monga S.P., Sanderson S.O., Prieto J., Roberts L.R., Fernandez-Zapico M.E.
    J. Biol. Chem. 288:21389-21398(2013) [PubMed] [Europe PMC] [Abstract]
• mammary gland alveolus development Source: MGIInferred from mutant phenotypeⁱ
  • "Impaired mammary gland development in Cyl-1(-/-) mice during pregnancy and lactation is epithelial cell autonomous."
    Fantl V., Edwards P.A., Steel J.H., Vonderhaar B.K., Dickson C.
    Dev. Biol. 212:1-11(1999) [PubMed] [Europe PMC] [Abstract]
• mammary gland epithelial cell proliferation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development."
    Cao Y., Bonizzi G., Seagroves T.N., Greten F.R., Johnson R., Schmidt E.V., Karin M.
    Cell 107:763-775(2001) [PubMed] [Europe PMC] [Abstract]
• mitotic G1 DNA damage checkpoint Source: UniProtKB
• mitotic cell cycle phase transition Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell cycle arrest Source: UniProtKB
• negative regulation of epithelial cell differentiation Source: MGIInferred from genetic interactionⁱ
  • "Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice."
    Hulit J., Wang C., Li Z., Albanese C., Rao M., Di Vizio D., Shah S., Byers S.W., Mahmood R., Augenlicht L.H., Russell R., Pestell R.G.
    Mol. Cell. Biol. 24:7598-7611(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from mutant phenotypeⁱ
  • "Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice."
    Hulit J., Wang C., Li Z., Albanese C., Rao M., Di Vizio D., Shah S., Byers S.W., Mahmood R., Augenlicht L.H., Russell R., Pestell R.G.
    Mol. Cell. Biol. 24:7598-7611(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of G1/S transition of mitotic cell cycle Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
• positive regulation of cell population proliferation Source: MGI
• positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
• positive regulation of epithelial cell proliferation Source: MGIInferred from genetic interactionⁱ
  • "Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice."
    Hulit J., Wang C., Li Z., Albanese C., Rao M., Di Vizio D., Shah S., Byers S.W., Mahmood R., Augenlicht L.H., Russell R., Pestell R.G.
    Mol. Cell. Biol. 24:7598-7611(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mammary gland epithelial cell proliferation Source: MGIInferred from genetic interactionⁱ
  • "PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development."
    Chan C.B., Liu X., Ensslin M.A., Dillehay D.L., Ormandy C.J., Sohn P., Serra R., Ye K.
    EMBO J. 29:956-968(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: UniProtKB
• protein phosphorylation Source: MGIInferred from direct assayⁱ
  • "GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress."
    Vairapandi M., Balliet A.G., Hoffman B., Liebermann D.A.
    J. Cell. Physiol. 192:327-338(2002) [PubMed] [Europe PMC] [Abstract]
  • "Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase."
    Diehl J.A., Yang W., Rimerman R.A., Xiao H., Emili A.
    Mol. Cell. Biol. 23:1764-1774(2003) [PubMed] [Europe PMC] [Abstract]
• re-entry into mitotic cell cycle Source: MGIInferred from direct assayⁱ
  • "Mitotic clonal expansion: a synchronous process required for adipogenesis."
    Tang Q.Q., Otto T.C., Lane M.D.
    Proc. Natl. Acad. Sci. U.S.A. 100:44-49(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of G1/S transition of mitotic cell cycle Source: MGIInferred from genetic interactionⁱ
  • "Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation."
    Capaldo C.T., Koch S., Kwon M., Laur O., Parkos C.A., Nusrat A.
    Mol. Biol. Cell 22:1677-1685(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of cell cycle Source: MGIInferred from direct assayⁱ
  • "Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells."
    Jena N., Deng M., Sicinska E., Sicinski P., Daley G.Q.
    Cancer Res. 62:535-541(2002) [PubMed] [Europe PMC] [Abstract]
  • "Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase."
    Diehl J.A., Yang W., Rimerman R.A., Xiao H., Emili A.
    Mol. Cell. Biol. 23:1764-1774(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to UV-A Source: UniProtKB
• response to X-ray Source: Ensembl
• response to calcium ion Source: Ensembl
• response to corticosterone Source: Ensembl
• response to estradiol Source: Ensembl
• response to estrogen Source: Ensembl
• response to ethanol Source: Ensembl
• response to iron ion Source: Ensembl
• response to leptin Source: MGI
• response to magnesium ion Source: Ensembl
• response to organonitrogen compound Source: MGI
• response to vitamin E Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• enzyme binding Source: MGI
• histone deacetylase binding Source: MGI
• proline-rich region binding Source: MGI
• protein kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.6

    "Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation."
    Barbash O., Egan E., Pontano L.L., Kosak J., Diehl J.A.
    Oncogene 28:4317-4325(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: UBIQUITINATION AT LYS-269, INTERACTION WITH CDKN1B AND CDK4, SUBUNIT, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-269 AND THR-286.
• transcription factor binding Source: MGI

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEHQLLCCEV ETIRRAYPDT NLLNDRVLRA MLKTEETCAP SVSYFKCVQK 
        60         70         80         90        100
EIVPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPLKKSRLQ 
       110        120        130        140        150
LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW 
       160        170        180        190        200
NLAAMTPHDF IEHFLSKMPE ADENKQTIRK HAQTFVALCA TDVKFISNPP 
       210        220        230        240        250
SMVAAGSVVA AMQGLNLGSP NNFLSCYRTT HFLSRVIKCD PDCLRACQEQ 
       260        270        280        290 
IEALLESSLR QAQQNVDPKA TEEEGEVEEE AGLACTPTDV RDVDI      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot