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UniProtKB - P25311 (ZA2G_HUMAN)
Protein
Zinc-alpha-2-glycoprotein
Gene
AZGP1
Organism
Homo sapiens (Human)
Status
Functioni
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.
Caution
It is uncertain whether Met-1 or Met-4 is the initiator.Curated
GO - Molecular functioni
- protein transmembrane transporter activity Source: UniProtKB
- ribonuclease activity Source: UniProtKB
GO - Biological processi
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: GO_Central
- cell adhesion Source: UniProtKB
- detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- retina homeostasis Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P25311 |
Reactomei | R-HSA-5223345, Miscellaneous transport and binding events |
SignaLinki | P25311 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc-alpha-2-glycoproteinShort name: Zn-alpha-2-GP Short name: Zn-alpha-2-glycoprotein |
Gene namesi | Name:AZGP1 Synonyms:ZAG, ZNGP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:910, AZGP1 |
MIMi | 194460, gene |
neXtProti | NX_P25311 |
VEuPathDBi | HostDB:ENSG00000160862 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 563 |
OpenTargetsi | ENSG00000160862 |
PharmGKBi | PA25203 |
Miscellaneous databases
Pharosi | P25311, Tbio |
Chemistry databases
DrugBanki | DB09130, Copper DB03721, N-acetyl-alpha-neuraminic acid |
Genetic variation databases
BioMutai | AZGP1 |
DMDMi | 292495049 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 2 PublicationsAdd BLAST | 20 | |
ChainiPRO_0000019012 | 21 – 298 | Zinc-alpha-2-glycoproteinAdd BLAST | 278 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Glycosylationi | 109 | N-linked (GlcNAc...) (complex) asparagine5 Publications | 1 | |
Glycosylationi | 112 | N-linked (GlcNAc...) asparagine5 Publications | 1 | |
Disulfide bondi | 123 ↔ 186 | |||
Glycosylationi | 128 | N-linked (GlcNAc...) (complex) asparagine9 Publications | 1 | |
Disulfide bondi | 225 ↔ 280 | |||
Glycosylationi | 259 | N-linked (GlcNAc...) asparagine3 Publications | 1 |
Post-translational modificationi
N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.11 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acidProteomic databases
CPTACi | non-CPTAC-1167 non-CPTAC-2709 |
EPDi | P25311 |
jPOSTi | P25311 |
MassIVEi | P25311 |
MaxQBi | P25311 |
PaxDbi | P25311 |
PeptideAtlasi | P25311 |
PRIDEi | P25311 |
ProteomicsDBi | 54267 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00166729 |
SWISS-2DPAGEi | P25311 |
PTM databases
CarbonylDBi | P25311 |
GlyConnecti | 692, 108 N-Linked glycans (3 sites), 1 O-Linked glycan (1 site) |
GlyGeni | P25311, 5 sites, 118 N-linked glycans (4 sites) |
iPTMneti | P25311 |
PhosphoSitePlusi | P25311 |
Expressioni
Tissue specificityi
Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver.
Gene expression databases
Bgeei | ENSG00000160862, Expressed in minor salivary gland and 207 other tissues |
ExpressionAtlasi | P25311, baseline and differential |
Genevisiblei | P25311, HS |
Organism-specific databases
HPAi | ENSG00000160862, Tissue enhanced (liver, salivary gland) |
Interactioni
Subunit structurei
Interacts with PIP.
1 PublicationBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 107040, 114 interactors |
CORUMi | P25311 |
IntActi | P25311, 36 interactors |
MINTi | P25311 |
STRINGi | 9606.ENSP00000292401 |
Miscellaneous databases
RNActi | P25311, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P25311 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P25311 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 207 – 292 | Ig-like C1-typeAdd BLAST | 86 |
Sequence similaritiesi
Belongs to the MHC class I family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RWW3, Eukaryota |
GeneTreei | ENSGT01040000240404 |
HOGENOMi | CLU_047501_0_1_1 |
InParanoidi | P25311 |
OMAi | YQSWVVV |
OrthoDBi | 912212at2759 |
PhylomeDBi | P25311 |
TreeFami | TF336617 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P25311-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRMVPVLLS LLLLLGPAVP QENQDGRYSL TYIYTGLSKH VEDVPAFQAL
60 70 80 90 100
GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET
110 120 130 140 150
LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE
160 170 180 190 200
IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI
210 220 230 240 250
LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL
260 270 280 290
RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JEV0 | C9JEV0_HUMAN | Zinc-alpha-2-glycoprotein | AZGP1 | 227 | Annotation score: | ||
H7BZJ8 | H7BZJ8_HUMAN | Zinc-alpha-2-glycoprotein | AZGP1 | 85 | Annotation score: |
Sequence cautioni
The sequence AAA61311 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA03123 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA14417 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA42438 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | V → S in CAA42438 (PubMed:1915885).Curated | 1 | |
Sequence conflicti | 5 | V → L in CAA42438 (PubMed:1915885).Curated | 1 | |
Sequence conflicti | 33 | I → V in AAH05306 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 85 | Q → E AA sequence (PubMed:3422450).Curated | 1 | |
Sequence conflicti | 96 – 97 | Missing AA sequence (PubMed:3422450).Curated | 2 | |
Sequence conflicti | 244 | E → Q AA sequence (PubMed:3422450).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59766 mRNA Translation: CAA42438.1 Different initiation. D14034 Genomic DNA Translation: BAA03123.1 Different initiation. X69953 Genomic DNA Translation: CAA49574.1 AC004522 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23862.1 CH471091 Genomic DNA Translation: EAW76621.1 CH471091 Genomic DNA Translation: EAW76622.1 BC005306 mRNA Translation: AAH05306.1 BC033830 mRNA Translation: AAH33830.1 D90427 mRNA Translation: BAA14417.1 Different initiation. M76707 mRNA Translation: AAA61311.1 Different initiation. |
CCDSi | CCDS5680.1 |
PIRi | A54175 |
RefSeqi | NP_001176.1, NM_001185.3 |
Genome annotation databases
Ensembli | ENST00000292401; ENSP00000292401; ENSG00000160862 |
GeneIDi | 563 |
KEGGi | hsa:563 |
MANE-Selecti | ENST00000292401.9; ENSP00000292401.4; NM_001185.4; NP_001176.1 |
UCSCi | uc003ush.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59766 mRNA Translation: CAA42438.1 Different initiation. D14034 Genomic DNA Translation: BAA03123.1 Different initiation. X69953 Genomic DNA Translation: CAA49574.1 AC004522 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23862.1 CH471091 Genomic DNA Translation: EAW76621.1 CH471091 Genomic DNA Translation: EAW76622.1 BC005306 mRNA Translation: AAH05306.1 BC033830 mRNA Translation: AAH33830.1 D90427 mRNA Translation: BAA14417.1 Different initiation. M76707 mRNA Translation: AAA61311.1 Different initiation. |
CCDSi | CCDS5680.1 |
PIRi | A54175 |
RefSeqi | NP_001176.1, NM_001185.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1T7V | X-ray | 1.95 | A | 21-298 | [»] | |
1T7W | X-ray | 2.70 | A | 21-298 | [»] | |
1T7X | X-ray | 3.10 | A | 21-298 | [»] | |
1T7Y | X-ray | 2.80 | A | 21-298 | [»] | |
1T7Z | X-ray | 3.00 | A | 21-298 | [»] | |
1T80 | X-ray | 2.10 | A | 21-298 | [»] | |
1ZAG | X-ray | 2.80 | A/B/C/D | 25-298 | [»] | |
3ES6 | X-ray | 3.23 | A | 21-298 | [»] | |
6R2U | X-ray | 2.49 | A/B/C/D/E/F | 21-298 | [»] | |
SMRi | P25311 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107040, 114 interactors |
CORUMi | P25311 |
IntActi | P25311, 36 interactors |
MINTi | P25311 |
STRINGi | 9606.ENSP00000292401 |
Chemistry databases
DrugBanki | DB09130, Copper DB03721, N-acetyl-alpha-neuraminic acid |
PTM databases
CarbonylDBi | P25311 |
GlyConnecti | 692, 108 N-Linked glycans (3 sites), 1 O-Linked glycan (1 site) |
GlyGeni | P25311, 5 sites, 118 N-linked glycans (4 sites) |
iPTMneti | P25311 |
PhosphoSitePlusi | P25311 |
Genetic variation databases
BioMutai | AZGP1 |
DMDMi | 292495049 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00166729 |
SWISS-2DPAGEi | P25311 |
Proteomic databases
CPTACi | non-CPTAC-1167 non-CPTAC-2709 |
EPDi | P25311 |
jPOSTi | P25311 |
MassIVEi | P25311 |
MaxQBi | P25311 |
PaxDbi | P25311 |
PeptideAtlasi | P25311 |
PRIDEi | P25311 |
ProteomicsDBi | 54267 |
Protocols and materials databases
Antibodypediai | 848, 364 antibodies from 33 providers |
DNASUi | 563 |
Genome annotation databases
Ensembli | ENST00000292401; ENSP00000292401; ENSG00000160862 |
GeneIDi | 563 |
KEGGi | hsa:563 |
MANE-Selecti | ENST00000292401.9; ENSP00000292401.4; NM_001185.4; NP_001176.1 |
UCSCi | uc003ush.4, human |
Organism-specific databases
CTDi | 563 |
DisGeNETi | 563 |
GeneCardsi | AZGP1 |
HGNCi | HGNC:910, AZGP1 |
HPAi | ENSG00000160862, Tissue enhanced (liver, salivary gland) |
MIMi | 194460, gene |
neXtProti | NX_P25311 |
OpenTargetsi | ENSG00000160862 |
PharmGKBi | PA25203 |
VEuPathDBi | HostDB:ENSG00000160862 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RWW3, Eukaryota |
GeneTreei | ENSGT01040000240404 |
HOGENOMi | CLU_047501_0_1_1 |
InParanoidi | P25311 |
OMAi | YQSWVVV |
OrthoDBi | 912212at2759 |
PhylomeDBi | P25311 |
TreeFami | TF336617 |
Enzyme and pathway databases
PathwayCommonsi | P25311 |
Reactomei | R-HSA-5223345, Miscellaneous transport and binding events |
SignaLinki | P25311 |
Miscellaneous databases
BioGRID-ORCSi | 563, 31 hits in 1034 CRISPR screens |
ChiTaRSi | AZGP1, human |
EvolutionaryTracei | P25311 |
GeneWikii | AZGP1 |
GenomeRNAii | 563 |
Pharosi | P25311, Tbio |
PROi | PR:P25311 |
RNActi | P25311, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160862, Expressed in minor salivary gland and 207 other tissues |
ExpressionAtlasi | P25311, baseline and differential |
Genevisiblei | P25311, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ZA2G_HUMAN | |
Accessioni | P25311Primary (citable) accession number: P25311 Secondary accession number(s): D6W5T8 Q8N4N0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | March 23, 2010 | |
Last modified: | February 23, 2022 | |
This is version 215 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families