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Protein

Zinc-alpha-2-glycoprotein

Gene

AZGP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

GO - Molecular functioni

  • protein transmembrane transporter activity Source: UniProtKB
  • ribonuclease activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-alpha-2-glycoprotein
Short name:
Zn-alpha-2-GP
Short name:
Zn-alpha-2-glycoprotein
Gene namesi
Name:AZGP1
Synonyms:ZAG, ZNGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000160862.12
HGNCiHGNC:910 AZGP1
MIMi194460 gene
neXtProtiNX_P25311

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi563
OpenTargetsiENSG00000160862
PharmGKBiPA25203

Chemistry databases

DrugBankiDB03721 N-acetyl-alpha-neuraminic acid

Polymorphism and mutation databases

BioMutaiAZGP1
DMDMi292495049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 202 PublicationsAdd BLAST20
ChainiPRO_000001901221 – 298Zinc-alpha-2-glycoproteinAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Pyrrolidone carboxylic acid1 Publication1
Glycosylationi109N-linked (GlcNAc...) (complex) asparagine5 Publications1
Glycosylationi112N-linked (GlcNAc...) asparagine5 Publications1
Disulfide bondi123 ↔ 186
Glycosylationi128N-linked (GlcNAc...) (complex) asparagine9 Publications1
Disulfide bondi225 ↔ 280
Glycosylationi259N-linked (GlcNAc...) asparagine3 Publications1

Post-translational modificationi

N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.11 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP25311
MaxQBiP25311
PaxDbiP25311
PeptideAtlasiP25311
PRIDEiP25311
ProteomicsDBi54267

2D gel databases

REPRODUCTION-2DPAGEiIPI00166729
SWISS-2DPAGEiP25311

PTM databases

CarbonylDBiP25311
GlyConnecti692
iPTMnetiP25311
PhosphoSitePlusiP25311
UniCarbKBiP25311

Expressioni

Tissue specificityi

Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver.

Gene expression databases

BgeeiENSG00000160862 Expressed in 195 organ(s), highest expression level in minor salivary gland
CleanExiHS_AZGP1
ExpressionAtlasiP25311 baseline and differential
GenevisibleiP25311 HS

Organism-specific databases

HPAiCAB016087
CAB032276
HPA012582

Interactioni

Subunit structurei

Interacts with PIP.1 Publication

Protein-protein interaction databases

BioGridi107040, 27 interactors
CORUMiP25311
IntActiP25311, 16 interactors
MINTiP25311
STRINGi9606.ENSP00000292401

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP25311
SMRiP25311
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25311

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 292Ig-like C1-typeAdd BLAST86

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9FR Eukaryota
ENOG4111CJX LUCA
GeneTreeiENSGT00740000114936
HOGENOMiHOG000296917
HOVERGENiHBG016709
InParanoidiP25311
OMAiTYQSWVV
OrthoDBiEOG091G0K1X
PhylomeDBiP25311
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P25311-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRMVPVLLS LLLLLGPAVP QENQDGRYSL TYIYTGLSKH VEDVPAFQAL
60 70 80 90 100
GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET
110 120 130 140 150
LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE
160 170 180 190 200
IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI
210 220 230 240 250
LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL
260 270 280 290
RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS
Length:298
Mass (Da):34,259
Last modified:March 23, 2010 - v2
Checksum:i006A153A8E32A0B1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JEV0C9JEV0_HUMAN
Zinc-alpha-2-glycoprotein
AZGP1
227Annotation score:
H7BZJ8H7BZJ8_HUMAN
Zinc-alpha-2-glycoprotein
AZGP1
85Annotation score:

Sequence cautioni

The sequence AAA61311 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA03123 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA14417 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA42438 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2V → S in CAA42438 (PubMed:1915885).Curated1
Sequence conflicti5V → L in CAA42438 (PubMed:1915885).Curated1
Sequence conflicti33I → V in AAH05306 (PubMed:15489334).Curated1
Sequence conflicti85Q → E AA sequence (PubMed:3422450).Curated1
Sequence conflicti96 – 97Missing AA sequence (PubMed:3422450).Curated2
Sequence conflicti244E → Q AA sequence (PubMed:3422450).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59766 mRNA Translation: CAA42438.1 Different initiation.
D14034 Genomic DNA Translation: BAA03123.1 Different initiation.
X69953 Genomic DNA Translation: CAA49574.1
AC004522 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23862.1
CH471091 Genomic DNA Translation: EAW76621.1
CH471091 Genomic DNA Translation: EAW76622.1
BC005306 mRNA Translation: AAH05306.1
BC033830 mRNA Translation: AAH33830.1
D90427 mRNA Translation: BAA14417.1 Different initiation.
M76707 mRNA Translation: AAA61311.1 Different initiation.
CCDSiCCDS5680.1
PIRiA54175
RefSeqiNP_001176.1, NM_001185.3
UniGeneiHs.546239

Genome annotation databases

EnsembliENST00000292401; ENSP00000292401; ENSG00000160862
GeneIDi563
KEGGihsa:563
UCSCiuc003ush.4 human

Similar proteinsi

Entry informationi

Entry nameiZA2G_HUMAN
AccessioniPrimary (citable) accession number: P25311
Secondary accession number(s): D6W5T8
, O60386, Q5XKQ4, Q8N4N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 23, 2010
Last modified: September 12, 2018
This is version 193 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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