AZGP1

Functionⁱ

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

GO - Molecular functionⁱ

protein transmembrane transporter activity
Source: UniProtKB
Non-traceable author statementⁱ
- 6896906
ribonuclease activity
Source: UniProtKB
Non-traceable author statementⁱ
- 10462714

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 9813179
detection of chemical stimulus involved in sensory perception of bitter taste
Source: UniProtKB
Inferred from direct assayⁱ
- 24248522
negative regulation of cell proliferation
Source: UniProtKB
Non-traceable author statementⁱ
- 10462714
retina homeostasis
Source: UniProtKB
Inferred from high throughput expression patternⁱ
- 23580065
transmembrane transport Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5223345 Miscellaneous transport and binding events

Reactomeⁱ

R-HSA-5223345 Miscellaneous transport and binding events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc-alpha-2-glycoprotein Short name: Zn-alpha-2-GP Short name: Zn-alpha-2-glycoprotein
Gene namesⁱ	Name:AZGP1 Synonyms:ZAG, ZNGP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160862.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:910 AZGP1
MIMⁱ	194460 gene
neXtProtⁱ	NX_P25311

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	563
Open Targets More...OpenTargetsⁱ	ENSG00000160862
PharmGKBⁱ	PA25203

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB03721 N-acetyl-alpha-neuraminic acid

DrugBankⁱ

DB03721 N-acetyl-alpha-neuraminic acid

Polymorphism and mutation databases

BioMutaⁱ	AZGP1
DMDMⁱ	292495049

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	2 PublicationsAdd BLAST		20
ChainⁱPRO_0000019012	21 – 298	Zinc-alpha-2-glycoproteinAdd BLAST		278

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	21	Pyrrolidone carboxylic acid1 Publication	1
Glycosylationⁱ	109	N-linked (GlcNAc...) (complex) asparagine5 Publications	1
Glycosylationⁱ	112	N-linked (GlcNAc...) asparagine5 Publications	1
Disulfide bondⁱ	123 ↔ 186
Glycosylationⁱ	128	N-linked (GlcNAc...) (complex) asparagine9 Publications	1
Disulfide bondⁱ	225 ↔ 280
Glycosylationⁱ	259	N-linked (GlcNAc...) asparagine3 Publications	1

Post-translational modificationⁱ

N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.11 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDⁱ	P25311
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P25311
PaxDbⁱ	P25311
PeptideAtlas More...PeptideAtlasⁱ	P25311
PRIDEⁱ	P25311
ProteomicsDBⁱ	54267

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00166729
SWISS-2DPAGEⁱ	P25311

PTM databases

CarbonylDBⁱ	P25311
GlyConnectⁱ	692
iPTMnetⁱ	P25311
PhosphoSitePlusⁱ	P25311
UniCarbKBⁱ	P25311

Expressionⁱ

Tissue specificityⁱ

Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver.

Gene expression databases

Bgeeⁱ	ENSG00000160862 Expressed in 195 organ(s), highest expression level in minor salivary gland
CleanExⁱ	HS_AZGP1
ExpressionAtlasⁱ	P25311 baseline and differential
Genevisibleⁱ	P25311 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016087 CAB032276 HPA012582

HPAⁱ

CAB016087
CAB032276
HPA012582

Interactionⁱ

Subunit structureⁱ

Interacts with PIP.1 Publication

Protein-protein interaction databases

BioGridⁱ	107040, 27 interactors
CORUMⁱ	P25311
IntActⁱ	P25311, 16 interactors
Molecular INTeraction database More...MINTⁱ	P25311
STRINGⁱ	9606.ENSP00000292401

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	27 – 39	Combined sources	13
Beta strandⁱ	42 – 44	Combined sources	3
Beta strandⁱ	46 – 53	Combined sources	8
Beta strandⁱ	56 – 62	Combined sources	7
Turnⁱ	63 – 65	Combined sources	3
Helixⁱ	72 – 76	Combined sources	5
Beta strandⁱ	79 – 81	Combined sources	3
Helixⁱ	83 – 107	Combined sources	25
Beta strandⁱ	116 – 126	Combined sources	11
Beta strandⁱ	129 – 139	Combined sources	11
Beta strandⁱ	142 – 148	Combined sources	7
Turnⁱ	149 – 152	Combined sources	4
Beta strandⁱ	153 – 156	Combined sources	4
Helixⁱ	159 – 168	Combined sources	10
Helixⁱ	173 – 183	Combined sources	11
Helixⁱ	185 – 196	Combined sources	12
Helixⁱ	198 – 201	Combined sources	4
Beta strandⁱ	208 – 215	Combined sources	8
Beta strandⁱ	217 – 219	Combined sources	3
Beta strandⁱ	221 – 233	Combined sources	13
Beta strandⁱ	235 – 241	Combined sources	7
Beta strandⁱ	244 – 246	Combined sources	3
Beta strandⁱ	249 – 256	Combined sources	8
Turnⁱ	257 – 260	Combined sources	4
Beta strandⁱ	261 – 270	Combined sources	10
Beta strandⁱ	278 – 284	Combined sources	7
Beta strandⁱ	291 – 294	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P25311
SMRⁱ	P25311
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P25311

EvolutionaryTraceⁱ

P25311

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	207 – 292	Ig-like C1-typeAdd BLAST		86

Sequence similaritiesⁱ

Belongs to the MHC class I family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J9FR Eukaryota ENOG4111CJX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00740000114936
HOGENOMⁱ	HOG000296917
HOVERGENⁱ	HBG016709
InParanoidⁱ	P25311
OMAⁱ	TYQSWVV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0K1X
PhylomeDBⁱ	P25311
TreeFamⁱ	TF336617

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog IPR001039 MHC_I_a_a1/a2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00129 MHC_I, 1 hit
PRINTSⁱ	PR01638 MHCCLASSI
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.ⁱShow all

P25311-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVRMVPVLLS LLLLLGPAVP QENQDGRYSL TYIYTGLSKH VEDVPAFQAL 
        60         70         80         90        100
GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET 
       110        120        130        140        150
LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE 
       160        170        180        190        200
IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI 
       210        220        230        240        250
LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL 
       260        270        280        290 
RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS

Length:298

Mass (Da):34,259

Last modified:March 23, 2010 - v2

Checksum:ⁱ006A153A8E32A0B1

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	C9JEV0	C9JEV0_HUMAN		Zinc-alpha-2-glycoprotein Zinc-alpha-2-glycoprotein	AZGP1	227	Annotation score:
	H7BZJ8	H7BZJ8_HUMAN		Zinc-alpha-2-glycoprotein Zinc-alpha-2-glycoprotein	AZGP1	85	Annotation score:

Sequence cautionⁱ

The sequence AAA61311 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAA03123 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAA14417 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAA42438 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	2	V → S in CAA42438 (PubMed:1915885).Curated	1
Sequence conflictⁱ	5	V → L in CAA42438 (PubMed:1915885).Curated	1
Sequence conflictⁱ	33	I → V in AAH05306 (PubMed:15489334).Curated	1
Sequence conflictⁱ	85	Q → E AA sequence (PubMed:3422450).Curated	1
Sequence conflictⁱ	96 – 97	Missing AA sequence (PubMed:3422450).Curated	2
Sequence conflictⁱ	244	E → Q AA sequence (PubMed:3422450).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X59766 mRNA Translation: CAA42438.1 Different initiation. D14034 Genomic DNA Translation: BAA03123.1 Different initiation. X69953 Genomic DNA Translation: CAA49574.1 AC004522 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23862.1 CH471091 Genomic DNA Translation: EAW76621.1 CH471091 Genomic DNA Translation: EAW76622.1 BC005306 mRNA Translation: AAH05306.1 BC033830 mRNA Translation: AAH33830.1 D90427 mRNA Translation: BAA14417.1 Different initiation. M76707 mRNA Translation: AAA61311.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5680.1
PIRⁱ	A54175
NCBI Reference Sequences More...RefSeqⁱ	NP_001176.1, NM_001185.3
UniGeneⁱ	Hs.546239

Genome annotation databases

Ensemblⁱ	ENST00000292401; ENSP00000292401; ENSG00000160862
GeneIDⁱ	563
KEGGⁱ	hsa:563
UCSC genome browser More...UCSCⁱ	uc003ush.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P25311	Testicular tissue protein Li 227		HUMAN		298	UniRef100_P25311
UPI0000112F90		HUMAN		274

Protein	Similar proteins		Species	Score	Length	Source
P25311	Testicular tissue protein Li 227		HUMAN		298	UniRef90_P25311
Alpha-2-glycoprotein 1, zinc-binding		PONAB		341
Alpha-2-glycoprotein 1, zinc-binding		PANPA		298
Alpha-2-glycoprotein 1, zinc-binding		GORGO		298
Alpha-2-glycoprotein 1, zinc-binding		MACFA		298
+20

Protein	Similar proteins		Species	Score	Length	Source
P25311	Testicular tissue protein Li 227		HUMAN		298	UniRef50_P25311
Alpha-2-glycoprotein 1, zinc-binding		PONAB		341
Alpha-2-glycoprotein 1, zinc-binding		GORGO		298
Alpha-2-glycoprotein 1, zinc-binding		RHIRO		298
Alpha-2-glycoprotein 1, zinc-binding		RHIBE		298
+29

Entry informationⁱ

Entry nameⁱ	ZA2G_HUMAN
Accessionⁱ	P25311Primary (citable) accession number: P25311 Secondary accession number(s): D6W5T8 , O60386, Q5XKQ4, Q8N4N0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	March 23, 2010
	Last modified:	September 12, 2018
	This is version 193 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P25311 (ZA2G_HUMAN)

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Zinc-alpha-2-glycoprotein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Nucleus

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ