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Protein

Lysozyme M1

Gene

acm

Organism
Streptomyces globisporus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86PROSITE-ProRule annotation1
Active sitei177PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH25 Glycoside Hydrolase Family 25

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme M1 (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase M1
Gene namesi
Name:acm
OrganismiStreptomyces globisporus
Taxonomic identifieri1908 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000018517? – 771 Publication
Signal peptidei1 – ?Sequence analysis
ChainiPRO_000001851878 – 294Lysozyme M1Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi185 ↔ 2241 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP25310

Structurei

Secondary structure

1294
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi81 – 87Combined sources7
Helixi89 – 91Combined sources3
Helixi96 – 101Combined sources6
Beta strandi106 – 113Combined sources8
Turni114 – 116Combined sources3
Helixi122 – 131Combined sources10
Beta strandi135 – 141Combined sources7
Turni144 – 146Combined sources3
Helixi149 – 158Combined sources10
Beta strandi166 – 169Combined sources4
Beta strandi173 – 175Combined sources3
Beta strandi180 – 182Combined sources3
Turni184 – 187Combined sources4
Helixi190 – 208Combined sources19
Beta strandi213 – 216Combined sources4
Helixi218 – 225Combined sources8
Turni230 – 234Combined sources5
Beta strandi237 – 240Combined sources4
Beta strandi253 – 255Combined sources3
Beta strandi257 – 267Combined sources11
Beta strandi270 – 281Combined sources12
Helixi283 – 291Combined sources9

3D structure databases

ProteinModelPortaliP25310
SMRiP25310
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25310

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 25 family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR002053 Glyco_hydro_25
IPR008270 Glyco_hydro_25_AS
IPR018077 Glyco_hydro_fam25_subgr
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF01183 Glyco_hydro_25, 1 hit
SMARTiView protein in SMART
SM00641 Glyco_25, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00953 GLYCOSYL_HYDROL_F25, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAYSSLARR GRRPAVVLLG GLVSASLALT LAPTAAAAPL APPPGKDVGP
60 70 80 90 100
GEAYMGVGTR IEQGLGAGPD ERTIGPADTS GVQGIDVSHW QGSINWSSVK
110 120 130 140 150
SAGMSFAYIK ATEGTNYKDD RFSANYTNAY NAGIIRGAYH FARPNASSGT
160 170 180 190 200
AQADYFASNG GGWSRDNRTL PGVLDIEHNP SGAMCYGLST TQMRTWINDF
210 220 230 240 250
HARYKARTTR DVVIYTTASW WNTCTGSWNG MAAKSPFWVA HWGVSAPTVP
260 270 280 290
SGFPTWTFWQ YSATGRVGGV SGDVDRNKFN GSAARLLALA NNTA
Length:294
Mass (Da):31,169
Last modified:May 1, 1992 - v1
Checksum:iD96EFE914FA04997
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30645 Genomic DNA Translation: AAA26687.1
PIRiJQ0529 MUSMM1

Similar proteinsi

Entry informationi

Entry nameiLYSM1_STRGL
AccessioniPrimary (citable) accession number: P25310
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 10, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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