UniProtKB - P25305 (CXB3_RAT)
Protein
Gap junction beta-3 protein
Gene
Gjb3
Organism
Rattus norvegicus (Rat)
Status
Functioni
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
GO - Molecular functioni
- gap junction channel activity Source: GO_Central
GO - Biological processi
- cell-cell signaling Source: GO_Central
- cellular response to retinoic acid Source: RGD
- in utero embryonic development Source: RGD
- placenta development Source: RGD
- skin development Source: RGD
- spermatogenesis Source: RGD
Enzyme and pathway databases
Reactomei | R-RNO-190861, Gap junction assembly |
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction beta-3 proteinAlternative name(s): Connexin-31 Short name: Cx31 |
Gene namesi | Name:Gjb3 Synonyms:Cxn-31 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2695, Gjb3 |
Subcellular locationi
Plasma membrane
Other locations
Plasma Membrane
- connexin complex Source: GO_Central
Other locations
- cell-cell junction Source: RGD
- cytoplasm Source: RGD
- gap junction Source: RGD
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 20 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 21 – 40 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 41 – 75 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 76 – 98 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 99 – 126 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 127 – 149 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 150 – 188 | ExtracellularSequence analysisAdd BLAST | 39 | |
Transmembranei | 189 – 211 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 212 – 270 | CytoplasmicSequence analysisAdd BLAST | 59 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057864 | 1 – 270 | Gap junction beta-3 proteinAdd BLAST | 270 |
Proteomic databases
PaxDbi | P25305 |
PRIDEi | P25305 |
PTM databases
iPTMneti | P25305 |
PhosphoSitePlusi | P25305 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000014372, Expressed in jejunum and 16 other tissues |
Genevisiblei | P25305, RN |
Interactioni
Subunit structurei
A connexon is composed of a hexamer of connexins.
Interacts with CNST (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019266 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRC0, Eukaryota |
GeneTreei | ENSGT00990000203557 |
HOGENOMi | CLU_037388_4_1_1 |
InParanoidi | P25305 |
OMAi | CIVLTVC |
OrthoDBi | 902090at2759 |
PhylomeDBi | P25305 |
TreeFami | TF329606 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002269, Connexin31 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit PTHR11984:SF65, PTHR11984:SF65, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01140, CONNEXINB3 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P25305-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDWKKLQDLL SGVNQYSTAF GRIWLSVVFV FRVLVYVVAA ERVWGDEQKD
60 70 80 90 100
FDCNTRQPGC TNVCYDNFFP ISNIRLWALQ LIFVTCPSML VILHVAYREE
110 120 130 140 150
RERKHRQKHG EHCAKLYSHP GKKHGGLWWT YLFSLIFKLI IELVFLYVLH
160 170 180 190 200
TLWHGFTMPR LVQCASVVPC PNTVDCYIAR PTEKKVFTYF MVGASAVCII
210 220 230 240 250
LTICEICYLI FHRIMRGLSK DKSTKSISSP KSSSRASTCR CHHKLLESGD
260 270
LEAVPADDKL QASAPSLTPI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59936 Genomic DNA Translation: AAA40997.1 |
PIRi | A38737 |
RefSeqi | NP_062113.1, NM_019240.1 XP_006238907.1, XM_006238845.3 |
Genome annotation databases
Ensembli | ENSRNOT00000019266; ENSRNOP00000019266; ENSRNOG00000014372 |
GeneIDi | 29585 |
KEGGi | rno:29585 |
UCSCi | RGD:2695, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59936 Genomic DNA Translation: AAA40997.1 |
PIRi | A38737 |
RefSeqi | NP_062113.1, NM_019240.1 XP_006238907.1, XM_006238845.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019266 |
PTM databases
iPTMneti | P25305 |
PhosphoSitePlusi | P25305 |
Proteomic databases
PaxDbi | P25305 |
PRIDEi | P25305 |
Genome annotation databases
Ensembli | ENSRNOT00000019266; ENSRNOP00000019266; ENSRNOG00000014372 |
GeneIDi | 29585 |
KEGGi | rno:29585 |
UCSCi | RGD:2695, rat |
Organism-specific databases
CTDi | 2707 |
RGDi | 2695, Gjb3 |
Phylogenomic databases
eggNOGi | ENOG502QRC0, Eukaryota |
GeneTreei | ENSGT00990000203557 |
HOGENOMi | CLU_037388_4_1_1 |
InParanoidi | P25305 |
OMAi | CIVLTVC |
OrthoDBi | 902090at2759 |
PhylomeDBi | P25305 |
TreeFami | TF329606 |
Enzyme and pathway databases
Reactomei | R-RNO-190861, Gap junction assembly |
Miscellaneous databases
PROi | PR:P25305 |
Gene expression databases
Bgeei | ENSRNOG00000014372, Expressed in jejunum and 16 other tissues |
Genevisiblei | P25305, RN |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002269, Connexin31 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit PTHR11984:SF65, PTHR11984:SF65, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01140, CONNEXINB3 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXB3_RAT | |
Accessioni | P25305Primary (citable) accession number: P25305 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families