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Protein

DNA repair protein RAD57

Gene

RAD57

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the repair of X-ray-induced damage to DNA and in meiosis. It may act in part by stabilizing a repair complex of other RAD genes.

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi125 – 132ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • DNA recombinase assembly Source: SGD
  • heteroduplex formation Source: SGD
  • meiotic DNA recombinase assembly Source: SGD
  • reciprocal meiotic recombination Source: GO_Central
  • response to ionizing radiation Source: GO_Central
  • strand invasion Source: GO_Central
  • telomere maintenance via recombination Source: SGD

Keywordsi

Biological processDNA damage, DNA repair, Meiosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29626-MONOMER
ReactomeiR-SCE-5693579 Homologous DNA Pairing and Strand Exchange
R-SCE-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD57
Gene namesi
Name:RAD57
Ordered Locus Names:YDR004W
ORF Names:YD8119.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR004W
SGDiS000002411 RAD57

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001229561 – 460DNA repair protein RAD57Add BLAST460

Proteomic databases

PaxDbiP25301
PRIDEiP25301

PTM databases

iPTMnetiP25301

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32057, 253 interactors
ComplexPortaliCPX-3139 RAD55-RAD57 complex
DIPiDIP-4774N
IntActiP25301, 17 interactors
STRINGi4932.YDR004W

Structurei

3D structure databases

ProteinModelPortaliP25301
SMRiP25301
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family.Curated

Phylogenomic databases

GeneTreeiENSGT00860000133731
HOGENOMiHOG000141828
InParanoidiP25301
KOiK10958
OMAiCQDLESQ
OrthoDBiEOG092C2P9C

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013632 DNA_recomb/repair_Rad51_C
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25301-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRALSIKFD NTYMDLYDEL PESKLLYDEE FSYLLDAVRQ NGVCVVDFLT
60 70 80 90 100
LTPKELARLI QRSINEVFRF QQLLVHEYNE KYLEICEKNS ISPDNGPECF
110 120 130 140 150
TTADVAMDEL LGGGIFTHGI TEIFGESSTG KSQLLMQLAL SVQLSEPAGG
160 170 180 190 200
LGGKCVYITT EGDLPTQRLE SMLSSRPAYE KLGITQSNIF TVSCNDLINQ
210 220 230 240 250
EHIINVQLPI LLERSKGSIK LVIIDSISHH LRVELQNKSF RESQENKNYL
260 270 280 290 300
DRMAEKLQIL AHDYSLSVVV ANQVGDKPLA NSPVAHRTYV TDYDYQLGWL
310 320 330 340 350
VGWKNSTILY RQMNSLLGAS SNNDEILSDD EDYMLIERVM STVNDRNYDF
360 370 380 390 400
FSKKKPPIIE NKTVERNSSS PISRQSKKRK FDYRVPNLGL TWSNHVSTRI
410 420 430 440 450
LLQKSFKAST IIQRGEAHLY KGGDSASFWQ VKRTMKVVYS TFAKPGQIAY
460
QITKRGIETA
Length:460
Mass (Da):52,247
Last modified:May 1, 1992 - v1
Checksum:iFCB80C31721AD344
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65061 Genomic DNA Translation: AAA34950.1
Z48008 Genomic DNA Translation: CAA88064.1
BK006938 Genomic DNA Translation: DAA11852.1
PIRiJQ1275
RefSeqiNP_010287.1, NM_001180312.1

Genome annotation databases

EnsemblFungiiYDR004W; YDR004W; YDR004W
GeneIDi851567
KEGGisce:YDR004W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65061 Genomic DNA Translation: AAA34950.1
Z48008 Genomic DNA Translation: CAA88064.1
BK006938 Genomic DNA Translation: DAA11852.1
PIRiJQ1275
RefSeqiNP_010287.1, NM_001180312.1

3D structure databases

ProteinModelPortaliP25301
SMRiP25301
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32057, 253 interactors
ComplexPortaliCPX-3139 RAD55-RAD57 complex
DIPiDIP-4774N
IntActiP25301, 17 interactors
STRINGi4932.YDR004W

PTM databases

iPTMnetiP25301

Proteomic databases

PaxDbiP25301
PRIDEiP25301

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR004W; YDR004W; YDR004W
GeneIDi851567
KEGGisce:YDR004W

Organism-specific databases

EuPathDBiFungiDB:YDR004W
SGDiS000002411 RAD57

Phylogenomic databases

GeneTreeiENSGT00860000133731
HOGENOMiHOG000141828
InParanoidiP25301
KOiK10958
OMAiCQDLESQ
OrthoDBiEOG092C2P9C

Enzyme and pathway databases

BioCyciYEAST:G3O-29626-MONOMER
ReactomeiR-SCE-5693579 Homologous DNA Pairing and Strand Exchange
R-SCE-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

PROiPR:P25301

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013632 DNA_recomb/repair_Rad51_C
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAD57_YEAST
AccessioniPrimary (citable) accession number: P25301
Secondary accession number(s): D6VRZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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Main funding by: National Institutes of Health

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