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Protein

rRNA methyltransferase 1, mitochondrial

Gene

MRM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 2270 (Gm2270) in the 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This modification seems to be important for the normal accumulation of the mitochondrial large ribosomal subunit.1 Publication

Miscellaneous

Present with 2760 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + guanosine(2270) in 21S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(2270) in 21S rRNA.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-33707-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA methyltransferase 1, mitochondrial1 Publication (EC:2.1.1.-1 Publication)
Alternative name(s):
21S rRNA (guanosine(2270)-2'-O)-methyltransferase1 Publication
21S rRNA [Gm2270] 2'-O-methyltransferase1 Publication
Mitochondrial large ribosomal RNA ribose methylase1 Publication
Petite colonies protein 561 Publication
Gene namesi
Name:MRM11 Publication
Synonyms:PET561 Publication
Ordered Locus Names:YOR201CImported
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR201C
SGDiS000005727 MRM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20MitochondrionSequence analysisAdd BLAST20
ChainiPRO_000005832121 – 412rRNA methyltransferase 1, mitochondrialAdd BLAST392

Proteomic databases

MaxQBiP25270
PaxDbiP25270
PRIDEiP25270
TopDownProteomicsiP25270

PTM databases

iPTMnetiP25270

Interactioni

Protein-protein interaction databases

BioGridi34597, 155 interactors
DIPiDIP-2603N
IntActiP25270, 12 interactors
MINTiP25270
STRINGi4932.YOR201C

Structurei

3D structure databases

ProteinModelPortaliP25270
SMRiP25270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000018761
HOGENOMiHOG000248090
InParanoidiP25270
KOiK15507
OMAiKYAHVHA
OrthoDBiEOG092C56A3

Family and domain databases

Gene3Di3.40.1280.10, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR029064 L30e-like
IPR004441 rRNA_MeTrfase_TrmH
IPR001537 SpoU_MeTrfase
IPR013123 SpoU_subst-bd
IPR029026 tRNA_m1G_MTases_N
PANTHERiPTHR12029:SF58 PTHR12029:SF58, 1 hit
PfamiView protein in Pfam
PF00588 SpoU_methylase, 1 hit
PF08032 SpoU_sub_bind, 1 hit
SMARTiView protein in SMART
SM00967 SpoU_sub_bind, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
SSF75217 SSF75217, 1 hit
TIGRFAMsiTIGR00186 rRNA_methyl_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25270-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLTNAVFK RYLAVTPSAH QALKTRIKKK SSSFDKFFPQ QSNSRKKQWE
60 70 80 90 100
TLNEDKASWF KRKYAHVHAR EQDRAADPYG KKKAHVEKLK EIKNQAKLNQ
110 120 130 140 150
KSHKSKFQNK DIALKLMNDN PIFEYVYGTN SVYAALLNPS RNCHSRLLYH
160 170 180 190 200
GTIPSKFLQI VDELKVTTEL VDKHRLNLLT NYGVHNNIAL ETKPLQPVEI
210 220 230 240 250
AYLGDMDTSS AALSIHELGF NNENIPHELP YGTKTDAKKF PLGLYLDEIT
260 270 280 290 300
DPHNIGAIIR SAYFLGVDFI VMSRRNCSPL TPVVSKTSSG ALELLPIFYV
310 320 330 340 350
DKPLEFFTKS QEMGGWTFIT SHLANATSEK YTVGKTISMH DLNGLCNELP
360 370 380 390 400
VVLVVGNESQ GVRTNLKMRS DFFVEIPFGG IEKGNRAPEP IVDSLNVSVA
410
TALLIDNILT CK
Length:412
Mass (Da):46,387
Last modified:February 1, 1996 - v2
Checksum:iC01B10254C0EDEA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19947 Genomic DNA Translation: AAA74564.1
Z75107 Genomic DNA Translation: CAA99414.1
X03245 Genomic DNA Translation: CAA27002.1
BK006948 Genomic DNA Translation: DAA10974.1
PIRiS48881
RefSeqiNP_014844.3, NM_001183620.3

Genome annotation databases

EnsemblFungiiYOR201C; YOR201C; YOR201C
GeneIDi854376
KEGGisce:YOR201C

Similar proteinsi

Entry informationi

Entry nameiMRM1_YEAST
AccessioniPrimary (citable) accession number: P25270
Secondary accession number(s): D6W2Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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