UniProtKB - P25205 (MCM3_HUMAN)

BLAST

>sp|P25205|MCM3_HUMAN DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3
MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEK
RANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCF
LSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEE
NNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGT
YRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLA
KSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLC
TAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRT
AIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFD
LLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQ
DTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQ
DSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEK
EKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQV
HTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPF
SSVEIQAALSKMQDDNQVMVSEGIIFLI

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History
Entry version 212 (12 Sep 2018)
Sequence version 3 (14 Aug 2001)
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Protein

DNA replication licensing factor MCM3

Gene

MCM3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

Miscellaneous

Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. The MCM2-7 hexamer is the proposed physiological active complex.

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	345 – 352	ATPSequence analysis		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
DNA binding
Source: ProtInc
Traceable author statementⁱ
- 1549468
helicase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA replication Source: Reactome
DNA replication initiation
Source: ProtInc
Traceable author statementⁱ
- 1549468
G1/S transition of mitotic cell cycle Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Helicase, Hydrolase
Biological process	Cell cycle, DNA replication
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-176187 Activation of ATR in response to replication stress R-HSA-176974 Unwinding of DNA R-HSA-68867 Assembly of the pre-replicative complex R-HSA-68949 Orc1 removal from chromatin R-HSA-68962 Activation of the pre-replicative complex R-HSA-69052 Switching of origins to a post-replicative state
SIGNORⁱ	P25205

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA replication licensing factor MCM3 (EC:3.6.4.12) Alternative name(s): DNA polymerase alpha holoenzyme-associated protein P1 P1-MCM3 RLF subunit beta p102
Gene namesⁱ	Name:MCM3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112118.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6945 MCM3
MIMⁱ	602693 gene
neXtProtⁱ	NX_P25205

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	535	S → A: 50% reduction in phosphorylation by ATM or ATR. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4172
Open Targets More...OpenTargetsⁱ	ENSG00000112118
PharmGKBⁱ	PA30691

Polymorphism and mutation databases

BioMutaⁱ	MCM3
DMDMⁱ	19857543

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000194093	2 – 808	DNA replication licensing factor MCM3Add BLAST		807

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	160	PhosphoserineCombined sources	1
Modified residueⁱ	275	PhosphoserineCombined sources	1
Modified residueⁱ	293	N6-acetyllysineBy similarity	1
Modified residueⁱ	535	Phosphoserine; by ATM1 Publication	1
Modified residueⁱ	547	N6-acetyllysineBy similarity	1
Modified residueⁱ	611	PhosphoserineCombined sources	1
Modified residueⁱ	668	PhosphoserineCombined sources	1
Modified residueⁱ	672	PhosphoserineCombined sources	1
Modified residueⁱ	674	PhosphothreonineCombined sources	1
Modified residueⁱ	681	PhosphoserineCombined sources	1
Modified residueⁱ	708	PhosphotyrosineCombined sources	1
Modified residueⁱ	711	PhosphoserineCombined sources	1
Modified residueⁱ	713	PhosphothreonineCombined sources	1
Modified residueⁱ	722	PhosphothreonineCombined sources	1
Modified residueⁱ	725	PhosphothreonineCombined sources	1
Modified residueⁱ	728	PhosphoserineBy similarity	1
Modified residueⁱ	734	PhosphoserineBy similarity	1

Post-translational modificationⁱ

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.1 Publication

Keywords - PTMⁱ

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P25205
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P25205
PaxDbⁱ	P25205
PeptideAtlas More...PeptideAtlasⁱ	P25205
PRIDEⁱ	P25205
ProteomicsDBⁱ	54265

PTM databases

iPTMnetⁱ	P25205
PhosphoSitePlusⁱ	P25205
SwissPalmⁱ	P25205

Miscellaneous databases

PMAP-CutDBⁱ	P25205

PMAP-CutDBⁱ

P25205

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000112118 Expressed in 229 organ(s), highest expression level in embryo
CleanExⁱ	HS_MCM3
ExpressionAtlasⁱ	P25205 baseline and differential
Genevisibleⁱ	P25205 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002162 HPA004789 HPA004790

HPAⁱ

CAB002162
HPA004789
HPA004790

Interactionⁱ

Subunit structureⁱ

Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (Probable). Associated with the replication-specific DNA polymerase alpha. Interacts with MCMBP. Interacts with ANKRD17.Curated3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HIST2H4B	P62805	2	EBI-355153,EBI-302023
MCM2	P49736	6	EBI-355153,EBI-374819
MCM5	P33992	4	EBI-355153,EBI-359410
MCM6	Q14566	3	EBI-355153,EBI-374900
MCMBP	Q9BTE3	11	EBI-355153,EBI-749378
ORC2	Q13416	2	EBI-355153,EBI-374957

Protein-protein interaction databases

BioGridⁱ	110340, 132 interactors
ComplexPortalⁱ	CPX-2940 MCM complex
CORUMⁱ	P25205
Database of interacting proteins More...DIPⁱ	DIP-31726N
IntActⁱ	P25205, 60 interactors
Molecular INTeraction database More...MINTⁱ	P25205
STRINGⁱ	9606.ENSP00000229854

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P25205
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	295 – 502	MCMAdd BLAST		208

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	477 – 480	Arginine finger		4

Sequence similaritiesⁱ

Belongs to the MCM family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0479 Eukaryota COG1241 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000141082
HOGENOMⁱ	HOG000224126
HOVERGENⁱ	HBG104962
InParanoidⁱ	P25205
KEGG Orthology (KO) More...KOⁱ	K02541
OMAⁱ	YQSKVRE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02B0
PhylomeDBⁱ	P25205
TreeFamⁱ	TF106459

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR031327 MCM IPR008046 Mcm3 IPR018525 MCM_CS IPR001208 MCM_dom IPR027925 MCM_N IPR033762 MCM_OB IPR012340 NA-bd_OB-fold IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR11630 PTHR11630, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00493 MCM, 1 hit PF14551 MCM_N, 1 hit PF17207 MCM_OB, 1 hit
PRINTSⁱ	PR01657 MCMFAMILY PR01659 MCMPROTEIN3
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit SM00350 MCM, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit SSF52540 SSF52540, 2 hits
PROSITEⁱ	View protein in PROSITE PS00847 MCM_1, 1 hit PS50051 MCM_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: P25205-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGTVVLDDV ELREAQRDYL DFLDDEEDQG IYQSKVRELI SDNQYRLIVN 
        60         70         80         90        100
VNDLRRKNEK RANRLLNNAF EELVAFQRAL KDFVASIDAT YAKQYEEFYV 
       110        120        130        140        150
GLEGSFGSKH VSPRTLTSCF LSCVVCVEGI VTKCSLVRPK VVRSVHYCPA 
       160        170        180        190        200
TKKTIERRYS DLTTLVAFPS SSVYPTKDEE NNPLETEYGL SVYKDHQTIT 
       210        220        230        240        250
IQEMPEKAPA GQLPRSVDVI LDDDLVDKAK PGDRVQVVGT YRCLPGKKGG 
       260        270        280        290        300
YTSGTFRTVL IACNVKQMSK DAQPSFSAED IAKIKKFSKT RSKDIFDQLA 
       310        320        330        340        350
KSLAPSIHGH DYVKKAILCL LLGGVERDLE NGSHIRGDIN ILLIGDPSVA 
       360        370        380        390        400
KSQLLRYVLC TAPRAIPTTG RGSSGVGLTA AVTTDQETGE RRLEAGAMVL 
       410        420        430        440        450
ADRGVVCIDE FDKMSDMDRT AIHEVMEQGR VTIAKAGIHA RLNARCSVLA 
       460        470        480        490        500
AANPVYGRYD QYKTPMENIG LQDSLLSRFD LLFIMLDQMD PEQDREISDH 
       510        520        530        540        550
VLRMHRYRAP GEQDGDAMPL GSAVDILATD DPNFSQEDQQ DTQIYEKHDN 
       560        570        580        590        600
LLHGTKKKKE KMVSAAFMKK YIHVAKIIKP VLTQESATYI AEEYSRLRSQ 
       610        620        630        640        650
DSMSSDTART SPVTARTLET LIRLATAHAK ARMSKTVDLQ DAEEAVELVQ 
       660        670        680        690        700
YAYFKKVLEK EKKRKKRSED ESETEDEEEK SQEDQEQKRK RRKTRQPDAK 
       710        720        730        740        750
DGDSYDPYDF SDTEEEMPQV HTPKTADSQE TKESQKVELS ESRLKAFKVA 
       760        770        780        790        800
LLDVFREAHA QSIGMNRLTE SINRDSEEPF SSVEIQAALS KMQDDNQVMV 

SEGIIFLI

Length:808

Mass (Da):90,981

Last modified:August 14, 2001 - v3

Checksum:ⁱC967C068B7090558

Isoform 2 (identifier: P25205-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLPRSPPLPRGNLWWREEFGSFRAGVESSWEPPRDFGGGSSLAAGM

« Hide

        10         20         30         40         50
MLPRSPPLPR GNLWWREEFG SFRAGVESSW EPPRDFGGGS SLAAGMAGTV 
        60         70         80         90        100
VLDDVELREA QRDYLDFLDD EEDQGIYQSK VRELISDNQY RLIVNVNDLR 
       110        120        130        140        150
RKNEKRANRL LNNAFEELVA FQRALKDFVA SIDATYAKQY EEFYVGLEGS 
       160        170        180        190        200
FGSKHVSPRT LTSCFLSCVV CVEGIVTKCS LVRPKVVRSV HYCPATKKTI 
       210        220        230        240        250
ERRYSDLTTL VAFPSSSVYP TKDEENNPLE TEYGLSVYKD HQTITIQEMP 
       260        270        280        290        300
EKAPAGQLPR SVDVILDDDL VDKAKPGDRV QVVGTYRCLP GKKGGYTSGT 
       310        320        330        340        350
FRTVLIACNV KQMSKDAQPS FSAEDIAKIK KFSKTRSKDI FDQLAKSLAP 
       360        370        380        390        400
SIHGHDYVKK AILCLLLGGV ERDLENGSHI RGDINILLIG DPSVAKSQLL 
       410        420        430        440        450
RYVLCTAPRA IPTTGRGSSG VGLTAAVTTD QETGERRLEA GAMVLADRGV 
       460        470        480        490        500
VCIDEFDKMS DMDRTAIHEV MEQGRVTIAK AGIHARLNAR CSVLAAANPV 
       510        520        530        540        550
YGRYDQYKTP MENIGLQDSL LSRFDLLFIM LDQMDPEQDR EISDHVLRMH 
       560        570        580        590        600
RYRAPGEQDG DAMPLGSAVD ILATDDPNFS QEDQQDTQIY EKHDNLLHGT 
       610        620        630        640        650
KKKKEKMVSA AFMKKYIHVA KIIKPVLTQE SATYIAEEYS RLRSQDSMSS 
       660        670        680        690        700
DTARTSPVTA RTLETLIRLA TAHAKARMSK TVDLQDAEEA VELVQYAYFK 
       710        720        730        740        750
KVLEKEKKRK KRSEDESETE DEEEKSQEDQ EQKRKRRKTR QPDAKDGDSY 
       760        770        780        790        800
DPYDFSDTEE EMPQVHTPKT ADSQETKESQ KVELSESRLK AFKVALLDVF 
       810        820        830        840        850
REAHAQSIGM NRLTESINRD SEEPFSSVEI QAALSKMQDD NQVMVSEGII 

FLI

Note: No experimental confirmation available.

Show »

Length:853

Mass (Da):95,908

Checksum:ⁱE3EFA82D0E088CF1

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
J3KQ69	J3KQ69_HUMAN	DNA replication licensing factor MC... DNA replication licensing factor MCM3	MCM3	818	Annotation score:
Q7Z6P5	Q7Z6P5_HUMAN	DNA replication licensing factor MC... DNA replication licensing factor MCM3	MCM3	328	Annotation score:
M0QYS9	M0QYS9_HUMAN	DNA replication licensing factor MC... DNA replication licensing factor MCM3	MCM3	77	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	230 – 231	KP → NA in BAA07267 (PubMed:7758114).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014810	105	S → G. Corresponds to variant dbSNP:rs2307332Ensembl.	1
Natural variantⁱVAR_014811	280	D → V1 PublicationCorresponds to variant dbSNP:rs2307329Ensembl.	1
Natural variantⁱVAR_014812	287	F → L1 PublicationCorresponds to variant dbSNP:rs2307328Ensembl.	1
Natural variantⁱVAR_020516	590	I → L1 PublicationCorresponds to variant dbSNP:rs17240063Ensembl.	1
Natural variantⁱVAR_020517	774	R → W1 PublicationCorresponds to variant dbSNP:rs2230239Ensembl.	1
Natural variantⁱVAR_020427	777	E → K1 PublicationCorresponds to variant dbSNP:rs2230240Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057050	1	M → MLPRSPPLPRGNLWWREEFG SFRAGVESSWEPPRDFGGGS SLAAGM in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62153 mRNA Translation: CAA44078.2 D38073 mRNA Translation: BAA07267.1 AK301704 mRNA Translation: BAG63176.1 AY621074 Genomic DNA Translation: AAT27321.1 AL034343 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04367.1 BC001626 mRNA Translation: AAH01626.1 BC003509 mRNA Translation: AAH03509.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4940.2 [P25205-2]
PIRⁱ	S62594
NCBI Reference Sequences More...RefSeqⁱ	NP_001257401.1, NM_001270472.1 NP_002379.3, NM_002388.4 [P25205-2]
UniGeneⁱ	Hs.179565

Genome annotation databases

Ensemblⁱ	ENST00000229854; ENSP00000229854; ENSG00000112118 [P25205-1] ENST00000596288; ENSP00000472940; ENSG00000112118 [P25205-2] ENST00000616552; ENSP00000480987; ENSG00000112118 [P25205-2]
GeneIDⁱ	4172
KEGGⁱ	hsa:4172
UCSC genome browser More...UCSCⁱ	uc003pan.2 human [P25205-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P25205	Isoform 2 of DNA replication licensing factor MCM3		HUMAN		853	UniRef100_P25205
DNA helicase (Fragment)		HUMAN		808

Protein	Similar proteins		Species	Score	Length	Source
P25205	Isoform 2 of DNA replication licensing factor MCM3		HUMAN		853	UniRef90_P25205
DNA helicase		PAPAN		853
DNA helicase		MANLE		853
DNA helicase		CERAT		853
DNA helicase		PROCO		853
+23

Protein	Similar proteins		Species	Score	Length	Source
P25205	Isoform 2 of DNA replication licensing factor MCM3		HUMAN		853	UniRef50_P25205
DNA helicase		PROCO		853
DNA helicase		CERAT		853
DNA helicase		PAPAN		853
DNA helicase		MANLE		853
+24

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62153 mRNA Translation: CAA44078.2 D38073 mRNA Translation: BAA07267.1 AK301704 mRNA Translation: BAG63176.1 AY621074 Genomic DNA Translation: AAT27321.1 AL034343 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04367.1 BC001626 mRNA Translation: AAH01626.1 BC003509 mRNA Translation: AAH03509.2
CCDSⁱ	CCDS4940.2 [P25205-2]
PIRⁱ	S62594
RefSeqⁱ	NP_001257401.1, NM_001270472.1 NP_002379.3, NM_002388.4 [P25205-2]
UniGeneⁱ	Hs.179565

3D structure databases

ProteinModelPortalⁱ	P25205
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110340, 132 interactors
ComplexPortalⁱ	CPX-2940 MCM complex
CORUMⁱ	P25205
DIPⁱ	DIP-31726N
IntActⁱ	P25205, 60 interactors
MINTⁱ	P25205
STRINGⁱ	9606.ENSP00000229854

PTM databases

iPTMnetⁱ	P25205
PhosphoSitePlusⁱ	P25205
SwissPalmⁱ	P25205

Polymorphism and mutation databases

BioMutaⁱ	MCM3
DMDMⁱ	19857543

Proteomic databases

EPDⁱ	P25205
MaxQBⁱ	P25205
PaxDbⁱ	P25205
PeptideAtlasⁱ	P25205
PRIDEⁱ	P25205
ProteomicsDBⁱ	54265

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4172
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000229854; ENSP00000229854; ENSG00000112118 [P25205-1] ENST00000596288; ENSP00000472940; ENSG00000112118 [P25205-2] ENST00000616552; ENSP00000480987; ENSG00000112118 [P25205-2]
GeneIDⁱ	4172
KEGGⁱ	hsa:4172
UCSCⁱ	uc003pan.2 human [P25205-1]

Organism-specific databases

CTDⁱ	4172
DisGeNETⁱ	4172
EuPathDBⁱ	HostDB:ENSG00000112118.17
GeneCardsⁱ	MCM3
HGNCⁱ	HGNC:6945 MCM3
HPAⁱ	CAB002162 HPA004789 HPA004790
MIMⁱ	602693 gene
neXtProtⁱ	NX_P25205
OpenTargetsⁱ	ENSG00000112118
PharmGKBⁱ	PA30691
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0479 Eukaryota COG1241 LUCA
GeneTreeⁱ	ENSGT00900000141082
HOGENOMⁱ	HOG000224126
HOVERGENⁱ	HBG104962
InParanoidⁱ	P25205
KOⁱ	K02541
OMAⁱ	YQSKVRE
OrthoDBⁱ	EOG091G02B0
PhylomeDBⁱ	P25205
TreeFamⁱ	TF106459

Enzyme and pathway databases

Reactomeⁱ	R-HSA-176187 Activation of ATR in response to replication stress R-HSA-176974 Unwinding of DNA R-HSA-68867 Assembly of the pre-replicative complex R-HSA-68949 Orc1 removal from chromatin R-HSA-68962 Activation of the pre-replicative complex R-HSA-69052 Switching of origins to a post-replicative state
SIGNORⁱ	P25205

Miscellaneous databases

ChiTaRSⁱ	MCM3 human
GeneWikiⁱ	MCM3
GenomeRNAiⁱ	4172
PMAP-CutDBⁱ	P25205
Protein Ontology More...PROⁱ	PR:P25205
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112118 Expressed in 229 organ(s), highest expression level in embryo
CleanExⁱ	HS_MCM3
ExpressionAtlasⁱ	P25205 baseline and differential
Genevisibleⁱ	P25205 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR031327 MCM IPR008046 Mcm3 IPR018525 MCM_CS IPR001208 MCM_dom IPR027925 MCM_N IPR033762 MCM_OB IPR012340 NA-bd_OB-fold IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR11630 PTHR11630, 1 hit
Pfamⁱ	View protein in Pfam PF00493 MCM, 1 hit PF14551 MCM_N, 1 hit PF17207 MCM_OB, 1 hit
PRINTSⁱ	PR01657 MCMFAMILY PR01659 MCMPROTEIN3
SMARTⁱ	View protein in SMART SM00382 AAA, 1 hit SM00350 MCM, 1 hit
SUPFAMⁱ	SSF50249 SSF50249, 1 hit SSF52540 SSF52540, 2 hits
PROSITEⁱ	View protein in PROSITE PS00847 MCM_1, 1 hit PS50051 MCM_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MCM3_HUMAN
Accessionⁱ	P25205Primary (citable) accession number: P25205 Secondary accession number(s): B4DWW4 , Q92660, Q9BTR3, Q9NUE7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	August 14, 2001
	Last modified:	September 12, 2018
	This is version 212 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P25205 (MCM3_HUMAN)

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DNA replication licensing factor MCM3

MCM3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ