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Entry version 181 (07 Apr 2021)
Sequence version 2 (19 Jul 2005)
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Protein

Maternal effect protein staufen

Gene

stau

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein which forms ribonucleoprotein complexes (RNPs) that play critical roles in the localization, translational repression and turnover of RNAs during embryogenesis, neurotransmission and neurogenesis (PubMed:10698941, PubMed:1712672, PubMed:8001156, PubMed:17178403). In the oocyte, essential for the localization of both the osk/oskar mRNA to the posterior pole and bcd/bicoid RNA to the anterior pole, and is therefore required for the correct anterior-posterior patterning of the developing embryo (PubMed:10698941, PubMed:1712672, PubMed:8001156). Association with osk or bcd at their respective poles, appears to promote the formation and stabilization of the ribonucleoprotein complexes (PubMed:1712672, PubMed:8001156). Integral component of diverse neuritic ribonucleoprotein complexes (RNPs) that mediate the transport, translation and turnover of neuronal RNAs during neuorgenesis and the translation repression of synaptic transcripts in preparation for their dendritic targeting (PubMed:17178403).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei606RNA1
Binding sitei608RNA1
Binding sitei628RNA1
Binding sitei629RNA1
Binding sitei632RNA1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, RNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Maternal effect protein staufen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:stau
ORF Names:CG5753
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003520, stau

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi581 – 582SQ → AA: Affects RNA binding without altering the conformation of the domain. 1 Publication2
Mutagenesisi584 – 585HE → AA: Affects RNA binding without altering the conformation of the domain. 1 Publication2
Mutagenesisi586I → A: Crucial for the structure of DRBM 3. 1 Publication1
Mutagenesisi596F → A: Crucial for the structure of DRBM 3. 1 Publication1
Mutagenesisi599 – 602LREE → AAAA: Strongly reduces RNA binding. 1 Publication4
Mutagenesisi606H → A: Abolishes RNA binding without altering the conformation of the domain. 1 Publication1
Mutagenesisi608K → A: Abolishes RNA binding without altering the conformation of the domain. 1 Publication1
Mutagenesisi628 – 629KK → AA: Abolishes RNA binding without altering the conformation of the domain. 1 Publication2
Mutagenesisi632K → A: Abolishes RNA binding without altering the conformation of the domain. 1 Publication1
Mutagenesisi633 – 634KR → AA: No effect on RNA binding. 1 Publication2
Mutagenesisi635 – 636AA → SS: Crucial for the structure of DRBM 3. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000722501 – 1026Maternal effect protein staufenAdd BLAST1026

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei563Phosphoserine1 Publication1
Modified residuei570Phosphoserine1 Publication1
Modified residuei650Phosphothreonine1 Publication1
Modified residuei655Phosphothreonine1 Publication1
Modified residuei676Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P25159

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P25159

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Polar granules at the posterior pole of the oocyte, and by the time the egg is laid, at the anterior pole.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003520, Expressed in head and 60 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P25159, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P25159, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of neuronal ribonucleoprotein complexes (RNPs) that contains at least various translational repressor and mRNA turnover proteins such as me31B, tral, Upf1, AGO2 and sometimes Fmr1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
62749, 88 interactors

Protein interaction database and analysis system

More...
IntActi
P25159, 6 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0085962

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11026
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P25159

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P25159

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini311 – 378DRBM 1PROSITE-ProRule annotationAdd BLAST68
Domaini490 – 557DRBM 2PROSITE-ProRule annotationAdd BLAST68
Domaini578 – 645DRBM 3PROSITE-ProRule annotationAdd BLAST68
Domaini711 – 781DRBM 4PROSITE-ProRule annotationAdd BLAST71
Domaini951 – 1018DRBM 5PROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 82Gln/His/Pro-richAdd BLAST80
Compositional biasi134 – 177Pro-richAdd BLAST44
Compositional biasi421 – 521Pro-richAdd BLAST101
Compositional biasi873 – 947Ser-richAdd BLAST75

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a proline-rich domain. The insertion of this domain in the DRBM 2 domain is required for stau-oskar mRNA localization.
DRBM 3 domain binds optimally to stem-loops containing 12 bp (in vitro).

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3732, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P25159

Identification of Orthologs from Complete Genome Data

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OMAi
GHMQLHP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P25159

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014720, dsRBD_dom
IPR032478, Staufen_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00035, dsrm, 4 hits
PF16482, Staufen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00358, DSRM, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50137, DS_RBD, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: P25159-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQHNVHAARP APHIRAAHHH SHSHAHMHLH PGMEQHLGPS LQQQQQPPPP
60 70 80 90 100
PQQPPHRDLH ARLNHHHLHA QQQQQQQTSS NQAGAVAAAG AAYHHGNINS
110 120 130 140 150
NSGSNISSNS NQMQKIRQQH QHLSSSNGLL GNQPPGPPPQ AFNPLAGNPA
160 170 180 190 200
ALAYNQLPPH PPHHMAAHLG SYAAPPPHYY MSQAKPAKYN HYGSNANSNS
210 220 230 240 250
GSNNSNSNYA PKAILQNTYR NQKVVVPPVV QEVTPVPEPP VTTNNATTNS
260 270 280 290 300
TSNSTVIASE PVTQEDTSQK PETRQEPASA DDHVSTGNID ATGALSNEDT
310 320 330 340 350
SSSGRGGKDK TPMCLVNELA RYNKITHQYR LTEERGPAHC KTFTVTLMLG
360 370 380 390 400
DEEYSADGFK IKKAQHLAAS KAIEETMYKH PPPKIRRSEE GGPMRTHITP
410 420 430 440 450
TVELNALAMK LGQRTFYLLD PTQIPPTDSI VPPEFAGGHL LTAPGPGMPQ
460 470 480 490 500
PPPPPAYALR QRLGNGFVPI PSQPMHPHFF HGPGQRPFPP KFPSRFALPP
510 520 530 540 550
PLGAHVHHGP NGPFPSVPTP PSKITLFVGK QKFVGIGRTL QQAKHDAAAR
560 570 580 590 600
ALQVLKTQAI SASEEALEDS MDEGDKKSPI SQVHEIGIKR NMTVHFKVLR
610 620 630 640 650
EEGPAHMKNF ITACIVGSIV TEGEGNGKKV SKKRAAEKML VELQKLPPLT
660 670 680 690 700
PTKQTPLKRI KVKTPGKSGA AAREGSVVSG TDGPTQTGKP ERRKRLNPPK
710 720 730 740 750
DKLIDMDDAD NPITKLIQLQ QTRKEKEPIF ELIAKNGNET ARRREFVMEV
760 770 780 790 800
SASGSTARGT GNSKKLAKRN AAQALFELLE AVQVTPTNET QSSEECSTSA
810 820 830 840 850
TMSAVTAPAV EATAEGKVPM VATPVGPMPG ILILRQNKKP AKKRDQIVIV
860 870 880 890 900
KSNVESKEEE ANKEVAVAAE ENSNNSANSG DSSNSSSGDS QATEAASESA
910 920 930 940 950
LNTSTGSNTS GVSSNSSNVG ANTDGNNHAE SKNNTESSSN STSNTQSAGV
960 970 980 990 1000
HMKEQLLYLS KLLDFEVNFS DYPKGNHNEF LTIVTLSTHP PQICHGVGKS
1010 1020
SEESQNDAAS NALKILSKLG LNNAMK
Length:1,026
Mass (Da):110,283
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D390391F988B0A2
GO
Isoform B (identifier: P25159-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:914
Mass (Da):98,029
Checksum:iAB307F84F318C6E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JGK6E1JGK6_DROME
Staufen, isoform C
stau Dmel\CG5753, Dmstau, dStau, STAU, Stau
1,025Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84G → A in AAA73062 (PubMed:1712672).Curated1
Sequence conflicti684 – 685PT → TM in AAA73062 (PubMed:1712672).Curated2
Sequence conflicti797S → C in AAA73062 (PubMed:1712672).Curated1
Sequence conflicti841Missing in AAQ23615 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0147811 – 112Missing in isoform B. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M69111 mRNA Translation: AAA73062.1
AE013599 Genomic DNA Translation: AAF57752.1
AE013599 Genomic DNA Translation: AAF57753.1
BT003228 mRNA Translation: AAO24983.1
BT010297 mRNA Translation: AAQ23615.1

Protein sequence database of the Protein Information Resource

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PIRi
A40315

NCBI Reference Sequences

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RefSeqi
NP_001163185.1, NM_001169714.2
NP_476751.1, NM_057403.4 [P25159-1]
NP_725748.1, NM_166263.2 [P25159-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0086783; FBpp0085962; FBgn0003520 [P25159-1]
FBtr0086784; FBpp0085963; FBgn0003520 [P25159-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
37065

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG5753

UCSC genome browser

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UCSCi
CG5753-RA, d. melanogaster [P25159-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69111 mRNA Translation: AAA73062.1
AE013599 Genomic DNA Translation: AAF57752.1
AE013599 Genomic DNA Translation: AAF57753.1
BT003228 mRNA Translation: AAO24983.1
BT010297 mRNA Translation: AAQ23615.1
PIRiA40315
RefSeqiNP_001163185.1, NM_001169714.2
NP_476751.1, NM_057403.4 [P25159-1]
NP_725748.1, NM_166263.2 [P25159-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EKZNMR-A571-646[»]
1STUNMR-A579-646[»]
5CFFX-ray2.50E/F/G/H953-1019[»]
SMRiP25159
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi62749, 88 interactors
IntActiP25159, 6 interactors
STRINGi7227.FBpp0085962

PTM databases

iPTMnetiP25159

Proteomic databases

PaxDbiP25159

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P25159, 2 sequenced antibodies

Genome annotation databases

EnsemblMetazoaiFBtr0086783; FBpp0085962; FBgn0003520 [P25159-1]
FBtr0086784; FBpp0085963; FBgn0003520 [P25159-2]
GeneIDi37065
KEGGidme:Dmel_CG5753
UCSCiCG5753-RA, d. melanogaster [P25159-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
37065
FlyBaseiFBgn0003520, stau

Phylogenomic databases

eggNOGiKOG3732, Eukaryota
InParanoidiP25159
OMAiGHMQLHP
PhylomeDBiP25159

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
37065, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
stau, fly
EvolutionaryTraceiP25159

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
37065

Protein Ontology

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PROi
PR:P25159

Gene expression databases

BgeeiFBgn0003520, Expressed in head and 60 other tissues
ExpressionAtlasiP25159, baseline and differential
GenevisibleiP25159, DM

Family and domain databases

InterProiView protein in InterPro
IPR014720, dsRBD_dom
IPR032478, Staufen_C
PfamiView protein in Pfam
PF00035, dsrm, 4 hits
PF16482, Staufen_C, 1 hit
SMARTiView protein in SMART
SM00358, DSRM, 4 hits
PROSITEiView protein in PROSITE
PS50137, DS_RBD, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAU_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25159
Secondary accession number(s): Q6NQY8
, Q86PB7, Q9V8B8, Q9V8B9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 19, 2005
Last modified: April 7, 2021
This is version 181 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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