UniProtKB - P25144 (CCPA_BACSU)
Protein
Catabolite control protein A
Gene
ccpA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Interacts with either P-Ser-HPr or P-Ser-Crh, leading to the formation of a complex that binds to DNA at the catabolite-response elements (cre). Binding to DNA allows activation or repression of many different genes and operons.5 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 6 – 25 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription activator activity Source: CollecTF
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription repressor activity Source: CollecTF
- transcription regulatory region sequence-specific DNA binding Source: CollecTF
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: CACAO
- positive regulation of transcription, DNA-templated Source: CollecTF
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | BSUB:BSU29740-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Catabolite control protein AAlternative name(s): Glucose-resistance amylase regulator |
Gene namesi | Name:ccpA Synonyms:alsA, amyR, graR Ordered Locus Names:BSU29740 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000107925 | 1 – 334 | Catabolite control protein AAdd BLAST | 334 |
Proteomic databases
jPOSTi | P25144 |
PaxDbi | P25144 |
PRIDEi | P25144 |
Interactioni
Subunit structurei
Homodimer.
Interacts with P-Ser-HPr and P-Ser-Crh.
3 PublicationsBinary interactionsi
Hide detailsP25144
With | #Exp. | IntAct |
---|---|---|
codY [P39779] | 3 | EBI-5247535,EBI-7827914 |
ptsH [P08877] | 3 | EBI-5247535,EBI-1034482 |
rpoA [P20429] | 5 | EBI-5247535,EBI-5247865 |
Protein-protein interaction databases
IntActi | P25144, 222 interactors |
MINTi | P25144 |
STRINGi | 224308.BSU29740 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P25144 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P25144 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 58 | HTH lacI-typePROSITE-ProRule annotationAdd BLAST | 58 |
Phylogenomic databases
eggNOGi | COG1609, Bacteria |
InParanoidi | P25144 |
OMAi | HSEFVFM |
PhylomeDBi | P25144 |
Family and domain databases
CDDi | cd01392, HTH_LacI, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR006377, CcpA IPR000843, HTH_LacI IPR010982, Lambda_DNA-bd_dom_sf IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00356, LacI, 1 hit |
PRINTSi | PR00036, HTHLACI |
SMARTi | View protein in SMART SM00354, HTH_LACI, 1 hit |
SUPFAMi | SSF47413, SSF47413, 1 hit SSF53822, SSF53822, 1 hit |
TIGRFAMsi | TIGR01481, ccpA, 1 hit |
PROSITEi | View protein in PROSITE PS00356, HTH_LACI_1, 1 hit PS50932, HTH_LACI_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P25144-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNITIYDVA REANVSMATV SRVVNGNPNV KPTTRKKVLE AIERLGYRPN
60 70 80 90 100
AVARGLASKK TTTVGVIIPD ISSIFYSELA RGIEDIATMY KYNIILSNSD
110 120 130 140 150
QNMEKELHLL NTMLGKQVDG IVFMGGNITD EHVAEFKRSP VPIVLAASVE
160 170 180 190 200
EQEETPSVAI DYEQAIYDAV KLLVDKGHTD IAFVSGPMAE PINRSKKLQG
210 220 230 240 250
YKRALEEANL PFNEQFVAEG DYTYDSGLEA LQHLMSLDKK PTAILSATDE
260 270 280 290 300
MALGIIHAAQ DQGLSIPEDL DIIGFDNTRL SLMVRPQLST VVQPTYDIGA
310 320 330
VAMRLLTKLM NKEPVEEHIV ELPHRIELRK STKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85182 Genomic DNA Translation: AAA22501.1 AF008220 Genomic DNA Translation: AAC00299.1 AL009126 Genomic DNA Translation: CAB14952.1 |
PIRi | S15318 |
RefSeqi | NP_390852.1, NC_000964.3 WP_003229285.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14952; CAB14952; BSU29740 |
GeneIDi | 51992585 935942 |
KEGGi | bsu:BSU29740 |
PATRICi | fig|224308.179.peg.3232 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85182 Genomic DNA Translation: AAA22501.1 AF008220 Genomic DNA Translation: AAC00299.1 AL009126 Genomic DNA Translation: CAB14952.1 |
PIRi | S15318 |
RefSeqi | NP_390852.1, NC_000964.3 WP_003229285.1, NZ_JNCM01000036.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ZVV | X-ray | 2.98 | A/B/G | 5-333 | [»] | |
2FEP | X-ray | 2.45 | A | 58-334 | [»] | |
3OQM | X-ray | 2.96 | A/C | 3-334 | [»] | |
3OQN | X-ray | 3.30 | A/C | 3-334 | [»] | |
3OQO | X-ray | 2.97 | A/C | 3-333 | [»] | |
SMRi | P25144 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P25144, 222 interactors |
MINTi | P25144 |
STRINGi | 224308.BSU29740 |
Proteomic databases
jPOSTi | P25144 |
PaxDbi | P25144 |
PRIDEi | P25144 |
Genome annotation databases
EnsemblBacteriai | CAB14952; CAB14952; BSU29740 |
GeneIDi | 51992585 935942 |
KEGGi | bsu:BSU29740 |
PATRICi | fig|224308.179.peg.3232 |
Phylogenomic databases
eggNOGi | COG1609, Bacteria |
InParanoidi | P25144 |
OMAi | HSEFVFM |
PhylomeDBi | P25144 |
Enzyme and pathway databases
BioCyci | BSUB:BSU29740-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P25144 |
PROi | PR:P25144 |
Gene expression databases
CollecTFi | EXPREG_000009c0 |
Family and domain databases
CDDi | cd01392, HTH_LacI, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR006377, CcpA IPR000843, HTH_LacI IPR010982, Lambda_DNA-bd_dom_sf IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00356, LacI, 1 hit |
PRINTSi | PR00036, HTHLACI |
SMARTi | View protein in SMART SM00354, HTH_LACI, 1 hit |
SUPFAMi | SSF47413, SSF47413, 1 hit SSF53822, SSF53822, 1 hit |
TIGRFAMsi | TIGR01481, ccpA, 1 hit |
PROSITEi | View protein in PROSITE PS00356, HTH_LACI_1, 1 hit PS50932, HTH_LACI_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCPA_BACSU | |
Accessioni | P25144Primary (citable) accession number: P25144 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references