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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila ambigua (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
OrganismiDrosophila ambigua (Fruit fly)
Taxonomic identifieri7216 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012099 Damb\Adh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000544531 – 254Alcohol dehydrogenaseAdd BLAST254

Proteomic databases

PRIDEiP25139

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP25139
SMRiP25139
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P25139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTNKNVIF VAGLGGIGLD TSRELVKRDL KNLVILDRID NPAAIAELKA
60 70 80 90 100
INPKVTVTFY PYDVTVPISE TTKLLKTIFA QLKTVDVLIN GAGILDDYQI
110 120 130 140 150
ERTIAVNYTG LVNTTTAILD FWDKRKGGPG GIICNIGSVT GFNAIYQVPV
160 170 180 190 200
YSGSKAAVVN FTSSLAKLAP ITGVTAYTVN PGITKTTLVH KFNSWLDVEP
210 220 230 240 250
NVAEKLLEHP TQTSQQCAEN FVKAIELNKN GAIWNLDLGT LEPITWTQHW

DSGI
Length:254
Mass (Da):27,618
Last modified:May 1, 1992 - v1
Checksum:i7DF055D723545B06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54813 Genomic DNA Translation: CAA38581.1
PIRiS16453

Similar proteinsi

Entry informationi

Entry nameiADH_DROAM
AccessioniPrimary (citable) accession number: P25139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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