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Protein

Tumor necrosis factor receptor superfamily member 1B

Gene

Tnfrsf1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5669034 TNFs bind their physiological receptors
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 1B
Alternative name(s):
Tumor necrosis factor receptor 2
Short name:
TNF-R2
Tumor necrosis factor receptor type II
Short name:
TNF-RII
Short name:
TNFR-II
p75
p80 TNF-alpha receptor
CD_antigen: CD120b
Gene namesi
Name:Tnfrsf1b
Synonyms:Tnfr-2, Tnfr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1314883 Tnfrsf1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 258ExtracellularSequence analysisAdd BLAST236
Transmembranei259 – 288HelicalSequence analysisAdd BLAST30
Topological domaini289 – 474CytoplasmicSequence analysisAdd BLAST186

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000003455023 – 474Tumor necrosis factor receptor superfamily member 1BAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi40 ↔ 54PROSITE-ProRule annotation
Disulfide bondi55 ↔ 68PROSITE-ProRule annotation
Disulfide bondi58 ↔ 76PROSITE-ProRule annotation
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi79 ↔ 94PROSITE-ProRule annotation
Disulfide bondi97 ↔ 111PROSITE-ProRule annotation
Disulfide bondi101 ↔ 119PROSITE-ProRule annotation
Disulfide bondi121 ↔ 127PROSITE-ProRule annotation
Disulfide bondi136 ↔ 145PROSITE-ProRule annotation
Disulfide bondi139 ↔ 163PROSITE-ProRule annotation
Disulfide bondi166 ↔ 181PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208O-linked (GalNAc...) threonineBy similarity1
Glycosylationi224O-linked (GalNAc...) threonineBy similarity1
Modified residuei331PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP25119
PaxDbiP25119
PeptideAtlasiP25119
PRIDEiP25119

PTM databases

PhosphoSitePlusiP25119
SwissPalmiP25119

Expressioni

Gene expression databases

BgeeiENSMUSG00000028599 Expressed in 172 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiP25119 baseline and differential
GenevisibleiP25119 MM

Interactioni

Subunit structurei

Binds to TRAF2. Interacts with BMX. Interacts (activated form) with XPNPEP3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204250, 4 interactors
DIPiDIP-60902N
IntActiP25119, 4 interactors
MINTiP25119
STRINGi10090.ENSMUSP00000030336

Structurei

3D structure databases

ProteinModelPortaliP25119
SMRiP25119
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 77TNFR-Cys 1Add BLAST39
Repeati78 – 119TNFR-Cys 2Add BLAST42
Repeati120 – 164TNFR-Cys 3Add BLAST45
Repeati165 – 203TNFR-Cys 4Add BLAST39

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ06 Eukaryota
ENOG410YPQW LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000132845
HOVERGENiHBG054237
InParanoidiP25119
KOiK05141
OMAiCRPHRIC
OrthoDBiEOG091G03XW
PhylomeDBiP25119
TreeFamiTF331157

Family and domain databases

CDDicd10577 TNFRSF1B, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020411 TNFR_1B
IPR033996 TNFRSF1B_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01919 TNFACTORR1B
SMARTiView protein in SMART
SM00208 TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P25119-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPAALWVAL VFELQLWATG HTVPAQVVLT PYKPEPGYEC QISQEYYDRK
60 70 80 90 100
AQMCCAKCPP GQYVKHFCNK TSDTVCADCE ASMYTQVWNQ FRTCLSCSSS
110 120 130 140 150
CTTDQVEIRA CTKQQNRVCA CEAGRYCALK THSGSCRQCM RLSKCGPGFG
160 170 180 190 200
VASSRAPNGN VLCKACAPGT FSDTTSSTDV CRPHRICSIL AIPGNASTDA
210 220 230 240 250
VCAPESPTLS AIPRTLYVSQ PEPTRSQPLD QEPGPSQTPS ILTSLGSTPI
260 270 280 290 300
IEQSTKGGIS LPIGLIVGVT SLGLLMLGLV NCIILVQRKK KPSCLQRDAK
310 320 330 340 350
VPHVPDEKSQ DAVGLEQQHL LTTAPSSSSS SLESSASAGD RRAPPGGHPQ
360 370 380 390 400
ARVMAEAQGF QEARASSRIS DSSHGSHGTH VNVTCIVNVC SSSDHSSQCS
410 420 430 440 450
SQASATVGDP DAKPSASPKD EQVPFSQEEC PSQSPCETTE TLQSHEKPLP
460 470
LGVPDMGMKP SQAGWFDQIA VKVA
Length:474
Mass (Da):50,320
Last modified:May 1, 1992 - v1
Checksum:i462EAE398C4D6563
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RG55D6RG55_MOUSE
Tumor necrosis factor receptor supe...
Tnfrsf1b
55Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78D → DSDTVCAD in CAA74969 (PubMed:9740674).Curated1
Sequence conflicti102T → S in CAA74969 (PubMed:9740674).Curated1
Sequence conflicti108I → T in CAA74969 (PubMed:9740674).Curated1
Sequence conflicti283I → F in CAA74969 (PubMed:9740674).Curated1
Sequence conflicti331S → SS in CAA74969 (PubMed:9740674).Curated1
Sequence conflicti360F → S in CAA74969 (PubMed:9740674).Curated1
Sequence conflicti436C → Y in CAA74969 (PubMed:9740674).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60469 mRNA Translation: AAA39752.1
M59378 mRNA Translation: AAA40463.1
Y14619
, Y14620, Y14621, Y14622, Y14679, Y14623 Genomic DNA Translation: CAA74969.1
U39488 Genomic DNA Translation: AAA85021.1
X87128 Genomic DNA Translation: CAA60618.1
CCDSiCCDS18914.1
PIRiB38634
RefSeqiNP_035740.2, NM_011610.3
UniGeneiMm.235328

Genome annotation databases

EnsembliENSMUST00000030336; ENSMUSP00000030336; ENSMUSG00000028599
GeneIDi21938
KEGGimmu:21938
UCSCiuc008vrt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60469 mRNA Translation: AAA39752.1
M59378 mRNA Translation: AAA40463.1
Y14619
, Y14620, Y14621, Y14622, Y14679, Y14623 Genomic DNA Translation: CAA74969.1
U39488 Genomic DNA Translation: AAA85021.1
X87128 Genomic DNA Translation: CAA60618.1
CCDSiCCDS18914.1
PIRiB38634
RefSeqiNP_035740.2, NM_011610.3
UniGeneiMm.235328

3D structure databases

ProteinModelPortaliP25119
SMRiP25119
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204250, 4 interactors
DIPiDIP-60902N
IntActiP25119, 4 interactors
MINTiP25119
STRINGi10090.ENSMUSP00000030336

PTM databases

PhosphoSitePlusiP25119
SwissPalmiP25119

Proteomic databases

EPDiP25119
PaxDbiP25119
PeptideAtlasiP25119
PRIDEiP25119

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030336; ENSMUSP00000030336; ENSMUSG00000028599
GeneIDi21938
KEGGimmu:21938
UCSCiuc008vrt.1 mouse

Organism-specific databases

CTDi7133
MGIiMGI:1314883 Tnfrsf1b

Phylogenomic databases

eggNOGiENOG410IJ06 Eukaryota
ENOG410YPQW LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000132845
HOVERGENiHBG054237
InParanoidiP25119
KOiK05141
OMAiCRPHRIC
OrthoDBiEOG091G03XW
PhylomeDBiP25119
TreeFamiTF331157

Enzyme and pathway databases

ReactomeiR-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5669034 TNFs bind their physiological receptors
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiTnfrsf1b mouse
PROiPR:P25119
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028599 Expressed in 172 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiP25119 baseline and differential
GenevisibleiP25119 MM

Family and domain databases

CDDicd10577 TNFRSF1B, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020411 TNFR_1B
IPR033996 TNFRSF1B_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01919 TNFACTORR1B
SMARTiView protein in SMART
SM00208 TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTNR1B_MOUSE
AccessioniPrimary (citable) accession number: P25119
Secondary accession number(s): O88734, P97893
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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