UniProtKB - P25119 (TNR1B_MOUSE)
Protein
Tumor necrosis factor receptor superfamily member 1B
Gene
Tnfrsf1b
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).By similarity
GO - Molecular functioni
- tumor necrosis factor-activated receptor activity Source: MGI
- tumor necrosis factor binding Source: MGI
- ubiquitin protein ligase binding Source: MGI
GO - Biological processi
- aging Source: Ensembl
- aortic valve development Source: BHF-UCL
- cell surface receptor signaling pathway Source: MGI
- cellular response to growth factor stimulus Source: Ensembl
- cellular response to lipopolysaccharide Source: MGI
- extrinsic apoptotic signaling pathway Source: MGI
- glial cell-neuron signaling Source: ARUK-UCL
- immune response Source: MGI
- inflammatory response Source: MGI
- intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
- negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
- negative regulation of cell death Source: ARUK-UCL
- negative regulation of extracellular matrix constituent secretion Source: BHF-UCL
- negative regulation of inflammatory response Source: MGI
- negative regulation of neuroinflammatory response Source: ARUK-UCL
- negative regulation of neuron death Source: ARUK-UCL
- positive regulation of apoptotic process involved in morphogenesis Source: BHF-UCL
- positive regulation of membrane protein ectodomain proteolysis Source: MGI
- positive regulation of myelination Source: ARUK-UCL
- positive regulation of oligodendrocyte differentiation Source: ARUK-UCL
- pulmonary valve development Source: BHF-UCL
- regulation of cytokine production involved in immune response Source: ARUK-UCL
- regulation of myelination Source: ARUK-UCL
- regulation of neuroinflammatory response Source: ARUK-UCL
- regulation of RNA biosynthetic process Source: ARUK-UCL
- regulation of T cell cytokine production Source: ARUK-UCL
- regulation of T cell proliferation Source: ARUK-UCL
- RNA destabilization Source: MGI
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
Reactomei | R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5669034, TNFs bind their physiological receptors R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member 1BAlternative name(s): Tumor necrosis factor receptor 2 Short name: TNF-R2 Tumor necrosis factor receptor type II Short name: TNF-RII Short name: TNFR-II p75 p80 TNF-alpha receptor CD_antigen: CD120b |
Gene namesi | Name:Tnfrsf1b Synonyms:Tnfr-2, Tnfr2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1314883, Tnfrsf1b |
Subcellular locationi
Other locations
Nucleus
- nucleus Source: MGI
Other locations
- axon Source: MGI
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
- membrane raft Source: BHF-UCL
- neuronal cell body Source: MGI
- perinuclear region of cytoplasm Source: MGI
- varicosity Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 258 | ExtracellularSequence analysisAdd BLAST | 236 | |
Transmembranei | 259 – 288 | HelicalSequence analysisAdd BLAST | 30 | |
Topological domaini | 289 – 474 | CytoplasmicSequence analysisAdd BLAST | 186 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Add BLAST | 22 | |
ChainiPRO_0000034550 | 23 – 474 | Tumor necrosis factor receptor superfamily member 1BAdd BLAST | 452 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 30 | O-linked (GalNAc...) threonineBy similarity | 1 | |
Disulfide bondi | 40 ↔ 54 | PROSITE-ProRule annotation | ||
Disulfide bondi | 55 ↔ 68 | PROSITE-ProRule annotation | ||
Disulfide bondi | 58 ↔ 76 | PROSITE-ProRule annotation | ||
Glycosylationi | 69 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 79 ↔ 94 | PROSITE-ProRule annotation | ||
Disulfide bondi | 97 ↔ 111 | PROSITE-ProRule annotation | ||
Disulfide bondi | 101 ↔ 119 | PROSITE-ProRule annotation | ||
Disulfide bondi | 121 ↔ 127 | PROSITE-ProRule annotation | ||
Disulfide bondi | 136 ↔ 145 | PROSITE-ProRule annotation | ||
Disulfide bondi | 139 ↔ 163 | PROSITE-ProRule annotation | ||
Disulfide bondi | 166 ↔ 181 | PROSITE-ProRule annotation | ||
Glycosylationi | 195 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 208 | O-linked (GalNAc...) threonineBy similarity | 1 | |
Glycosylationi | 224 | O-linked (GalNAc...) threonineBy similarity | 1 | |
Modified residuei | 331 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P25119 |
PaxDbi | P25119 |
PeptideAtlasi | P25119 |
PRIDEi | P25119 |
PTM databases
GlyGeni | P25119, 5 sites |
PhosphoSitePlusi | P25119 |
SwissPalmi | P25119 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028599, Expressed in bone marrow macrophage and 199 other tissues |
ExpressionAtlasi | P25119, baseline and differential |
Genevisiblei | P25119, MM |
Interactioni
Subunit structurei
Binds to TRAF2.
Interacts with BMX.
Interacts (activated form) with XPNPEP3.
By similarityGO - Molecular functioni
- tumor necrosis factor binding Source: MGI
- ubiquitin protein ligase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204250, 4 interactors |
DIPi | DIP-60902N |
IntActi | P25119, 4 interactors |
MINTi | P25119 |
STRINGi | 10090.ENSMUSP00000030336 |
Miscellaneous databases
RNActi | P25119, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 39 – 77 | TNFR-Cys 1Add BLAST | 39 | |
Repeati | 78 – 119 | TNFR-Cys 2Add BLAST | 42 | |
Repeati | 120 – 164 | TNFR-Cys 3Add BLAST | 45 | |
Repeati | 165 – 203 | TNFR-Cys 4Add BLAST | 39 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZ23, Eukaryota |
GeneTreei | ENSGT00940000161800 |
HOGENOMi | CLU_047256_0_0_1 |
InParanoidi | P25119 |
OMAi | DRICSCP |
OrthoDBi | 559890at2759 |
PhylomeDBi | P25119 |
TreeFami | TF331157 |
Family and domain databases
CDDi | cd10577, TNFRSF1B, 1 hit |
InterProi | View protein in InterPro IPR001368, TNFR/NGFR_Cys_rich_reg IPR020411, TNFR_1B IPR033996, TNFRSF1B_N |
Pfami | View protein in Pfam PF00020, TNFR_c6, 2 hits |
PRINTSi | PR01919, TNFACTORR1B |
SMARTi | View protein in SMART SM00208, TNFR, 4 hits |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 2 hits PS50050, TNFR_NGFR_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P25119-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPAALWVAL VFELQLWATG HTVPAQVVLT PYKPEPGYEC QISQEYYDRK
60 70 80 90 100
AQMCCAKCPP GQYVKHFCNK TSDTVCADCE ASMYTQVWNQ FRTCLSCSSS
110 120 130 140 150
CTTDQVEIRA CTKQQNRVCA CEAGRYCALK THSGSCRQCM RLSKCGPGFG
160 170 180 190 200
VASSRAPNGN VLCKACAPGT FSDTTSSTDV CRPHRICSIL AIPGNASTDA
210 220 230 240 250
VCAPESPTLS AIPRTLYVSQ PEPTRSQPLD QEPGPSQTPS ILTSLGSTPI
260 270 280 290 300
IEQSTKGGIS LPIGLIVGVT SLGLLMLGLV NCIILVQRKK KPSCLQRDAK
310 320 330 340 350
VPHVPDEKSQ DAVGLEQQHL LTTAPSSSSS SLESSASAGD RRAPPGGHPQ
360 370 380 390 400
ARVMAEAQGF QEARASSRIS DSSHGSHGTH VNVTCIVNVC SSSDHSSQCS
410 420 430 440 450
SQASATVGDP DAKPSASPKD EQVPFSQEEC PSQSPCETTE TLQSHEKPLP
460 470
LGVPDMGMKP SQAGWFDQIA VKVA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RG55 | D6RG55_MOUSE | Tumor necrosis factor receptor supe... | Tnfrsf1b | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 78 | D → DSDTVCAD in CAA74969 (PubMed:9740674).Curated | 1 | |
Sequence conflicti | 102 | T → S in CAA74969 (PubMed:9740674).Curated | 1 | |
Sequence conflicti | 108 | I → T in CAA74969 (PubMed:9740674).Curated | 1 | |
Sequence conflicti | 283 | I → F in CAA74969 (PubMed:9740674).Curated | 1 | |
Sequence conflicti | 331 | S → SS in CAA74969 (PubMed:9740674).Curated | 1 | |
Sequence conflicti | 360 | F → S in CAA74969 (PubMed:9740674).Curated | 1 | |
Sequence conflicti | 436 | C → Y in CAA74969 (PubMed:9740674).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60469 mRNA Translation: AAA39752.1 M59378 mRNA Translation: AAA40463.1 Y14619 , Y14620, Y14621, Y14622, Y14679, Y14623 Genomic DNA Translation: CAA74969.1 U39488 Genomic DNA Translation: AAA85021.1 X87128 Genomic DNA Translation: CAA60618.1 |
CCDSi | CCDS18914.1 |
PIRi | B38634 |
RefSeqi | NP_035740.2, NM_011610.3 |
Genome annotation databases
Ensembli | ENSMUST00000030336; ENSMUSP00000030336; ENSMUSG00000028599 |
GeneIDi | 21938 |
KEGGi | mmu:21938 |
UCSCi | uc008vrt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60469 mRNA Translation: AAA39752.1 M59378 mRNA Translation: AAA40463.1 Y14619 , Y14620, Y14621, Y14622, Y14679, Y14623 Genomic DNA Translation: CAA74969.1 U39488 Genomic DNA Translation: AAA85021.1 X87128 Genomic DNA Translation: CAA60618.1 |
CCDSi | CCDS18914.1 |
PIRi | B38634 |
RefSeqi | NP_035740.2, NM_011610.3 |
3D structure databases
SMRi | P25119 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204250, 4 interactors |
DIPi | DIP-60902N |
IntActi | P25119, 4 interactors |
MINTi | P25119 |
STRINGi | 10090.ENSMUSP00000030336 |
PTM databases
GlyGeni | P25119, 5 sites |
PhosphoSitePlusi | P25119 |
SwissPalmi | P25119 |
Proteomic databases
EPDi | P25119 |
PaxDbi | P25119 |
PeptideAtlasi | P25119 |
PRIDEi | P25119 |
Protocols and materials databases
Antibodypediai | 1344, 949 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000030336; ENSMUSP00000030336; ENSMUSG00000028599 |
GeneIDi | 21938 |
KEGGi | mmu:21938 |
UCSCi | uc008vrt.1, mouse |
Organism-specific databases
CTDi | 7133 |
MGIi | MGI:1314883, Tnfrsf1b |
Phylogenomic databases
eggNOGi | ENOG502RZ23, Eukaryota |
GeneTreei | ENSGT00940000161800 |
HOGENOMi | CLU_047256_0_0_1 |
InParanoidi | P25119 |
OMAi | DRICSCP |
OrthoDBi | 559890at2759 |
PhylomeDBi | P25119 |
TreeFami | TF331157 |
Enzyme and pathway databases
Reactomei | R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5669034, TNFs bind their physiological receptors R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 21938, 1 hit in 18 CRISPR screens |
ChiTaRSi | Tnfrsf1b, mouse |
PROi | PR:P25119 |
RNActi | P25119, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028599, Expressed in bone marrow macrophage and 199 other tissues |
ExpressionAtlasi | P25119, baseline and differential |
Genevisiblei | P25119, MM |
Family and domain databases
CDDi | cd10577, TNFRSF1B, 1 hit |
InterProi | View protein in InterPro IPR001368, TNFR/NGFR_Cys_rich_reg IPR020411, TNFR_1B IPR033996, TNFRSF1B_N |
Pfami | View protein in Pfam PF00020, TNFR_c6, 2 hits |
PRINTSi | PR01919, TNFACTORR1B |
SMARTi | View protein in SMART SM00208, TNFR, 4 hits |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 2 hits PS50050, TNFR_NGFR_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNR1B_MOUSE | |
Accessioni | P25119Primary (citable) accession number: P25119 Secondary accession number(s): O88734, P97893 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot