Tumor necrosis factor receptor superfamily member 1B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• tumor necrosis factor-activated receptor activity Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.2

    "Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor."
    Goodwin R.G., Anderson D., Jerzy R., Davis T., Brannan C.I., Copeland N.G., Jenkins N.A., Smith C.A.
    Mol. Cell. Biol. 11:3020-3026(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• tumor necrosis factor binding Source: MGI
• ubiquitin protein ligase binding Source: MGI

GO - Biological processⁱ

• aging Source: Ensembl
• aortic valve development Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Notch-Tnf signalling is required for development and homeostasis of arterial valves."
    Wang Y., Wu B., Farrar E., Lui W., Lu P., Zhang D., Alfieri C.M., Mao K., Chu M., Yang D., Xu D., Rauchman M., Taylor V., Conway S.J., Yutzey K.E., Butcher J.T., Zhou B.
    Eur Heart J 38:675-686(2017) [PubMed] [Europe PMC] [Abstract]
• cell surface receptor signaling pathway Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation."
    Peschon J.J., Torrance D.S., Stocking K.L., Glaccum M.B., Otten C., Willis C.R., Charrier K., Morrissey P.J., Ware C.B., Mohler K.M.
    J Immunol 160:943-952(1998) [PubMed] [Europe PMC] [Abstract]
• cellular response to growth factor stimulus Source: Ensembl
• cellular response to lipopolysaccharide Source: MGI
• extrinsic apoptotic signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice."
    Erickson S.L., de Sauvage F.J., Kikly K., Carver-Moore K., Pitts-Meek S., Gillett N., Sheehan K.C., Schreiber R.D., Goeddel D.V., Moore M.W.
    Nature 372:560-563(1994) [PubMed] [Europe PMC] [Abstract]
• glial cell-neuron signaling Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination."
    Madsen P.M., Motti D., Karmally S., Szymkowski D.E., Lambertsen K.L., Bethea J.R., Brambilla R.
    J Neurosci 36:5128-5143(2016) [PubMed] [Europe PMC] [Abstract]
• immune response Source: MGI
• inflammatory response Source: MGIInferred from mutant phenotypeⁱ
  • "TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation."
    Peschon J.J., Torrance D.S., Stocking K.L., Glaccum M.B., Otten C., Willis C.R., Charrier K., Morrissey P.J., Ware C.B., Mohler K.M.
    J Immunol 160:943-952(1998) [PubMed] [Europe PMC] [Abstract]
• intrinsic apoptotic signaling pathway in response to DNA damage Source: MGIInferred from mutant phenotypeⁱ
  • "p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation."
    Song L., Li J., Ye J., Yu G., Ding J., Zhang D., Ouyang W., Dong Z., Kim S.O., Huang C.
    Mol Cell Biol 27:2713-2731(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cardiac muscle hypertrophy Source: BHF-UCLInferred from genetic interactionⁱ
  • "Notch-Tnf signalling is required for development and homeostasis of arterial valves."
    Wang Y., Wu B., Farrar E., Lui W., Lu P., Zhang D., Alfieri C.M., Mao K., Chu M., Yang D., Xu D., Rauchman M., Taylor V., Conway S.J., Yutzey K.E., Butcher J.T., Zhou B.
    Eur Heart J 38:675-686(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell death Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination."
    Madsen P.M., Motti D., Karmally S., Szymkowski D.E., Lambertsen K.L., Bethea J.R., Brambilla R.
    J Neurosci 36:5128-5143(2016) [PubMed] [Europe PMC] [Abstract]
• negative regulation of extracellular matrix constituent secretion Source: BHF-UCLInferred from genetic interactionⁱ
  • "Notch-Tnf signalling is required for development and homeostasis of arterial valves."
    Wang Y., Wu B., Farrar E., Lui W., Lu P., Zhang D., Alfieri C.M., Mao K., Chu M., Yang D., Xu D., Rauchman M., Taylor V., Conway S.J., Yutzey K.E., Butcher J.T., Zhou B.
    Eur Heart J 38:675-686(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response Source: MGIInferred from mutant phenotypeⁱ
  • "Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome."
    Carballo E., Blackshear P.J.
    Blood 98:2389-2395(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuroinflammatory response Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination."
    Madsen P.M., Motti D., Karmally S., Szymkowski D.E., Lambertsen K.L., Bethea J.R., Brambilla R.
    J Neurosci 36:5128-5143(2016) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron death Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination."
    Madsen P.M., Motti D., Karmally S., Szymkowski D.E., Lambertsen K.L., Bethea J.R., Brambilla R.
    J Neurosci 36:5128-5143(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process involved in morphogenesis Source: BHF-UCLInferred from genetic interactionⁱ
  • "Notch-Tnf signalling is required for development and homeostasis of arterial valves."
    Wang Y., Wu B., Farrar E., Lui W., Lu P., Zhang D., Alfieri C.M., Mao K., Chu M., Yang D., Xu D., Rauchman M., Taylor V., Conway S.J., Yutzey K.E., Butcher J.T., Zhou B.
    Eur Heart J 38:675-686(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of membrane protein ectodomain proteolysis Source: MGI
• positive regulation of myelination Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination."
    Madsen P.M., Motti D., Karmally S., Szymkowski D.E., Lambertsen K.L., Bethea J.R., Brambilla R.
    J Neurosci 36:5128-5143(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of oligodendrocyte differentiation Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination."
    Madsen P.M., Motti D., Karmally S., Szymkowski D.E., Lambertsen K.L., Bethea J.R., Brambilla R.
    J Neurosci 36:5128-5143(2016) [PubMed] [Europe PMC] [Abstract]
• pulmonary valve development Source: BHF-UCLInferred from genetic interactionⁱ
  • "Notch-Tnf signalling is required for development and homeostasis of arterial valves."
    Wang Y., Wu B., Farrar E., Lui W., Lu P., Zhang D., Alfieri C.M., Mao K., Chu M., Yang D., Xu D., Rauchman M., Taylor V., Conway S.J., Yutzey K.E., Butcher J.T., Zhou B.
    Eur Heart J 38:675-686(2017) [PubMed] [Europe PMC] [Abstract]
• regulation of cytokine production involved in immune response Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis."
    Gao H., Danzi M.C., Choi C.S., Taherian M., Dalby-Hansen C., Ellman D.G., Madsen P.M., Bixby J.L., Lemmon V.P., Lambertsen K.L., Brambilla R.
    Cell Rep 18:198-212(2017) [PubMed] [Europe PMC] [Abstract]
• regulation of myelination Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis."
    Gao H., Danzi M.C., Choi C.S., Taherian M., Dalby-Hansen C., Ellman D.G., Madsen P.M., Bixby J.L., Lemmon V.P., Lambertsen K.L., Brambilla R.
    Cell Rep 18:198-212(2017) [PubMed] [Europe PMC] [Abstract]
• regulation of neuroinflammatory response Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis."
    Gao H., Danzi M.C., Choi C.S., Taherian M., Dalby-Hansen C., Ellman D.G., Madsen P.M., Bixby J.L., Lemmon V.P., Lambertsen K.L., Brambilla R.
    Cell Rep 18:198-212(2017) [PubMed] [Europe PMC] [Abstract]
• regulation of RNA biosynthetic process Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination."
    Madsen P.M., Motti D., Karmally S., Szymkowski D.E., Lambertsen K.L., Bethea J.R., Brambilla R.
    J Neurosci 36:5128-5143(2016) [PubMed] [Europe PMC] [Abstract]
• regulation of T cell cytokine production Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis."
    Gao H., Danzi M.C., Choi C.S., Taherian M., Dalby-Hansen C., Ellman D.G., Madsen P.M., Bixby J.L., Lemmon V.P., Lambertsen K.L., Brambilla R.
    Cell Rep 18:198-212(2017) [PubMed] [Europe PMC] [Abstract]
• regulation of T cell proliferation Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis."
    Gao H., Danzi M.C., Choi C.S., Taherian M., Dalby-Hansen C., Ellman D.G., Madsen P.M., Bixby J.L., Lemmon V.P., Lambertsen K.L., Brambilla R.
    Cell Rep 18:198-212(2017) [PubMed] [Europe PMC] [Abstract]
• RNA destabilization Source: MGIInferred from mutant phenotypeⁱ
  • "Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome."
    Carballo E., Blackshear P.J.
    Blood 98:2389-2395(2001) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• tumor necrosis factor binding Source: MGI
• ubiquitin protein ligase binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAPAALWVAL VFELQLWATG HTVPAQVVLT PYKPEPGYEC QISQEYYDRK 
        60         70         80         90        100
AQMCCAKCPP GQYVKHFCNK TSDTVCADCE ASMYTQVWNQ FRTCLSCSSS 
       110        120        130        140        150
CTTDQVEIRA CTKQQNRVCA CEAGRYCALK THSGSCRQCM RLSKCGPGFG 
       160        170        180        190        200
VASSRAPNGN VLCKACAPGT FSDTTSSTDV CRPHRICSIL AIPGNASTDA 
       210        220        230        240        250
VCAPESPTLS AIPRTLYVSQ PEPTRSQPLD QEPGPSQTPS ILTSLGSTPI 
       260        270        280        290        300
IEQSTKGGIS LPIGLIVGVT SLGLLMLGLV NCIILVQRKK KPSCLQRDAK 
       310        320        330        340        350
VPHVPDEKSQ DAVGLEQQHL LTTAPSSSSS SLESSASAGD RRAPPGGHPQ 
       360        370        380        390        400
ARVMAEAQGF QEARASSRIS DSSHGSHGTH VNVTCIVNVC SSSDHSSQCS 
       410        420        430        440        450
SQASATVGDP DAKPSASPKD EQVPFSQEEC PSQSPCETTE TLQSHEKPLP 
       460        470 
LGVPDMGMKP SQAGWFDQIA VKVA                             

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot