Tnfrsf1b

Functionⁱ

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).By similarity

GO - Molecular functionⁱ

tumor necrosis factor-activated receptor activity
Source: MGI
Inferred from physical interactionⁱ
- 1645445
tumor necrosis factor binding Source: Ensembl
ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
aortic valve development
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 26491108
cell proliferation
Source: MGI
Traceable author statementⁱ
- 7990930
cell surface receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 9551933
cellular response to growth factor stimulus Source: Ensembl
cellular response to lipopolysaccharide Source: MGI
extrinsic apoptotic signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 7990930
immune response Source: MGI
inflammatory response
Source: MGI
Inferred from mutant phenotypeⁱ
- 9551933
intrinsic apoptotic signaling pathway in response to DNA damage
Source: MGI
Inferred from mutant phenotypeⁱ
- 17242187
negative regulation of cardiac muscle hypertrophy
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 26491108
negative regulation of extracellular matrix constituent secretion
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 26491108
negative regulation of inflammatory response
Source: MGI
Inferred from mutant phenotypeⁱ
- 11588035
positive regulation of apoptotic process involved in morphogenesis
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 26491108
positive regulation of membrane protein ectodomain proteolysis Source: MGI
pulmonary valve development
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 26491108
RNA destabilization
Source: MGI
Inferred from mutant phenotypeⁱ
- 11588035

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5668541 TNFR2 non-canonical NF-kB pathway R-MMU-5669034 TNFs bind their physiological receptors R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5669034 TNFs bind their physiological receptors
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor receptor superfamily member 1B Alternative name(s): Tumor necrosis factor receptor 2 Short name: TNF-R2 Tumor necrosis factor receptor type II Short name: TNF-RII Short name: TNFR-II p75 p80 TNF-alpha receptor CD_antigen: CD120b
Gene namesⁱ	Name:Tnfrsf1b Synonyms:Tnfr-2, Tnfr2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:1314883 Tnfrsf1b

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	23 – 258	ExtracellularSequence analysisAdd BLAST	236
Transmembraneⁱ	259 – 288	HelicalSequence analysisAdd BLAST	30
Topological domainⁱ	289 – 474	CytoplasmicSequence analysisAdd BLAST	186

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Add BLAST		22
ChainⁱPRO_0000034550	23 – 474	Tumor necrosis factor receptor superfamily member 1BAdd BLAST		452

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	30	O-linked (GalNAc...) threonineBy similarity	1
Disulfide bondⁱ	40 ↔ 54	PROSITE-ProRule annotation
Disulfide bondⁱ	55 ↔ 68	PROSITE-ProRule annotation
Disulfide bondⁱ	58 ↔ 76	PROSITE-ProRule annotation
Glycosylationⁱ	69	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	79 ↔ 94	PROSITE-ProRule annotation
Disulfide bondⁱ	97 ↔ 111	PROSITE-ProRule annotation
Disulfide bondⁱ	101 ↔ 119	PROSITE-ProRule annotation
Disulfide bondⁱ	121 ↔ 127	PROSITE-ProRule annotation
Disulfide bondⁱ	136 ↔ 145	PROSITE-ProRule annotation
Disulfide bondⁱ	139 ↔ 163	PROSITE-ProRule annotation
Disulfide bondⁱ	166 ↔ 181	PROSITE-ProRule annotation
Glycosylationⁱ	195	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	208	O-linked (GalNAc...) threonineBy similarity	1
Glycosylationⁱ	224	O-linked (GalNAc...) threonineBy similarity	1
Modified residueⁱ	331	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P25119
PaxDbⁱ	P25119
PeptideAtlas More...PeptideAtlasⁱ	P25119
PRIDEⁱ	P25119

PTM databases

PhosphoSitePlusⁱ	P25119
SwissPalmⁱ	P25119

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028599 Expressed in 172 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasⁱ	P25119 baseline and differential
Genevisibleⁱ	P25119 MM

Interactionⁱ

Subunit structureⁱ

Binds to TRAF2. Interacts with BMX. Interacts (activated form) with XPNPEP3.By similarity

GO - Molecular functionⁱ

tumor necrosis factor binding Source: Ensembl
ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204250, 4 interactors
Database of interacting proteins More...DIPⁱ	DIP-60902N
IntActⁱ	P25119, 4 interactors
Molecular INTeraction database More...MINTⁱ	P25119
STRINGⁱ	10090.ENSMUSP00000030336

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P25119
SMRⁱ	P25119
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	39 – 77	TNFR-Cys 1Add BLAST	39
Repeatⁱ	78 – 119	TNFR-Cys 2Add BLAST	42
Repeatⁱ	120 – 164	TNFR-Cys 3Add BLAST	45
Repeatⁱ	165 – 203	TNFR-Cys 4Add BLAST	39

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJ06 Eukaryota ENOG410YPQW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119204
HOGENOMⁱ	HOG000132845
HOVERGENⁱ	HBG054237
InParanoidⁱ	P25119
KEGG Orthology (KO) More...KOⁱ	K05141
OMAⁱ	CRPHRIC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03XW
PhylomeDBⁱ	P25119
TreeFamⁱ	TF331157

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10577 TNFRSF1B, 1 hit
InterProⁱ	View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR020411 TNFR_1B IPR033996 TNFRSF1B_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00020 TNFR_c6, 2 hits
PRINTSⁱ	PR01919 TNFACTORR1B
SMARTⁱ	View protein in SMART SM00208 TNFR, 4 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 2 hits PS50050 TNFR_NGFR_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P25119-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPAALWVAL VFELQLWATG HTVPAQVVLT PYKPEPGYEC QISQEYYDRK 
        60         70         80         90        100
AQMCCAKCPP GQYVKHFCNK TSDTVCADCE ASMYTQVWNQ FRTCLSCSSS 
       110        120        130        140        150
CTTDQVEIRA CTKQQNRVCA CEAGRYCALK THSGSCRQCM RLSKCGPGFG 
       160        170        180        190        200
VASSRAPNGN VLCKACAPGT FSDTTSSTDV CRPHRICSIL AIPGNASTDA 
       210        220        230        240        250
VCAPESPTLS AIPRTLYVSQ PEPTRSQPLD QEPGPSQTPS ILTSLGSTPI 
       260        270        280        290        300
IEQSTKGGIS LPIGLIVGVT SLGLLMLGLV NCIILVQRKK KPSCLQRDAK 
       310        320        330        340        350
VPHVPDEKSQ DAVGLEQQHL LTTAPSSSSS SLESSASAGD RRAPPGGHPQ 
       360        370        380        390        400
ARVMAEAQGF QEARASSRIS DSSHGSHGTH VNVTCIVNVC SSSDHSSQCS 
       410        420        430        440        450
SQASATVGDP DAKPSASPKD EQVPFSQEEC PSQSPCETTE TLQSHEKPLP 
       460        470 
LGVPDMGMKP SQAGWFDQIA VKVA

Length:474

Mass (Da):50,320

Last modified:May 1, 1992 - v1

Checksum:ⁱ462EAE398C4D6563

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RG55	D6RG55_MOUSE		Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 1B	Tnfrsf1b	55	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	78	D → DSDTVCAD in CAA74969 (PubMed:9740674).Curated	1
Sequence conflictⁱ	102	T → S in CAA74969 (PubMed:9740674).Curated	1
Sequence conflictⁱ	108	I → T in CAA74969 (PubMed:9740674).Curated	1
Sequence conflictⁱ	283	I → F in CAA74969 (PubMed:9740674).Curated	1
Sequence conflictⁱ	331	S → SS in CAA74969 (PubMed:9740674).Curated	1
Sequence conflictⁱ	360	F → S in CAA74969 (PubMed:9740674).Curated	1
Sequence conflictⁱ	436	C → Y in CAA74969 (PubMed:9740674).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60469 mRNA Translation: AAA39752.1 M59378 mRNA Translation: AAA40463.1 Y14619 Y14623 Genomic DNA Translation: CAA74969.1 U39488 Genomic DNA Translation: AAA85021.1 X87128 Genomic DNA Translation: CAA60618.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18914.1
PIRⁱ	B38634
NCBI Reference Sequences More...RefSeqⁱ	NP_035740.2, NM_011610.3
UniGeneⁱ	Mm.235328

Genome annotation databases

Ensemblⁱ	ENSMUST00000030336; ENSMUSP00000030336; ENSMUSG00000028599
GeneIDⁱ	21938
KEGGⁱ	mmu:21938
UCSC genome browser More...UCSCⁱ	uc008vrt.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P25119	Tumor necrosis factor receptor superfamily, member 1b		MOUSE		474	UniRef100_P25119

Protein	Similar proteins		Species	Score	Length	Source
P25119	Tumor necrosis factor receptor superfamily, member 1b		MOUSE		474	UniRef90_P25119
UPI000A310742		MUSPA		474
UPI000A314ED0		MUSCR		474
Uncharacterized protein		MOUSE		474
Tumour necrosis factor receptor 2 protein (Fragment)		MOUSE		459

Protein	Similar proteins		Species	Score	Length	Source
P25119	Tumor necrosis factor receptor superfamily member 1B	)	HUMAN		461	UniRef50_P20333
Tumor necrosis factor receptor superfamily member 1B		RAT		474
Uncharacterized protein		MACFA		463
Tumor necrosis factor receptor superfamily member 1B (Fragment)		MACMU		170
Uncharacterized protein		MACNE		462
+171

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60469 mRNA Translation: AAA39752.1 M59378 mRNA Translation: AAA40463.1 Y14619 Y14623 Genomic DNA Translation: CAA74969.1 U39488 Genomic DNA Translation: AAA85021.1 X87128 Genomic DNA Translation: CAA60618.1
CCDSⁱ	CCDS18914.1
PIRⁱ	B38634
RefSeqⁱ	NP_035740.2, NM_011610.3
UniGeneⁱ	Mm.235328

3D structure databases

ProteinModelPortalⁱ	P25119
SMRⁱ	P25119
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204250, 4 interactors
DIPⁱ	DIP-60902N
IntActⁱ	P25119, 4 interactors
MINTⁱ	P25119
STRINGⁱ	10090.ENSMUSP00000030336

PTM databases

PhosphoSitePlusⁱ	P25119
SwissPalmⁱ	P25119

Proteomic databases

EPDⁱ	P25119
PaxDbⁱ	P25119
PeptideAtlasⁱ	P25119
PRIDEⁱ	P25119

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000030336; ENSMUSP00000030336; ENSMUSG00000028599
GeneIDⁱ	21938
KEGGⁱ	mmu:21938
UCSCⁱ	uc008vrt.1 mouse

Organism-specific databases

CTDⁱ	7133
MGIⁱ	MGI:1314883 Tnfrsf1b

Phylogenomic databases

eggNOGⁱ	ENOG410IJ06 Eukaryota ENOG410YPQW LUCA
GeneTreeⁱ	ENSGT00760000119204
HOGENOMⁱ	HOG000132845
HOVERGENⁱ	HBG054237
InParanoidⁱ	P25119
KOⁱ	K05141
OMAⁱ	CRPHRIC
OrthoDBⁱ	EOG091G03XW
PhylomeDBⁱ	P25119
TreeFamⁱ	TF331157

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5668541 TNFR2 non-canonical NF-kB pathway R-MMU-5669034 TNFs bind their physiological receptors R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5669034 TNFs bind their physiological receptors
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	Tnfrsf1b mouse
Protein Ontology More...PROⁱ	PR:P25119
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028599 Expressed in 172 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasⁱ	P25119 baseline and differential
Genevisibleⁱ	P25119 MM

Family and domain databases

CDDⁱ	cd10577 TNFRSF1B, 1 hit
InterProⁱ	View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR020411 TNFR_1B IPR033996 TNFRSF1B_N
Pfamⁱ	View protein in Pfam PF00020 TNFR_c6, 2 hits
PRINTSⁱ	PR01919 TNFACTORR1B
SMARTⁱ	View protein in SMART SM00208 TNFR, 4 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 2 hits PS50050 TNFR_NGFR_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNR1B_MOUSE
Accessionⁱ	P25119Primary (citable) accession number: P25119 Secondary accession number(s): O88734, P97893
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	May 1, 1992
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P25119 (TNR1B_MOUSE)

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Tumor necrosis factor receptor superfamily member 1B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ