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Protein

Proteinase-activated receptor 1

Gene

F2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
SIGNORiP25116

Names & Taxonomyi

Protein namesi
Recommended name:
Proteinase-activated receptor 1
Short name:
PAR-1
Alternative name(s):
Coagulation factor II receptor
Thrombin receptor
Gene namesi
Name:F2R
Synonyms:CF2R, PAR1, TR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000181104.6
HGNCiHGNC:3537 F2R
MIMi187930 gene
neXtProtiNX_P25116

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini42 – 102ExtracellularSequence analysisAdd BLAST61
Transmembranei103 – 128Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini129 – 137CytoplasmicSequence analysis9
Transmembranei138 – 157Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini158 – 176ExtracellularSequence analysisAdd BLAST19
Transmembranei177 – 198Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini199 – 218CytoplasmicSequence analysisAdd BLAST20
Transmembranei219 – 239Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini240 – 268ExtracellularSequence analysisAdd BLAST29
Transmembranei269 – 288Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini289 – 311CytoplasmicSequence analysisAdd BLAST23
Transmembranei312 – 334Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini335 – 350ExtracellularSequence analysisAdd BLAST16
Transmembranei351 – 374Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini375 – 425CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2149
OpenTargetsiENSG00000181104
PharmGKBiPA27946

Chemistry databases

ChEMBLiCHEMBL3974
DrugBankiDB05692 SCH-530348
DB05361 SR-123781A
DB00086 Streptokinase
DB09030 Vorapaxar
GuidetoPHARMACOLOGYi347

Polymorphism and mutation databases

BioMutaiF2R
DMDMi20178318

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
PropeptideiPRO_000001274022 – 41Add BLAST20
ChainiPRO_000001274142 – 425Proteinase-activated receptor 1Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi175 ↔ 254PROSITE-ProRule annotation
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei418PhosphoserineCombined sources1

Post-translational modificationi

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41 – 42Cleavage; by thrombin2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP25116
PaxDbiP25116
PeptideAtlasiP25116
PRIDEiP25116
ProteomicsDBi54263

PTM databases

iPTMnetiP25116
PhosphoSitePlusiP25116
SwissPalmiP25116

Miscellaneous databases

PMAP-CutDBiP25116

Expressioni

Tissue specificityi

Platelets and vascular endothelial cells.

Gene expression databases

BgeeiENSG00000181104 Expressed in 175 organ(s), highest expression level in decidua
CleanExiHS_F2R
ExpressionAtlasiP25116 baseline and differential
GenevisibleiP25116 HS

Organism-specific databases

HPAiCAB008973
CAB012962

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108448, 21 interactors
DIPiDIP-29703N
IntActiP25116, 19 interactors
MINTiP25116
STRINGi9606.ENSP00000321326

Chemistry databases

BindingDBiP25116

Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP25116
SMRiP25116
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25116

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 60Asp/Glu-rich (acidic)4

Domaini

The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin.

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJCV Eukaryota
ENOG4110Q89 LUCA
GeneTreeiENSGT00920000148955
HOGENOMiHOG000232200
HOVERGENiHBG108233
InParanoidiP25116
KOiK03914
OMAiYASIMLM
OrthoDBiEOG091G0I94
PhylomeDBiP25116
TreeFamiTF330775

Family and domain databases

CDDicd15369 7tmA_PAR1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003912 Protea_act_rcpt
IPR000935 Thrmbn_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01428 PROTEASEAR
PR00908 THROMBINR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P25116-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPRRLLLVA ACFSLCGPLL SARTRARRPE SKATNATLDP RSFLLRNPND
60 70 80 90 100
KYEPFWEDEE KNESGLTEYR LVSINKSSPL QKQLPAFISE DASGYLTSSW
110 120 130 140 150
LTLFVPSVYT GVFVVSLPLN IMAIVVFILK MKVKKPAVVY MLHLATADVL
160 170 180 190 200
FVSVLPFKIS YYFSGSDWQF GSELCRFVTA AFYCNMYASI LLMTVISIDR
210 220 230 240 250
FLAVVYPMQS LSWRTLGRAS FTCLAIWALA IAGVVPLLLK EQTIQVPGLN
260 270 280 290 300
ITTCHDVLNE TLLEGYYAYY FSAFSAVFFF VPLIISTVCY VSIIRCLSSS
310 320 330 340 350
AVANRSKKSR ALFLSAAVFC IFIICFGPTN VLLIAHYSFL SHTSTTEAAY
360 370 380 390 400
FAYLLCVCVS SISCCIDPLI YYYASSECQR YVYSILCCKE SSDPSSYNSS
410 420
GQLMASKMDT CSSNLNNSIY KKLLT
Length:425
Mass (Da):47,441
Last modified:April 16, 2002 - v2
Checksum:i41B742A99EEC96AB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAL6G3XAL6_HUMAN
Coagulation factor II (Thrombin) re...
F2R hCG_37484
102Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238L → V in AAA36743 (PubMed:1672265).Curated1
Sequence conflicti364C → S in AAA36743 (PubMed:1672265).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014167166S → G1 PublicationCorresponds to variant dbSNP:rs5893Ensembl.1
Natural variantiVAR_049432187Y → N. Corresponds to variant dbSNP:rs2230849Ensembl.1
Natural variantiVAR_049433257V → L. Corresponds to variant dbSNP:rs2227832Ensembl.1
Natural variantiVAR_060680268A → P. Corresponds to variant dbSNP:rs1055103Ensembl.1
Natural variantiVAR_060681335A → V2 PublicationsCorresponds to variant dbSNP:rs17849599Ensembl.1
Natural variantiVAR_049434412S → Y. Corresponds to variant dbSNP:rs2227799Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62424 mRNA Translation: AAA36743.1
AF391809 Genomic DNA Translation: AAK69768.1
BT007279 mRNA Translation: AAP35943.1
BC002464 mRNA Translation: AAH02464.1
BC051909 mRNA Translation: AAH51909.1
CCDSiCCDS4032.1
PIRiA37912
RefSeqiNP_001298242.1, NM_001311313.1
NP_001983.2, NM_001992.4
UniGeneiHs.482562

Genome annotation databases

EnsembliENST00000319211; ENSP00000321326; ENSG00000181104
GeneIDi2149
KEGGihsa:2149
UCSCiuc003ken.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62424 mRNA Translation: AAA36743.1
AF391809 Genomic DNA Translation: AAK69768.1
BT007279 mRNA Translation: AAP35943.1
BC002464 mRNA Translation: AAH02464.1
BC051909 mRNA Translation: AAH51909.1
CCDSiCCDS4032.1
PIRiA37912
RefSeqiNP_001298242.1, NM_001311313.1
NP_001983.2, NM_001992.4
UniGeneiHs.482562

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NRNX-ray3.10R38-60[»]
1NROX-ray3.10R38-64[»]
1NRPX-ray3.00R38-60[»]
1NRQX-ray3.50R40-60[»]
1NRRX-ray2.40R43-60[»]
3BEFX-ray2.20C/F49-57[»]
3HKIX-ray2.20C/F42-62[»]
3HKJX-ray2.60C/F42-62[»]
3LU9X-ray1.80C/F33-57[»]
3VW7X-ray2.20A86-395[»]
ProteinModelPortaliP25116
SMRiP25116
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108448, 21 interactors
DIPiDIP-29703N
IntActiP25116, 19 interactors
MINTiP25116
STRINGi9606.ENSP00000321326

Chemistry databases

BindingDBiP25116
ChEMBLiCHEMBL3974
DrugBankiDB05692 SCH-530348
DB05361 SR-123781A
DB00086 Streptokinase
DB09030 Vorapaxar
GuidetoPHARMACOLOGYi347

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25116
PhosphoSitePlusiP25116
SwissPalmiP25116

Polymorphism and mutation databases

BioMutaiF2R
DMDMi20178318

Proteomic databases

MaxQBiP25116
PaxDbiP25116
PeptideAtlasiP25116
PRIDEiP25116
ProteomicsDBi54263

Protocols and materials databases

DNASUi2149
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319211; ENSP00000321326; ENSG00000181104
GeneIDi2149
KEGGihsa:2149
UCSCiuc003ken.5 human

Organism-specific databases

CTDi2149
DisGeNETi2149
EuPathDBiHostDB:ENSG00000181104.6
GeneCardsiF2R
H-InvDBiHIX0004960
HGNCiHGNC:3537 F2R
HPAiCAB008973
CAB012962
MIMi187930 gene
neXtProtiNX_P25116
OpenTargetsiENSG00000181104
PharmGKBiPA27946
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJCV Eukaryota
ENOG4110Q89 LUCA
GeneTreeiENSGT00920000148955
HOGENOMiHOG000232200
HOVERGENiHBG108233
InParanoidiP25116
KOiK03914
OMAiYASIMLM
OrthoDBiEOG091G0I94
PhylomeDBiP25116
TreeFamiTF330775

Enzyme and pathway databases

ReactomeiR-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
SIGNORiP25116

Miscellaneous databases

ChiTaRSiF2R human
EvolutionaryTraceiP25116
GeneWikiiCoagulation_factor_II_receptor
GenomeRNAii2149
PMAP-CutDBiP25116
PROiPR:P25116
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181104 Expressed in 175 organ(s), highest expression level in decidua
CleanExiHS_F2R
ExpressionAtlasiP25116 baseline and differential
GenevisibleiP25116 HS

Family and domain databases

CDDicd15369 7tmA_PAR1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003912 Protea_act_rcpt
IPR000935 Thrmbn_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01428 PROTEASEAR
PR00908 THROMBINR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAR1_HUMAN
AccessioniPrimary (citable) accession number: P25116
Secondary accession number(s): Q53XV0, Q96RF7, Q9BUN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: April 16, 2002
Last modified: November 7, 2018
This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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