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UniProtKB - P25115 (DRD5_RAT)
Protein
D(1B) dopamine receptor
Gene
Drd5
Organism
Rattus norvegicus (Rat)
Status
Functioni
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO - Molecular functioni
- dopamine binding Source: RGD
- dopamine neurotransmitter receptor activity Source: MGI
- dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD
- G-protein alpha-subunit binding Source: RGD
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- adenylate cyclase-activating dopamine receptor signaling pathway Source: RGD
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- associative learning Source: RGD
- cellular response to catecholamine stimulus Source: RGD
- dopamine receptor signaling pathway Source: RGD
- long-term synaptic depression Source: RGD
- mating behavior Source: RGD
- negative regulation of blood pressure Source: RGD
- negative regulation of cell migration Source: RGD
- negative regulation of NAD(P)H oxidase activity Source: RGD
- negative regulation of protein kinase activity Source: RGD
- norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: RGD
- reactive oxygen species metabolic process Source: RGD
- regulation of female receptivity Source: RGD
- regulation of postsynaptic membrane neurotransmitter receptor levels Source: SynGO
- regulation of systemic arterial blood pressure by vasopressin Source: RGD
- response to amphetamine Source: RGD
- response to cocaine Source: RGD
- sensitization Source: RGD
- transmission of nerve impulse Source: RGD
- visual learning Source: RGD
- wound healing Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-390651, Dopamine receptors |
Names & Taxonomyi
Protein namesi | Recommended name: D(1B) dopamine receptorAlternative name(s): D(5) dopamine receptor Dopamine D5 receptor |
Gene namesi | Name:Drd5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2523, Drd5 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- brush border membrane Source: RGD
- ciliary membrane Source: RGD
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic density membrane Source: SynGO
- plasma membrane Source: RGD
Other locations
- axon Source: RGD
- cilium Source: RGD
- dendrite Source: RGD
- dendritic spine Source: RGD
- glutamatergic synapse Source: SynGO
- neuronal cell body Source: RGD
- non-motile cilium Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 64 | Helical; Name=1Sequence analysisAdd BLAST | 26 | |
Topological domaini | 65 – 75 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 76 – 102 | Helical; Name=2Sequence analysisAdd BLAST | 27 | |
Topological domaini | 103 – 111 | ExtracellularSequence analysis | 9 | |
Transmembranei | 112 – 134 | Helical; Name=3Sequence analysisAdd BLAST | 23 | |
Topological domaini | 135 – 153 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 154 – 179 | Helical; Name=4Sequence analysisAdd BLAST | 26 | |
Topological domaini | 180 – 215 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 216 – 240 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 241 – 289 | CytoplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 290 – 317 | Helical; Name=6Sequence analysisAdd BLAST | 28 | |
Topological domaini | 318 – 335 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 336 – 357 | Helical; Name=7Sequence analysisAdd BLAST | 22 | |
Topological domaini | 358 – 475 | CytoplasmicSequence analysisAdd BLAST | 118 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069408 | 1 – 475 | D(1B) dopamine receptorAdd BLAST | 475 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 7 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 111 ↔ 211 | PROSITE-ProRule annotation | ||
Lipidationi | 370 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P25115 |
PTM databases
CarbonylDBi | P25115 |
GlyGeni | P25115, 1 site |
PhosphoSitePlusi | P25115 |
Expressioni
Tissue specificityi
Brain, in the lateral mammillary nuclei, the anterior pretectal nuclei, and several layers of the hippocampus.
Interactioni
GO - Molecular functioni
- G-protein alpha-subunit binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247243, 1 interactor |
STRINGi | 10116.ENSRNOP00000007074 |
Chemistry databases
BindingDBi | P25115 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 415 – 443 | DisorderedSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P25115 |
OrthoDBi | 1045889at2759 |
PhylomeDBi | P25115 |
Family and domain databases
InterProi | View protein in InterPro IPR000497, Dopamine_D5_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00566, DOPAMINED1BR PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P25115-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPPGRNRTA QPARLGLQRQ LAQVDAPAGS ATPLGPAQVV TAGLLTLLIV
60 70 80 90 100
WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE
110 120 130 140 150
VAGYWPFGTF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM
160 170 180 190 200
TQRVALVMVG LAWTLSILIS FIPVQLNWHR DKAGSQGQEG LLSNGTPWEE
210 220 230 240 250
GWELEGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI
260 270 280 290 300
RRISSLERAA EHAQSCRSRG AYEPDPSLRA SIKKETKVFK TLSMIMGVFV
310 320 330 340 350
CCWLPFFILN CMVPFCSSGD AEGPKTGFPC VSETTFDIFV WFGWANSSLN
360 370 380 390 400
PIIYAFNADF RKVFAQLLGC SHFCFRTPVQ TVNISNELIS YNQDTVFHKE
410 420 430 440 450
IATAYVHMIP NAVSSGDREV GEEEEEGPFD HMSQISPTTP DGDLAAESVW
460 470
ELDCEEEVSL GKISPLTPNC FDKTA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V6N6 | G3V6N6_RAT | D(1B) dopamine receptor | Drd5 rCG_35801 | 475 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M69118 Genomic DNA Translation: AAA41072.1 |
PIRi | A41271 |
RefSeqi | NP_036900.1, NM_012768.1 |
Genome annotation databases
GeneIDi | 25195 |
KEGGi | rno:25195 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M69118 Genomic DNA Translation: AAA41072.1 |
PIRi | A41271 |
RefSeqi | NP_036900.1, NM_012768.1 |
3D structure databases
AlphaFoldDBi | P25115 |
SMRi | P25115 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247243, 1 interactor |
STRINGi | 10116.ENSRNOP00000007074 |
Chemistry databases
BindingDBi | P25115 |
ChEMBLi | CHEMBL2281 |
DrugCentrali | P25115 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
CarbonylDBi | P25115 |
GlyGeni | P25115, 1 site |
PhosphoSitePlusi | P25115 |
Proteomic databases
PaxDbi | P25115 |
Genome annotation databases
GeneIDi | 25195 |
KEGGi | rno:25195 |
Organism-specific databases
CTDi | 1816 |
RGDi | 2523, Drd5 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P25115 |
OrthoDBi | 1045889at2759 |
PhylomeDBi | P25115 |
Enzyme and pathway databases
Reactomei | R-RNO-390651, Dopamine receptors |
Miscellaneous databases
PROi | PR:P25115 |
Family and domain databases
InterProi | View protein in InterPro IPR000497, Dopamine_D5_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00566, DOPAMINED1BR PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DRD5_RAT | |
Accessioni | P25115Primary (citable) accession number: P25115 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families