D(1B) dopamine receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• dopamine binding Source: RGDInferred from sequence orthologyⁱ
  • "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1."
    Sunahara R.K., Guan H.-C., O'Dowd B.F., Seeman P., Laurier L.G., Ng G., George S.R., Torchia J., van Tol H.H.M., Niznik H.B.
    Nature 350:614-619(1991) [PubMed] [Europe PMC] [Abstract]
• dopamine neurotransmitter receptor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor."
    Tiberi M., Jarvie K.R., Silvia C., Falardeau P., Gingrich J.A., Godinot N., Bertrand L., Yang-Feng T.L., Fremeau R.T. Jr., Caron M.G.
    Proc. Natl. Acad. Sci. U.S.A. 88:7491-7495(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression."
    Lemon N., Manahan-Vaughan D.
    J. Neurosci. 26:7723-7729(2006) [PubMed] [Europe PMC] [Abstract]
• drug binding Source: RGDInferred from direct assayⁱ
  • "Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression."
    Lemon N., Manahan-Vaughan D.
    J. Neurosci. 26:7723-7729(2006) [PubMed] [Europe PMC] [Abstract]
• G-protein alpha-subunit binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron."
    Zheng S., Yu P., Zeng C., Wang Z., Yang Z., Andrews P.M., Felder R.A., Jose P.A.
    Hypertension 41:604-610(2003) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-activating dopamine receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors."
    Yasunari K., Maeda K., Nakamura M., Yoshikawa J.
    J. Cardiovasc. Pharmacol. 41 Suppl 1:S33-8(2003) [PubMed] [Europe PMC] [Abstract]
  • "Dopamine D1/D5 receptor activation fails to initiate an activity-independent late-phase LTP in rat hippocampus."
    Mockett B.G., Brooks W.M., Tate W.P., Abraham W.C.
    Brain Res. 1021:92-100(2004) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor."
    Tiberi M., Jarvie K.R., Silvia C., Falardeau P., Gingrich J.A., Godinot N., Bertrand L., Yang-Feng T.L., Fremeau R.T. Jr., Caron M.G.
    Proc. Natl. Acad. Sci. U.S.A. 88:7491-7495(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• associative learning Source: RGDInferred from sequence orthologyⁱ
  • "Dopamine D5 receptor modulates male and female sexual behavior in mice."
    Kudwa A.E., Dominguez-Salazar E., Cabrera D.M., Sibley D.R., Rissman E.F.
    Psychopharmacology (Berl.) 180:206-214(2005) [PubMed] [Europe PMC] [Abstract]
• cellular response to catecholamine stimulus Source: RGDInferred from sequence orthologyⁱ
  • "Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system."
    Sakihama T., Masuda K., Sato T., Doi T., Kodama T., Hamakubo T.
    J. Biotechnol. 135:28-33(2008) [PubMed] [Europe PMC] [Abstract]
• dopamine receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • Ref.1

    "Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor."
    Tiberi M., Jarvie K.R., Silvia C., Falardeau P., Gingrich J.A., Godinot N., Bertrand L., Yang-Feng T.L., Fremeau R.T. Jr., Caron M.G.
    Proc. Natl. Acad. Sci. U.S.A. 88:7491-7495(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• long-term synaptic depression Source: RGDInferred from sequence orthologyⁱ
  • "Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity."
    Centonze D., Grande C., Saulle E., Martin A.B., Gubellini P., Pavon N., Pisani A., Bernardi G., Moratalla R., Calabresi P.
    J. Neurosci. 23:8506-8512(2003) [PubMed] [Europe PMC] [Abstract]
• mating behavior Source: RGDInferred from sequence orthologyⁱ
  • "Dopamine D5 receptor modulates male and female sexual behavior in mice."
    Kudwa A.E., Dominguez-Salazar E., Cabrera D.M., Sibley D.R., Rissman E.F.
    Psychopharmacology (Berl.) 180:206-214(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of blood pressure Source: RGDInferred from sequence orthologyⁱ
  • "Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive."
    Hollon T.R., Bek M.J., Lachowicz J.E., Ariano M.A., Mezey E., Ramachandran R., Wersinger S.R., Soares-da-Silva P., Liu Z.F., Grinberg A., Drago J., Young W.S., Westphal H., Jose P.A., Sibley D.R.
    J. Neurosci. 22:10801-10810(2002) [PubMed] [Europe PMC] [Abstract]
  • "D5 dopamine receptor regulation of phospholipase D."
    Yang Z., Asico L.D., Yu P., Wang Z., Jones J.E., Bai R.K., Sibley D.R., Felder R.A., Jose P.A.
    Am. J. Physiol. Heart Circ. Physiol. 288:H55-61(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell migration Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors."
    Yasunari K., Maeda K., Nakamura M., Yoshikawa J.
    J. Cardiovasc. Pharmacol. 41 Suppl 1:S33-8(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of NAD(P)H oxidase activity Source: RGDInferred from sequence orthologyⁱ
  • "D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure."
    Yang Z., Asico L.D., Yu P., Wang Z., Jones J.E., Escano C.S., Wang X., Quinn M.T., Sibley D.R., Romero G.G., Felder R.A., Jose P.A.
    Am. J. Physiol. Regul. Integr. Comp. Physiol. 290:R96-R104(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein kinase activity Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors."
    Yasunari K., Maeda K., Nakamura M., Yoshikawa J.
    J. Cardiovasc. Pharmacol. 41 Suppl 1:S33-8(2003) [PubMed] [Europe PMC] [Abstract]
• norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: RGDInferred from sequence orthologyⁱ
  • "Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive."
    Hollon T.R., Bek M.J., Lachowicz J.E., Ariano M.A., Mezey E., Ramachandran R., Wersinger S.R., Soares-da-Silva P., Liu Z.F., Grinberg A., Drago J., Young W.S., Westphal H., Jose P.A., Sibley D.R.
    J. Neurosci. 22:10801-10810(2002) [PubMed] [Europe PMC] [Abstract]
• reactive oxygen species metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure."
    Yang Z., Asico L.D., Yu P., Wang Z., Jones J.E., Escano C.S., Wang X., Quinn M.T., Sibley D.R., Romero G.G., Felder R.A., Jose P.A.
    Am. J. Physiol. Regul. Integr. Comp. Physiol. 290:R96-R104(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of female receptivity Source: RGDInferred from sequence orthologyⁱ
  • "Dopamine D5 receptor modulates male and female sexual behavior in mice."
    Kudwa A.E., Dominguez-Salazar E., Cabrera D.M., Sibley D.R., Rissman E.F.
    Psychopharmacology (Berl.) 180:206-214(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of long-term neuronal synaptic plasticity Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression."
    Lemon N., Manahan-Vaughan D.
    J. Neurosci. 26:7723-7729(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of systemic arterial blood pressure by vasopressin Source: RGDInferred from sequence orthologyⁱ
  • "Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive."
    Hollon T.R., Bek M.J., Lachowicz J.E., Ariano M.A., Mezey E., Ramachandran R., Wersinger S.R., Soares-da-Silva P., Liu Z.F., Grinberg A., Drago J., Young W.S., Westphal H., Jose P.A., Sibley D.R.
    J. Neurosci. 22:10801-10810(2002) [PubMed] [Europe PMC] [Abstract]
• response to amphetamine Source: RGDInferred from sequence orthologyⁱ
  • "Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A receptor knockout mice."
    Karper P.E., De la Rosa H., Newman E.R., Krall C.M., Nazarian A., McDougall S.A., Crawford C.A.
    Psychopharmacology (Berl.) 159:407-414(2002) [PubMed] [Europe PMC] [Abstract]
• response to cocaine Source: RGDInferred from sequence orthologyⁱ
  • "Locomotor and discriminative-stimulus effects of cocaine in dopamine D5 receptor knockout mice."
    Elliot E.E., Sibley D.R., Katz J.L.
    Psychopharmacology (Berl.) 169:161-168(2003) [PubMed] [Europe PMC] [Abstract]
• sensitization Source: RGDInferred from sequence orthologyⁱ
  • "Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A receptor knockout mice."
    Karper P.E., De la Rosa H., Newman E.R., Krall C.M., Nazarian A., McDougall S.A., Crawford C.A.
    Psychopharmacology (Berl.) 159:407-414(2002) [PubMed] [Europe PMC] [Abstract]
• synaptic transmission, dopaminergic Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression."
    Lemon N., Manahan-Vaughan D.
    J. Neurosci. 26:7723-7729(2006) [PubMed] [Europe PMC] [Abstract]
• transmission of nerve impulse Source: RGDInferred from sequence orthologyⁱ
  • "Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons."
    Centonze D., Grande C., Usiello A., Gubellini P., Erbs E., Martin A.B., Pisani A., Tognazzi N., Bernardi G., Moratalla R., Borrelli E., Calabresi P.
    J. Neurosci. 23:6245-6254(2003) [PubMed] [Europe PMC] [Abstract]
• visual learning Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression."
    Lemon N., Manahan-Vaughan D.
    J. Neurosci. 26:7723-7729(2006) [PubMed] [Europe PMC] [Abstract]
  • "Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory."
    O'Carroll C.M., Martin S.J., Sandin J., Frenguelli B., Morris R.G.
    Learn. Mem. 13:760-769(2006) [PubMed] [Europe PMC] [Abstract]
• wound healing Source: RGDInferred from sequence orthologyⁱ
  • "Susceptibility of dopamine D5 receptor targeted mice to cysteamine."
    Hunyady B., Palkovits M., Mozsik G., Molnar J., Feher K., Toth Z., Zolyomi A., Szalayova I., Key S., Sibley D.R., Mezey E
    J. Physiol. Paris 95:147-151(2001) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• G-protein alpha-subunit binding Source: RGDInferred from physical interactionⁱ
  • "Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron."
    Zheng S., Yu P., Zeng C., Wang Z., Yang Z., Andrews P.M., Felder R.A., Jose P.A.
    Hypertension 41:604-610(2003) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MLPPGRNRTA QPARLGLQRQ LAQVDAPAGS ATPLGPAQVV TAGLLTLLIV 
        60         70         80         90        100
WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE 
       110        120        130        140        150
VAGYWPFGTF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM 
       160        170        180        190        200
TQRVALVMVG LAWTLSILIS FIPVQLNWHR DKAGSQGQEG LLSNGTPWEE 
       210        220        230        240        250
GWELEGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI 
       260        270        280        290        300
RRISSLERAA EHAQSCRSRG AYEPDPSLRA SIKKETKVFK TLSMIMGVFV 
       310        320        330        340        350
CCWLPFFILN CMVPFCSSGD AEGPKTGFPC VSETTFDIFV WFGWANSSLN 
       360        370        380        390        400
PIIYAFNADF RKVFAQLLGC SHFCFRTPVQ TVNISNELIS YNQDTVFHKE 
       410        420        430        440        450
IATAYVHMIP NAVSSGDREV GEEEEEGPFD HMSQISPTTP DGDLAAESVW 
       460        470 
ELDCEEEVSL GKISPLTPNC FDKTA                            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. SIMILARITY comments
   Index of protein domains and families