UniProtKB - P25108 (ACHA_RAT)
Protein
Acetylcholine receptor subunit alpha
Gene
Chrna1
Organism
Rattus norvegicus (Rat)
Status
Functioni
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
GO - Molecular functioni
- acetylcholine binding Source: Ensembl
- acetylcholine-gated cation-selective channel activity Source: RGD
- acetylcholine receptor activity Source: Ensembl
- neurotransmitter receptor activity Source: GO_Central
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: RGD
GO - Biological processi
- cation transport Source: RGD
- chemical synaptic transmission Source: GO_Central
- ion transmembrane transport Source: GO_Central
- muscle cell cellular homeostasis Source: RGD
- musculoskeletal movement Source: RGD
- nervous system process Source: GO_Central
- neuromuscular junction development Source: RGD
- neuromuscular process Source: RGD
- neuromuscular synaptic transmission Source: RGD
- neuronal action potential Source: RGD
- neuron cellular homeostasis Source: RGD
- regulation of membrane potential Source: RGD
- signal transduction Source: GO_Central
- skeletal muscle contraction Source: RGD
- skeletal muscle tissue growth Source: RGD
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-629594, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-RNO-629597, Highly calcium permeable nicotinic acetylcholine receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Acetylcholine receptor subunit alpha |
Gene namesi | Name:Chrna1 Synonyms:Acra |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 69277, Chrna1 |
Subcellular locationi
Plasma Membrane
- acetylcholine-gated channel complex Source: RGD
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic specialization membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- cell surface Source: RGD
- membrane Source: RGD
- neuromuscular junction Source: RGD
- neuron projection Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 230 | ExtracellularSequence analysisAdd BLAST | 210 | |
Transmembranei | 231 – 255 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 263 – 281 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 297 – 316 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 317 – 428 | CytoplasmicSequence analysisAdd BLAST | 112 | |
Transmembranei | 429 – 447 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | By similarityAdd BLAST | 20 | |
ChainiPRO_0000000307 | 21 – 457 | Acetylcholine receptor subunit alphaAdd BLAST | 437 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 148 ↔ 162 | By similarity | ||
Glycosylationi | 161 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 212 ↔ 213 | Associated with receptor activationBy similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P25108 |
PTM databases
GlyGeni | P25108, 1 site |
PhosphoSitePlusi | P25108 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000018286, Expressed in esophagus and 10 other tissues |
Genevisiblei | P25108, RN |
Interactioni
Subunit structurei
Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (By similarity).
By similarityProtein-protein interaction databases
ComplexPortali | CPX-253, Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma CPX-258, Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon |
STRINGi | 10116.ENSRNOP00000024706 |
Chemistry databases
BindingDBi | P25108 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily. [View classification]Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3645, Eukaryota |
GeneTreei | ENSGT00940000156851 |
HOGENOMi | CLU_018074_1_0_1 |
InParanoidi | P25108 |
OMAi | STHIMPE |
OrthoDBi | 381858at2759 |
PhylomeDBi | P25108 |
TreeFami | TF315605 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P25108-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELTAVLLLL GLCSAGTVLG SEHETRLVAK LFKDYSSVVR PVGDHREIVQ
60 70 80 90 100
VTVGLQLIQL INVDEVNQIV TTNVRLKQQW VDYNLKWNPD DYGGVKKIHI
110 120 130 140 150
PSEKIWRPDV VLYNNADGDF AIVKFTKVLL DYTGHITWTP PAIFKSYCEI
160 170 180 190 200
IVTHFPFDEQ NCSMKLGTWT YDGSVVAINP ESDQPDLSNF MESGEWVIKE
210 220 230 240 250
ARGWKHWVFY SCCPNTPYLD ITYHFVMQRL PLYFIVNVII PCLLFSFLTS
260 270 280 290 300
LVFYLPTDSG EKMTLSISVL LSLTVFLLVI VELIPSTSSA VPLIGKYMLF
310 320 330 340 350
TMVFVIASII ITVIVINTHH RSPSTHIMPE WVRKVFIDTI PNIMFFSTMK
360 370 380 390 400
RPSRDKQEKR IFTEDIDISD ISGKPGPPPM GFHSPLIKHP EVKSAIEGVK
410 420 430 440 450
YIAETMKSDQ ESNNASEEWK YVAMVMDHIL LGVFMLVCLI GTLAVFAGRL
IELHQQG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74832 mRNA Translation: CAA52826.1 |
PIRi | S13872 |
RefSeqi | NP_077811.1, NM_024485.1 |
Genome annotation databases
Ensembli | ENSRNOT00000024706; ENSRNOP00000024706; ENSRNOG00000018286 |
GeneIDi | 79557 |
KEGGi | rno:79557 |
UCSCi | RGD:69277, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74832 mRNA Translation: CAA52826.1 |
PIRi | S13872 |
RefSeqi | NP_077811.1, NM_024485.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
ComplexPortali | CPX-253, Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-gamma CPX-258, Muscle-type nicotinic acetylcholine receptor complex, alpha1-beta1-delta-epsilon |
STRINGi | 10116.ENSRNOP00000024706 |
Chemistry databases
BindingDBi | P25108 |
ChEMBLi | CHEMBL3885509 |
DrugCentrali | P25108 |
PTM databases
GlyGeni | P25108, 1 site |
PhosphoSitePlusi | P25108 |
Proteomic databases
PaxDbi | P25108 |
Protocols and materials databases
ABCDi | P25108, 3 sequenced antibodies |
Genome annotation databases
Ensembli | ENSRNOT00000024706; ENSRNOP00000024706; ENSRNOG00000018286 |
GeneIDi | 79557 |
KEGGi | rno:79557 |
UCSCi | RGD:69277, rat |
Organism-specific databases
CTDi | 1134 |
RGDi | 69277, Chrna1 |
Phylogenomic databases
eggNOGi | KOG3645, Eukaryota |
GeneTreei | ENSGT00940000156851 |
HOGENOMi | CLU_018074_1_0_1 |
InParanoidi | P25108 |
OMAi | STHIMPE |
OrthoDBi | 381858at2759 |
PhylomeDBi | P25108 |
TreeFami | TF315605 |
Enzyme and pathway databases
Reactomei | R-RNO-629594, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-RNO-629597, Highly calcium permeable nicotinic acetylcholine receptors |
Miscellaneous databases
PROi | PR:P25108 |
Gene expression databases
Bgeei | ENSRNOG00000018286, Expressed in esophagus and 10 other tissues |
Genevisiblei | P25108, RN |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACHA_RAT | |
Accessioni | P25108Primary (citable) accession number: P25108 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families