The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P25105 (PTAFR_HUMAN)
Protein
Platelet-activating factor receptor
Gene
PTAFR
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
4 PublicationsGO - Molecular functioni
- G protein-coupled purinergic nucleotide receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: ProtInc
- lipopolysaccharide binding Source: Ensembl
- lipopolysaccharide immune receptor activity Source: Ensembl
- mitogen-activated protein kinase binding Source: Ensembl
- phospholipid binding Source: UniProtKB
- platelet activating factor receptor activity Source: UniProtKB
GO - Biological processi
- cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Source: Ensembl
- cellular response to cAMP Source: Ensembl
- cellular response to fatty acid Source: Ensembl
- cellular response to gravity Source: Ensembl
- chemotaxis Source: ProtInc
- G protein-coupled receptor signaling pathway Source: UniProtKB
- immune response Source: ProtInc
- inflammatory response Source: ProtInc
- inositol trisphosphate biosynthetic process Source: Ensembl
- negative regulation of blood pressure Source: Ensembl
- parturition Source: Ensembl
- phosphatidylinositol-mediated signaling Source: UniProtKB
- positive regulation of cellular extravasation Source: Ensembl
- positive regulation of gastro-intestinal system smooth muscle contraction Source: Ensembl
- positive regulation of inositol phosphate biosynthetic process Source: Ensembl
- positive regulation of interleukin-6 production Source: Ensembl
- positive regulation of leukocyte tethering or rolling Source: Ensembl
- positive regulation of maternal process involved in parturition Source: Ensembl
- positive regulation of neutrophil degranulation Source: Ensembl
- positive regulation of phospholipase C activity Source: Ensembl
- positive regulation of sensory perception of pain Source: Ensembl
- positive regulation of smooth muscle cell proliferation Source: Ensembl
- positive regulation of transcytosis Source: Ensembl
- positive regulation of translation Source: Ensembl
- positive regulation of tumor necrosis factor production Source: Ensembl
- positive regulation of voltage-gated chloride channel activity Source: Ensembl
- regulation of transcription by RNA polymerase II Source: Ensembl
- response to dexamethasone Source: Ensembl
- response to symbiotic bacterium Source: Ensembl
- transcytosis Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Chemotaxis |
Enzyme and pathway databases
PathwayCommonsi | P25105 |
Reactomei | R-HSA-373076, Class A/1 (Rhodopsin-like receptors) R-HSA-416476, G alpha (q) signalling events R-HSA-6783783, Interleukin-10 signaling R-HSA-6798695, Neutrophil degranulation R-HSA-877300, Interferon gamma signaling |
SignaLinki | P25105 |
SIGNORi | P25105 |
Protein family/group databases
TCDBi | 9.A.14.13.3, the g-protein-coupled receptor (gpcr) family |
Chemistry databases
SwissLipidsi | SLP:000001565 |
Names & Taxonomyi
Protein namesi | Recommended name: Platelet-activating factor receptorShort name: PAF-R Short name: PAFr |
Gene namesi | Name:PTAFR Synonyms:PAFR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9582, PTAFR |
MIMi | 173393, gene |
neXtProti | NX_P25105 |
VEuPathDBi | HostDB:ENSG00000169403 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB
- secretory granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 38 | Helical; Name=1Sequence analysisAdd BLAST | 22 | |
Topological domaini | 39 – 54 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 55 – 74 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 75 – 91 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 92 – 113 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 114 – 133 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 134 – 155 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 156 – 184 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 185 – 205 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 206 – 233 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 234 – 254 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 255 – 276 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 277 – 296 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 297 – 342 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5724 |
OpenTargetsi | ENSG00000169403 |
PharmGKBi | PA33933 |
Miscellaneous databases
Pharosi | P25105, Tchem |
Chemistry databases
ChEMBLi | CHEMBL250 |
DrugBanki | DB09166, Etizolam DB02261, Platelet Activating Factor DB11614, Rupatadine |
DrugCentrali | P25105 |
GuidetoPHARMACOLOGYi | 334 |
Genetic variation databases
BioMutai | PTAFR |
DMDMi | 129557 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070092 | 1 – 342 | Platelet-activating factor receptorAdd BLAST | 342 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 90 ↔ 173 | PROSITE-ProRule annotation | ||
Glycosylationi | 169 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P25105 |
jPOSTi | P25105 |
MassIVEi | P25105 |
PaxDbi | P25105 |
PeptideAtlasi | P25105 |
PRIDEi | P25105 |
ProteomicsDBi | 54261 |
PTM databases
GlyGeni | P25105, 1 site |
iPTMneti | P25105 |
PhosphoSitePlusi | P25105 |
Expressioni
Tissue specificityi
Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.3 Publications
Inductioni
By CSF2/GM-CSF, IL5/interleukin-5 and n-butyrate.1 Publication
Gene expression databases
Bgeei | ENSG00000169403, Expressed in blood and 230 other tissues |
Genevisiblei | P25105, HS |
Organism-specific databases
HPAi | ENSG00000169403, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with ARRB1.
1 PublicationBinary interactionsi
P25105
With | #Exp. | IntAct |
---|---|---|
PTK2 [Q05397] | 2 | EBI-3906092,EBI-702142 |
GO - Molecular functioni
- mitogen-activated protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 111696, 50 interactors |
CORUMi | P25105 |
IntActi | P25105, 16 interactors |
MINTi | P25105 |
STRINGi | 9606.ENSP00000362965 |
Chemistry databases
BindingDBi | P25105 |
Miscellaneous databases
RNActi | P25105, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QTQI, Eukaryota |
GeneTreei | ENSGT00980000198579 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | P25105 |
OMAi | AIHVIIC |
OrthoDBi | 800525at2759 |
PhylomeDBi | P25105 |
TreeFami | TF350009 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002282, PAF_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01153, PAFRECEPTOR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P25105-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPHDSSHMD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPCKKFN
60 70 80 90 100
EIKIFMVNLT MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN
110 120 130 140 150
TYCSVAFLGV ITYNRFQAVT RPIKTAQANT RKRGISLSLV IWVAIVGAAS
160 170 180 190 200
YFLILDSTNT VPDSAGSGNV TRCFEHYEKG SVPVLIIHIF IVFSFFLVFL
210 220 230 240 250
IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV FIICFVPHHV
260 270 280 290 300
VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF
310 320 330 340
RKHLTEKFYS MRSSRKCSRA TTDTVTEVVV PFNQIPGNSL KN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 28 | L → P in AAA60108 (Ref. 6) Curated | 1 | |
Sequence conflicti | 66 | F → L in AAA60108 (Ref. 6) Curated | 1 | |
Sequence conflicti | 95 | C → R in AAA60108 (Ref. 6) Curated | 1 | |
Sequence conflicti | 227 – 228 | KR → TG in AAA60214 (PubMed:1322356).Curated | 2 | |
Sequence conflicti | 227 – 228 | KR → TT in AAA60108 (Ref. 6) Curated | 2 | |
Sequence conflicti | 247 | P → A in AAA60108 (Ref. 6) Curated | 1 | |
Sequence conflicti | 316 | K → N in AAB24695 (PubMed:1281995).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011851 | 224 | A → D1 PublicationCorresponds to variant dbSNP:rs5938Ensembl. | 1 | |
Natural variantiVAR_011852 | 338 | N → S1 PublicationCorresponds to variant dbSNP:rs5939Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80436 mRNA Translation: AAA60001.1 D10202 mRNA Translation: BAA01050.1 M76674 mRNA Translation: AAA60002.1 M88177 Genomic DNA Translation: AAA60214.1 S52624 mRNA Translation: AAB24695.2 L07334 mRNA Translation: AAA60108.1 S56396 Genomic DNA Translation: AAB25755.1 AY275466 mRNA Translation: AAP32298.1 BT009801 mRNA Translation: AAP88803.1 AK290240 mRNA Translation: BAF82929.1 CH471059 Genomic DNA Translation: EAX07711.1 BC013816 mRNA Translation: AAH13816.1 BC063000 mRNA Translation: AAH63000.1 |
CCDSi | CCDS318.1 |
PIRi | A40191 |
RefSeqi | NP_000943.1, NM_000952.4 NP_001158193.1, NM_001164721.1 NP_001158194.1, NM_001164722.2 NP_001158195.1, NM_001164723.2 |
Genome annotation databases
Ensembli | ENST00000305392.3; ENSP00000301974.3; ENSG00000169403.12 ENST00000373857.8; ENSP00000362965.3; ENSG00000169403.12 ENST00000539896.1; ENSP00000442658.1; ENSG00000169403.12 |
GeneIDi | 5724 |
KEGGi | hsa:5724 |
MANE-Selecti | ENST00000373857.8; ENSP00000362965.3; NM_000952.5; NP_000943.1 |
UCSCi | uc001bpl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80436 mRNA Translation: AAA60001.1 D10202 mRNA Translation: BAA01050.1 M76674 mRNA Translation: AAA60002.1 M88177 Genomic DNA Translation: AAA60214.1 S52624 mRNA Translation: AAB24695.2 L07334 mRNA Translation: AAA60108.1 S56396 Genomic DNA Translation: AAB25755.1 AY275466 mRNA Translation: AAP32298.1 BT009801 mRNA Translation: AAP88803.1 AK290240 mRNA Translation: BAF82929.1 CH471059 Genomic DNA Translation: EAX07711.1 BC013816 mRNA Translation: AAH13816.1 BC063000 mRNA Translation: AAH63000.1 |
CCDSi | CCDS318.1 |
PIRi | A40191 |
RefSeqi | NP_000943.1, NM_000952.4 NP_001158193.1, NM_001164721.1 NP_001158194.1, NM_001164722.2 NP_001158195.1, NM_001164723.2 |
3D structure databases
AlphaFoldDBi | P25105 |
SMRi | P25105 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111696, 50 interactors |
CORUMi | P25105 |
IntActi | P25105, 16 interactors |
MINTi | P25105 |
STRINGi | 9606.ENSP00000362965 |
Chemistry databases
BindingDBi | P25105 |
ChEMBLi | CHEMBL250 |
DrugBanki | DB09166, Etizolam DB02261, Platelet Activating Factor DB11614, Rupatadine |
DrugCentrali | P25105 |
GuidetoPHARMACOLOGYi | 334 |
SwissLipidsi | SLP:000001565 |
Protein family/group databases
TCDBi | 9.A.14.13.3, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P25105, 1 site |
iPTMneti | P25105 |
PhosphoSitePlusi | P25105 |
Genetic variation databases
BioMutai | PTAFR |
DMDMi | 129557 |
Proteomic databases
EPDi | P25105 |
jPOSTi | P25105 |
MassIVEi | P25105 |
PaxDbi | P25105 |
PeptideAtlasi | P25105 |
PRIDEi | P25105 |
ProteomicsDBi | 54261 |
Protocols and materials databases
ABCDi | P25105, 1 sequenced antibody |
Antibodypediai | 30903, 191 antibodies from 26 providers |
DNASUi | 5724 |
Genome annotation databases
Ensembli | ENST00000305392.3; ENSP00000301974.3; ENSG00000169403.12 ENST00000373857.8; ENSP00000362965.3; ENSG00000169403.12 ENST00000539896.1; ENSP00000442658.1; ENSG00000169403.12 |
GeneIDi | 5724 |
KEGGi | hsa:5724 |
MANE-Selecti | ENST00000373857.8; ENSP00000362965.3; NM_000952.5; NP_000943.1 |
UCSCi | uc001bpl.4, human |
Organism-specific databases
CTDi | 5724 |
DisGeNETi | 5724 |
GeneCardsi | PTAFR |
HGNCi | HGNC:9582, PTAFR |
HPAi | ENSG00000169403, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 173393, gene |
neXtProti | NX_P25105 |
OpenTargetsi | ENSG00000169403 |
PharmGKBi | PA33933 |
VEuPathDBi | HostDB:ENSG00000169403 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTQI, Eukaryota |
GeneTreei | ENSGT00980000198579 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | P25105 |
OMAi | AIHVIIC |
OrthoDBi | 800525at2759 |
PhylomeDBi | P25105 |
TreeFami | TF350009 |
Enzyme and pathway databases
PathwayCommonsi | P25105 |
Reactomei | R-HSA-373076, Class A/1 (Rhodopsin-like receptors) R-HSA-416476, G alpha (q) signalling events R-HSA-6783783, Interleukin-10 signaling R-HSA-6798695, Neutrophil degranulation R-HSA-877300, Interferon gamma signaling |
SignaLinki | P25105 |
SIGNORi | P25105 |
Miscellaneous databases
BioGRID-ORCSi | 5724, 7 hits in 1078 CRISPR screens |
ChiTaRSi | PTAFR, human |
GeneWikii | Platelet-activating_factor_receptor |
GenomeRNAii | 5724 |
Pharosi | P25105, Tchem |
PROi | PR:P25105 |
RNActi | P25105, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169403, Expressed in blood and 230 other tissues |
Genevisiblei | P25105, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002282, PAF_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01153, PAFRECEPTOR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PTAFR_HUMAN | |
Accessioni | P25105Primary (citable) accession number: P25105 Secondary accession number(s): A3KMC8, A8K2H5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families