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UniProtKB - P25105 (PTAFR_HUMAN)

Entry version 191 (12 Aug 2020)
Sequence version 1 (01 May 1992)
Previous versions | rss
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Protein

Platelet-activating factor receptor

Gene

PTAFR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P25105

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-373076, Class A/1 (Rhodopsin-like receptors)
R-HSA-416476, G alpha (q) signalling events
R-HSA-6783783, Interleukin-10 signaling
R-HSA-6798695, Neutrophil degranulation
R-HSA-877300, Interferon gamma signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P25105

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.13.3, the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001565

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet-activating factor receptor
Short name:
PAF-R
Short name:
PAFr
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTAFR
Synonyms:PAFR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000169403.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:9582, PTAFR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		173393, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P25105

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 38Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini39 – 54CytoplasmicSequence analysisAdd BLAST16
Transmembranei55 – 74Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini75 – 91ExtracellularSequence analysisAdd BLAST17
Transmembranei92 – 113Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini114 – 133CytoplasmicSequence analysisAdd BLAST20
Transmembranei134 – 155Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini156 – 184ExtracellularSequence analysisAdd BLAST29
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 233CytoplasmicSequence analysisAdd BLAST28
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 276ExtracellularSequence analysisAdd BLAST22
Transmembranei277 – 296Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini297 – 342CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5724

Open Targets

More...OpenTargetsi		ENSG00000169403

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33933

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P25105, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL250

Drug and drug target database

More...DrugBanki		DB09166, Etizolam
DB02261, Platelet Activating Factor
DB11614, Rupatadine

DrugCentral

More...DrugCentrali		P25105

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		334

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PTAFR

Domain mapping of disease mutations (DMDM)

More...DMDMi		129557

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000700921 – 342Platelet-activating factor receptorAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi90 ↔ 173PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P25105

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P25105

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P25105

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P25105

PeptideAtlas

More...PeptideAtlasi		P25105

PRoteomics IDEntifications database

More...PRIDEi		P25105

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54261

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P25105, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P25105

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P25105

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By CSF2/GM-CSF, IL5/interleukin-5 and n-butyrate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169403, Expressed in blood and 229 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P25105, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000169403, Tissue enriched (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARRB1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111696, 11 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P25105

Protein interaction database and analysis system

More...IntActi		P25105, 15 interactors

Molecular INTeraction database

More...MINTi		P25105

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362965

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P25105

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P25105, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P25105

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTQI, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00980000198579

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_8_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P25105

KEGG Orthology (KO)

More...KOi		K04279

Identification of Orthologs from Complete Genome Data

More...OMAi		KCSRQTT

Database of Orthologous Groups

More...OrthoDBi		800525at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P25105

TreeFam database of animal gene trees

More...TreeFami		TF350009

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR002282, PAF_rcpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR01153, PAFRECEPTOR

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P25105-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPHDSSHMD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPCKKFN 
        60         70         80         90        100
EIKIFMVNLT MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN 
       110        120        130        140        150
TYCSVAFLGV ITYNRFQAVT RPIKTAQANT RKRGISLSLV IWVAIVGAAS 
       160        170        180        190        200
YFLILDSTNT VPDSAGSGNV TRCFEHYEKG SVPVLIIHIF IVFSFFLVFL 
       210        220        230        240        250
IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV FIICFVPHHV 
       260        270        280        290        300
VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF 
       310        320        330        340 
RKHLTEKFYS MRSSRKCSRA TTDTVTEVVV PFNQIPGNSL KN
Length:342
Mass (Da):39,203
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i890073C9EBA79228
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28L → P in AAA60108 (Ref. 6) Curated1
Sequence conflicti66F → L in AAA60108 (Ref. 6) Curated1
Sequence conflicti95C → R in AAA60108 (Ref. 6) Curated1
Sequence conflicti227 – 228KR → TG in AAA60214 (PubMed:1322356).Curated2
Sequence conflicti227 – 228KR → TT in AAA60108 (Ref. 6) Curated2
Sequence conflicti247P → A in AAA60108 (Ref. 6) Curated1
Sequence conflicti316K → N in AAB24695 (PubMed:1281995).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011851224A → D1 PublicationCorresponds to variant dbSNP:rs5938Ensembl.1
Natural variantiVAR_011852338N → S1 PublicationCorresponds to variant dbSNP:rs5939Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M80436 mRNA Translation: AAA60001.1
D10202 mRNA Translation: BAA01050.1
M76674 mRNA Translation: AAA60002.1
M88177 Genomic DNA Translation: AAA60214.1
S52624 mRNA Translation: AAB24695.2
L07334 mRNA Translation: AAA60108.1
S56396 Genomic DNA Translation: AAB25755.1
AY275466 mRNA Translation: AAP32298.1
BT009801 mRNA Translation: AAP88803.1
AK290240 mRNA Translation: BAF82929.1
CH471059 Genomic DNA Translation: EAX07711.1
BC013816 mRNA Translation: AAH13816.1
BC063000 mRNA Translation: AAH63000.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS318.1

Protein sequence database of the Protein Information Resource

More...PIRi		A40191

NCBI Reference Sequences

More...RefSeqi		NP_000943.1, NM_000952.4
NP_001158193.1, NM_001164721.1
NP_001158194.1, NM_001164722.2
NP_001158195.1, NM_001164723.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000305392; ENSP00000301974; ENSG00000169403
ENST00000373857; ENSP00000362965; ENSG00000169403
ENST00000539896; ENSP00000442658; ENSG00000169403

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5724

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5724

UCSC genome browser

More...UCSCi		uc001bpl.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80436 mRNA Translation: AAA60001.1
D10202 mRNA Translation: BAA01050.1
M76674 mRNA Translation: AAA60002.1
M88177 Genomic DNA Translation: AAA60214.1
S52624 mRNA Translation: AAB24695.2
L07334 mRNA Translation: AAA60108.1
S56396 Genomic DNA Translation: AAB25755.1
AY275466 mRNA Translation: AAP32298.1
BT009801 mRNA Translation: AAP88803.1
AK290240 mRNA Translation: BAF82929.1
CH471059 Genomic DNA Translation: EAX07711.1
BC013816 mRNA Translation: AAH13816.1
BC063000 mRNA Translation: AAH63000.1
CCDSiCCDS318.1
PIRiA40191
RefSeqiNP_000943.1, NM_000952.4
NP_001158193.1, NM_001164721.1
NP_001158194.1, NM_001164722.2
NP_001158195.1, NM_001164723.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B0Xmodel-A1-342[»]
SMRiP25105
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111696, 11 interactors
CORUMiP25105
IntActiP25105, 15 interactors
MINTiP25105
STRINGi9606.ENSP00000362965

Chemistry databases

BindingDBiP25105
ChEMBLiCHEMBL250
DrugBankiDB09166, Etizolam
DB02261, Platelet Activating Factor
DB11614, Rupatadine
DrugCentraliP25105
GuidetoPHARMACOLOGYi334
SwissLipidsiSLP:000001565

Protein family/group databases

TCDBi9.A.14.13.3, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP25105, 1 site
iPTMnetiP25105
PhosphoSitePlusiP25105

Polymorphism and mutation databases

BioMutaiPTAFR
DMDMi129557

Proteomic databases

EPDiP25105
jPOSTiP25105
MassIVEiP25105
PaxDbiP25105
PeptideAtlasiP25105
PRIDEiP25105
ProteomicsDBi54261

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P25105, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30903, 179 antibodies

The DNASU plasmid repository

More...DNASUi		5724

Genome annotation databases

EnsembliENST00000305392; ENSP00000301974; ENSG00000169403
ENST00000373857; ENSP00000362965; ENSG00000169403
ENST00000539896; ENSP00000442658; ENSG00000169403
GeneIDi5724
KEGGihsa:5724
UCSCiuc001bpl.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5724
DisGeNETi5724
EuPathDBiHostDB:ENSG00000169403.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		PTAFR
HGNCiHGNC:9582, PTAFR
HPAiENSG00000169403, Tissue enriched (blood)
MIMi173393, gene
neXtProtiNX_P25105
OpenTargetsiENSG00000169403
PharmGKBiPA33933

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTQI, Eukaryota
GeneTreeiENSGT00980000198579
HOGENOMiCLU_009579_8_2_1
InParanoidiP25105
KOiK04279
OMAiKCSRQTT
OrthoDBi800525at2759
PhylomeDBiP25105
TreeFamiTF350009

Enzyme and pathway databases

PathwayCommonsiP25105
ReactomeiR-HSA-373076, Class A/1 (Rhodopsin-like receptors)
R-HSA-416476, G alpha (q) signalling events
R-HSA-6783783, Interleukin-10 signaling
R-HSA-6798695, Neutrophil degranulation
R-HSA-877300, Interferon gamma signaling
SIGNORiP25105

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5724, 5 hits in 884 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PTAFR, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Platelet-activating_factor_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5724
PharosiP25105, Tchem

Protein Ontology

More...PROi		PR:P25105
RNActiP25105, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000169403, Expressed in blood and 229 other tissues
GenevisibleiP25105, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR002282, PAF_rcpt
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR01153, PAFRECEPTOR
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTAFR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25105
Secondary accession number(s): A3KMC8, A8K2H5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: August 12, 2020
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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