Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 183 (13 Feb 2019)
Sequence version 1 (01 May 1992)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Platelet-activating factor receptor

Gene

PTAFR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-416476 G alpha (q) signalling events
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P25105

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.13.3 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001565

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet-activating factor receptor
Short name:
PAF-R
Short name:
PAFr
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTAFR
Synonyms:PAFR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169403.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9582 PTAFR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
173393 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P25105

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 38Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini39 – 54CytoplasmicSequence analysisAdd BLAST16
Transmembranei55 – 74Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini75 – 91ExtracellularSequence analysisAdd BLAST17
Transmembranei92 – 113Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini114 – 133CytoplasmicSequence analysisAdd BLAST20
Transmembranei134 – 155Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini156 – 184ExtracellularSequence analysisAdd BLAST29
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 233CytoplasmicSequence analysisAdd BLAST28
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 276ExtracellularSequence analysisAdd BLAST22
Transmembranei277 – 296Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini297 – 342CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5724

Open Targets

More...
OpenTargetsi
ENSG00000169403

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33933

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL250

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
334

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTAFR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
129557

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000700921 – 342Platelet-activating factor receptorAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi90 ↔ 173PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P25105

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P25105

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P25105

PeptideAtlas

More...
PeptideAtlasi
P25105

PRoteomics IDEntifications database

More...
PRIDEi
P25105

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54261

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P25105

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P25105

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By CSF2/GM-CSF, IL5/interleukin-5 and n-butyrate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169403 Expressed in 219 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P25105 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027543

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARRB1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111696, 10 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P25105

Protein interaction database and analysis system

More...
IntActi
P25105, 15 interactors

Molecular INTeraction database

More...
MINTi
P25105

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301974

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P25105

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B0Xmodel-A1-342[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P25105

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P25105

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIY4 Eukaryota
ENOG410YB0R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154180

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013041

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG101106

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P25105

KEGG Orthology (KO)

More...
KOi
K04279

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKFLCNL

Database of Orthologous Groups

More...
OrthoDBi
953529at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P25105

TreeFam database of animal gene trees

More...
TreeFami
TF350009

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002282 PAF_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN
PR01153 PAFRECEPTOR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P25105-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPHDSSHMD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPCKKFN
60 70 80 90 100
EIKIFMVNLT MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN
110 120 130 140 150
TYCSVAFLGV ITYNRFQAVT RPIKTAQANT RKRGISLSLV IWVAIVGAAS
160 170 180 190 200
YFLILDSTNT VPDSAGSGNV TRCFEHYEKG SVPVLIIHIF IVFSFFLVFL
210 220 230 240 250
IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV FIICFVPHHV
260 270 280 290 300
VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF
310 320 330 340
RKHLTEKFYS MRSSRKCSRA TTDTVTEVVV PFNQIPGNSL KN
Length:342
Mass (Da):39,203
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i890073C9EBA79228
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28L → P in AAA60108 (Ref. 6) Curated1
Sequence conflicti66F → L in AAA60108 (Ref. 6) Curated1
Sequence conflicti95C → R in AAA60108 (Ref. 6) Curated1
Sequence conflicti227 – 228KR → TG in AAA60214 (PubMed:1322356).Curated2
Sequence conflicti227 – 228KR → TT in AAA60108 (Ref. 6) Curated2
Sequence conflicti247P → A in AAA60108 (Ref. 6) Curated1
Sequence conflicti316K → N in AAB24695 (PubMed:1281995).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011851224A → D1 PublicationCorresponds to variant dbSNP:rs5938Ensembl.1
Natural variantiVAR_011852338N → S1 PublicationCorresponds to variant dbSNP:rs5939Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M80436 mRNA Translation: AAA60001.1
D10202 mRNA Translation: BAA01050.1
M76674 mRNA Translation: AAA60002.1
M88177 Genomic DNA Translation: AAA60214.1
S52624 mRNA Translation: AAB24695.2
L07334 mRNA Translation: AAA60108.1
S56396 Genomic DNA Translation: AAB25755.1
AY275466 mRNA Translation: AAP32298.1
BT009801 mRNA Translation: AAP88803.1
AK290240 mRNA Translation: BAF82929.1
CH471059 Genomic DNA Translation: EAX07711.1
BC013816 mRNA Translation: AAH13816.1
BC063000 mRNA Translation: AAH63000.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS318.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A40191

NCBI Reference Sequences

More...
RefSeqi
NP_000943.1, NM_000952.4
NP_001158193.1, NM_001164721.1
NP_001158194.1, NM_001164722.2
NP_001158195.1, NM_001164723.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.77542

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305392; ENSP00000301974; ENSG00000169403
ENST00000373857; ENSP00000362965; ENSG00000169403
ENST00000539896; ENSP00000442658; ENSG00000169403

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5724

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5724

UCSC genome browser

More...
UCSCi
uc001bpl.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80436 mRNA Translation: AAA60001.1
D10202 mRNA Translation: BAA01050.1
M76674 mRNA Translation: AAA60002.1
M88177 Genomic DNA Translation: AAA60214.1
S52624 mRNA Translation: AAB24695.2
L07334 mRNA Translation: AAA60108.1
S56396 Genomic DNA Translation: AAB25755.1
AY275466 mRNA Translation: AAP32298.1
BT009801 mRNA Translation: AAP88803.1
AK290240 mRNA Translation: BAF82929.1
CH471059 Genomic DNA Translation: EAX07711.1
BC013816 mRNA Translation: AAH13816.1
BC063000 mRNA Translation: AAH63000.1
CCDSiCCDS318.1
PIRiA40191
RefSeqiNP_000943.1, NM_000952.4
NP_001158193.1, NM_001164721.1
NP_001158194.1, NM_001164722.2
NP_001158195.1, NM_001164723.2
UniGeneiHs.77542

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B0Xmodel-A1-342[»]
ProteinModelPortaliP25105
SMRiP25105
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111696, 10 interactors
CORUMiP25105
IntActiP25105, 15 interactors
MINTiP25105
STRINGi9606.ENSP00000301974

Chemistry databases

BindingDBiP25105
ChEMBLiCHEMBL250
GuidetoPHARMACOLOGYi334
SwissLipidsiSLP:000001565

Protein family/group databases

TCDBi9.A.14.13.3 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP25105
PhosphoSitePlusiP25105

Polymorphism and mutation databases

BioMutaiPTAFR
DMDMi129557

Proteomic databases

EPDiP25105
jPOSTiP25105
PaxDbiP25105
PeptideAtlasiP25105
PRIDEiP25105
ProteomicsDBi54261

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5724
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305392; ENSP00000301974; ENSG00000169403
ENST00000373857; ENSP00000362965; ENSG00000169403
ENST00000539896; ENSP00000442658; ENSG00000169403
GeneIDi5724
KEGGihsa:5724
UCSCiuc001bpl.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5724
DisGeNETi5724
EuPathDBiHostDB:ENSG00000169403.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTAFR
HGNCiHGNC:9582 PTAFR
HPAiHPA027543
MIMi173393 gene
neXtProtiNX_P25105
OpenTargetsiENSG00000169403
PharmGKBiPA33933

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIY4 Eukaryota
ENOG410YB0R LUCA
GeneTreeiENSGT00940000154180
HOGENOMiHOG000013041
HOVERGENiHBG101106
InParanoidiP25105
KOiK04279
OMAiPKFLCNL
OrthoDBi953529at2759
PhylomeDBiP25105
TreeFamiTF350009

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-416476 G alpha (q) signalling events
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
SIGNORiP25105

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PTAFR human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Platelet-activating_factor_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5724

Protein Ontology

More...
PROi
PR:P25105

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169403 Expressed in 219 organ(s), highest expression level in blood
GenevisibleiP25105 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002282 PAF_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01153 PAFRECEPTOR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTAFR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25105
Secondary accession number(s): A3KMC8, A8K2H5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: February 13, 2019
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again