Platelet-activating factor receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• G protein-coupled purinergic nucleotide receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.4

    "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1."
    Seyfried C.E., Schweickart V.L., Godiska R., Gray P.W.
    Genomics 13:832-834(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• lipopolysaccharide binding Source: Ensembl
• lipopolysaccharide immune receptor activity Source: Ensembl
• mitogen-activated protein kinase binding Source: Ensembl
• phospholipid binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor."
    Ye R.D., Prossnitz E.R., Zou A., Cochrane C.G.
    Biochem. Biophys. Res. Commun. 180:105-111(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  • Ref.2

    "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes."
    Nakamura M., Honda Z., Izumi T., Sakanaka C., Mutoh H., Minami M., Bito H., Seyama Y., Matsumoto T., Noma M., Shimizu T.
    J. Biol. Chem. 266:20400-20405(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
• platelet activating factor receptor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.5

    "Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart."
    Sugimoto T., Tsuchimochi H., McGregor C.G.A., Mutoh H., Shimizu T., Kurachi Y.
    Biochem. Biophys. Res. Commun. 189:617-624(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  • Ref.1

    "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor."
    Ye R.D., Prossnitz E.R., Zou A., Cochrane C.G.
    Biochem. Biophys. Res. Commun. 180:105-111(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  • Ref.2

    "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes."
    Nakamura M., Honda Z., Izumi T., Sakanaka C., Mutoh H., Minami M., Bito H., Seyama Y., Matsumoto T., Noma M., Shimizu T.
    J. Biol. Chem. 266:20400-20405(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.

GO - Biological processⁱ

• cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Source: Ensembl
• cellular response to cAMP Source: Ensembl
• cellular response to fatty acid Source: Ensembl
• cellular response to gravity Source: Ensembl
• chemotaxis Source: ProtIncTraceable author statementⁱ
  • "Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage."
    Haribabu B., Zhelev D.V., Pridgen B.C., Richardson R.M., Ali H., Snyderman R.
    J Biol Chem 274:37087-37092(1999) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.2

    "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes."
    Nakamura M., Honda Z., Izumi T., Sakanaka C., Mutoh H., Minami M., Bito H., Seyama Y., Matsumoto T., Noma M., Shimizu T.
    J. Biol. Chem. 266:20400-20405(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
• immune response Source: ProtIncTraceable author statementⁱ
  • "Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils."
    Kishimoto S., Shimadzu W., Izumi T., Shimizu T., Fukuda T., Makino S., Sugiura T., Waku K.
    J Immunol 157:4126-4132(1996) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: ProtIncTraceable author statementⁱ
  • "Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35-->p34.3 by fluorescence in situ hybridization."
    Chase P.B., Yang J.M., Thompson F.H., Halonen M., Regan J.W.
    Cytogenet Cell Genet 72:205-207(1996) [PubMed] [Europe PMC] [Abstract]
• inositol trisphosphate biosynthetic process Source: Ensembl
• negative regulation of blood pressure Source: Ensembl
• parturition Source: Ensembl
• phosphatidylinositol-mediated signaling Source: UniProtKBInferred from direct assayⁱ
  • Ref.2

    "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes."
    Nakamura M., Honda Z., Izumi T., Sakanaka C., Mutoh H., Minami M., Bito H., Seyama Y., Matsumoto T., Noma M., Shimizu T.
    J. Biol. Chem. 266:20400-20405(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
• positive regulation of cellular extravasation Source: Ensembl
• positive regulation of gastro-intestinal system smooth muscle contraction Source: Ensembl
• positive regulation of inositol phosphate biosynthetic process Source: Ensembl
• positive regulation of interleukin-6 production Source: Ensembl
• positive regulation of leukocyte tethering or rolling Source: Ensembl
• positive regulation of maternal process involved in parturition Source: Ensembl
• positive regulation of neutrophil degranulation Source: Ensembl
• positive regulation of phospholipase C activity Source: Ensembl
• positive regulation of sensory perception of pain Source: Ensembl
• positive regulation of smooth muscle cell proliferation Source: Ensembl
• positive regulation of transcytosis Source: Ensembl
• positive regulation of translation Source: Ensembl
• positive regulation of tumor necrosis factor production Source: Ensembl
• positive regulation of voltage-gated chloride channel activity Source: Ensembl
• regulation of transcription by RNA polymerase II Source: Ensembl
• response to dexamethasone Source: Ensembl
• response to symbiotic bacterium Source: Ensembl
• transcytosis Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• mitogen-activated protein kinase binding Source: Ensembl

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEPHDSSHMD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPCKKFN 
        60         70         80         90        100
EIKIFMVNLT MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN 
       110        120        130        140        150
TYCSVAFLGV ITYNRFQAVT RPIKTAQANT RKRGISLSLV IWVAIVGAAS 
       160        170        180        190        200
YFLILDSTNT VPDSAGSGNV TRCFEHYEKG SVPVLIIHIF IVFSFFLVFL 
       210        220        230        240        250
IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV FIICFVPHHV 
       260        270        280        290        300
VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF 
       310        320        330        340 
RKHLTEKFYS MRSSRKCSRA TTDTVTEVVV PFNQIPGNSL KN         

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
3. Human entries with genetic variants
   List of human entries with genetic variants
4. Human variants curated from literature reports
   Index of human variants curated from literature reports
5. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
6. SIMILARITY comments
   Index of protein domains and families