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UniProtKB - P25104 (AGTR1_BOVIN)
Protein
Type-1 angiotensin II receptor
Gene
AGTR1
Organism
Bos taurus (Bovine)
Status
Functioni
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- angiotensin type II receptor activity Source: Ensembl
- angiotensin type I receptor activity Source: GO_Central
- bradykinin receptor binding Source: Ensembl
- G protein-coupled receptor activity Source: GO_Central
- protein heterodimerization activity Source: Ensembl
GO - Biological processi
- calcium-mediated signaling Source: Ensembl
- cell chemotaxis Source: Ensembl
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- kidney development Source: Ensembl
- positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: Ensembl
- positive regulation of cellular protein metabolic process Source: Ensembl
- positive regulation of cholesterol esterification Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: Ensembl
- positive regulation of phospholipase A2 activity Source: Ensembl
- regulation of vasoconstriction Source: Ensembl
- Rho protein signal transduction Source: Ensembl
- viral entry into host cell Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-BTA-375276, Peptide ligand-binding receptors R-BTA-8856825, Cargo recognition for clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Type-1 angiotensin II receptorAlternative name(s): Angiotensin II type-1 receptor Short name: AT1 |
Gene namesi | Name:AGTR1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000045633 |
VGNCi | VGNC:25745, AGTR1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 52 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 53 – 64 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 65 – 87 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Topological domaini | 88 – 102 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 103 – 124 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 125 – 142 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 143 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 163 – 192 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 193 – 214 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 215 – 240 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 241 – 262 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 263 – 275 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 276 – 296 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 359 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069150 | 1 – 359 | Type-1 angiotensin II receptorAdd BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 101 ↔ 180 | PROSITE-ProRule annotation | ||
Glycosylationi | 176 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 355 | S-palmitoyl cysteineSequence analysis | 1 |
Post-translational modificationi
C-terminal Ser or Thr residues may be phosphorylated.
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | P25104 |
Expressioni
Tissue specificityi
Adrenal medulla, cortex and kidney.
Gene expression databases
Bgeei | ENSBTAG00000045633, Expressed in adrenal gland and 85 other tissues |
Interactioni
Subunit structurei
Interacts with MAS1 (By similarity).
Interacts with ARRB1 (By similarity).
Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).
By similarityGO - Molecular functioni
- bradykinin receptor binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000055053 |
Chemistry databases
BindingDBi | P25104 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 336 – 359 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 336 – 351 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234534 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P25104 |
OMAi | QVFHFMQ |
OrthoDBi | 810397at2759 |
TreeFami | TF330024 |
Family and domain databases
InterProi | View protein in InterPro IPR000190, ATII_AT1_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00635, ANGIOTENSN1R PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P25104-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MILNSSTEDG IKRIQDDCPK AGRHNYIFIM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLLAGLAS LPTIIHRNVF FIENTNITVC AFHYESQNST LPVGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK TLKKAYEIQK NKPRKDDIFK IILAIVLFFF
260 270 280 290 300
FSWVPHQIFT FMDVLIQLGL IRDCKIEDIV DTAMPITICL AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK KYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSENGNSSTK
KPAPCIEVE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62294 mRNA Translation: CAA44182.1 |
RefSeqi | NP_776658.1, NM_174233.2 |
Genome annotation databases
Ensembli | ENSBTAT00000063575; ENSBTAP00000055053; ENSBTAG00000045633 |
GeneIDi | 281607 |
KEGGi | bta:281607 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62294 mRNA Translation: CAA44182.1 |
RefSeqi | NP_776658.1, NM_174233.2 |
3D structure databases
AlphaFoldDBi | P25104 |
SMRi | P25104 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000055053 |
Chemistry databases
BindingDBi | P25104 |
ChEMBLi | CHEMBL3374 |
DrugCentrali | P25104 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PaxDbi | P25104 |
Genome annotation databases
Ensembli | ENSBTAT00000063575; ENSBTAP00000055053; ENSBTAG00000045633 |
GeneIDi | 281607 |
KEGGi | bta:281607 |
Organism-specific databases
CTDi | 185 |
VEuPathDBi | HostDB:ENSBTAG00000045633 |
VGNCi | VGNC:25745, AGTR1 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234534 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P25104 |
OMAi | QVFHFMQ |
OrthoDBi | 810397at2759 |
TreeFami | TF330024 |
Enzyme and pathway databases
Reactomei | R-BTA-375276, Peptide ligand-binding receptors R-BTA-8856825, Cargo recognition for clathrin-mediated endocytosis |
Miscellaneous databases
PROi | PR:P25104 |
Gene expression databases
Bgeei | ENSBTAG00000045633, Expressed in adrenal gland and 85 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000190, ATII_AT1_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00635, ANGIOTENSN1R PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AGTR1_BOVIN | |
Accessioni | P25104Primary (citable) accession number: P25104 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families