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Protein

Endothelin-1 receptor

Gene

EDNRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • endothelin receptor activity Source: UniProtKB
  • phosphatidylinositol phospholipase C activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

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SIGNORi
P25101

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endothelin-1 receptorCurated
Alternative name(s):
Endothelin receptor type AImported
Short name:
ET-A
Short name:
ETA-R
Short name:
hET-AR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EDNRAImported
Synonyms:ETA, ETRA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000151617.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3179 EDNRA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
131243 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P25101

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 80ExtracellularSequence analysisAdd BLAST60
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei81 – 102Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini103 – 112CytoplasmicSequence analysis10
Transmembranei113 – 132Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini133 – 159ExtracellularSequence analysisAdd BLAST27
Transmembranei160 – 181Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini182 – 205CytoplasmicSequence analysisAdd BLAST24
Transmembranei206 – 229Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini230 – 256ExtracellularSequence analysisAdd BLAST27
Transmembranei257 – 278Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini279 – 306CytoplasmicSequence analysisAdd BLAST28
Transmembranei307 – 328Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini329 – 347ExtracellularSequence analysisAdd BLAST19
Transmembranei348 – 372Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini373 – 427CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mandibulofacial dysostosis with alopecia (MFDA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mandibulofacial dysostosis, a disorder characterized by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids. MFDA features include maxillary dysmorphism with dysplastic zygomatic arch, hypoplastic mandible, scalp alopecia, scant eyebrows and eyelashes, severe hypoplasia or aplasia of eyelids, small cupped dysplastic ears, conductive hearing loss, cleft palate, dental anomalies, micrognathia, and limited jaw mobility.
See also OMIM:616367
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073788129Y → F in MFDA. 1 PublicationCorresponds to variant dbSNP:rs786205230EnsemblClinVar.1
Natural variantiVAR_073789303E → K in MFDA. 1 PublicationCorresponds to variant dbSNP:rs876657388EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1909

MalaCards human disease database

More...
MalaCardsi
EDNRA
MIMi616367 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000151617

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
443995 Mandibulofacial dysostosis with alopecia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27617

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL252

Drug and drug target database

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DrugBanki
DB00945 Acetylsalicylic acid
DB05367 Actelion-1
DB06403 Ambrisentan
DB00559 Bosentan
DB04883 Darusentan
DB08932 Macitentan
DB05206 PS433540
DB06268 Sitaxentan
DB05290 SPP 301

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
219

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EDNRA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
119606

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001272121 – 427Endothelin-1 receptorAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi158 ↔ 239PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei425PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P25101

PeptideAtlas

More...
PeptideAtlasi
P25101

PRoteomics IDEntifications database

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PRIDEi
P25101

ProteomicsDB human proteome resource

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ProteomicsDBi
54256
54257 [P25101-2]
54258 [P25101-3]
54259 [P25101-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P25101

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P25101

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P25101

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000151617 Expressed in 204 organ(s), highest expression level in uterine cervix

CleanEx database of gene expression profiles

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CleanExi
HS_EDNRA

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P25101 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB018957
HPA013774

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HDAC7 and KAT5.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108231, 21 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P25101

Database of interacting proteins

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DIPi
DIP-48718N

Protein interaction database and analysis system

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IntActi
P25101, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000315011

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P25101

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P25101

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157109

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000169267

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051443

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P25101

KEGG Orthology (KO)

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KOi
K04197

Identification of Orthologs from Complete Genome Data

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OMAi
YDEMDKN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0CJV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P25101

TreeFam database of animal gene trees

More...
TreeFami
TF331292

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000499 Endthln_rcpt
IPR002175 ETA_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00570 ENDOTHELINAR
PR00366 ENDOTHELINR
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P25101-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METLCLRASF WLALVGCVIS DNPERYSTNL SNHVDDFTTF RGTELSFLVT
60 70 80 90 100
THQPTNLVLP SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT
110 120 130 140 150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH
160 170 180 190 200
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL
210 220 230 240 250
VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YRGEQHKTCM LNATSKFMEF
260 270 280 290 300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
310 320 330 340 350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYNEMDKNR CELLSFLLLM
360 370 380 390 400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM
410 420
NGTSIQWKNH DQNNHNTDRS SHKDSMN
Length:427
Mass (Da):48,722
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i207272D4A231404F
GO
Isoform 2 (identifier: P25101-2) [UniParc]FASTAAdd to basket
Also known as: Delta-3

The sequence of this isoform differs from the canonical sequence as follows:
     141-161: LLAGRWPFDHNDFGVFLCKLF → VQSSCLLESCSGNWDSFGNCH
     162-427: Missing.

Show »
Length:161
Mass (Da):17,820
Checksum:iB6227E27C1B05915
GO
Isoform 3 (identifier: P25101-3) [UniParc]FASTAAdd to basket
Also known as: Delta-4

The sequence of this isoform differs from the canonical sequence as follows:
     183-187: RYRAV → SSTKM
     188-427: Missing.

Show »
Length:187
Mass (Da):20,763
Checksum:i60E5564BDE6D7A96
GO
Isoform 4 (identifier: P25101-4) [UniParc]FASTAAdd to basket
Also known as: Delta-3,4

The sequence of this isoform differs from the canonical sequence as follows:
     141-249: Missing.

Show »
Length:318
Mass (Da):36,489
Checksum:i0423FAA16DB6A9BF
GO
Isoform 5 (identifier: P25101-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):23,803
Checksum:i01C9764279D905CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti110C → Y in AAB23644 (PubMed:1415318).Curated1
Sequence conflicti115P → H in AAH22511 (PubMed:15489334).Curated1
Sequence conflicti207V → A in AAA58447 (PubMed:8440682).Curated1
Sequence conflicti232R → K in BAH14302 (PubMed:14702039).Curated1
Sequence conflicti234E → G in AAA58447 (PubMed:8440682).Curated1
Sequence conflicti280C → G in AAA58447 (PubMed:8440682).Curated1
Sequence conflicti300Q → H in BAG65268 (PubMed:14702039).Curated1
Sequence conflicti322L → V in AAH22511 (PubMed:15489334).Curated1
Sequence conflicti345S → G in BAG65268 (PubMed:14702039).Curated1
Sequence conflicti409N → D in AAH22511 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073788129Y → F in MFDA. 1 PublicationCorresponds to variant dbSNP:rs786205230EnsemblClinVar.1
Natural variantiVAR_035758136I → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_073789303E → K in MFDA. 1 PublicationCorresponds to variant dbSNP:rs876657388EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0455781 – 225Missing in isoform 5. 1 PublicationAdd BLAST225
Alternative sequenceiVSP_011061141 – 249Missing in isoform 4. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_011059141 – 161LLAGR…LCKLF → VQSSCLLESCSGNWDSFGNC H in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011060162 – 427Missing in isoform 2. 1 PublicationAdd BLAST266
Alternative sequenceiVSP_011062183 – 187RYRAV → SSTKM in isoform 3. 1 Publication5
Alternative sequenceiVSP_011063188 – 427Missing in isoform 3. 1 PublicationAdd BLAST240

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
S63938 mRNA Translation: AAB20278.1
S67127 mRNA Translation: AAB20407.1
X61950 mRNA Translation: CAA43953.1
D90348 mRNA Translation: BAA14359.1
S57498 mRNA Translation: AAB25530.2
L06622 mRNA Translation: AAA58447.1
D11151 Genomic DNA Translation: BAA01920.1
S45956 mRNA Translation: AAB23644.1
S81539 mRNA Translation: AAB36325.1
S81542 mRNA Translation: AAB36326.1
S81545 mRNA Translation: AAB36327.1
AY275462 mRNA Translation: AAP32294.1
AY422989 Genomic DNA Translation: AAQ87880.1
AK304451 mRNA Translation: BAG65268.1
AK312812 mRNA Translation: BAG35670.1
AK315931 mRNA Translation: BAH14302.1
AC093908 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05019.1
CH471056 Genomic DNA Translation: EAX05021.1
BC022511 mRNA Translation: AAH22511.1
S55772 Genomic DNA Translation: AAB25212.1
AF014826 mRNA Translation: AAB94859.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3769.1 [P25101-1]
CCDS54810.1 [P25101-4]

Protein sequence database of the Protein Information Resource

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PIRi
A44158

NCBI Reference Sequences

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RefSeqi
NP_001159527.1, NM_001166055.1 [P25101-4]
NP_001243212.1, NM_001256283.1
NP_001948.1, NM_001957.3 [P25101-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.183713

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000324300; ENSP00000315011; ENSG00000151617 [P25101-1]
ENST00000358556; ENSP00000351359; ENSG00000151617 [P25101-4]
ENST00000506066; ENSP00000425281; ENSG00000151617 [P25101-4]
ENST00000510697; ENSP00000427259; ENSG00000151617 [P25101-3]
ENST00000511804; ENSP00000425354; ENSG00000151617 [P25101-5]
ENST00000648866; ENSP00000496976; ENSG00000151617 [P25101-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1909

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1909

UCSC genome browser

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UCSCi
uc003iky.4 human [P25101-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63938 mRNA Translation: AAB20278.1
S67127 mRNA Translation: AAB20407.1
X61950 mRNA Translation: CAA43953.1
D90348 mRNA Translation: BAA14359.1
S57498 mRNA Translation: AAB25530.2
L06622 mRNA Translation: AAA58447.1
D11151 Genomic DNA Translation: BAA01920.1
S45956 mRNA Translation: AAB23644.1
S81539 mRNA Translation: AAB36325.1
S81542 mRNA Translation: AAB36326.1
S81545 mRNA Translation: AAB36327.1
AY275462 mRNA Translation: AAP32294.1
AY422989 Genomic DNA Translation: AAQ87880.1
AK304451 mRNA Translation: BAG65268.1
AK312812 mRNA Translation: BAG35670.1
AK315931 mRNA Translation: BAH14302.1
AC093908 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05019.1
CH471056 Genomic DNA Translation: EAX05021.1
BC022511 mRNA Translation: AAH22511.1
S55772 Genomic DNA Translation: AAB25212.1
AF014826 mRNA Translation: AAB94859.1
CCDSiCCDS3769.1 [P25101-1]
CCDS54810.1 [P25101-4]
PIRiA44158
RefSeqiNP_001159527.1, NM_001166055.1 [P25101-4]
NP_001243212.1, NM_001256283.1
NP_001948.1, NM_001957.3 [P25101-1]
UniGeneiHs.183713

3D structure databases

ProteinModelPortaliP25101
SMRiP25101
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108231, 21 interactors
CORUMiP25101
DIPiDIP-48718N
IntActiP25101, 4 interactors
STRINGi9606.ENSP00000315011

Chemistry databases

ChEMBLiCHEMBL252
DrugBankiDB00945 Acetylsalicylic acid
DB05367 Actelion-1
DB06403 Ambrisentan
DB00559 Bosentan
DB04883 Darusentan
DB08932 Macitentan
DB05206 PS433540
DB06268 Sitaxentan
DB05290 SPP 301
GuidetoPHARMACOLOGYi219

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiP25101
PhosphoSitePlusiP25101
SwissPalmiP25101

Polymorphism and mutation databases

BioMutaiEDNRA
DMDMi119606

Proteomic databases

PaxDbiP25101
PeptideAtlasiP25101
PRIDEiP25101
ProteomicsDBi54256
54257 [P25101-2]
54258 [P25101-3]
54259 [P25101-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1909
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324300; ENSP00000315011; ENSG00000151617 [P25101-1]
ENST00000358556; ENSP00000351359; ENSG00000151617 [P25101-4]
ENST00000506066; ENSP00000425281; ENSG00000151617 [P25101-4]
ENST00000510697; ENSP00000427259; ENSG00000151617 [P25101-3]
ENST00000511804; ENSP00000425354; ENSG00000151617 [P25101-5]
ENST00000648866; ENSP00000496976; ENSG00000151617 [P25101-5]
GeneIDi1909
KEGGihsa:1909
UCSCiuc003iky.4 human [P25101-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1909
DisGeNETi1909
EuPathDBiHostDB:ENSG00000151617.15

GeneCards: human genes, protein and diseases

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GeneCardsi
EDNRA
HGNCiHGNC:3179 EDNRA
HPAiCAB018957
HPA013774
MalaCardsiEDNRA
MIMi131243 gene
616367 phenotype
neXtProtiNX_P25101
OpenTargetsiENSG00000151617
Orphaneti443995 Mandibulofacial dysostosis with alopecia
PharmGKBiPA27617

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000157109
HOGENOMiHOG000169267
HOVERGENiHBG051443
InParanoidiP25101
KOiK04197
OMAiYDEMDKN
OrthoDBiEOG091G0CJV
PhylomeDBiP25101
TreeFamiTF331292

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP25101

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Endothelin_receptor_type_A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1909

Protein Ontology

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PROi
PR:P25101

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151617 Expressed in 204 organ(s), highest expression level in uterine cervix
CleanExiHS_EDNRA
GenevisibleiP25101 HS

Family and domain databases

InterProiView protein in InterPro
IPR000499 Endthln_rcpt
IPR002175 ETA_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00570 ENDOTHELINAR
PR00366 ENDOTHELINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEDNRA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25101
Secondary accession number(s): B2R723
, B4E2V6, B7Z9G6, D3DP03, E7ER36, O43441, Q16432, Q16433, Q8TBH2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: December 5, 2018
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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