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UniProtKB - P25101 (EDNRA_HUMAN)

Entry version 213 (23 Feb 2022)
Sequence version 1 (01 May 1992)
Previous versions | rss
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Protein

Endothelin-1 receptor

Gene

EDNRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P25101

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-375276, Peptide ligand-binding receptors
R-HSA-416476, G alpha (q) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P25101

SIGNOR Signaling Network Open Resource

More...SIGNORi		P25101

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endothelin-1 receptorCurated
Alternative name(s):
Endothelin receptor type AImported
Short name:
ET-A
Short name:
ETA-R
Short name:
hET-AR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EDNRAImported
Synonyms:ETA, ETRA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3179, EDNRA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		131243, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P25101

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151617

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 80ExtracellularSequence analysisAdd BLAST60
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei81 – 102Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini103 – 112CytoplasmicSequence analysis10
Transmembranei113 – 132Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini133 – 159ExtracellularSequence analysisAdd BLAST27
Transmembranei160 – 181Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini182 – 205CytoplasmicSequence analysisAdd BLAST24
Transmembranei206 – 229Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini230 – 256ExtracellularSequence analysisAdd BLAST27
Transmembranei257 – 278Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini279 – 306CytoplasmicSequence analysisAdd BLAST28
Transmembranei307 – 328Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini329 – 347ExtracellularSequence analysisAdd BLAST19
Transmembranei348 – 372Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini373 – 427CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mandibulofacial dysostosis with alopecia (MFDA)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of mandibulofacial dysostosis, a disorder characterized by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids. MFDA features include maxillary dysmorphism with dysplastic zygomatic arch, hypoplastic mandible, scalp alopecia, scant eyebrows and eyelashes, severe hypoplasia or aplasia of eyelids, small cupped dysplastic ears, conductive hearing loss, cleft palate, dental anomalies, micrognathia, and limited jaw mobility.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073788129Y → F in MFDA. 1 PublicationCorresponds to variant dbSNP:rs786205230EnsemblClinVar.1
Natural variantiVAR_073789303E → K in MFDA. 1 PublicationCorresponds to variant dbSNP:rs876657388EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Hypotrichosis

Organism-specific databases

DisGeNET

More...DisGeNETi		1909

MalaCards human disease database

More...MalaCardsi		EDNRA
MIMi616367, phenotype

Open Targets

More...OpenTargetsi		ENSG00000151617

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		586, Cystic fibrosis
443995, Mandibulofacial dysostosis with alopecia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27617

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P25101, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL252

Drug and drug target database

More...DrugBanki		DB04674, 2-HYDROXY-3,5-DIIODOBENZOIC ACID
DB00945, Acetylsalicylic acid
DB05367, Actelion-1
DB06403, Ambrisentan
DB06199, Atrasentan
DB00559, Bosentan
DB06677, Clazosentan
DB04883, Darusentan
DB06460, Enrasentan
DB08932, Macitentan
DB06268, Sitaxentan
DB12548, Sparsentan
DB05290, SPP 301
DB06558, Tezosentan

DrugCentral

More...DrugCentrali		P25101

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		219

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EDNRA

Domain mapping of disease mutations (DMDM)

More...DMDMi		119606

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001272121 – 427Endothelin-1 receptorAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi158 ↔ 239PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei425PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P25101

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P25101

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P25101

PeptideAtlas

More...PeptideAtlasi		P25101

PRoteomics IDEntifications database

More...PRIDEi		P25101

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17708
54256 [P25101-1]
54258 [P25101-3]
54259 [P25101-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P25101, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P25101

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P25101

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P25101

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151617, Expressed in uterine cervix and 217 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P25101, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151617, Tissue enhanced (seminal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HDAC7 and KAT5.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108231, 48 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P25101

Database of interacting proteins

More...DIPi		DIP-48718N

Protein interaction database and analysis system

More...IntActi		P25101, 13 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000315011

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P25101

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P25101, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P25101

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni406 – 427DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi412 – 427Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01020000230470

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_096205_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P25101

Identification of Orthologs from Complete Genome Data

More...OMAi		CVPLICT

Database of Orthologous Groups

More...OrthoDBi		876925at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P25101

TreeFam database of animal gene trees

More...TreeFami		TF331292

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000499, Endthln_rcpt
IPR002175, ETA_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00570, ENDOTHELINAR
PR00366, ENDOTHELINR
PR00237, GPCRRHODOPSN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P25101-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METLCLRASF WLALVGCVIS DNPERYSTNL SNHVDDFTTF RGTELSFLVT 
        60         70         80         90        100
THQPTNLVLP SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT 
       110        120        130        140        150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH 
       160        170        180        190        200
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL 
       210        220        230        240        250
VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YRGEQHKTCM LNATSKFMEF 
       260        270        280        290        300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 
       310        320        330        340        350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYNEMDKNR CELLSFLLLM 
       360        370        380        390        400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM 
       410        420 
NGTSIQWKNH DQNNHNTDRS SHKDSMN
Length:427
Mass (Da):48,722
Last modified:May 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i207272D4A231404F
GO
Isoform 2 (identifier: P25101-2) [UniParc]FASTAAdd to basket
Also known as: Delta-3

The sequence of this isoform differs from the canonical sequence as follows:
     141-161: LLAGRWPFDHNDFGVFLCKLF → VQSSCLLESCSGNWDSFGNCH
     162-427: Missing.

Show »
Length:161
Mass (Da):17,820
Checksum:iB6227E27C1B05915
GO
Isoform 3 (identifier: P25101-3) [UniParc]FASTAAdd to basket
Also known as: Delta-4

The sequence of this isoform differs from the canonical sequence as follows:
     183-187: RYRAV → SSTKM
     188-427: Missing.

Show »
Length:187
Mass (Da):20,763
Checksum:i60E5564BDE6D7A96
GO
Isoform 4 (identifier: P25101-4) [UniParc]FASTAAdd to basket
Also known as: Delta-3,4

The sequence of this isoform differs from the canonical sequence as follows:
     141-249: Missing.

Show »
Length:318
Mass (Da):36,489
Checksum:i0423FAA16DB6A9BF
GO
Isoform 5 (identifier: P25101-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.

Show »
Length:202
Mass (Da):23,803
Checksum:i01C9764279D905CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti110C → Y in AAB23644 (PubMed:1415318).Curated1
Sequence conflicti115P → H in AAH22511 (PubMed:15489334).Curated1
Sequence conflicti207V → A in AAA58447 (PubMed:8440682).Curated1
Sequence conflicti232R → K in BAH14302 (PubMed:14702039).Curated1
Sequence conflicti234E → G in AAA58447 (PubMed:8440682).Curated1
Sequence conflicti280C → G in AAA58447 (PubMed:8440682).Curated1
Sequence conflicti300Q → H in BAG65268 (PubMed:14702039).Curated1
Sequence conflicti322L → V in AAH22511 (PubMed:15489334).Curated1
Sequence conflicti345S → G in BAG65268 (PubMed:14702039).Curated1
Sequence conflicti409N → D in AAH22511 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073788129Y → F in MFDA. 1 PublicationCorresponds to variant dbSNP:rs786205230EnsemblClinVar.1
Natural variantiVAR_035758136I → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_073789303E → K in MFDA. 1 PublicationCorresponds to variant dbSNP:rs876657388EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0455781 – 225Missing in isoform 5. 1 PublicationAdd BLAST225
Alternative sequenceiVSP_011061141 – 249Missing in isoform 4. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_011059141 – 161LLAGR…LCKLF → VQSSCLLESCSGNWDSFGNC H in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011060162 – 427Missing in isoform 2. 1 PublicationAdd BLAST266
Alternative sequenceiVSP_011062183 – 187RYRAV → SSTKM in isoform 3. 1 Publication5
Alternative sequenceiVSP_011063188 – 427Missing in isoform 3. 1 PublicationAdd BLAST240

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S63938 mRNA Translation: AAB20278.1
S67127 mRNA Translation: AAB20407.1
X61950 mRNA Translation: CAA43953.1
D90348 mRNA Translation: BAA14359.1
S57498 mRNA Translation: AAB25530.2
L06622 mRNA Translation: AAA58447.1
D11151 Genomic DNA Translation: BAA01920.1
S45956 mRNA Translation: AAB23644.1
S81539 mRNA Translation: AAB36325.1
S81542 mRNA Translation: AAB36326.1
S81545 mRNA Translation: AAB36327.1
AY275462 mRNA Translation: AAP32294.1
AY422989 Genomic DNA Translation: AAQ87880.1
AK304451 mRNA Translation: BAG65268.1
AK312812 mRNA Translation: BAG35670.1
AK315931 mRNA Translation: BAH14302.1
AC093908 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05019.1
CH471056 Genomic DNA Translation: EAX05021.1
BC022511 mRNA Translation: AAH22511.1
S55772 Genomic DNA Translation: AAB25212.1
AF014826 mRNA Translation: AAB94859.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3769.1 [P25101-1]
CCDS54810.1 [P25101-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A44158

NCBI Reference Sequences

More...RefSeqi		NP_001159527.1, NM_001166055.1 [P25101-4]
NP_001243212.1, NM_001256283.1
NP_001948.1, NM_001957.3 [P25101-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324300; ENSP00000315011; ENSG00000151617
ENST00000358556; ENSP00000351359; ENSG00000151617 [P25101-4]
ENST00000506066; ENSP00000425281; ENSG00000151617 [P25101-4]
ENST00000510697; ENSP00000427259; ENSG00000151617 [P25101-3]
ENST00000511804; ENSP00000425354; ENSG00000151617 [P25101-5]
ENST00000648866; ENSP00000496976; ENSG00000151617 [P25101-5]
ENST00000651419; ENSP00000498969; ENSG00000151617

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1909

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1909

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000651419.1; ENSP00000498969.1; NM_001957.4; NP_001948.1

UCSC genome browser

More...UCSCi		uc003iky.4, human [P25101-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S63938 mRNA Translation: AAB20278.1
S67127 mRNA Translation: AAB20407.1
X61950 mRNA Translation: CAA43953.1
D90348 mRNA Translation: BAA14359.1
S57498 mRNA Translation: AAB25530.2
L06622 mRNA Translation: AAA58447.1
D11151 Genomic DNA Translation: BAA01920.1
S45956 mRNA Translation: AAB23644.1
S81539 mRNA Translation: AAB36325.1
S81542 mRNA Translation: AAB36326.1
S81545 mRNA Translation: AAB36327.1
AY275462 mRNA Translation: AAP32294.1
AY422989 Genomic DNA Translation: AAQ87880.1
AK304451 mRNA Translation: BAG65268.1
AK312812 mRNA Translation: BAG35670.1
AK315931 mRNA Translation: BAH14302.1
AC093908 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05019.1
CH471056 Genomic DNA Translation: EAX05021.1
BC022511 mRNA Translation: AAH22511.1
S55772 Genomic DNA Translation: AAB25212.1
AF014826 mRNA Translation: AAB94859.1
CCDSiCCDS3769.1 [P25101-1]
CCDS54810.1 [P25101-4]
PIRiA44158
RefSeqiNP_001159527.1, NM_001166055.1 [P25101-4]
NP_001243212.1, NM_001256283.1
NP_001948.1, NM_001957.3 [P25101-1]

3D structure databases

SMRiP25101
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108231, 48 interactors
CORUMiP25101
DIPiDIP-48718N
IntActiP25101, 13 interactors
STRINGi9606.ENSP00000315011

Chemistry databases

BindingDBiP25101
ChEMBLiCHEMBL252
DrugBankiDB04674, 2-HYDROXY-3,5-DIIODOBENZOIC ACID
DB00945, Acetylsalicylic acid
DB05367, Actelion-1
DB06403, Ambrisentan
DB06199, Atrasentan
DB00559, Bosentan
DB06677, Clazosentan
DB04883, Darusentan
DB06460, Enrasentan
DB08932, Macitentan
DB06268, Sitaxentan
DB12548, Sparsentan
DB05290, SPP 301
DB06558, Tezosentan
DrugCentraliP25101
GuidetoPHARMACOLOGYi219

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP25101, 2 sites
iPTMnetiP25101
PhosphoSitePlusiP25101
SwissPalmiP25101

Genetic variation databases

BioMutaiEDNRA
DMDMi119606

Proteomic databases

jPOSTiP25101
MassIVEiP25101
PaxDbiP25101
PeptideAtlasiP25101
PRIDEiP25101
ProteomicsDBi17708
54256 [P25101-1]
54258 [P25101-3]
54259 [P25101-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2942, 351 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		1909

Genome annotation databases

EnsembliENST00000324300; ENSP00000315011; ENSG00000151617
ENST00000358556; ENSP00000351359; ENSG00000151617 [P25101-4]
ENST00000506066; ENSP00000425281; ENSG00000151617 [P25101-4]
ENST00000510697; ENSP00000427259; ENSG00000151617 [P25101-3]
ENST00000511804; ENSP00000425354; ENSG00000151617 [P25101-5]
ENST00000648866; ENSP00000496976; ENSG00000151617 [P25101-5]
ENST00000651419; ENSP00000498969; ENSG00000151617
GeneIDi1909
KEGGihsa:1909
MANE-SelectiENST00000651419.1; ENSP00000498969.1; NM_001957.4; NP_001948.1
UCSCiuc003iky.4, human [P25101-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1909
DisGeNETi1909

GeneCards: human genes, protein and diseases

More...GeneCardsi		EDNRA
HGNCiHGNC:3179, EDNRA
HPAiENSG00000151617, Tissue enhanced (seminal)
MalaCardsiEDNRA
MIMi131243, gene
616367, phenotype
neXtProtiNX_P25101
OpenTargetsiENSG00000151617
Orphaneti586, Cystic fibrosis
443995, Mandibulofacial dysostosis with alopecia
PharmGKBiPA27617
VEuPathDBiHostDB:ENSG00000151617

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT01020000230470
HOGENOMiCLU_096205_1_0_1
InParanoidiP25101
OMAiCVPLICT
OrthoDBi876925at2759
PhylomeDBiP25101
TreeFamiTF331292

Enzyme and pathway databases

PathwayCommonsiP25101
ReactomeiR-HSA-375276, Peptide ligand-binding receptors
R-HSA-416476, G alpha (q) signalling events
SignaLinkiP25101
SIGNORiP25101

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1909, 3 hits in 1040 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		EDNRA, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Endothelin_receptor_type_A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1909
PharosiP25101, Tclin

Protein Ontology

More...PROi		PR:P25101
RNActiP25101, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151617, Expressed in uterine cervix and 217 other tissues
GenevisibleiP25101, HS

Family and domain databases

InterProiView protein in InterPro
IPR000499, Endthln_rcpt
IPR002175, ETA_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00570, ENDOTHELINAR
PR00366, ENDOTHELINR
PR00237, GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEDNRA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25101
Secondary accession number(s): B2R723
, B4E2V6, B7Z9G6, D3DP03, E7ER36, O43441, Q16432, Q16433, Q8TBH2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: February 23, 2022
This is version 213 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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