ADRA1D

Functionⁱ

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

GO - Molecular functionⁱ

alpha1-adrenergic receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10820200
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 1656955
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 10820200
DNA metabolic process
Source: ProtInc
Traceable author statementⁱ
- 10969806
G-protein coupled receptor signaling pathway Source: Reactome
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 10820200
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: GO_Central
phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 10860850
positive regulation of cytosolic calcium ion concentration Source: GO_Central
positive regulation of smooth muscle contraction Source: GO_Central
positive regulation of vasoconstriction Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390696 Adrenoceptors R-HSA-416476 G alpha (q) signalling events R-HSA-416482 G alpha (12/13) signalling events
SIGNORⁱ	P25100

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-1D adrenergic receptor Alternative name(s): Alpha-1A adrenergic receptor Alpha-1D adrenoreceptor Short name: Alpha-1D adrenoceptor Alpha-adrenergic receptor 1a
Gene namesⁱ	Name:ADRA1D Synonyms:ADRA1A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171873.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:280 ADRA1D
MIMⁱ	104219 gene
neXtProtⁱ	NX_P25100

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 95	ExtracellularBy similarityAdd BLAST	95
Transmembraneⁱ	96 – 121	Helical; Name=1By similarityAdd BLAST	26
Topological domainⁱ	122 – 133	CytoplasmicBy similarityAdd BLAST	12
Transmembraneⁱ	134 – 159	Helical; Name=2By similarityAdd BLAST	26
Topological domainⁱ	160 – 169	ExtracellularBy similarity	10
Transmembraneⁱ	170 – 192	Helical; Name=3By similarityAdd BLAST	23
Topological domainⁱ	193 – 213	CytoplasmicBy similarityAdd BLAST	21
Transmembraneⁱ	214 – 238	Helical; Name=4By similarityAdd BLAST	25
Topological domainⁱ	239 – 251	ExtracellularBy similarityAdd BLAST	13
Transmembraneⁱ	252 – 275	Helical; Name=5By similarityAdd BLAST	24
Topological domainⁱ	276 – 348	CytoplasmicBy similarityAdd BLAST	73
Transmembraneⁱ	349 – 373	Helical; Name=6By similarityAdd BLAST	25
Topological domainⁱ	374 – 380	ExtracellularBy similarity	7
Transmembraneⁱ	381 – 405	Helical; Name=7By similarityAdd BLAST	25
Topological domainⁱ	406 – 572	CytoplasmicBy similarityAdd BLAST	167

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	146
Open Targets More...OpenTargetsⁱ	ENSG00000171873
PharmGKBⁱ	PA24597

Chemistry databases

ChEMBLⁱ	CHEMBL223
Drug and drug target database More...DrugBankⁱ	DB00346 Alfuzosin DB00321 Amitriptyline DB00543 Amoxapine DB00182 Amphetamine DB01200 Bromocriptine DB00248 Cabergoline DB01136 Carvedilol DB00477 Chlorpromazine DB09202 Cirazoline DB00575 Clonidine DB00298 Dapiprazole DB01151 Desipramine DB00590 Doxazosin DB01142 Doxepin DB04855 Dronedarone DB06262 Droxidopa DB05492 Epicept NP-1 DB00668 Epinephrine DB01049 Ergoloid mesylate DB00696 Ergotamine DB00800 Fenoldopam DB00458 Imipramine DB00598 Labetalol DB00934 Maprotiline DB01365 Mephentermine DB01403 Methotrimeprazine DB00723 Methoxamine DB06148 Mianserin DB00211 Midodrine DB00370 Mirtazapine DB00622 Nicardipine DB00368 Norepinephrine DB00540 Nortriptyline DB00935 Oxymetazoline DB01186 Pergolide DB00925 Phenoxybenzamine DB00388 Phenylephrine DB00457 Prazosin DB00420 Promazine DB00777 Propiomazine DB01224 Quetiapine DB05469 R450 DB06144 Sertindole DB06207 Silodosin DB00706 Tamsulosin DB01162 Terazosin DB13025 Tiapride DB06694 Xylometazoline
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	24

Polymorphism and mutation databases

BioMutaⁱ	ADRA1D
DMDMⁱ	1168243

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069073	1 – 572	Alpha-1D adrenergic receptorAdd BLAST		572

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	65	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	82	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	419	S-palmitoyl cysteineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P25100
PeptideAtlas More...PeptideAtlasⁱ	P25100
PRIDEⁱ	P25100
ProteomicsDBⁱ	54255

PTM databases

iPTMnetⁱ	P25100
PhosphoSitePlusⁱ	P25100

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171873 Expressed in 92 organ(s), highest expression level in thoracic aorta
CleanExⁱ	HS_ADRA1A HS_ADRA1D
ExpressionAtlasⁱ	P25100 baseline and differential
Genevisibleⁱ	P25100 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038789

HPAⁱ

HPA038789

Interactionⁱ

Subunit structureⁱ

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.1 Publication

Protein-protein interaction databases

BioGridⁱ	106656, 13 interactors
IntActⁱ	P25100, 2 interactors
Molecular INTeraction database More...MINTⁱ	P25100
STRINGⁱ	9606.ENSP00000368766

Chemistry databases

BindingDBⁱ	P25100

BindingDBⁱ

P25100

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P25100
SMRⁱ	P25100
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	422 – 428	Poly-Arg		7

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239244
HOVERGENⁱ	HBG106962
InParanoidⁱ	P25100
KEGG Orthology (KO) More...KOⁱ	K04137
OMAⁱ	GATCQAY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P25100
TreeFamⁱ	TF331895

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR000363 ADRA1D_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24248:SF14 PTHR24248:SF14, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00240 ADRENRGCA1DR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P25100-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA 
        60         70         80         90        100
GGGGGVVGAG SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG 
       110        120        130        140        150
VFLAAFILMA VAGNLLVILS VACNRHLQTV TNYFIVNLAV ADLLLSATVL 
       160        170        180        190        200
PFSATMEVLG FWAFGRAFCD VWAAVDVLCC TASILSLCTI SVDRYVGVRH 
       210        220        230        240        250
SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP PDERFCGITE 
       260        270        280        290        300
EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS 
       310        320        330        340        350
EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL 
       360        370        380        390        400
AIVVGVFVLC WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL 
       410        420        430        440        450
IYPCSSREFK RAFLRLLRCQ CRRRRRRRPL WRVYGHHWRA STSGLRQDCA 
       460        470        480        490        500
PSSGDAPPGA PLALTALPDP DPEPPGTPEM QAPVASRRKP PSAFREWRLL 
       510        520        530        540        550
GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE AVSLGVPHEV 
       560        570 
AEGATCQAYE LADYSNLRET DI

Length:572

Mass (Da):60,463

Last modified:November 1, 1995 - v2

Checksum:ⁱEBEB134CF20A4988

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	1 – 83	MTFRD…GDVNG → MAAALRSVMMAGYLSEWRTP TYRSTEMVQRLRMEAVQHST S (PubMed:1656955).CuratedAdd BLAST	83
Sequence conflictⁱ	31	S → G in AAB31163 (PubMed:8024574).Curated	1
Sequence conflictⁱ	489 – 572	KPPSA…RETDI → SHPAPSASGGCWGRSGDPRP SCAPKSPACRTRSPPGARSA QRQRAPSAQRWRLCP (PubMed:1656955).CuratedAdd BLAST	84
Sequence conflictⁱ	522	R → P in AAB31163 (PubMed:8024574).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M76446 mRNA Translation: AAA35496.1 U03864 mRNA Translation: AAB60351.1 L31772 mRNA Translation: AAB59487.1 S70782 mRNA Translation: AAB31163.2 D29952 Genomic DNA Translation: BAA06222.1 AL121675 Genomic DNA No translation available. AL357040 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13079.1
PIRⁱ	I39369 JH0447
NCBI Reference Sequences More...RefSeqⁱ	NP_000669.1, NM_000678.3
UniGeneⁱ	Hs.557

Genome annotation databases

Ensemblⁱ	ENST00000379453; ENSP00000368766; ENSG00000171873
GeneIDⁱ	146
KEGGⁱ	hsa:146
UCSC genome browser More...UCSCⁱ	uc002wkr.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P25100	Adrenergic, alpha-1D-, receptor		HUMAN		572	UniRef100_P25100
ADRA1D isoform 1		PANTR		572

Protein	Similar proteins		Species	Score	Length	Source
P25100	Adrenergic, alpha-1D-, receptor		HUMAN		572	UniRef90_P25100
ADRA1D isoform 1		PANTR		572
Adrenoceptor alpha 1D		PROCO		577
alpha-1D adrenergic receptor		DIPOR		575
ADRA1D isoform 1		PONAB		573
+34

Protein	Similar proteins		Species	Score	Length	Source
P25100	Adrenergic, alpha-1D-, receptor		HUMAN		572	UniRef50_P25100
ADRA1D isoform 1		PANTR		572
Adrenoceptor alpha 1D		PROCO		577
alpha-1D adrenergic receptor		DIPOR		575
ADRA1D isoform 1		PONAB		573
+109

Entry informationⁱ

Entry nameⁱ	ADA1D_HUMAN
Accessionⁱ	P25100Primary (citable) accession number: P25100 Secondary accession number(s): Q9NPY0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	November 1, 1995
	Last modified:	September 12, 2018
	This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P25100 (ADA1D_HUMAN)

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Alpha-1D adrenergic receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ