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UniProtKB - P25100 (ADA1D_HUMAN)
Protein
Alpha-1D adrenergic receptor
Gene
ADRA1D
Organism
Homo sapiens (Human)
Status
Functioni
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
GO - Molecular functioni
- alpha1-adrenergic receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
- identical protein binding Source: IntAct
GO - Biological processi
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: ProtInc
- cell-cell signaling Source: GO_Central
- G protein-coupled receptor signaling pathway Source: ProtInc
- neuron-glial cell signaling Source: ARUK-UCL
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of heart rate by epinephrine-norepinephrine Source: GO_Central
- positive regulation of MAPK cascade Source: GO_Central
- positive regulation of vasoconstriction Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P25100 |
Reactomei | R-HSA-390696, Adrenoceptors R-HSA-416476, G alpha (q) signalling events R-HSA-416482, G alpha (12/13) signalling events |
SignaLinki | P25100 |
SIGNORi | P25100 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-1D adrenergic receptorAlternative name(s): Alpha-1A adrenergic receptor Alpha-1D adrenoreceptor Short name: Alpha-1D adrenoceptor Alpha-adrenergic receptor 1a |
Gene namesi | Name:ADRA1D Synonyms:ADRA1A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:280, ADRA1D |
MIMi | 104219, gene |
neXtProti | NX_P25100 |
VEuPathDBi | HostDB:ENSG00000171873 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 95 | ExtracellularBy similarityAdd BLAST | 95 | |
Transmembranei | 96 – 121 | Helical; Name=1By similarityAdd BLAST | 26 | |
Topological domaini | 122 – 133 | CytoplasmicBy similarityAdd BLAST | 12 | |
Transmembranei | 134 – 159 | Helical; Name=2By similarityAdd BLAST | 26 | |
Topological domaini | 160 – 169 | ExtracellularBy similarity | 10 | |
Transmembranei | 170 – 192 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 193 – 213 | CytoplasmicBy similarityAdd BLAST | 21 | |
Transmembranei | 214 – 238 | Helical; Name=4By similarityAdd BLAST | 25 | |
Topological domaini | 239 – 251 | ExtracellularBy similarityAdd BLAST | 13 | |
Transmembranei | 252 – 275 | Helical; Name=5By similarityAdd BLAST | 24 | |
Topological domaini | 276 – 348 | CytoplasmicBy similarityAdd BLAST | 73 | |
Transmembranei | 349 – 373 | Helical; Name=6By similarityAdd BLAST | 25 | |
Topological domaini | 374 – 380 | ExtracellularBy similarity | 7 | |
Transmembranei | 381 – 405 | Helical; Name=7By similarityAdd BLAST | 25 | |
Topological domaini | 406 – 572 | CytoplasmicBy similarityAdd BLAST | 167 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 146 |
OpenTargetsi | ENSG00000171873 |
PharmGKBi | PA24597 |
Miscellaneous databases
Pharosi | P25100, Tclin |
Chemistry databases
ChEMBLi | CHEMBL223 |
DrugBanki | DB00346, Alfuzosin DB00321, Amitriptyline DB00543, Amoxapine DB00182, Amphetamine DB09229, Aranidipine DB09204, Arotinolol DB01200, Bromocriptine DB00490, Buspirone DB00248, Cabergoline DB01136, Carvedilol DB00477, Chlorpromazine DB09202, Cirazoline DB00575, Clonidine DB00298, Dapiprazole DB01151, Desipramine DB01576, Dextroamphetamine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB11278, DL-Methylephedrine DB00841, Dobutamine DB09167, Dosulepin DB00590, Doxazosin DB01142, Doxepin DB04855, Dronedarone DB06262, Droxidopa DB05492, Epicept NP-1 DB00668, Epinephrine DB01049, Ergoloid mesylate DB00696, Ergotamine DB01175, Escitalopram DB09194, Etoperidone DB00800, Fenoldopam DB00458, Imipramine DB11577, Indigotindisulfonic acid DB00598, Labetalol DB09195, Lorpiprazole DB00934, Maprotiline DB01365, Mephentermine DB01403, Methotrimeprazine DB00723, Methoxamine DB06148, Mianserin DB00211, Midodrine DB00370, Mirtazapine DB09205, Moxisylyte DB00622, Nicardipine DB00368, Norepinephrine DB00540, Nortriptyline DB06229, Ocaperidone DB00935, Oxymetazoline DB00715, Paroxetine DB01186, Pergolide DB08922, Perospirone DB00925, Phenoxybenzamine DB00692, Phentolamine DB00388, Phenylephrine DB09286, Pipamperone DB06153, Pizotifen DB00457, Prazosin DB00433, Prochlorperazine DB01069, Promethazine DB01224, Quetiapine DB00908, Quinidine DB05469, R450 DB11124, Racepinephrine DB00243, Ranolazine DB00268, Ropinirole DB06144, Sertindole DB06207, Silodosin DB09203, Synephrine DB00706, Tamsulosin DB01162, Terazosin DB13025, Tiapride DB00697, Tizanidine DB00661, Verapamil DB06694, Xylometazoline |
DrugCentrali | P25100 |
GuidetoPHARMACOLOGYi | 24 |
Genetic variation databases
BioMutai | ADRA1D |
DMDMi | 1168243 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069073 | 1 – 572 | Alpha-1D adrenergic receptorAdd BLAST | 572 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 82 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 419 | S-palmitoyl cysteineSequence analysis | 1 |
Post-translational modificationi
Palmitoylated. Palmitoylation by ZDHHC21 may increase the expression of the receptor and regulate downstream signaling.By similarity
Keywords - PTMi
Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P25100 |
PeptideAtlasi | P25100 |
PRIDEi | P25100 |
ProteomicsDBi | 54255 |
PTM databases
GlyGeni | P25100, 2 sites |
iPTMneti | P25100 |
PhosphoSitePlusi | P25100 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171873, Expressed in thoracic aorta and 115 other tissues |
ExpressionAtlasi | P25100, baseline and differential |
Genevisiblei | P25100, HS |
Organism-specific databases
HPAi | ENSG00000171873, Tissue enhanced (brain, cervix) |
Interactioni
Subunit structurei
Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
1 PublicationBinary interactionsi
P25100
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 106656, 16 interactors |
IntActi | P25100, 29 interactors |
MINTi | P25100 |
STRINGi | 9606.ENSP00000368766 |
Chemistry databases
BindingDBi | P25100 |
Miscellaneous databases
RNActi | P25100, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 77 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 444 – 488 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 463 – 479 | Pro residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160795 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | P25100 |
OMAi | GATCQAY |
OrthoDBi | 1095345at2759 |
PhylomeDBi | P25100 |
TreeFami | TF331895 |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR000363, ADRA1D_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24248:SF14, PTHR24248:SF14, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00240, ADRENRGCA1DR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P25100-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA
60 70 80 90 100
GGGGGVVGAG SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG
110 120 130 140 150
VFLAAFILMA VAGNLLVILS VACNRHLQTV TNYFIVNLAV ADLLLSATVL
160 170 180 190 200
PFSATMEVLG FWAFGRAFCD VWAAVDVLCC TASILSLCTI SVDRYVGVRH
210 220 230 240 250
SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP PDERFCGITE
260 270 280 290 300
EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS
310 320 330 340 350
EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL
360 370 380 390 400
AIVVGVFVLC WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL
410 420 430 440 450
IYPCSSREFK RAFLRLLRCQ CRRRRRRRPL WRVYGHHWRA STSGLRQDCA
460 470 480 490 500
PSSGDAPPGA PLALTALPDP DPEPPGTPEM QAPVASRRKP PSAFREWRLL
510 520 530 540 550
GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE AVSLGVPHEV
560 570
AEGATCQAYE LADYSNLRET DI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 – 83 | MTFRD…GDVNG → MAAALRSVMMAGYLSEWRTP TYRSTEMVQRLRMEAVQHST S (PubMed:1656955).CuratedAdd BLAST | 83 | |
Sequence conflicti | 31 | S → G in AAB31163 (PubMed:8024574).Curated | 1 | |
Sequence conflicti | 489 – 572 | KPPSA…RETDI → SHPAPSASGGCWGRSGDPRP SCAPKSPACRTRSPPGARSA QRQRAPSAQRWRLCP (PubMed:1656955).CuratedAdd BLAST | 84 | |
Sequence conflicti | 522 | R → P in AAB31163 (PubMed:8024574).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M76446 mRNA Translation: AAA35496.1 U03864 mRNA Translation: AAB60351.1 L31772 mRNA Translation: AAB59487.1 S70782 mRNA Translation: AAB31163.2 D29952 Genomic DNA Translation: BAA06222.1 AL121675 Genomic DNA No translation available. AL357040 Genomic DNA No translation available. |
CCDSi | CCDS13079.1 |
PIRi | I39369 JH0447 |
RefSeqi | NP_000669.1, NM_000678.3 |
Genome annotation databases
Ensembli | ENST00000379453; ENSP00000368766; ENSG00000171873 |
GeneIDi | 146 |
KEGGi | hsa:146 |
MANE-Selecti | ENST00000379453.6; ENSP00000368766.4; NM_000678.4; NP_000669.1 |
UCSCi | uc002wkr.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M76446 mRNA Translation: AAA35496.1 U03864 mRNA Translation: AAB60351.1 L31772 mRNA Translation: AAB59487.1 S70782 mRNA Translation: AAB31163.2 D29952 Genomic DNA Translation: BAA06222.1 AL121675 Genomic DNA No translation available. AL357040 Genomic DNA No translation available. |
CCDSi | CCDS13079.1 |
PIRi | I39369 JH0447 |
RefSeqi | NP_000669.1, NM_000678.3 |
3D structure databases
SMRi | P25100 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106656, 16 interactors |
IntActi | P25100, 29 interactors |
MINTi | P25100 |
STRINGi | 9606.ENSP00000368766 |
Chemistry databases
BindingDBi | P25100 |
ChEMBLi | CHEMBL223 |
DrugBanki | DB00346, Alfuzosin DB00321, Amitriptyline DB00543, Amoxapine DB00182, Amphetamine DB09229, Aranidipine DB09204, Arotinolol DB01200, Bromocriptine DB00490, Buspirone DB00248, Cabergoline DB01136, Carvedilol DB00477, Chlorpromazine DB09202, Cirazoline DB00575, Clonidine DB00298, Dapiprazole DB01151, Desipramine DB01576, Dextroamphetamine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB11278, DL-Methylephedrine DB00841, Dobutamine DB09167, Dosulepin DB00590, Doxazosin DB01142, Doxepin DB04855, Dronedarone DB06262, Droxidopa DB05492, Epicept NP-1 DB00668, Epinephrine DB01049, Ergoloid mesylate DB00696, Ergotamine DB01175, Escitalopram DB09194, Etoperidone DB00800, Fenoldopam DB00458, Imipramine DB11577, Indigotindisulfonic acid DB00598, Labetalol DB09195, Lorpiprazole DB00934, Maprotiline DB01365, Mephentermine DB01403, Methotrimeprazine DB00723, Methoxamine DB06148, Mianserin DB00211, Midodrine DB00370, Mirtazapine DB09205, Moxisylyte DB00622, Nicardipine DB00368, Norepinephrine DB00540, Nortriptyline DB06229, Ocaperidone DB00935, Oxymetazoline DB00715, Paroxetine DB01186, Pergolide DB08922, Perospirone DB00925, Phenoxybenzamine DB00692, Phentolamine DB00388, Phenylephrine DB09286, Pipamperone DB06153, Pizotifen DB00457, Prazosin DB00433, Prochlorperazine DB01069, Promethazine DB01224, Quetiapine DB00908, Quinidine DB05469, R450 DB11124, Racepinephrine DB00243, Ranolazine DB00268, Ropinirole DB06144, Sertindole DB06207, Silodosin DB09203, Synephrine DB00706, Tamsulosin DB01162, Terazosin DB13025, Tiapride DB00697, Tizanidine DB00661, Verapamil DB06694, Xylometazoline |
DrugCentrali | P25100 |
GuidetoPHARMACOLOGYi | 24 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P25100, 2 sites |
iPTMneti | P25100 |
PhosphoSitePlusi | P25100 |
Genetic variation databases
BioMutai | ADRA1D |
DMDMi | 1168243 |
Proteomic databases
PaxDbi | P25100 |
PeptideAtlasi | P25100 |
PRIDEi | P25100 |
ProteomicsDBi | 54255 |
Protocols and materials databases
Antibodypediai | 7918, 161 antibodies from 32 providers |
DNASUi | 146 |
Genome annotation databases
Ensembli | ENST00000379453; ENSP00000368766; ENSG00000171873 |
GeneIDi | 146 |
KEGGi | hsa:146 |
MANE-Selecti | ENST00000379453.6; ENSP00000368766.4; NM_000678.4; NP_000669.1 |
UCSCi | uc002wkr.3, human |
Organism-specific databases
CTDi | 146 |
DisGeNETi | 146 |
GeneCardsi | ADRA1D |
HGNCi | HGNC:280, ADRA1D |
HPAi | ENSG00000171873, Tissue enhanced (brain, cervix) |
MIMi | 104219, gene |
neXtProti | NX_P25100 |
OpenTargetsi | ENSG00000171873 |
PharmGKBi | PA24597 |
VEuPathDBi | HostDB:ENSG00000171873 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160795 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | P25100 |
OMAi | GATCQAY |
OrthoDBi | 1095345at2759 |
PhylomeDBi | P25100 |
TreeFami | TF331895 |
Enzyme and pathway databases
PathwayCommonsi | P25100 |
Reactomei | R-HSA-390696, Adrenoceptors R-HSA-416476, G alpha (q) signalling events R-HSA-416482, G alpha (12/13) signalling events |
SignaLinki | P25100 |
SIGNORi | P25100 |
Miscellaneous databases
BioGRID-ORCSi | 146, 8 hits in 1041 CRISPR screens |
ChiTaRSi | ADRA1D, human |
GeneWikii | Alpha-1D_adrenergic_receptor |
GenomeRNAii | 146 |
Pharosi | P25100, Tclin |
PROi | PR:P25100 |
RNActi | P25100, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171873, Expressed in thoracic aorta and 115 other tissues |
ExpressionAtlasi | P25100, baseline and differential |
Genevisiblei | P25100, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR000363, ADRA1D_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24248:SF14, PTHR24248:SF14, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00240, ADRENRGCA1DR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADA1D_HUMAN | |
Accessioni | P25100Primary (citable) accession number: P25100 Secondary accession number(s): Q9NPY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families