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Protein

Alpha-1D adrenergic receptor

Gene

ADRA1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

GO - Molecular functioni

  • adrenergic receptor activity Source: GO_Central
  • alpha1-adrenergic receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
SIGNORiP25100

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Short name:
Alpha-1D adrenoceptor
Alpha-adrenergic receptor 1a
Gene namesi
Name:ADRA1D
Synonyms:ADRA1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000171873.7
HGNCiHGNC:280 ADRA1D
MIMi104219 gene
neXtProtiNX_P25100

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 95ExtracellularBy similarityAdd BLAST95
Transmembranei96 – 121Helical; Name=1By similarityAdd BLAST26
Topological domaini122 – 133CytoplasmicBy similarityAdd BLAST12
Transmembranei134 – 159Helical; Name=2By similarityAdd BLAST26
Topological domaini160 – 169ExtracellularBy similarity10
Transmembranei170 – 192Helical; Name=3By similarityAdd BLAST23
Topological domaini193 – 213CytoplasmicBy similarityAdd BLAST21
Transmembranei214 – 238Helical; Name=4By similarityAdd BLAST25
Topological domaini239 – 251ExtracellularBy similarityAdd BLAST13
Transmembranei252 – 275Helical; Name=5By similarityAdd BLAST24
Topological domaini276 – 348CytoplasmicBy similarityAdd BLAST73
Transmembranei349 – 373Helical; Name=6By similarityAdd BLAST25
Topological domaini374 – 380ExtracellularBy similarity7
Transmembranei381 – 405Helical; Name=7By similarityAdd BLAST25
Topological domaini406 – 572CytoplasmicBy similarityAdd BLAST167

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi146
OpenTargetsiENSG00000171873
PharmGKBiPA24597

Chemistry databases

ChEMBLiCHEMBL223
DrugBankiDB00346 Alfuzosin
DB00321 Amitriptyline
DB00543 Amoxapine
DB00182 Amphetamine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01136 Carvedilol
DB00477 Chlorpromazine
DB09202 Cirazoline
DB00575 Clonidine
DB00298 Dapiprazole
DB01151 Desipramine
DB00590 Doxazosin
DB01142 Doxepin
DB04855 Dronedarone
DB06262 Droxidopa
DB05492 Epicept NP-1
DB00668 Epinephrine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB00800 Fenoldopam
DB00458 Imipramine
DB00598 Labetalol
DB00934 Maprotiline
DB01365 Mephentermine
DB01403 Methotrimeprazine
DB00723 Methoxamine
DB06148 Mianserin
DB00211 Midodrine
DB00370 Mirtazapine
DB00622 Nicardipine
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00935 Oxymetazoline
DB01186 Pergolide
DB00925 Phenoxybenzamine
DB00388 Phenylephrine
DB00457 Prazosin
DB00420 Promazine
DB00777 Propiomazine
DB01224 Quetiapine
DB05469 R450
DB06144 Sertindole
DB06207 Silodosin
DB00706 Tamsulosin
DB01162 Terazosin
DB13025 Tiapride
DB06694 Xylometazoline
GuidetoPHARMACOLOGYi24

Polymorphism and mutation databases

BioMutaiADRA1D
DMDMi1168243

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690731 – 572Alpha-1D adrenergic receptorAdd BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi419S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25100
PeptideAtlasiP25100
PRIDEiP25100
ProteomicsDBi54255

PTM databases

iPTMnetiP25100
PhosphoSitePlusiP25100

Expressioni

Gene expression databases

BgeeiENSG00000171873 Expressed in 92 organ(s), highest expression level in thoracic aorta
CleanExiHS_ADRA1A
HS_ADRA1D
ExpressionAtlasiP25100 baseline and differential
GenevisibleiP25100 HS

Organism-specific databases

HPAiHPA038789

Interactioni

Subunit structurei

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.1 Publication

Protein-protein interaction databases

BioGridi106656, 13 interactors
IntActiP25100, 2 interactors
MINTiP25100
STRINGi9606.ENSP00000368766

Chemistry databases

BindingDBiP25100

Structurei

3D structure databases

ProteinModelPortaliP25100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi422 – 428Poly-Arg7

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239244
HOVERGENiHBG106962
InParanoidiP25100
KOiK04137
OMAiGATCQAY
OrthoDBiEOG091G06VI
PhylomeDBiP25100
TreeFamiTF331895

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000363 ADRA1D_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF14 PTHR24248:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00240 ADRENRGCA1DR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25100-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA
60 70 80 90 100
GGGGGVVGAG SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG
110 120 130 140 150
VFLAAFILMA VAGNLLVILS VACNRHLQTV TNYFIVNLAV ADLLLSATVL
160 170 180 190 200
PFSATMEVLG FWAFGRAFCD VWAAVDVLCC TASILSLCTI SVDRYVGVRH
210 220 230 240 250
SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP PDERFCGITE
260 270 280 290 300
EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS
310 320 330 340 350
EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL
360 370 380 390 400
AIVVGVFVLC WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL
410 420 430 440 450
IYPCSSREFK RAFLRLLRCQ CRRRRRRRPL WRVYGHHWRA STSGLRQDCA
460 470 480 490 500
PSSGDAPPGA PLALTALPDP DPEPPGTPEM QAPVASRRKP PSAFREWRLL
510 520 530 540 550
GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE AVSLGVPHEV
560 570
AEGATCQAYE LADYSNLRET DI
Length:572
Mass (Da):60,463
Last modified:November 1, 1995 - v2
Checksum:iEBEB134CF20A4988
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 83MTFRD…GDVNG → MAAALRSVMMAGYLSEWRTP TYRSTEMVQRLRMEAVQHST S (PubMed:1656955).CuratedAdd BLAST83
Sequence conflicti31S → G in AAB31163 (PubMed:8024574).Curated1
Sequence conflicti489 – 572KPPSA…RETDI → SHPAPSASGGCWGRSGDPRP SCAPKSPACRTRSPPGARSA QRQRAPSAQRWRLCP (PubMed:1656955).CuratedAdd BLAST84
Sequence conflicti522R → P in AAB31163 (PubMed:8024574).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76446 mRNA Translation: AAA35496.1
U03864 mRNA Translation: AAB60351.1
L31772 mRNA Translation: AAB59487.1
S70782 mRNA Translation: AAB31163.2
D29952 Genomic DNA Translation: BAA06222.1
AL121675 Genomic DNA No translation available.
AL357040 Genomic DNA No translation available.
CCDSiCCDS13079.1
PIRiI39369
JH0447
RefSeqiNP_000669.1, NM_000678.3
UniGeneiHs.557

Genome annotation databases

EnsembliENST00000379453; ENSP00000368766; ENSG00000171873
GeneIDi146
KEGGihsa:146
UCSCiuc002wkr.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76446 mRNA Translation: AAA35496.1
U03864 mRNA Translation: AAB60351.1
L31772 mRNA Translation: AAB59487.1
S70782 mRNA Translation: AAB31163.2
D29952 Genomic DNA Translation: BAA06222.1
AL121675 Genomic DNA No translation available.
AL357040 Genomic DNA No translation available.
CCDSiCCDS13079.1
PIRiI39369
JH0447
RefSeqiNP_000669.1, NM_000678.3
UniGeneiHs.557

3D structure databases

ProteinModelPortaliP25100
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106656, 13 interactors
IntActiP25100, 2 interactors
MINTiP25100
STRINGi9606.ENSP00000368766

Chemistry databases

BindingDBiP25100
ChEMBLiCHEMBL223
DrugBankiDB00346 Alfuzosin
DB00321 Amitriptyline
DB00543 Amoxapine
DB00182 Amphetamine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01136 Carvedilol
DB00477 Chlorpromazine
DB09202 Cirazoline
DB00575 Clonidine
DB00298 Dapiprazole
DB01151 Desipramine
DB00590 Doxazosin
DB01142 Doxepin
DB04855 Dronedarone
DB06262 Droxidopa
DB05492 Epicept NP-1
DB00668 Epinephrine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB00800 Fenoldopam
DB00458 Imipramine
DB00598 Labetalol
DB00934 Maprotiline
DB01365 Mephentermine
DB01403 Methotrimeprazine
DB00723 Methoxamine
DB06148 Mianserin
DB00211 Midodrine
DB00370 Mirtazapine
DB00622 Nicardipine
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00935 Oxymetazoline
DB01186 Pergolide
DB00925 Phenoxybenzamine
DB00388 Phenylephrine
DB00457 Prazosin
DB00420 Promazine
DB00777 Propiomazine
DB01224 Quetiapine
DB05469 R450
DB06144 Sertindole
DB06207 Silodosin
DB00706 Tamsulosin
DB01162 Terazosin
DB13025 Tiapride
DB06694 Xylometazoline
GuidetoPHARMACOLOGYi24

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25100
PhosphoSitePlusiP25100

Polymorphism and mutation databases

BioMutaiADRA1D
DMDMi1168243

Proteomic databases

PaxDbiP25100
PeptideAtlasiP25100
PRIDEiP25100
ProteomicsDBi54255

Protocols and materials databases

DNASUi146
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379453; ENSP00000368766; ENSG00000171873
GeneIDi146
KEGGihsa:146
UCSCiuc002wkr.3 human

Organism-specific databases

CTDi146
DisGeNETi146
EuPathDBiHostDB:ENSG00000171873.7
GeneCardsiADRA1D
HGNCiHGNC:280 ADRA1D
HPAiHPA038789
MIMi104219 gene
neXtProtiNX_P25100
OpenTargetsiENSG00000171873
PharmGKBiPA24597
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239244
HOVERGENiHBG106962
InParanoidiP25100
KOiK04137
OMAiGATCQAY
OrthoDBiEOG091G06VI
PhylomeDBiP25100
TreeFamiTF331895

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
SIGNORiP25100

Miscellaneous databases

ChiTaRSiADRA1D human
GeneWikiiAlpha-1D_adrenergic_receptor
GenomeRNAii146
PROiPR:P25100
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171873 Expressed in 92 organ(s), highest expression level in thoracic aorta
CleanExiHS_ADRA1A
HS_ADRA1D
ExpressionAtlasiP25100 baseline and differential
GenevisibleiP25100 HS

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000363 ADRA1D_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF14 PTHR24248:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00240 ADRENRGCA1DR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA1D_HUMAN
AccessioniPrimary (citable) accession number: P25100
Secondary accession number(s): Q9NPY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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