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UniProtKB - P25100 (ADA1D_HUMAN)

Entry version 173 (12 Aug 2020)
Sequence version 2 (01 Nov 1995)
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Protein

Alpha-1D adrenergic receptor

Gene

ADRA1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P25100

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390696, Adrenoceptors
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		P25100

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Short name:
Alpha-1D adrenoceptor
Alpha-adrenergic receptor 1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADRA1D
Synonyms:ADRA1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000171873.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:280, ADRA1D

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		104219, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P25100

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 95ExtracellularBy similarityAdd BLAST95
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei96 – 121Helical; Name=1By similarityAdd BLAST26
Topological domaini122 – 133CytoplasmicBy similarityAdd BLAST12
Transmembranei134 – 159Helical; Name=2By similarityAdd BLAST26
Topological domaini160 – 169ExtracellularBy similarity10
Transmembranei170 – 192Helical; Name=3By similarityAdd BLAST23
Topological domaini193 – 213CytoplasmicBy similarityAdd BLAST21
Transmembranei214 – 238Helical; Name=4By similarityAdd BLAST25
Topological domaini239 – 251ExtracellularBy similarityAdd BLAST13
Transmembranei252 – 275Helical; Name=5By similarityAdd BLAST24
Topological domaini276 – 348CytoplasmicBy similarityAdd BLAST73
Transmembranei349 – 373Helical; Name=6By similarityAdd BLAST25
Topological domaini374 – 380ExtracellularBy similarity7
Transmembranei381 – 405Helical; Name=7By similarityAdd BLAST25
Topological domaini406 – 572CytoplasmicBy similarityAdd BLAST167

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		146

Open Targets

More...OpenTargetsi		ENSG00000171873

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24597

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P25100, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL223

Drug and drug target database

More...DrugBanki		DB00346, Alfuzosin
DB00321, Amitriptyline
DB00543, Amoxapine
DB00182, Amphetamine
DB09229, Aranidipine
DB09204, Arotinolol
DB01200, Bromocriptine
DB00490, Buspirone
DB00248, Cabergoline
DB01136, Carvedilol
DB00477, Chlorpromazine
DB09202, Cirazoline
DB00575, Clonidine
DB00298, Dapiprazole
DB01151, Desipramine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB11278, DL-Methylephedrine
DB00841, Dobutamine
DB09167, Dosulepin
DB00590, Doxazosin
DB01142, Doxepin
DB04855, Dronedarone
DB06262, Droxidopa
DB05492, Epicept NP-1
DB00668, Epinephrine
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB01175, Escitalopram
DB09194, Etoperidone
DB00800, Fenoldopam
DB00458, Imipramine
DB11577, Indigotindisulfonic acid
DB00598, Labetalol
DB09195, Lorpiprazole
DB00934, Maprotiline
DB01365, Mephentermine
DB01403, Methotrimeprazine
DB00723, Methoxamine
DB06148, Mianserin
DB00211, Midodrine
DB00370, Mirtazapine
DB09205, Moxisylyte
DB00622, Nicardipine
DB00368, Norepinephrine
DB00540, Nortriptyline
DB06229, Ocaperidone
DB00935, Oxymetazoline
DB00715, Paroxetine
DB01186, Pergolide
DB08922, Perospirone
DB00925, Phenoxybenzamine
DB00692, Phentolamine
DB00388, Phenylephrine
DB09286, Pipamperone
DB06153, Pizotifen
DB00457, Prazosin
DB00433, Prochlorperazine
DB00420, Promazine
DB01069, Promethazine
DB00777, Propiomazine
DB01224, Quetiapine
DB00908, Quinidine
DB05469, R450
DB11124, Racepinephrine
DB00243, Ranolazine
DB00268, Ropinirole
DB06144, Sertindole
DB06207, Silodosin
DB09203, Synephrine
DB00706, Tamsulosin
DB01162, Terazosin
DB13025, Tiapride
DB00697, Tizanidine
DB00661, Verapamil
DB06694, Xylometazoline

DrugCentral

More...DrugCentrali		P25100

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		24

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADRA1D

Domain mapping of disease mutations (DMDM)

More...DMDMi		1168243

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000690731 – 572Alpha-1D adrenergic receptorAdd BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi419S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P25100

PeptideAtlas

More...PeptideAtlasi		P25100

PRoteomics IDEntifications database

More...PRIDEi		P25100

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54255

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P25100, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P25100

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P25100

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171873, Expressed in thoracic aorta and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P25100, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P25100, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000171873, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106656, 14 interactors

Protein interaction database and analysis system

More...IntActi		P25100, 29 interactors

Molecular INTeraction database

More...MINTi		P25100

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000368766

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P25100

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P25100, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi422 – 428Poly-Arg7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160795

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_6_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P25100

KEGG Orthology (KO)

More...KOi		K04137

Identification of Orthologs from Complete Genome Data

More...OMAi		GATCQAY

Database of Orthologous Groups

More...OrthoDBi		1095345at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P25100

TreeFam database of animal gene trees

More...TreeFami		TF331895

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002233, ADR_fam
IPR000363, ADRA1D_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...PANTHERi		PTHR24248:SF14, PTHR24248:SF14, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01103, ADRENERGICR
PR00240, ADRENRGCA1DR
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P25100-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA 
        60         70         80         90        100
GGGGGVVGAG SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG 
       110        120        130        140        150
VFLAAFILMA VAGNLLVILS VACNRHLQTV TNYFIVNLAV ADLLLSATVL 
       160        170        180        190        200
PFSATMEVLG FWAFGRAFCD VWAAVDVLCC TASILSLCTI SVDRYVGVRH 
       210        220        230        240        250
SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP PDERFCGITE 
       260        270        280        290        300
EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS 
       310        320        330        340        350
EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL 
       360        370        380        390        400
AIVVGVFVLC WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL 
       410        420        430        440        450
IYPCSSREFK RAFLRLLRCQ CRRRRRRRPL WRVYGHHWRA STSGLRQDCA 
       460        470        480        490        500
PSSGDAPPGA PLALTALPDP DPEPPGTPEM QAPVASRRKP PSAFREWRLL 
       510        520        530        540        550
GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE AVSLGVPHEV 
       560        570 
AEGATCQAYE LADYSNLRET DI
Length:572
Mass (Da):60,463
Last modified:November 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBEB134CF20A4988
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 83MTFRD…GDVNG → MAAALRSVMMAGYLSEWRTP TYRSTEMVQRLRMEAVQHST S (PubMed:1656955).CuratedAdd BLAST83
Sequence conflicti31S → G in AAB31163 (PubMed:8024574).Curated1
Sequence conflicti489 – 572KPPSA…RETDI → SHPAPSASGGCWGRSGDPRP SCAPKSPACRTRSPPGARSA QRQRAPSAQRWRLCP (PubMed:1656955).CuratedAdd BLAST84
Sequence conflicti522R → P in AAB31163 (PubMed:8024574).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M76446 mRNA Translation: AAA35496.1
U03864 mRNA Translation: AAB60351.1
L31772 mRNA Translation: AAB59487.1
S70782 mRNA Translation: AAB31163.2
D29952 Genomic DNA Translation: BAA06222.1
AL121675 Genomic DNA No translation available.
AL357040 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13079.1

Protein sequence database of the Protein Information Resource

More...PIRi		I39369
JH0447

NCBI Reference Sequences

More...RefSeqi		NP_000669.1, NM_000678.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000379453; ENSP00000368766; ENSG00000171873

Database of genes from NCBI RefSeq genomes

More...GeneIDi		146

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:146

UCSC genome browser

More...UCSCi		uc002wkr.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76446 mRNA Translation: AAA35496.1
U03864 mRNA Translation: AAB60351.1
L31772 mRNA Translation: AAB59487.1
S70782 mRNA Translation: AAB31163.2
D29952 Genomic DNA Translation: BAA06222.1
AL121675 Genomic DNA No translation available.
AL357040 Genomic DNA No translation available.
CCDSiCCDS13079.1
PIRiI39369
JH0447
RefSeqiNP_000669.1, NM_000678.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi106656, 14 interactors
IntActiP25100, 29 interactors
MINTiP25100
STRINGi9606.ENSP00000368766

Chemistry databases

BindingDBiP25100
ChEMBLiCHEMBL223
DrugBankiDB00346, Alfuzosin
DB00321, Amitriptyline
DB00543, Amoxapine
DB00182, Amphetamine
DB09229, Aranidipine
DB09204, Arotinolol
DB01200, Bromocriptine
DB00490, Buspirone
DB00248, Cabergoline
DB01136, Carvedilol
DB00477, Chlorpromazine
DB09202, Cirazoline
DB00575, Clonidine
DB00298, Dapiprazole
DB01151, Desipramine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB11278, DL-Methylephedrine
DB00841, Dobutamine
DB09167, Dosulepin
DB00590, Doxazosin
DB01142, Doxepin
DB04855, Dronedarone
DB06262, Droxidopa
DB05492, Epicept NP-1
DB00668, Epinephrine
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB01175, Escitalopram
DB09194, Etoperidone
DB00800, Fenoldopam
DB00458, Imipramine
DB11577, Indigotindisulfonic acid
DB00598, Labetalol
DB09195, Lorpiprazole
DB00934, Maprotiline
DB01365, Mephentermine
DB01403, Methotrimeprazine
DB00723, Methoxamine
DB06148, Mianserin
DB00211, Midodrine
DB00370, Mirtazapine
DB09205, Moxisylyte
DB00622, Nicardipine
DB00368, Norepinephrine
DB00540, Nortriptyline
DB06229, Ocaperidone
DB00935, Oxymetazoline
DB00715, Paroxetine
DB01186, Pergolide
DB08922, Perospirone
DB00925, Phenoxybenzamine
DB00692, Phentolamine
DB00388, Phenylephrine
DB09286, Pipamperone
DB06153, Pizotifen
DB00457, Prazosin
DB00433, Prochlorperazine
DB00420, Promazine
DB01069, Promethazine
DB00777, Propiomazine
DB01224, Quetiapine
DB00908, Quinidine
DB05469, R450
DB11124, Racepinephrine
DB00243, Ranolazine
DB00268, Ropinirole
DB06144, Sertindole
DB06207, Silodosin
DB09203, Synephrine
DB00706, Tamsulosin
DB01162, Terazosin
DB13025, Tiapride
DB00697, Tizanidine
DB00661, Verapamil
DB06694, Xylometazoline
DrugCentraliP25100
GuidetoPHARMACOLOGYi24

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP25100, 2 sites
iPTMnetiP25100
PhosphoSitePlusiP25100

Polymorphism and mutation databases

BioMutaiADRA1D
DMDMi1168243

Proteomic databases

PaxDbiP25100
PeptideAtlasiP25100
PRIDEiP25100
ProteomicsDBi54255

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7918, 153 antibodies

The DNASU plasmid repository

More...DNASUi		146

Genome annotation databases

EnsembliENST00000379453; ENSP00000368766; ENSG00000171873
GeneIDi146
KEGGihsa:146
UCSCiuc002wkr.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		146
DisGeNETi146
EuPathDBiHostDB:ENSG00000171873.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADRA1D
HGNCiHGNC:280, ADRA1D
HPAiENSG00000171873, Tissue enhanced (brain)
MIMi104219, gene
neXtProtiNX_P25100
OpenTargetsiENSG00000171873
PharmGKBiPA24597

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00940000160795
HOGENOMiCLU_009579_11_6_1
InParanoidiP25100
KOiK04137
OMAiGATCQAY
OrthoDBi1095345at2759
PhylomeDBiP25100
TreeFamiTF331895

Enzyme and pathway databases

PathwayCommonsiP25100
ReactomeiR-HSA-390696, Adrenoceptors
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events
SIGNORiP25100

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		146, 6 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADRA1D, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Alpha-1D_adrenergic_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		146
PharosiP25100, Tclin

Protein Ontology

More...PROi		PR:P25100
RNActiP25100, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171873, Expressed in thoracic aorta and 114 other tissues
ExpressionAtlasiP25100, baseline and differential
GenevisibleiP25100, HS

Family and domain databases

InterProiView protein in InterPro
IPR002233, ADR_fam
IPR000363, ADRA1D_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF14, PTHR24248:SF14, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR01103, ADRENERGICR
PR00240, ADRENRGCA1DR
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADA1D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25100
Secondary accession number(s): Q9NPY0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1995
Last modified: August 12, 2020
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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