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Protein

Adenosine receptor A1

Gene

Adora1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-417973 Adenosine P1 receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:Adora1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2048 Adora1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 33Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini34 – 46CytoplasmicSequence analysisAdd BLAST13
Transmembranei47 – 69Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini70 – 80ExtracellularSequence analysisAdd BLAST11
Transmembranei81 – 102Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 146Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini147 – 176ExtracellularSequence analysisAdd BLAST30
Transmembranei177 – 201Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini202 – 235CytoplasmicSequence analysisAdd BLAST34
Transmembranei236 – 259Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini260 – 267ExtracellularSequence analysis8
Transmembranei268 – 292Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini293 – 326CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL318
GuidetoPHARMACOLOGYi18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689941 – 326Adenosine receptor A1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi309S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP25099
PRIDEiP25099

PTM databases

iPTMnetiP25099
PhosphoSitePlusiP25099

Expressioni

Tissue specificityi

Widely expressed in brain and spinal cord.

Gene expression databases

BgeeiENSRNOG00000003442 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP25099 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247960, 2 interactors
IntActiP25099, 1 interactor
MINTiP25099
STRINGi10116.ENSRNOP00000004602

Chemistry databases

BindingDBiP25099

Structurei

3D structure databases

ProteinModelPortaliP25099
SMRiP25099
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP25099
KOiK04265
OMAiVWAVRIN
PhylomeDBiP25099
TreeFamiTF325296

Family and domain databases

InterProiView protein in InterPro
IPR001068 Adeno_A1_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00552 ADENOSINEA1R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25099-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKTVVT QRRAAVAIAG CWILSLVVGL TPMFGWNNLS
160 170 180 190 200
VVEQDWRANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL
310 320
KIWNDHFRCQ PKPPIDEDLP EEKAED
Length:326
Mass (Da):36,695
Last modified:November 1, 1997 - v2
Checksum:iE43785CA993CFF15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229 – 230EL → DV (PubMed:1658635).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69045 mRNA Translation: AAB07231.1
M64299 mRNA Translation: AAA74471.1
AB001089 mRNA Translation: BAA19231.1
AF042079 mRNA Translation: AAC03772.1
PIRiA40376
RefSeqiNP_058851.2, NM_017155.2
XP_006249921.1, XM_006249859.3
XP_006249923.1, XM_006249861.3
UniGeneiRn.32078

Genome annotation databases

EnsembliENSRNOT00000004602; ENSRNOP00000004602; ENSRNOG00000003442
ENSRNOT00000078993; ENSRNOP00000073958; ENSRNOG00000003442
GeneIDi29290
KEGGirno:29290
UCSCiRGD:2048 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69045 mRNA Translation: AAB07231.1
M64299 mRNA Translation: AAA74471.1
AB001089 mRNA Translation: BAA19231.1
AF042079 mRNA Translation: AAC03772.1
PIRiA40376
RefSeqiNP_058851.2, NM_017155.2
XP_006249921.1, XM_006249859.3
XP_006249923.1, XM_006249861.3
UniGeneiRn.32078

3D structure databases

ProteinModelPortaliP25099
SMRiP25099
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247960, 2 interactors
IntActiP25099, 1 interactor
MINTiP25099
STRINGi10116.ENSRNOP00000004602

Chemistry databases

BindingDBiP25099
ChEMBLiCHEMBL318
GuidetoPHARMACOLOGYi18

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25099
PhosphoSitePlusiP25099

Proteomic databases

PaxDbiP25099
PRIDEiP25099

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004602; ENSRNOP00000004602; ENSRNOG00000003442
ENSRNOT00000078993; ENSRNOP00000073958; ENSRNOG00000003442
GeneIDi29290
KEGGirno:29290
UCSCiRGD:2048 rat

Organism-specific databases

CTDi134
RGDi2048 Adora1

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP25099
KOiK04265
OMAiVWAVRIN
PhylomeDBiP25099
TreeFamiTF325296

Enzyme and pathway databases

ReactomeiR-RNO-417973 Adenosine P1 receptors
R-RNO-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:P25099

Gene expression databases

BgeeiENSRNOG00000003442 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP25099 RN

Family and domain databases

InterProiView protein in InterPro
IPR001068 Adeno_A1_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00552 ADENOSINEA1R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAA1R_RAT
AccessioniPrimary (citable) accession number: P25099
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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