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UniProtKB - P25099 (AA1R_RAT)
Protein
Adenosine receptor A1
Gene
Adora1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
GO - Molecular functioni
- G-protein beta/gamma-subunit complex binding Source: RGD
- G protein-coupled adenosine receptor activity Source: RGD
- G protein-coupled receptor binding Source: BHF-UCL
- heat shock protein binding Source: RGD
- heterotrimeric G-protein binding Source: RGD
- neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration Source: SynGO
- protein-containing complex binding Source: RGD
- protein heterodimerization activity Source: BHF-UCL
- purine nucleoside binding Source: RGD
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: RGD
- biomineralization Source: Ensembl
- cognition Source: RGD
- detection of temperature stimulus involved in sensory perception of pain Source: RGD
- excitatory postsynaptic potential Source: RGD
- fatty acid homeostasis Source: RGD
- G protein-coupled receptor signaling pathway Source: RGD
- lipid catabolic process Source: RGD
- negative regulation of acute inflammatory response Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of blood pressure Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of circadian sleep/wake cycle, non-REM sleep Source: RGD
- negative regulation of circadian sleep/wake cycle, sleep Source: RGD
- negative regulation of glutamate secretion Source: RGD
- negative regulation of heart contraction Source: RGD
- negative regulation of hormone secretion Source: RGD
- negative regulation of inflammatory response Source: RGD
- negative regulation of leukocyte migration Source: RGD
- negative regulation of lipid catabolic process Source: RGD
- negative regulation of long-term synaptic depression Source: RGD
- negative regulation of long-term synaptic potentiation Source: RGD
- negative regulation of mucus secretion Source: RGD
- negative regulation of neurotrophin production Source: RGD
- negative regulation of renal sodium excretion Source: RGD
- negative regulation of synaptic transmission, GABAergic Source: RGD
- negative regulation of synaptic transmission, glutamatergic Source: RGD
- negative regulation of systemic arterial blood pressure Source: RGD
- positive regulation of blood pressure Source: RGD
- positive regulation of epidermal growth factor-activated receptor activity Source: RGD
- positive regulation of lipid catabolic process Source: RGD
- positive regulation of MAPK cascade Source: RGD
- positive regulation of neuron death Source: RGD
- positive regulation of nucleoside transport Source: RGD
- positive regulation of peptide secretion Source: RGD
- positive regulation of potassium ion transport Source: RGD
- positive regulation of protein dephosphorylation Source: RGD
- positive regulation of systemic arterial blood pressure Source: RGD
- protein targeting to membrane Source: RGD
- regulation of cardiac muscle cell contraction Source: RGD
- regulation of cardiac muscle contraction Source: RGD
- regulation of glomerular filtration Source: RGD
- regulation of respiratory gaseous exchange by nervous system process Source: RGD
- regulation of sensory perception of pain Source: RGD
- relaxation of vascular associated smooth muscle Source: RGD
- response to hypoxia Source: RGD
- response to inorganic substance Source: RGD
- response to purine-containing compound Source: Ensembl
- temperature homeostasis Source: RGD
- triglyceride homeostasis Source: RGD
- vasodilation Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-417973, Adenosine P1 receptors R-RNO-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Adenosine receptor A1 |
Gene namesi | Name:Adora1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2048, Adora1 |
Subcellular locationi
Plasma membrane
Endoplasmic reticulum
- endoplasmic reticulum Source: RGD
Plasma Membrane
- axolemma Source: RGD
- basolateral plasma membrane Source: RGD
- integral component of postsynaptic membrane Source: SynGO-UCL
- integral component of presynaptic membrane Source: SynGO-UCL
- plasma membrane Source: RGD
- postsynaptic membrane Source: RGD
- presynaptic membrane Source: RGD
Other locations
- asymmetric synapse Source: RGD
- calyx of Held Source: SynGO
- cell body Source: BHF-UCL
- dendrite Source: BHF-UCL
- dendritic spine Source: RGD
- endomembrane system Source: RGD
- neuronal cell body Source: RGD
- postsynaptic density Source: RGD
- presynaptic active zone Source: RGD
- synapse Source: RGD
- terminal bouton Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | ExtracellularSequence analysis | 10 | |
Transmembranei | 11 – 33 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 34 – 46 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 47 – 69 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Topological domaini | 70 – 80 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 81 – 102 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 103 – 123 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 124 – 146 | Helical; Name=4Sequence analysisAdd BLAST | 23 | |
Topological domaini | 147 – 176 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 177 – 201 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 202 – 235 | CytoplasmicSequence analysisAdd BLAST | 34 | |
Transmembranei | 236 – 259 | Helical; Name=6Sequence analysisAdd BLAST | 24 | |
Topological domaini | 260 – 267 | ExtracellularSequence analysis | 8 | |
Transmembranei | 268 – 292 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 293 – 326 | CytoplasmicSequence analysisAdd BLAST | 34 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068994 | 1 – 326 | Adenosine receptor A1Add BLAST | 326 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 80 ↔ 169 | PROSITE-ProRule annotation | ||
Glycosylationi | 148 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 309 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P25099 |
PTM databases
GlyGeni | P25099, 2 sites |
iPTMneti | P25099 |
PhosphoSitePlusi | P25099 |
Expressioni
Tissue specificityi
Widely expressed in brain and spinal cord.
Gene expression databases
Bgeei | ENSRNOG00000003442, Expressed in brain and 21 other tissues |
Genevisiblei | P25099, RN |
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: BHF-UCL
- heat shock protein binding Source: RGD
- protein heterodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 247960, 2 interactors |
IntActi | P25099, 1 interactor |
MINTi | P25099 |
STRINGi | 10116.ENSRNOP00000004602 |
Chemistry databases
BindingDBi | P25099 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234555 |
HOGENOMi | CLU_009579_11_5_1 |
InParanoidi | P25099 |
OMAi | IWAVKMN |
OrthoDBi | 550297at2759 |
PhylomeDBi | P25099 |
TreeFami | TF325296 |
Family and domain databases
InterProi | View protein in InterPro IPR001068, Adeno_A1_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00552, ADENOSINEA1R PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P25099-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKTVVT QRRAAVAIAG CWILSLVVGL TPMFGWNNLS
160 170 180 190 200
VVEQDWRANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL
310 320
KIWNDHFRCQ PKPPIDEDLP EEKAED
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 229 – 230 | EL → DV (PubMed:1658635).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M69045 mRNA Translation: AAB07231.1 M64299 mRNA Translation: AAA74471.1 AB001089 mRNA Translation: BAA19231.1 AF042079 mRNA Translation: AAC03772.1 |
PIRi | A40376 |
RefSeqi | NP_058851.2, NM_017155.2 XP_006249921.1, XM_006249859.3 XP_006249923.1, XM_006249861.3 |
Genome annotation databases
Ensembli | ENSRNOT00000004602; ENSRNOP00000004602; ENSRNOG00000003442 |
GeneIDi | 29290 |
KEGGi | rno:29290 |
UCSCi | RGD:2048, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M69045 mRNA Translation: AAB07231.1 M64299 mRNA Translation: AAA74471.1 AB001089 mRNA Translation: BAA19231.1 AF042079 mRNA Translation: AAC03772.1 |
PIRi | A40376 |
RefSeqi | NP_058851.2, NM_017155.2 XP_006249921.1, XM_006249859.3 XP_006249923.1, XM_006249861.3 |
3D structure databases
AlphaFoldDBi | P25099 |
SMRi | P25099 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247960, 2 interactors |
IntActi | P25099, 1 interactor |
MINTi | P25099 |
STRINGi | 10116.ENSRNOP00000004602 |
Chemistry databases
BindingDBi | P25099 |
ChEMBLi | CHEMBL318 |
DrugCentrali | P25099 |
GuidetoPHARMACOLOGYi | 18 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P25099, 2 sites |
iPTMneti | P25099 |
PhosphoSitePlusi | P25099 |
Proteomic databases
PaxDbi | P25099 |
Protocols and materials databases
DNASUi | 29290 |
Genome annotation databases
Ensembli | ENSRNOT00000004602; ENSRNOP00000004602; ENSRNOG00000003442 |
GeneIDi | 29290 |
KEGGi | rno:29290 |
UCSCi | RGD:2048, rat |
Organism-specific databases
CTDi | 134 |
RGDi | 2048, Adora1 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234555 |
HOGENOMi | CLU_009579_11_5_1 |
InParanoidi | P25099 |
OMAi | IWAVKMN |
OrthoDBi | 550297at2759 |
PhylomeDBi | P25099 |
TreeFami | TF325296 |
Enzyme and pathway databases
Reactomei | R-RNO-417973, Adenosine P1 receptors R-RNO-418594, G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:P25099 |
Gene expression databases
Bgeei | ENSRNOG00000003442, Expressed in brain and 21 other tissues |
Genevisiblei | P25099, RN |
Family and domain databases
InterProi | View protein in InterPro IPR001068, Adeno_A1_rcpt IPR001634, Adenosn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00552, ADENOSINEA1R PR00424, ADENOSINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AA1R_RAT | |
Accessioni | P25099Primary (citable) accession number: P25099 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families