Adora1

Protein namesⁱ	Recommended name: Adenosine receptor A1
Gene namesⁱ	Name:Adora1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 13

Organism-specific databases

Rat genome database More...RGDⁱ	2048 Adora1

RGDⁱ

2048 Adora1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 10	ExtracellularSequence analysis	10
Transmembraneⁱ	11 – 33	Helical; Name=1Sequence analysisAdd BLAST	23
Topological domainⁱ	34 – 46	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	47 – 69	Helical; Name=2Sequence analysisAdd BLAST	23
Topological domainⁱ	70 – 80	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	81 – 102	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	103 – 123	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	124 – 146	Helical; Name=4Sequence analysisAdd BLAST	23
Topological domainⁱ	147 – 176	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	177 – 201	Helical; Name=5Sequence analysisAdd BLAST	25
Topological domainⁱ	202 – 235	CytoplasmicSequence analysisAdd BLAST	34
Transmembraneⁱ	236 – 259	Helical; Name=6Sequence analysisAdd BLAST	24
Topological domainⁱ	260 – 267	ExtracellularSequence analysis	8
Transmembraneⁱ	268 – 292	Helical; Name=7Sequence analysisAdd BLAST	25
Topological domainⁱ	293 – 326	CytoplasmicSequence analysisAdd BLAST	34

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL318
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	18

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068994	1 – 326	Adenosine receptor A1Add BLAST		326

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	80 ↔ 169	PROSITE-ProRule annotation
Glycosylationⁱ	148	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	159	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	309	S-palmitoyl cysteineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P25099
PRIDEⁱ	P25099

PTM databases

iPTMnetⁱ	P25099
PhosphoSitePlusⁱ	P25099

Expressionⁱ

Tissue specificityⁱ

Widely expressed in brain and spinal cord.

Gene expression databases

Bgeeⁱ	ENSRNOG00000003442 Expressed in 10 organ(s), highest expression level in brain
Genevisibleⁱ	P25099 RN

Interactionⁱ

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	247960, 2 interactors
IntActⁱ	P25099, 1 interactor
Molecular INTeraction database More...MINTⁱ	P25099
STRINGⁱ	10116.ENSRNOP00000004602

Chemistry databases

BindingDBⁱ

P25099

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P25099
SMRⁱ	P25099
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074524
HOGENOMⁱ	HOG000015770
HOVERGENⁱ	HBG106962
InParanoidⁱ	P25099
KEGG Orthology (KO) More...KOⁱ	K04265
OMAⁱ	VYAFRIH
PhylomeDBⁱ	P25099
TreeFamⁱ	TF325296

Family and domain databases

InterProⁱ	View protein in InterPro IPR001068 Adeno_A1_rcpt IPR001634 Adenosn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00552 ADENOSINEA1R PR00424 ADENOSINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P25099-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS 
        60         70         80         90        100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA 
       110        120        130        140        150
IAVDRYLRVK IPLRYKTVVT QRRAAVAIAG CWILSLVVGL TPMFGWNNLS 
       160        170        180        190        200
VVEQDWRANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY 
       210        220        230        240        250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL 
       260        270        280        290        300
HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL 
       310        320 
KIWNDHFRCQ PKPPIDEDLP EEKAED

Length:326

Mass (Da):36,695

Last modified:November 1, 1997 - v2

Checksum:ⁱE43785CA993CFF15

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	229 – 230	EL → DV (PubMed:1658635).Curated		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M69045 mRNA Translation: AAB07231.1 M64299 mRNA Translation: AAA74471.1 AB001089 mRNA Translation: BAA19231.1 AF042079 mRNA Translation: AAC03772.1
PIRⁱ	A40376
NCBI Reference Sequences More...RefSeqⁱ	NP_058851.2, NM_017155.2 XP_006249921.1, XM_006249859.3 XP_006249923.1, XM_006249861.3
UniGeneⁱ	Rn.32078

Genome annotation databases

Ensemblⁱ	ENSRNOT00000004602; ENSRNOP00000004602; ENSRNOG00000003442 ENSRNOT00000078993; ENSRNOP00000073958; ENSRNOG00000003442
GeneIDⁱ	29290
KEGGⁱ	rno:29290
UCSC genome browser More...UCSCⁱ	RGD:2048 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P25099	Adenosine receptor A1		RABIT		328	UniRef90_P25099
Adenosine receptor A1		BOVIN		326
Adenosine receptor A1		CANLF		326
Adenosine receptor A1		CAVPO		326
Adenosine receptor A1	)	HUMAN		326
+133

Protein	Similar proteins		Species	Score	Length	Source
P25099	Adenosine receptor A1		RABIT		328	UniRef50_P25099
Adenosine receptor A1		CAVPO		326
Adenosine receptor A1		BOVIN		326
Adenosine receptor A1		PONAB		326
Adenosine receptor A1		CANLF		326
+292

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M69045 mRNA Translation: AAB07231.1 M64299 mRNA Translation: AAA74471.1 AB001089 mRNA Translation: BAA19231.1 AF042079 mRNA Translation: AAC03772.1
PIRⁱ	A40376
RefSeqⁱ	NP_058851.2, NM_017155.2 XP_006249921.1, XM_006249859.3 XP_006249923.1, XM_006249861.3
UniGeneⁱ	Rn.32078

3D structure databases

ProteinModelPortalⁱ	P25099
SMRⁱ	P25099
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	247960, 2 interactors
IntActⁱ	P25099, 1 interactor
MINTⁱ	P25099
STRINGⁱ	10116.ENSRNOP00000004602

Chemistry databases

BindingDBⁱ	P25099
ChEMBLⁱ	CHEMBL318
GuidetoPHARMACOLOGYⁱ	18

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P25099
PhosphoSitePlusⁱ	P25099

Proteomic databases

PaxDbⁱ	P25099
PRIDEⁱ	P25099

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000004602; ENSRNOP00000004602; ENSRNOG00000003442 ENSRNOT00000078993; ENSRNOP00000073958; ENSRNOG00000003442
GeneIDⁱ	29290
KEGGⁱ	rno:29290
UCSCⁱ	RGD:2048 rat

Organism-specific databases

CTDⁱ	134
RGDⁱ	2048 Adora1

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00550000074524
HOGENOMⁱ	HOG000015770
HOVERGENⁱ	HBG106962
InParanoidⁱ	P25099
KOⁱ	K04265
OMAⁱ	VYAFRIH
PhylomeDBⁱ	P25099
TreeFamⁱ	TF325296

Enzyme and pathway databases

Reactomeⁱ	R-RNO-417973 Adenosine P1 receptors R-RNO-418594 G alpha (i) signalling events

Reactomeⁱ

R-RNO-417973 Adenosine P1 receptors
R-RNO-418594 G alpha (i) signalling events

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P25099

PROⁱ

PR:P25099

Gene expression databases

Bgeeⁱ	ENSRNOG00000003442 Expressed in 10 organ(s), highest expression level in brain
Genevisibleⁱ	P25099 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR001068 Adeno_A1_rcpt IPR001634 Adenosn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00552 ADENOSINEA1R PR00424 ADENOSINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AA1R_RAT
Accessionⁱ	P25099Primary (citable) accession number: P25099
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P25099 (AA1R_RAT)

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Adenosine receptor A1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ