Adenosine receptor A1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• G-protein beta/gamma-subunit complex binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling."
    Pankevych H., Korkhov V., Freissmuth M., Nanoff C.
    J. Biol. Chem. 278:30283-30293(2003) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled adenosine receptor activity Source: RGDInferred from direct assayⁱ
  • "Expression cloning of rat cerebellar adenosine A1 receptor by coupling to Kir channels."
    Pfaff T., Karschin A.
    Neuroreport 8:2455-2460(1997) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Heteromeric association creates a P2Y-like adenosine receptor."
    Yoshioka K., Saitoh O., Nakata H.
    Proc. Natl. Acad. Sci. U.S.A. 98:7617-7622(2001) [PubMed] [Europe PMC] [Abstract]
  • "Hetero-oligomerization of adenosine A1 receptors with P2Y1 receptors in rat brains."
    Yoshioka K., Hosoda R., Kuroda Y., Nakata H.
    FEBS Lett. 531:299-303(2002) [PubMed] [Europe PMC] [Abstract]
• heat shock protein binding Source: RGDInferred from physical interactionⁱ
  • "The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane."
    Sarrio S., Casado V., Escriche M., Ciruela F., Mallol J., Canela E.I., Lluis C., Franco R.
    Mol. Cell. Biol. 20:5164-5174(2000) [PubMed] [Europe PMC] [Abstract]
• heterotrimeric G-protein binding Source: RGDInferred from direct assayⁱ
  • "Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling."
    Pankevych H., Korkhov V., Freissmuth M., Nanoff C.
    J. Biol. Chem. 278:30283-30293(2003) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration Source: SynGOInferred from direct assayⁱ
  • "Adenosine A(1) receptor-mediated presynaptic inhibition at the calyx of Held of immature rats."
    Kimura M., Saitoh N., Takahashi T.
    J. Physiol. (Lond.) 553:415-426(2003) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • "Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers."
    Ciruela F., Casado V., Rodrigues R.J., Lujan R., Burgueno J., Canals M., Borycz J., Rebola N., Goldberg S.R., Mallol J., Cortes A., Canela E.I., Lopez-Gimenez J.F., Milligan G., Lluis C., Cunha R.A., Ferre S., Franco R.
    J. Neurosci. 26:2080-2087(2006) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "Heteromeric association creates a P2Y-like adenosine receptor."
    Yoshioka K., Saitoh O., Nakata H.
    Proc. Natl. Acad. Sci. U.S.A. 98:7617-7622(2001) [PubMed] [Europe PMC] [Abstract]
• purine nucleoside binding Source: RGDInferred from physical interactionⁱ
  • "Tonic activity of the rat adipocyte A1-adenosine receptor."
    Liang H.X., Belardinelli L., Ozeck M.J., Shryock J.C.
    Br. J. Pharmacol. 135:1457-1466(2002) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of MAPKK activity Source: RGDInferred from direct assayⁱ
  • "Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling."
    Pankevych H., Korkhov V., Freissmuth M., Nanoff C.
    J. Biol. Chem. 278:30283-30293(2003) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Adenosine-stimulated atrial natriuretic peptide release through A1 receptor subtype."
    Yuan K., Cao C., Han J.H., Kim S.Z., Kim S.H.
    Hypertension 46:1381-1387(2005) [PubMed] [Europe PMC] [Abstract]
• cognition Source: RGDInferred from mutant phenotypeⁱ
  • "Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder."
    Pires V.A., Pamplona F.A., Pandolfo P., Fernandes D., Prediger R.D., Takahashi R.N.
    Behav Pharmacol 20:134-145(2009) [PubMed] [Europe PMC] [Abstract]
• detection of temperature stimulus involved in sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • "Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats."
    Horiuchi H., Ogata T., Morino T., Yamamoto H.
    Spinal Cord 48:685-690(2010) [PubMed] [Europe PMC] [Abstract]
• excitatory postsynaptic potential Source: RGDInferred from mutant phenotypeⁱ
  • "Tumor necrosis factor-alpha impairs the recovery of synaptic transmission from hypoxia in rat hippocampal slices."
    Batti L., O'Connor J.J.
    J. Neuroimmunol. 218:21-27(2010) [PubMed] [Europe PMC] [Abstract]
• fatty acid homeostasis Source: RGDInferred from direct assayⁱ
  • "Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies."
    Schoelch C., Kuhlmann J., Gossel M., Mueller G., Neumann-Haefelin C., Belz U., Kalisch J., Biemer-Daub G., Kramer W., Juretschke H.P., Herling A.W.
    Diabetes 53:1920-1926(2004) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling."
    Pankevych H., Korkhov V., Freissmuth M., Nanoff C.
    J. Biol. Chem. 278:30283-30293(2003) [PubMed] [Europe PMC] [Abstract]
• lipid catabolic process Source: RGDInferred from mutant phenotypeⁱ
  • "Effects of adenosine A1 receptor antagonism on lipogenesis and lipolysis in isolated rat adipocytes."
    Szkudelski T., Szkudelska K., Nogowski L.
    Physiol Res 58:863-871(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of acute inflammatory response Source: RGDInferred from direct assayⁱ
  • "The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats."
    Schrier D.J., Lesch M.E., Wright C.D., Gilbertsen R.B.
    J. Immunol. 145:1874-1879(1990) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: RGDInferred from direct assayⁱ
  • "A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity."
    Regan S.E., Broad M., Byford A.M., Lankford A.R., Cerniway R.J., Mayo M.W., Matherne G.P.
    Am. J. Physiol. Heart Circ. Physiol. 284:H859-66(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of blood pressure Source: RGDInferred from mutant phenotypeⁱ
  • "The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat."
    Walsh M.P., Marshall J.M.
    J. Physiol. (Lond.) 575:277-289(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of blood vessel diameter Source: RGDInferred from direct assayⁱ
  • "Study of an adenosine A1 receptor agonist on trigeminally evoked dural blood vessel dilation in the anaesthetized rat."
    Honey A.C., Bland-Ward P.A., Connor H.E., Feniuk W., Humphrey P.P.
    Cephalalgia 22:260-264(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: RGDInferred from direct assayⁱ
  • "Adenosine-regulated cell proliferation in pituitary folliculostellate and endocrine cells: differential roles for the A(1) and A(2B) adenosine receptors."
    Rees D.A., Lewis M.D., Lewis B.M., Smith P.J., Scanlon M.F., Ham J.
    Endocrinology 143:2427-2436(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of circadian sleep/wake cycle, non-REM sleep Source: RGDInferred from mutant phenotypeⁱ
  • "The role of the basal forebrain adenosine receptors in sleep homeostasis."
    Gass N., Porkka-Heiskanen T., Kalinchuk A.V.
    Neuroreport 20:1013-1018(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of circadian sleep/wake cycle, sleep Source: RGDInferred from direct assayⁱ
  • "Effects on sleep of microdialysis of adenosine A1 and A2a receptor analogs into the lateral preoptic area of rats."
    Methippara M.M., Kumar S., Alam M.N., Szymusiak R., McGinty D.
    Am. J. Physiol. Regul. Integr. Comp. Physiol. 289:R1715-23(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of glutamate secretion Source: RGDInferred from direct assayⁱ
  • "Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers."
    Ciruela F., Casado V., Rodrigues R.J., Lujan R., Burgueno J., Canals M., Borycz J., Rebola N., Goldberg S.R., Mallol J., Cortes A., Canela E.I., Lopez-Gimenez J.F., Milligan G., Lluis C., Cunha R.A., Ferre S., Franco R.
    J. Neurosci. 26:2080-2087(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of heart contraction Source: RGDInferred from mutant phenotypeⁱ
  • "Adenosine-stimulated atrial natriuretic peptide release through A1 receptor subtype."
    Yuan K., Cao C., Han J.H., Kim S.Z., Kim S.H.
    Hypertension 46:1381-1387(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of hormone secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Role of adenosine A1 receptor in the regulation of gastrin release."
    Yip L., Leung H.C., Kwok Y.N.
    J. Pharmacol. Exp. Ther. 310:477-487(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response Source: RGDInferred from sequence orthologyⁱ
  • "A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury."
    Sun C.X., Young H.W., Molina J.G., Volmer J.B., Schnermann J., Blackburn M.R.
    J. Clin. Invest. 115:35-43(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of leukocyte migration Source: RGDInferred from sequence orthologyⁱ
  • "A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury."
    Sun C.X., Young H.W., Molina J.G., Volmer J.B., Schnermann J., Blackburn M.R.
    J. Clin. Invest. 115:35-43(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of lipid catabolic process Source: RGDInferred from direct assayⁱ
  • "Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies."
    Schoelch C., Kuhlmann J., Gossel M., Mueller G., Neumann-Haefelin C., Belz U., Kalisch J., Biemer-Daub G., Kramer W., Juretschke H.P., Herling A.W.
    Diabetes 53:1920-1926(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of long-term synaptic depression Source: RGDInferred from sequence orthologyⁱ
  • "Functional cooperation of metabotropic adenosine and glutamate receptors regulates postsynaptic plasticity in the cerebellum."
    Kamikubo Y., Shimomura T., Fujita Y., Tabata T., Kashiyama T., Sakurai T., Fukurotani K., Kano M.
    J. Neurosci. 33:18661-18671(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of long-term synaptic potentiation Source: RGDInferred from mutant phenotypeⁱ
  • "Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices."
    Almeida T., Rodrigues R.J., de Mendonca A., Ribeiro J.A., Cunha R.A.
    Neuroscience 122:111-121(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of mucus secretion Source: RGDInferred from sequence orthologyⁱ
  • "A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury."
    Sun C.X., Young H.W., Molina J.G., Volmer J.B., Schnermann J., Blackburn M.R.
    J. Clin. Invest. 115:35-43(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neurotrophin production Source: RGDInferred from mutant phenotypeⁱ
  • "Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus."
    Katoh-Semba R., Kaneko R., Kitajima S., Tsuzuki M., Ichisaka S., Hata Y., Yamada H., Miyazaki N., Takahashi Y., Kato K.
    Neuroscience 163:352-361(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of renal sodium excretion Source: RGDInferred from mutant phenotypeⁱ
  • "Effects of the adenosine A1 receptor inhibitor FK 838 on proximal tubular fluid output in rats."
    Bak M., Thomsen K.
    Nephrol. Dial. Transplant. 19:1077-1082(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of synaptic transmission, GABAergic Source: RGDInferred from mutant phenotypeⁱ
  • "Adenosine A1 receptor-mediated presynaptic inhibition of GABAergic transmission in immature rat hippocampal CA1 neurons."
    Jeong H.J., Jang I.S., Nabekura J., Akaike N.
    J. Neurophysiol. 89:1214-1222(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of synaptic transmission, glutamatergic Source: RGDInferred from direct assayⁱ
  • "Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers."
    Ciruela F., Casado V., Rodrigues R.J., Lujan R., Burgueno J., Canals M., Borycz J., Rebola N., Goldberg S.R., Mallol J., Cortes A., Canela E.I., Lopez-Gimenez J.F., Milligan G., Lluis C., Cunha R.A., Ferre S., Franco R.
    J. Neurosci. 26:2080-2087(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of systemic arterial blood pressure Source: RGDInferred from direct assayⁱ
  • "Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneously hypertensive rat complicated with hyperglycemia."
    Ishikawa J., Mitani H., Bandoh T., Kimura M., Totsuka T., Hayashi S.
    Diabetes Res. Clin. Pract. 39:3-9(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of blood pressure Source: RGDInferred from direct assayⁱ
  • "Mechanisms mediating regional sympathoactivatory responses to stimulation of NTS A(1) adenosine receptors."
    Scislo T.J., O'Leary D.S.
    Am. J. Physiol. Heart Circ. Physiol. 283:H1588-99(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epidermal growth factor-activated receptor activity Source: RGDInferred from mutant phenotypeⁱ
  • "Adenosine A(1) receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro."
    Xie K.Q., Zhang L.M., Cao Y., Zhu J., Feng L.Y.
    Acta Pharmacol. Sin. 30:889-898(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of lipid catabolic process Source: RGDInferred from direct assayⁱ
  • "Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneously hypertensive rat complicated with hyperglycemia."
    Ishikawa J., Mitani H., Bandoh T., Kimura M., Totsuka T., Hayashi S.
    Diabetes Res. Clin. Pract. 39:3-9(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron death Source: RGDInferred from direct assayⁱ
  • "A1 adenosine receptor activation induces ventriculomegaly and white matter loss."
    Turner C.P., Yan H., Schwartz M., Othman T., Rivkees S.A.
    Neuroreport 13:1199-1204(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of nucleoside transport Source: RGDInferred from direct assayⁱ
  • "ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors."
    Duflot S., Riera B., Fernandez-Veledo S., Casado V., Norman R.I., Casado F.J., Lluis C., Franco R., Pastor-Anglada M.
    Mol. Cell. Biol. 24:2710-2719(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptide secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Adenosine-stimulated atrial natriuretic peptide release through A1 receptor subtype."
    Yuan K., Cao C., Han J.H., Kim S.Z., Kim S.H.
    Hypertension 46:1381-1387(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of potassium ion transport Source: RGDInferred from direct assayⁱ
  • "Expression cloning of rat cerebellar adenosine A1 receptor by coupling to Kir channels."
    Pfaff T., Karschin A.
    Neuroreport 8:2455-2460(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein dephosphorylation Source: RGDInferred from direct assayⁱ
  • "Antiadrenergic effects of adenosine A(1) receptor-mediated protein phosphatase 2a activation in the heart."
    Liu Q., Hofmann P.A.
    Am. J. Physiol. Heart Circ. Physiol. 283:H1314-21(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of systemic arterial blood pressure Source: RGDInferred from mutant phenotypeⁱ
  • "A new adenosine subtype-1 receptor antagonist, FK-838, attenuates salt-induced hypertension in Dahl salt-sensitive rats."
    Uehara Y., Numabe A., Hirawa N., Kawabata Y., Nagoshi H., Kaneko H., Gomi T., Goto A., Toyo-oka T., Omata M.
    Am. J. Hypertens. 8:1189-1199(1995) [PubMed] [Europe PMC] [Abstract]
• protein targeting to membrane Source: RGDInferred from mutant phenotypeⁱ
  • "Adenosine A(1) receptors selectively target protein kinase C isoforms to the caveolin-rich plasma membrane in cardiac myocytes."
    Yang Z., Sun W., Hu K.
    Biochim. Biophys. Acta 1793:1868-1875(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of cardiac muscle cell contraction Source: RGDInferred from direct assayⁱ
  • "Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse."
    Fenton R.A., Komatsu S., Ikebe M., Shea L.G., Dobson J.G. Jr.
    Am. J. Physiol. Heart Circ. Physiol. 297:H718-25(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of cardiac muscle contraction Source: RGDInferred from mutant phenotypeⁱ
  • "[Adenosine induces ventricular arrythmias in hearts with chronic chagas cardiomyopathy]."
    Alvarado-Tapias E., Rivas-Coppola M., Alvarado A., Bello M., Briceno M., Rodriguez-Bonfante C., Bonfante-Cabarcas R.
    Rev Esp Cardiol 63:478-482(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of glomerular filtration Source: RGDInferred from sequence orthologyⁱ
  • "Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR."
    Hashimoto S., Huang Y., Mizel D., Briggs J., Schnermann J.
    Acta Physiol. Scand. 181:455-462(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of respiratory gaseous exchange by nervous system process Source: RGDInferred from mutant phenotypeⁱ
  • "Respiratory and body temperature modulation by adenosine A1 receptors in the anteroventral preoptic region during normoxia and hypoxia."
    Barros R.C., Branco L.G., Carnio E.C.
    Respir Physiol Neurobiol 153:115-125(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of sensory perception of pain Source: RGDInferred from sequence orthologyⁱ
  • "Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine."
    Zylka M.J., Sowa N.A., Taylor-Blake B., Twomey M.A., Herrala A., Voikar V., Vihko P.
    Neuron 60:111-122(2008) [PubMed] [Europe PMC] [Abstract]
  • "Secretion and N-linked glycosylation are required for prostatic acid phosphatase catalytic and antinociceptive activity."
    Hurt J.K., Fitzpatrick B.J., Norris-Drouin J., Zylka M.J.
    PLoS ONE 7:e32741-e32741(2012) [PubMed] [Europe PMC] [Abstract]
• relaxation of vascular smooth muscle Source: RGDInferred from mutant phenotypeⁱ
  • "Contribution of NO, ATP-sensitive K+ channels and prostaglandins to adenosine receptor agonists-induced relaxation of the rat tail artery."
    Kedzior K., Szczepanska R., Kocic I.
    Pharmacol Rep 61:330-334(2009) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: RGDInferred from mutant phenotypeⁱ
  • "The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat."
    Walsh M.P., Marshall J.M.
    J. Physiol. (Lond.) 575:277-289(2006) [PubMed] [Europe PMC] [Abstract]
• temperature homeostasis Source: RGDInferred from mutant phenotypeⁱ
  • "Respiratory and body temperature modulation by adenosine A1 receptors in the anteroventral preoptic region during normoxia and hypoxia."
    Barros R.C., Branco L.G., Carnio E.C.
    Respir Physiol Neurobiol 153:115-125(2006) [PubMed] [Europe PMC] [Abstract]
• triglyceride homeostasis Source: RGDInferred from direct assayⁱ
  • "Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies."
    Schoelch C., Kuhlmann J., Gossel M., Mueller G., Neumann-Haefelin C., Belz U., Kalisch J., Biemer-Daub G., Kramer W., Juretschke H.P., Herling A.W.
    Diabetes 53:1920-1926(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• G protein-coupled receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Heteromeric association creates a P2Y-like adenosine receptor."
    Yoshioka K., Saitoh O., Nakata H.
    Proc. Natl. Acad. Sci. U.S.A. 98:7617-7622(2001) [PubMed] [Europe PMC] [Abstract]
  • "Hetero-oligomerization of adenosine A1 receptors with P2Y1 receptors in rat brains."
    Yoshioka K., Hosoda R., Kuroda Y., Nakata H.
    FEBS Lett. 531:299-303(2002) [PubMed] [Europe PMC] [Abstract]
• heat shock protein binding Source: RGDInferred from physical interactionⁱ
  • "The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane."
    Sarrio S., Casado V., Escriche M., Ciruela F., Mallol J., Canela E.I., Lluis C., Franco R.
    Mol. Cell. Biol. 20:5164-5174(2000) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "Heteromeric association creates a P2Y-like adenosine receptor."
    Yoshioka K., Saitoh O., Nakata H.
    Proc. Natl. Acad. Sci. U.S.A. 98:7617-7622(2001) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS 
        60         70         80         90        100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA 
       110        120        130        140        150
IAVDRYLRVK IPLRYKTVVT QRRAAVAIAG CWILSLVVGL TPMFGWNNLS 
       160        170        180        190        200
VVEQDWRANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY 
       210        220        230        240        250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL 
       260        270        280        290        300
HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL 
       310        320 
KIWNDHFRCQ PKPPIDEDLP EEKAED                           

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries