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UniProtKB - P25092 (GUC2C_HUMAN)

Entry version 201 (02 Dec 2020)
Sequence version 2 (02 Nov 2010)
Previous versions | rss
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Protein

Heat-stable enterotoxin receptor

Gene

GUCY2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Receptor
Biological processcGMP biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		4.6.1.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P25092

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8935690, Digestion
R-HSA-8942233, Intestinal infectious diseases

SIGNOR Signaling Network Open Resource

More...SIGNORi		P25092

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.85.1.1, the guanylate cyclase (gc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heat-stable enterotoxin receptor (EC:4.6.1.2)
Short name:
STA receptor
Short name:
hSTAR
Alternative name(s):
Guanylyl cyclase C
Short name:
GC-C
Intestinal guanylate cyclase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GUCY2C
Synonyms:GUC2C, STAR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000070019.4

Human Gene Nomenclature Database

More...HGNCi		HGNC:4688, GUCY2C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601330, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P25092

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 430ExtracellularSequence analysisAdd BLAST407
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei431 – 454HelicalSequence analysisAdd BLAST24
Topological domaini455 – 1073CytoplasmicSequence analysisAdd BLAST619

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diarrhea 6 (DIAR6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA relatively mild, early-onset chronic diarrhea that may be associated with increased susceptibility to inflammatory bowel disease, small bowel obstruction, and esophagitis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067724840S → I in DIAR6; activating mutation; exposure of the mutant receptor to its ligands results in markedly increased production of cyclic guanosine monophosphate. 1 PublicationCorresponds to variant dbSNP:rs587776871EnsemblClinVar.1
Meconium ileus (MECIL)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by intestinal obstruction due to inspissated meconium in the distal ileum and cecum, which develops in utero and presents shortly after birth as a failure to pass meconium. Meconium ileus is a known clinical manifestation of cystic fibrosis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068174387D → G in MECIL; activation of guanylate cyclase activity is 60% lower than in wild-type. 1 PublicationCorresponds to variant dbSNP:rs587776905EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		2984

MalaCards human disease database

More...MalaCardsi		GUCY2C
MIMi614616, phenotype
614665, phenotype

Open Targets

More...OpenTargetsi		ENSG00000070019

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		314373, Chronic infantile diarrhea due to guanylate cyclase 2C overactivity
103908, Congenital sodium diarrhea
314376, Intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29069

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P25092, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1795197

Drug and drug target database

More...DrugBanki		DB08890, Linaclotide

DrugCentral

More...DrugCentrali		P25092

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1750

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GUCY2C

Domain mapping of disease mutations (DMDM)

More...DMDMi		311033390

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001237624 – 1073Heat-stable enterotoxin receptorAdd BLAST1050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi32N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi75N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi79N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi195N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi284N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi307N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi345N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi402N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GC-C activation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei357Not glycosylated1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P25092

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P25092

MaxQB - The MaxQuant DataBase

More...MaxQBi		P25092

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P25092

PeptideAtlas

More...PeptideAtlasi		P25092

PRoteomics IDEntifications database

More...PRIDEi		P25092

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54253

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P25092, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P25092

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P25092

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000070019, Expressed in jejunal mucosa and 87 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P25092, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000070019, Tissue enriched (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

Interacts via its C-terminal region with PDZK2.

Interacts with the lectin chaperone VIP36.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109239, 2 interactors

Protein interaction database and analysis system

More...IntActi		P25092, 3 interactors

Molecular INTeraction database

More...MINTi		P25092

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261170

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P25092, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini489 – 749Protein kinasePROSITE-ProRule annotationAdd BLAST261
Domaini824 – 954Guanylate cyclasePROSITE-ProRule annotationAdd BLAST131

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain is predicted to be catalytically inactive.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1023, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155955

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001072_1_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P25092

Identification of Orthologs from Complete Genome Data

More...OMAi		VMCGGPE

Database of Orthologous Groups

More...OrthoDBi		229634at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P25092

Family and domain databases

Conserved Domains Database

More...CDDi		cd14044, PK_GC-C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.1230, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR042822, GC-C_PK
IPR011009, Kinase-like_dom_sf
IPR029787, Nucleotide_cyclase
IPR028082, Peripla_BP_I
IPR000719, Prot_kinase_dom
IPR001245, Ser-Thr/Tyr_kinase_cat_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00211, Guanylate_cyc, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00044, CYCc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53822, SSF53822, 1 hit
SSF55073, SSF55073, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P25092-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLLLDLAL WSLLFQPGWL SFSSQVSQNC HNGSYEISVL MMGNSAFAEP 
        60         70         80         90        100
LKNLEDAVNE GLEIVRGRLQ NAGLNVTVNA TFMYSDGLIH NSGDCRSSTC 
       110        120        130        140        150
EGLDLLRKIS NAQRMGCVLI GPSCTYSTFQ MYLDTELSYP MISAGSFGLS 
       160        170        180        190        200
CDYKETLTRL MSPARKLMYF LVNFWKTNDL PFKTYSWSTS YVYKNGTETE 
       210        220        230        240        250
DCFWYLNALE ASVSYFSHEL GFKVVLRQDK EFQDILMDHN RKSNVIIMCG 
       260        270        280        290        300
GPEFLYKLKG DRAVAEDIVI ILVDLFNDQY FEDNVTAPDY MKNVLVLTLS 
       310        320        330        340        350
PGNSLLNSSF SRNLSPTKRD FALAYLNGIL LFGHMLKIFL ENGENITTPK 
       360        370        380        390        400
FAHAFRNLTF EGYDGPVTLD DWGDVDSTMV LLYTSVDTKK YKVLLTYDTH 
       410        420        430        440        450
VNKTYPVDMS PTFTWKNSKL PNDITGRGPQ ILMIAVFTLT GAVVLLLLVA 
       460        470        480        490        500
LLMLRKYRKD YELRQKKWSH IPPENIFPLE TNETNHVSLK IDDDKRRDTI 
       510        520        530        540        550
QRLRQCKYDK KRVILKDLKH NDGNFTEKQK IELNKLLQID YYNLTKFYGT 
       560        570        580        590        600
VKLDTMIFGV IEYCERGSLR EVLNDTISYP DGTFMDWEFK ISVLYDIAKG 
       610        620        630        640        650
MSYLHSSKTE VHGRLKSTNC VVDSRMVVKI TDFGCNSILP PKKDLWTAPE 
       660        670        680        690        700
HLRQANISQK GDVYSYGIIA QEIILRKETF YTLSCRDRNE KIFRVENSNG 
       710        720        730        740        750
MKPFRPDLFL ETAEEKELEV YLLVKNCWEE DPEKRPDFKK IETTLAKIFG 
       760        770        780        790        800
LFHDQKNESY MDTLIRRLQL YSRNLEHLVE ERTQLYKAER DRADRLNFML 
       810        820        830        840        850
LPRLVVKSLK EKGFVEPELY EEVTIYFSDI VGFTTICKYS TPMEVVDMLN 
       860        870        880        890        900
DIYKSFDHIV DHHDVYKVET IGDAYMVASG LPKRNGNRHA IDIAKMALEI 
       910        920        930        940        950
LSFMGTFELE HLPGLPIWIR IGVHSGPCAA GVVGIKMPRY CLFGDTVNTA 
       960        970        980        990       1000
SRMESTGLPL RIHVSGSTIA ILKRTECQFL YEVRGETYLK GRGNETTYWL 
      1010       1020       1030       1040       1050
TGMKDQKFNL PTPPTVENQQ RLQAEFSDMI ANSLQKRQAA GIRSQKPRRV 
      1060       1070 
ASYKKGTLEY LQLNTTDKES TYF
Length:1,073
Mass (Da):123,403
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i486A4DE6F9097E22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti322A → R in AAB19934 (PubMed:1718270).Curated1
Sequence conflicti331L → V in AAB19934 (PubMed:1718270).Curated1
Sequence conflicti509D → V in AAB19934 (PubMed:1718270).Curated1
Sequence conflicti543N → T in AAB19934 (PubMed:1718270).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04222130C → R1 PublicationCorresponds to variant dbSNP:rs56142849Ensembl.1
Natural variantiVAR_04222261G → R in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_042223114R → Q1 PublicationCorresponds to variant dbSNP:rs56275235EnsemblClinVar.1
Natural variantiVAR_049253281F → L5 PublicationsCorresponds to variant dbSNP:rs1420635Ensembl.1
Natural variantiVAR_068174387D → G in MECIL; activation of guanylate cyclase activity is 60% lower than in wild-type. 1 PublicationCorresponds to variant dbSNP:rs587776905EnsemblClinVar.1
Natural variantiVAR_042224464R → L1 PublicationCorresponds to variant dbSNP:rs55684775Ensembl.1
Natural variantiVAR_042225610E → K1 PublicationCorresponds to variant dbSNP:rs55897626Ensembl.1
Natural variantiVAR_067724840S → I in DIAR6; activating mutation; exposure of the mutant receptor to its ligands results in markedly increased production of cyclic guanosine monophosphate. 1 PublicationCorresponds to variant dbSNP:rs587776871EnsemblClinVar.1
Natural variantiVAR_042226859I → V1 PublicationCorresponds to variant dbSNP:rs34890806Ensembl.1
Natural variantiVAR_0422271045Q → R1 PublicationCorresponds to variant dbSNP:rs35617837Ensembl.1
Natural variantiVAR_0422281072Y → C1 PublicationCorresponds to variant dbSNP:rs35179392EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S57551 mRNA Translation: AAB19934.2
M73489 mRNA Translation: AAA36655.1
AC007545 Genomic DNA No translation available.
AC010168 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96324.1
BC136544 mRNA Translation: AAI36545.1
BC136545 mRNA Translation: AAI36546.1
U20230 Genomic DNA Translation: AAC50381.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8664.1

Protein sequence database of the Protein Information Resource

More...PIRi		A40940, OYHUHX

NCBI Reference Sequences

More...RefSeqi		NP_004954.2, NM_004963.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261170; ENSP00000261170; ENSG00000070019

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2984

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2984

UCSC genome browser

More...UCSCi		uc001rcd.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S57551 mRNA Translation: AAB19934.2
M73489 mRNA Translation: AAA36655.1
AC007545 Genomic DNA No translation available.
AC010168 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96324.1
BC136544 mRNA Translation: AAI36545.1
BC136545 mRNA Translation: AAI36546.1
U20230 Genomic DNA Translation: AAC50381.1
CCDSiCCDS8664.1
PIRiA40940, OYHUHX
RefSeqiNP_004954.2, NM_004963.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi109239, 2 interactors
IntActiP25092, 3 interactors
MINTiP25092
STRINGi9606.ENSP00000261170

Chemistry databases

ChEMBLiCHEMBL1795197
DrugBankiDB08890, Linaclotide
DrugCentraliP25092
GuidetoPHARMACOLOGYi1750

Protein family/group databases

TCDBi8.A.85.1.1, the guanylate cyclase (gc) family

PTM databases

GlyGeniP25092, 8 sites
iPTMnetiP25092
PhosphoSitePlusiP25092

Polymorphism and mutation databases

BioMutaiGUCY2C
DMDMi311033390

Proteomic databases

jPOSTiP25092
MassIVEiP25092
MaxQBiP25092
PaxDbiP25092
PeptideAtlasiP25092
PRIDEiP25092
ProteomicsDBi54253

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P25092, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12046, 253 antibodies

The DNASU plasmid repository

More...DNASUi		2984

Genome annotation databases

EnsembliENST00000261170; ENSP00000261170; ENSG00000070019
GeneIDi2984
KEGGihsa:2984
UCSCiuc001rcd.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2984
DisGeNETi2984
EuPathDBiHostDB:ENSG00000070019.4

GeneCards: human genes, protein and diseases

More...GeneCardsi		GUCY2C
HGNCiHGNC:4688, GUCY2C
HPAiENSG00000070019, Tissue enriched (intestine)
MalaCardsiGUCY2C
MIMi601330, gene
614616, phenotype
614665, phenotype
neXtProtiNX_P25092
OpenTargetsiENSG00000070019
Orphaneti314373, Chronic infantile diarrhea due to guanylate cyclase 2C overactivity
103908, Congenital sodium diarrhea
314376, Intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency
PharmGKBiPA29069

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1023, Eukaryota
GeneTreeiENSGT00940000155955
HOGENOMiCLU_001072_1_3_1
InParanoidiP25092
OMAiVMCGGPE
OrthoDBi229634at2759
PhylomeDBiP25092

Enzyme and pathway databases

BRENDAi4.6.1.2, 2681
PathwayCommonsiP25092
ReactomeiR-HSA-8935690, Digestion
R-HSA-8942233, Intestinal infectious diseases
SIGNORiP25092

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2984, 2 hits in 847 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GUCY2C, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Guanylate_cyclase_2C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2984
PharosiP25092, Tclin

Protein Ontology

More...PROi		PR:P25092
RNActiP25092, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000070019, Expressed in jejunal mucosa and 87 other tissues
GenevisibleiP25092, HS

Family and domain databases

CDDicd14044, PK_GC-C, 1 hit
Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054, A/G_cyclase
IPR018297, A/G_cyclase_CS
IPR042822, GC-C_PK
IPR011009, Kinase-like_dom_sf
IPR029787, Nucleotide_cyclase
IPR028082, Peripla_BP_I
IPR000719, Prot_kinase_dom
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF00211, Guanylate_cyc, 1 hit
PF07714, PK_Tyr_Ser-Thr, 1 hit
SMARTiView protein in SMART
SM00044, CYCc, 1 hit
SUPFAMiSSF53822, SSF53822, 1 hit
SSF55073, SSF55073, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00452, GUANYLATE_CYCLASE_1, 1 hit
PS50125, GUANYLATE_CYCLASE_2, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGUC2C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25092
Secondary accession number(s): B2RMY6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: November 2, 2010
Last modified: December 2, 2020
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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