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Protein

N-formyl peptide receptor 2

Gene

FPR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).By similarity2 Publications

GO - Molecular functioni

  • cargo receptor activity Source: ARUK-UCL
  • G protein-coupled receptor activity Source: GO_Central
  • N-formyl peptide receptor activity Source: GO_Central
  • scavenger receptor binding Source: ARUK-UCL

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-6798695 Neutrophil degranulation
SIGNORiP25090

Names & Taxonomyi

Protein namesi
Recommended name:
N-formyl peptide receptor 2
Alternative name(s):
FMLP-related receptor I
Short name:
FMLP-R-I
Formyl peptide receptor-like 1
HM63
Lipoxin A4 receptor
Short name:
LXA4 receptor
RFP
Gene namesi
Name:FPR2
Synonyms:FPRH1, FPRL1, LXA4R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171049.8
HGNCiHGNC:3827 FPR2
MIMi136538 gene
neXtProtiNX_P25090

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 50Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini51 – 61CytoplasmicSequence analysisAdd BLAST11
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 100ExtracellularSequence analysisAdd BLAST17
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 162Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini163 – 205ExtracellularSequence analysisAdd BLAST43
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 242CytoplasmicSequence analysisAdd BLAST16
Transmembranei243 – 266Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini267 – 286ExtracellularSequence analysisAdd BLAST20
Transmembranei287 – 306Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini307 – 351CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2358
OpenTargetsiENSG00000171049
PharmGKBiPA162388901

Chemistry databases

ChEMBLiCHEMBL4227
GuidetoPHARMACOLOGYi223

Polymorphism and mutation databases

BioMutaiFPR2
DMDMi399504

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694511 – 351N-formyl peptide receptor 2Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25090
PeptideAtlasiP25090
PRIDEiP25090
ProteomicsDBi54252
TopDownProteomicsiP25090

PTM databases

iPTMnetiP25090
PhosphoSitePlusiP25090

Expressioni

Tissue specificityi

Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.1 Publication

Gene expression databases

BgeeiENSG00000171049 Expressed in 103 organ(s), highest expression level in blood
CleanExiHS_FPR2
ExpressionAtlasiP25090 baseline and differential
GenevisibleiP25090 HS

Organism-specific databases

HPAiHPA029154

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108641, 77 interactors
IntActiP25090, 3 interactors
STRINGi9606.ENSP00000340191

Chemistry databases

BindingDBiP25090

Structurei

3D structure databases

ProteinModelPortaliP25090
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0H Eukaryota
ENOG410YB48 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG107927
InParanoidiP25090
KOiK04173
OMAiYCTFNFA
OrthoDBiEOG091G09ZK
PhylomeDBiP25090
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR027347 Formyl_pep_2/3_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PTHR24225:SF16 PTHR24225:SF16, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P25090-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METNFSTPLN EYEEVSYESA GYTVLRILPL VVLGVTFVLG VLGNGLVIWV
60 70 80 90 100
AGFRMTRTVT TICYLNLALA DFSFTATLPF LIVSMAMGEK WPFGWFLCKL
110 120 130 140 150
IHIVVDINLF GSVFLIGFIA LDRCICVLHP VWAQNHRTVS LAMKVIVGPW
160 170 180 190 200
ILALVLTLPV FLFLTTVTIP NGDTYCTFNF ASWGGTPEER LKVAITMLTA
210 220 230 240 250
RGIIRFVIGF SLPMSIVAIC YGLIAAKIHK KGMIKSSRPL RVLTAVVASF
260 270 280 290 300
FICWFPFQLV ALLGTVWLKE MLFYGKYKII DILVNPTSSL AFFNSCLNPM
310 320 330 340 350
LYVFVGQDFR ERLIHSLPTS LERALSEDSA PTNDTAANSA SPPAETELQA

M
Length:351
Mass (Da):38,964
Last modified:July 1, 1993 - v2
Checksum:iDC6A1D77AFC0D780
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXD3M0QXD3_HUMAN
N-formyl peptide receptor 2
FPR2
136Annotation score:
M0R222M0R222_HUMAN
N-formyl peptide receptor 2
FPR2
124Annotation score:
M0QZ89M0QZ89_HUMAN
N-formyl peptide receptor 2
FPR2
88Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti339S → C in AAA58481 (PubMed:1612600).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76672 mRNA Translation: AAA58481.1
X63819 mRNA Translation: CAA45319.1
M88107 mRNA Translation: AAA60070.1
M84562 mRNA Translation: AAA52473.1
D10922 mRNA Translation: BAA01720.1
U81501 mRNA Translation: AAB51133.1
AF054013 mRNA Translation: AAC13684.1
AY225226 Genomic DNA Translation: AAO67711.1
AK290557 mRNA Translation: BAF83246.1
AC018755 Genomic DNA Translation: AAF87844.1
CH471135 Genomic DNA Translation: EAW72043.1
BC029125 mRNA Translation: AAH29125.1
BC071722 mRNA Translation: AAH71722.1
CCDSiCCDS12840.1
PIRiB42009
RefSeqiNP_001005738.1, NM_001005738.1
NP_001453.1, NM_001462.3
XP_006723183.1, XM_006723120.3
XP_016882031.1, XM_017026542.1
UniGeneiHs.99855

Genome annotation databases

EnsembliENST00000340023; ENSP00000340191; ENSG00000171049
ENST00000598776; ENSP00000468897; ENSG00000171049
ENST00000598953; ENSP00000468876; ENSG00000171049
GeneIDi2358
KEGGihsa:2358
UCSCiuc002pxr.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76672 mRNA Translation: AAA58481.1
X63819 mRNA Translation: CAA45319.1
M88107 mRNA Translation: AAA60070.1
M84562 mRNA Translation: AAA52473.1
D10922 mRNA Translation: BAA01720.1
U81501 mRNA Translation: AAB51133.1
AF054013 mRNA Translation: AAC13684.1
AY225226 Genomic DNA Translation: AAO67711.1
AK290557 mRNA Translation: BAF83246.1
AC018755 Genomic DNA Translation: AAF87844.1
CH471135 Genomic DNA Translation: EAW72043.1
BC029125 mRNA Translation: AAH29125.1
BC071722 mRNA Translation: AAH71722.1
CCDSiCCDS12840.1
PIRiB42009
RefSeqiNP_001005738.1, NM_001005738.1
NP_001453.1, NM_001462.3
XP_006723183.1, XM_006723120.3
XP_016882031.1, XM_017026542.1
UniGeneiHs.99855

3D structure databases

ProteinModelPortaliP25090
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108641, 77 interactors
IntActiP25090, 3 interactors
STRINGi9606.ENSP00000340191

Chemistry databases

BindingDBiP25090
ChEMBLiCHEMBL4227
GuidetoPHARMACOLOGYi223

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25090
PhosphoSitePlusiP25090

Polymorphism and mutation databases

BioMutaiFPR2
DMDMi399504

Proteomic databases

PaxDbiP25090
PeptideAtlasiP25090
PRIDEiP25090
ProteomicsDBi54252
TopDownProteomicsiP25090

Protocols and materials databases

DNASUi2358
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340023; ENSP00000340191; ENSG00000171049
ENST00000598776; ENSP00000468897; ENSG00000171049
ENST00000598953; ENSP00000468876; ENSG00000171049
GeneIDi2358
KEGGihsa:2358
UCSCiuc002pxr.4 human

Organism-specific databases

CTDi2358
DisGeNETi2358
EuPathDBiHostDB:ENSG00000171049.8
GeneCardsiFPR2
HGNCiHGNC:3827 FPR2
HPAiHPA029154
MIMi136538 gene
neXtProtiNX_P25090
OpenTargetsiENSG00000171049
PharmGKBiPA162388901
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0H Eukaryota
ENOG410YB48 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG107927
InParanoidiP25090
KOiK04173
OMAiYCTFNFA
OrthoDBiEOG091G09ZK
PhylomeDBiP25090
TreeFamiTF330976

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-6798695 Neutrophil degranulation
SIGNORiP25090

Miscellaneous databases

GeneWikiiFormyl_peptide_receptor_2
GenomeRNAii2358
PROiPR:P25090
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171049 Expressed in 103 organ(s), highest expression level in blood
CleanExiHS_FPR2
ExpressionAtlasiP25090 baseline and differential
GenevisibleiP25090 HS

Family and domain databases

InterProiView protein in InterPro
IPR027347 Formyl_pep_2/3_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PTHR24225:SF16 PTHR24225:SF16, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFPR2_HUMAN
AccessioniPrimary (citable) accession number: P25090
Secondary accession number(s): A8K3E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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