UniProtKB - P25090 (FPR2_HUMAN)
Protein
N-formyl peptide receptor 2
Gene
FPR2
Organism
Homo sapiens (Human)
Status
Functioni
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).By similarity2 Publications
GO - Molecular functioni
- amyloid-beta binding Source: ARUK-UCL
- cargo receptor activity Source: ARUK-UCL
- complement receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
- N-formyl peptide receptor activity Source: GO_Central
- scavenger receptor binding Source: ARUK-UCL
- signaling receptor activity Source: ARUK-UCL
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: ARUK-UCL
- astrocyte activation Source: ARUK-UCL
- calcium-mediated signaling Source: ARUK-UCL
- cell adhesion Source: ProtInc
- cell surface receptor signaling pathway Source: ARUK-UCL
- cellular response to amyloid-beta Source: ARUK-UCL
- chemotaxis Source: ProtInc
- complement receptor mediated signaling pathway Source: GO_Central
- defense response to bacterium Source: ARUK-UCL
- G protein-coupled receptor signaling pathway Source: ARUK-UCL
- immune response-regulating cell surface receptor signaling pathway Source: ARUK-UCL
- inflammatory response Source: GO_Central
- microglial cell activation Source: ARUK-UCL
- negative regulation of inflammatory response Source: ARUK-UCL
- neutrophil degranulation Source: Reactome
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
- positive chemotaxis Source: ARUK-UCL
- positive regulation of 1-phosphatidylinositol-3-kinase activity Source: ARUK-UCL
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
- positive regulation of innate immune response Source: ARUK-UCL
- positive regulation of monocyte chemotaxis Source: ARUK-UCL
- positive regulation of phagocytosis Source: ARUK-UCL
- positive regulation of protein phosphorylation Source: ARUK-UCL
- positive regulation of superoxide anion generation Source: ARUK-UCL
- receptor-mediated endocytosis Source: ARUK-UCL
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Chemotaxis |
Enzyme and pathway databases
PathwayCommonsi | P25090 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-444473, Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-6798695, Neutrophil degranulation |
SIGNORi | P25090 |
Names & Taxonomyi
Protein namesi | Recommended name: N-formyl peptide receptor 2Alternative name(s): FMLP-related receptor I Short name: FMLP-R-I Formyl peptide receptor-like 1 HM63 Lipoxin A4 receptor Short name: LXA4 receptor RFP |
Gene namesi | Name:FPR2 Synonyms:FPRH1, FPRL1, LXA4R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171049.8 |
HGNCi | HGNC:3827, FPR2 |
MIMi | 136538, gene |
neXtProti | NX_P25090 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein
Note: Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized.1 Publication
Plasma Membrane
- plasma membrane Source: ARUK-UCL
Other locations
- cytoplasm Source: ARUK-UCL
- ficolin-1-rich granule membrane Source: Reactome
- integral component of membrane Source: ProtInc
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 50 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 51 – 61 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 62 – 83 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 84 – 100 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 101 – 121 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 122 – 140 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 141 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 163 – 205 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 206 – 226 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 227 – 242 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 243 – 266 | Helical; Name=6Sequence analysisAdd BLAST | 24 | |
Topological domaini | 267 – 286 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 287 – 306 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 307 – 351 | CytoplasmicSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2358 |
OpenTargetsi | ENSG00000171049 |
PharmGKBi | PA162388901 |
Miscellaneous databases
Pharosi | P25090, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4227 |
GuidetoPHARMACOLOGYi | 223 |
Polymorphism and mutation databases
BioMutai | FPR2 |
DMDMi | 399504 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069451 | 1 – 351 | N-formyl peptide receptor 2Add BLAST | 351 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 98 ↔ 176 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P25090 |
MassIVEi | P25090 |
PaxDbi | P25090 |
PeptideAtlasi | P25090 |
PRIDEi | P25090 |
ProteomicsDBi | 54252 |
TopDownProteomicsi | P25090 |
PTM databases
GlyGeni | P25090, 1 site |
iPTMneti | P25090 |
PhosphoSitePlusi | P25090 |
Expressioni
Tissue specificityi
Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000171049, Expressed in blood and 120 other tissues |
ExpressionAtlasi | P25090, baseline and differential |
Genevisiblei | P25090, HS |
Organism-specific databases
HPAi | ENSG00000171049, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with Amyloid-beta protein 42, product of APP; the interaction takes place at the cell surface and the complex is then rapidly internalized.
1 Publication(Microbial infection) Interacts with Staphylococcus aureus protein SSL13; this interaction leads to the activation of neutrophils.
1 PublicationBinary interactionsi
Hide detailsP25090
With | #Exp. | IntAct |
---|---|---|
APOD [P05090] | 3 | EBI-17291771,EBI-715495 |
FXYD6 [Q9H0Q3] | 3 | EBI-17291771,EBI-713304 |
LRRC25 [Q8N386] | 3 | EBI-17291771,EBI-11304917 |
SSMEM1 [Q8WWF3] | 3 | EBI-17291771,EBI-17280858 |
GO - Molecular functioni
- scavenger receptor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 108641, 81 interactors |
IntActi | P25090, 75 interactors |
STRINGi | 9606.ENSP00000468897 |
Chemistry databases
BindingDBi | P25090 |
Miscellaneous databases
RNActi | P25090, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P25090 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222346 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | P25090 |
OMAi | PNGDTYC |
OrthoDBi | 910274at2759 |
PhylomeDBi | P25090 |
TreeFami | TF330976 |
Family and domain databases
InterProi | View protein in InterPro IPR027347, Formyl_pep_2/3_rcpt IPR000826, Formyl_rcpt-rel IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24225, PTHR24225, 1 hit PTHR24225:SF16, PTHR24225:SF16, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P25090-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METNFSTPLN EYEEVSYESA GYTVLRILPL VVLGVTFVLG VLGNGLVIWV
60 70 80 90 100
AGFRMTRTVT TICYLNLALA DFSFTATLPF LIVSMAMGEK WPFGWFLCKL
110 120 130 140 150
IHIVVDINLF GSVFLIGFIA LDRCICVLHP VWAQNHRTVS LAMKVIVGPW
160 170 180 190 200
ILALVLTLPV FLFLTTVTIP NGDTYCTFNF ASWGGTPEER LKVAITMLTA
210 220 230 240 250
RGIIRFVIGF SLPMSIVAIC YGLIAAKIHK KGMIKSSRPL RVLTAVVASF
260 270 280 290 300
FICWFPFQLV ALLGTVWLKE MLFYGKYKII DILVNPTSSL AFFNSCLNPM
310 320 330 340 350
LYVFVGQDFR ERLIHSLPTS LERALSEDSA PTNDTAANSA SPPAETELQA
M
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QXD3 | M0QXD3_HUMAN | N-formyl peptide receptor 2 | FPR2 | 136 | Annotation score: | ||
M0QZ89 | M0QZ89_HUMAN | N-formyl peptide receptor 2 | FPR2 | 88 | Annotation score: | ||
M0R222 | M0R222_HUMAN | N-formyl peptide receptor 2 | FPR2 | 124 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 339 | S → C in AAA58481 (PubMed:1612600).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M76672 mRNA Translation: AAA58481.1 X63819 mRNA Translation: CAA45319.1 M88107 mRNA Translation: AAA60070.1 M84562 mRNA Translation: AAA52473.1 D10922 mRNA Translation: BAA01720.1 U81501 mRNA Translation: AAB51133.1 AF054013 mRNA Translation: AAC13684.1 AY225226 Genomic DNA Translation: AAO67711.1 AK290557 mRNA Translation: BAF83246.1 AC018755 Genomic DNA Translation: AAF87844.1 CH471135 Genomic DNA Translation: EAW72043.1 BC029125 mRNA Translation: AAH29125.1 BC071722 mRNA Translation: AAH71722.1 |
CCDSi | CCDS12840.1 |
PIRi | B42009 |
RefSeqi | NP_001005738.1, NM_001005738.1 NP_001453.1, NM_001462.3 XP_006723183.1, XM_006723120.3 XP_016882031.1, XM_017026542.1 |
Genome annotation databases
Ensembli | ENST00000340023; ENSP00000340191; ENSG00000171049 ENST00000598776; ENSP00000468897; ENSG00000171049 ENST00000598953; ENSP00000468876; ENSG00000171049 |
GeneIDi | 2358 |
KEGGi | hsa:2358 |
UCSCi | uc002pxr.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M76672 mRNA Translation: AAA58481.1 X63819 mRNA Translation: CAA45319.1 M88107 mRNA Translation: AAA60070.1 M84562 mRNA Translation: AAA52473.1 D10922 mRNA Translation: BAA01720.1 U81501 mRNA Translation: AAB51133.1 AF054013 mRNA Translation: AAC13684.1 AY225226 Genomic DNA Translation: AAO67711.1 AK290557 mRNA Translation: BAF83246.1 AC018755 Genomic DNA Translation: AAF87844.1 CH471135 Genomic DNA Translation: EAW72043.1 BC029125 mRNA Translation: AAH29125.1 BC071722 mRNA Translation: AAH71722.1 |
CCDSi | CCDS12840.1 |
PIRi | B42009 |
RefSeqi | NP_001005738.1, NM_001005738.1 NP_001453.1, NM_001462.3 XP_006723183.1, XM_006723120.3 XP_016882031.1, XM_017026542.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6LW5 | X-ray | 2.80 | A | 3-322 | [»] | |
6OMM | electron microscopy | 3.17 | R | 1-342 | [»] | |
SMRi | P25090 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108641, 81 interactors |
IntActi | P25090, 75 interactors |
STRINGi | 9606.ENSP00000468897 |
Chemistry databases
BindingDBi | P25090 |
ChEMBLi | CHEMBL4227 |
GuidetoPHARMACOLOGYi | 223 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P25090, 1 site |
iPTMneti | P25090 |
PhosphoSitePlusi | P25090 |
Polymorphism and mutation databases
BioMutai | FPR2 |
DMDMi | 399504 |
Proteomic databases
jPOSTi | P25090 |
MassIVEi | P25090 |
PaxDbi | P25090 |
PeptideAtlasi | P25090 |
PRIDEi | P25090 |
ProteomicsDBi | 54252 |
TopDownProteomicsi | P25090 |
Protocols and materials databases
Antibodypediai | 19050, 395 antibodies |
DNASUi | 2358 |
Genome annotation databases
Ensembli | ENST00000340023; ENSP00000340191; ENSG00000171049 ENST00000598776; ENSP00000468897; ENSG00000171049 ENST00000598953; ENSP00000468876; ENSG00000171049 |
GeneIDi | 2358 |
KEGGi | hsa:2358 |
UCSCi | uc002pxr.4, human |
Organism-specific databases
CTDi | 2358 |
DisGeNETi | 2358 |
EuPathDBi | HostDB:ENSG00000171049.8 |
GeneCardsi | FPR2 |
HGNCi | HGNC:3827, FPR2 |
HPAi | ENSG00000171049, Group enriched (blood, lymphoid tissue) |
MIMi | 136538, gene |
neXtProti | NX_P25090 |
OpenTargetsi | ENSG00000171049 |
PharmGKBi | PA162388901 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222346 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | P25090 |
OMAi | PNGDTYC |
OrthoDBi | 910274at2759 |
PhylomeDBi | P25090 |
TreeFami | TF330976 |
Enzyme and pathway databases
PathwayCommonsi | P25090 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-444473, Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-6798695, Neutrophil degranulation |
SIGNORi | P25090 |
Miscellaneous databases
BioGRID-ORCSi | 2358, 3 hits in 841 CRISPR screens |
GeneWikii | Formyl_peptide_receptor_2 |
GenomeRNAii | 2358 |
Pharosi | P25090, Tchem |
PROi | PR:P25090 |
RNActi | P25090, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171049, Expressed in blood and 120 other tissues |
ExpressionAtlasi | P25090, baseline and differential |
Genevisiblei | P25090, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027347, Formyl_pep_2/3_rcpt IPR000826, Formyl_rcpt-rel IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24225, PTHR24225, 1 hit PTHR24225:SF16, PTHR24225:SF16, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FPR2_HUMAN | |
Accessioni | P25090Primary (citable) accession number: P25090 Secondary accession number(s): A8K3E2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 184 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries