Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-1 receptor antagonist protein

Gene

Il1rn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-1, type I receptor binding Source: RGD
  • interleukin-1 receptor antagonist activity Source: InterPro
  • interleukin-1 receptor binding Source: RGD

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor antagonist protein
Short name:
IL-1RN
Short name:
IL-1ra
Short name:
IRAP
Alternative name(s):
IL1 inhibitor
Gene namesi
Name:Il1rn
Synonyms:Il-1ra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621159 Il1rn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000001533327 – 178Interleukin-1 receptor antagonist proteinAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi92 ↔ 142By similarity
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25086
PRIDEiP25086

Expressioni

Gene expression databases

GenevisibleiP25086 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007949

Structurei

3D structure databases

ProteinModelPortaliP25086
SMRiP25086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZQ4 Eukaryota
ENOG41119SQ LUCA
HOGENOMiHOG000231506
HOVERGENiHBG052099
InParanoidiP25086
KOiK05481
OrthoDBiEOG091G0PWA
PhylomeDBiP25086
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR008996 IL1/FGF
IPR039348 IL1RA
PANTHERiPTHR45042 PTHR45042, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01360 INTRLEUKIN1X
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P25086-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEICRGPYSH LISLLLILLF RSESAGHPAG KRPCKMQAFR IWDTNQKTFY
60 70 80 90 100
LRNNQLIAGY LQGPNTKLEE KIDMVPIDFR NVFLGIHGGK LCLSCVKSGD
110 120 130 140 150
DTKLQLEEVN ITDLNKNKEE DKRFTFIRSE TGPTTSFESL ACPGWFLCTT
160 170
LEADHPVSLT NTPKEPCTVT KFYFQEDQ
Length:178
Mass (Da):20,282
Last modified:May 1, 1992 - v1
Checksum:iF3A5754FB6C51B03
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UHE2A0A0H2UHE2_RAT
Interleukin-1
Il1rn rCG_45371
159Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63101 Genomic DNA Translation: AAA41434.1
BC070930 mRNA Translation: AAH70930.1
PIRiC40956
RefSeqiNP_071530.1, NM_022194.2
UniGeneiRn.162640

Genome annotation databases

GeneIDi60582
KEGGirno:60582
UCSCiRGD:621159 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63101 Genomic DNA Translation: AAA41434.1
BC070930 mRNA Translation: AAH70930.1
PIRiC40956
RefSeqiNP_071530.1, NM_022194.2
UniGeneiRn.162640

3D structure databases

ProteinModelPortaliP25086
SMRiP25086
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007949

Proteomic databases

PaxDbiP25086
PRIDEiP25086

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi60582
KEGGirno:60582
UCSCiRGD:621159 rat

Organism-specific databases

CTDi3557
RGDi621159 Il1rn

Phylogenomic databases

eggNOGiENOG410IZQ4 Eukaryota
ENOG41119SQ LUCA
HOGENOMiHOG000231506
HOVERGENiHBG052099
InParanoidiP25086
KOiK05481
OrthoDBiEOG091G0PWA
PhylomeDBiP25086
TreeFamiTF300203

Miscellaneous databases

PROiPR:P25086

Gene expression databases

GenevisibleiP25086 RN

Family and domain databases

InterProiView protein in InterPro
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003297 IL-1RA/IL-36
IPR008996 IL1/FGF
IPR039348 IL1RA
PANTHERiPTHR45042 PTHR45042, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01360 INTRLEUKIN1X
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL1RA_RAT
AccessioniPrimary (citable) accession number: P25086
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again