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Protein

Signal transducer CD24

Gene

CD24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein tyrosine kinase activator activity Source: UniProtKB

GO - Biological processi

  • B cell receptor transport into membrane raft Source: UniProtKB
  • cell activation Source: UniProtKB
  • cell-cell adhesion Source: UniProtKB
  • cell migration Source: UniProtKB
  • chemokine receptor transport out of membrane raft Source: UniProtKB
  • cholesterol homeostasis Source: UniProtKB
  • glomerular parietal epithelial cell differentiation Source: UniProtKB
  • glomerular visceral epithelial cell differentiation Source: UniProtKB
  • immune response-regulating cell surface receptor signaling pathway Source: UniProtKB
  • intrinsic apoptotic signaling pathway Source: UniProtKB
  • negative regulation of transforming growth factor beta3 production Source: UniProtKB
  • positive regulation of activated T cell proliferation Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of MAP kinase activity Source: UniProtKB
  • positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  • regulation of cytokine-mediated signaling pathway Source: UniProtKB
  • regulation of epithelial cell differentiation Source: UniProtKB
  • regulation of MAPK cascade Source: UniProtKB
  • regulation of phosphorylation Source: UniProtKB
  • respiratory burst Source: UniProtKB
  • response to estrogen Source: UniProtKB
  • response to hypoxia Source: UniProtKB
  • response to molecule of bacterial origin Source: UniProtKB
  • T cell costimulation Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-373760 L1CAM interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer CD24
Alternative name(s):
Small cell lung carcinoma cluster 4 antigen
CD_antigen: CD24
Gene namesi
Name:CD24
Synonyms:CD24A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000272398.5
HGNCiHGNC:1645 CD24
MIMi600074 gene
neXtProtiNX_P25063

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Multiple sclerosis (MS)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
See also OMIM:126200

Organism-specific databases

DisGeNETi100133941
MIMi126200 phenotype
OpenTargetsiENSG00000272398
Orphaneti802 Multiple sclerosis
PharmGKBiPA26202

Polymorphism and mutation databases

BioMutaiCD24

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PeptideiPRO_000002089327 – 59Signal transducer CD24Add BLAST33
PropeptideiPRO_000002089460 – 80Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi59GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

Extensively O-glycosylated.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PeptideAtlasiP25063
PRIDEiP25063
ProteomicsDBi54249

Expressioni

Tissue specificityi

B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.2 Publications

Inductioni

Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.

Gene expression databases

CleanExiHS_CD24

Organism-specific databases

HPAiHPA045879

Interactioni

Subunit structurei

Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K-562 and in Burkitt's lymphoma.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LYNP079486EBI-6267018,EBI-79452

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107372, 4 interactors
IntActiP25063, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP25063
SMRiP25063
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD24 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000018829
InParanoidiP25063
KOiK06469
OMAiQTSVAPF

Family and domain databases

InterProiView protein in InterPro
IPR028029 CD24
PANTHERiPTHR16676 PTHR16676, 1 hit
PfamiView protein in Pfam
PF14984 CD24, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P25063-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRAMVARLG LGLLLLALLL PTQIYSSETT TGTSSNSSQS TSNSGLAPNP
60 70 80
TNATTKAAGG ALQSTASLFV VSLSLLHLYS
Length:80
Mass (Da):8,083
Last modified:March 28, 2018 - v3
Checksum:iDB1988B6808F833F
GO
Isoform 2 (identifier: P25063-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGRAMVARLGLGLLLLALLLPTQ → MVGRFCPESP...ETLAGAGAKK

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:129
Mass (Da):12,968
Checksum:iFA759EECF3DBF2F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12G → W in AAD14170 (PubMed:7959762).Curated1
Sequence conflicti27 – 28SE → R in AFJ05147 (PubMed:26444008).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03157644S → T1 Publication1
Natural variantiVAR_01615657A → V May be associated with an increased risk for multiple sclerosis; homozygous patients express higher levels of CD24 on peripheral blood T-cells than homozygous controls. 3 PublicationsCorresponds to variant dbSNP:rs878859113Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0593591 – 23MGRAM…LLPTQ → MVGRFCPESPPGFVRVAATS AVSLDPPSGEPRPGCGYPGP RSAASRVYGCTAPARETGGW AWETLAGAGAKK in isoform 2. Add BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58664 mRNA Translation: AAA35665.1
L33930 mRNA Translation: AAB58807.1
X69397 mRNA Translation: CAA49195.1
FJ226006 Genomic DNA Translation: ACI46150.1
JN036721 Genomic DNA Translation: AFJ05147.1
BT007404 mRNA Translation: AAP36068.1
FP885534 Genomic DNA No translation available.
DA518957 mRNA No translation available.
BC064619 mRNA Translation: AAH64619.1
S75311 mRNA Translation: AAD14170.1
CCDSiCCDS75499.1 [P25063-1]
CCDS78166.1 [P25063-2]
PIRiI56114 A48996
RefSeqiNP_001278666.1, NM_001291737.1 [P25063-1]
NP_001278667.1, NM_001291738.1 [P25063-1]
NP_001278668.1, NM_001291739.1 [P25063-2]
NP_037362.1, NM_013230.3 [P25063-1]
UniGeneiHs.644105
Hs.712050

Genome annotation databases

EnsembliENST00000606017; ENSP00000475625; ENSG00000272398 [P25063-1]
ENST00000610952; ENSP00000483838; ENSG00000272398 [P25063-1]
ENST00000619133; ENSP00000483985; ENSG00000272398 [P25063-1]
ENST00000622315; ENSP00000481841; ENSG00000272398 [P25063-2]
GeneIDi100133941
KEGGihsa:100133941
UCSCiuc032xhb.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD24_HUMAN
AccessioniPrimary (citable) accession number: P25063
Secondary accession number(s): A0A087WYI6
, B6EC88, Q16257, Q53XS0, R4I4T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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