UniProtKB - P25042 (ROX1_YEAST)
Protein
Repressor ROX1
Gene
ROX1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Transcription factor that represses the expression of HEM13, COX5B, ANB1, CYC7 or AAC3 (hypoxic function). Binds to the DNA sequence 5'-RRRTAACAAGAG-3'.
Miscellaneous
Present with 238 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 10 – 83 | HMG boxPROSITE-ProRule annotationAdd BLAST | 74 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: SGD
- DNA binding, bending Source: SGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: SGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: SGD
- transcription corepressor activity Source: SGD
GO - Biological processi
- cellular response to osmotic stress Source: SGD
- negative regulation of transcription by RNA polymerase II Source: SGD
- negative regulation of transcription from RNA polymerase II promoter in response to stress Source: SGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Repressor ROX1Alternative name(s): Heme-dependent repression factor Hypoxic function repressor |
Gene namesi | Name:ROX1 Ordered Locus Names:YPR065W ORF Names:YP9499.20 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006269, ROX1 |
VEuPathDBi | FungiDB:YPR065W |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048574 | 1 – 368 | Repressor ROX1Add BLAST | 368 |
Proteomic databases
MaxQBi | P25042 |
PaxDbi | P25042 |
PRIDEi | P25042 |
PTM databases
iPTMneti | P25042 |
Expressioni
Inductioni
By heme.
Interactioni
Protein-protein interaction databases
BioGRIDi | 36237, 209 interactors |
DIPi | DIP-4651N |
IntActi | P25042, 10 interactors |
MINTi | P25042 |
STRINGi | 4932.YPR065W |
Miscellaneous databases
RNActi | P25042, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 102 – 123 | Gln-richAdd BLAST | 22 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
HOGENOMi | CLU_752616_0_0_1 |
InParanoidi | P25042 |
OMAi | XNSINNS |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P25042-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPKSSTPKI PRPKNAFILF RQHYHRILID EWTAQGVEIP HNSNISKIIG
60 70 80 90 100
TKWKGLQPED KAHWENLAEK EKLEHERKYP EYKYKPVRKS KKKQLLLKEI
110 120 130 140 150
EQQQQQQQKE QQQQKQSQPQ LQQPFNNNIV LMKRAHSLSP SSSVSSSNSY
160 170 180 190 200
QFQLNNDLKR LPIPSVNTSN YMVSRSLSGL PLTHDKTARD LPQLSSQLNS
210 220 230 240 250
IPYYSAPHDP STRHHYLNVA QAQPRANSTP QLPFISSIIN NSSQTPVTTT
260 270 280 290 300
TTSTTTATSS PGKFSSSPNS SVLENNRLNS INNSNQYLPP PLLPSLQDFQ
310 320 330 340 350
LDQYQQLKQM GPTYIVKPLS HTRNNLLSTT TPTHHHIPHI PNQNIPLHQI
360
INSSNTEVTA KTSLVSPK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60458 Genomic DNA Translation: CAA42991.1 Z49219 Genomic DNA Translation: CAA89182.1 Z71255 Genomic DNA Translation: CAA94973.1 BK006949 Genomic DNA Translation: DAA11485.1 |
PIRi | A54430 |
RefSeqi | NP_015390.1, NM_001184162.1 |
Genome annotation databases
EnsemblFungii | YPR065W_mRNA; YPR065W; YPR065W |
GeneIDi | 856178 |
KEGGi | sce:YPR065W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60458 Genomic DNA Translation: CAA42991.1 Z49219 Genomic DNA Translation: CAA89182.1 Z71255 Genomic DNA Translation: CAA94973.1 BK006949 Genomic DNA Translation: DAA11485.1 |
PIRi | A54430 |
RefSeqi | NP_015390.1, NM_001184162.1 |
3D structure databases
SMRi | P25042 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36237, 209 interactors |
DIPi | DIP-4651N |
IntActi | P25042, 10 interactors |
MINTi | P25042 |
STRINGi | 4932.YPR065W |
PTM databases
iPTMneti | P25042 |
Proteomic databases
MaxQBi | P25042 |
PaxDbi | P25042 |
PRIDEi | P25042 |
Genome annotation databases
EnsemblFungii | YPR065W_mRNA; YPR065W; YPR065W |
GeneIDi | 856178 |
KEGGi | sce:YPR065W |
Organism-specific databases
SGDi | S000006269, ROX1 |
VEuPathDBi | FungiDB:YPR065W |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
HOGENOMi | CLU_752616_0_0_1 |
InParanoidi | P25042 |
OMAi | XNSINNS |
Miscellaneous databases
PROi | PR:P25042 |
RNActi | P25042, protein |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ROX1_YEAST | |
Accessioni | P25042Primary (citable) accession number: P25042 Secondary accession number(s): D6W469 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names