Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-X-C chemokine receptor type 2

Gene

CXCR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

GO - Molecular functioni

  • C-C chemokine binding Source: GO_Central
  • C-C chemokine receptor activity Source: GO_Central
  • chemokine binding Source: GO_Central
  • C-X-C chemokine receptor activity Source: UniProtKB
  • G protein-coupled receptor activity Source: UniProtKB
  • interleukin-8 binding Source: UniProtKB
  • interleukin-8 receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP25025
SIGNORiP25025

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
CDw128b
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name:
IL-8R B
IL-8 receptor type 2
CD_antigen: CD182
Gene namesi
Name:CXCR2
Synonyms:IL8RB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000180871.7
HGNCiHGNC:6027 CXCR2
MIMi146928 gene
neXtProtiNX_P25025

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 75Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini76 – 84CytoplasmicSequence analysis9
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini106 – 120ExtracellularSequence analysisAdd BLAST15
Transmembranei121 – 142Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini143 – 163CytoplasmicSequence analysisAdd BLAST21
Transmembranei164 – 183Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini184 – 208ExtracellularSequence analysisAdd BLAST25
Transmembranei209 – 231Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini232 – 251CytoplasmicSequence analysisAdd BLAST20
Transmembranei252 – 273Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini274 – 294ExtracellularSequence analysisAdd BLAST21
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 360CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3579
MalaCardsiCXCR2
OpenTargetsiENSG00000180871
Orphaneti420699 Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency
PharmGKBiPA29843

Chemistry databases

ChEMBLiCHEMBL2434
GuidetoPHARMACOLOGYi69

Polymorphism and mutation databases

BioMutaiCXCR2
DMDMi1352454

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693371 – 360C-X-C chemokine receptor type 2Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 196PROSITE-ProRule annotation
Modified residuei347Phosphoserine1 Publication1
Modified residuei351Phosphoserine1 Publication1
Modified residuei352Phosphoserine1 Publication1
Modified residuei353Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP25025
PeptideAtlasiP25025
PRIDEiP25025
ProteomicsDBi54246

PTM databases

iPTMnetiP25025
PhosphoSitePlusiP25025

Expressioni

Gene expression databases

BgeeiENSG00000180871 Expressed in 159 organ(s), highest expression level in blood
CleanExiHS_IL8RB
ExpressionAtlasiP25025 baseline and differential
GenevisibleiP25025 HS

Organism-specific databases

HPAiCAB016268
HPA031999
HPA032017

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CXCL8P101453EBI-2835281,EBI-3917999

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109793, 8 interactors
CORUMiP25025
DIPiDIP-3782N
IntActiP25025, 17 interactors
MINTiP25025
STRINGi9606.ENSP00000319635

Chemistry databases

BindingDBiP25025

Structurei

Secondary structure

1360
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP25025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHI Eukaryota
ENOG410Y9Y6 LUCA
GeneTreeiENSGT00930000150843
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP25025
KOiK05050
OMAiINKHAVV
OrthoDBiEOG091G0C7W
PhylomeDBiP25025
TreeFamiTF330966

Family and domain databases

CDDicd15178 7tmA_CXCR1_2, 1 hit
InterProiView protein in InterPro
IPR000057 Chemokine_CXCR2
IPR000174 Chemokine_CXCR_1/2
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00427 INTRLEUKIN8R
PR00573 INTRLEUKN8BR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P25025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF
60 70 80 90 100
VVIIYALVFL LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT
110 120 130 140 150
LPIWAASKVN GWIFGTFLCK VVSLLKEVNF YSGILLLACI SVDRYLAIVH
160 170 180 190 200
ATRTLTQKRY LVKFICLSIW GLSLLLALPV LLFRRTVYSS NVSPACYEDM
210 220 230 240 250
GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK AHMGQKHRAM
260 270 280 290 300
RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE
310 320 330 340 350
ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG
360
SSSGHTSTTL
Length:360
Mass (Da):40,759
Last modified:February 1, 1996 - v2
Checksum:i564F04A8BCC0A197
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JW47C9JW47_HUMAN
C-X-C chemokine receptor type 2
CXCR2
200Annotation score:
C9J1J7C9J1J7_HUMAN
C-X-C chemokine receptor type 2
CXCR2
172Annotation score:
C9J2F9C9J2F9_HUMAN
C-X-C chemokine receptor type 2
CXCR2
138Annotation score:
C9JG19C9JG19_HUMAN
C-X-C chemokine receptor type 2
CXCR2
135Annotation score:
Q6LCZ7Q6LCZ7_HUMAN
C-X-C chemokine receptor type 2
CXCR2 IL8RB
15Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01467980R → C1 PublicationCorresponds to variant dbSNP:rs1805038Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73969 mRNA Translation: AAA83148.1
M94582 mRNA Translation: AAA36108.1
M99412 Genomic DNA Translation: AAC14460.1
L19593 mRNA Translation: AAB59437.1
U11869 Genomic DNA Translation: AAB60656.1
AY714242 Genomic DNA Translation: AAT97985.1
BC037961 mRNA Translation: AAH37961.2
AB032733 Genomic DNA Translation: BAA92295.1
AB032734 Genomic DNA Translation: BAA92296.1
CCDSiCCDS2408.1
PIRiI37898 A53611
RefSeqiNP_001161770.1, NM_001168298.1
NP_001548.1, NM_001557.3
XP_005246587.1, XM_005246530.3
XP_016859479.1, XM_017003990.1
XP_016859480.1, XM_017003991.1
XP_016859481.1, XM_017003992.1
UniGeneiHs.846

Genome annotation databases

EnsembliENST00000318507; ENSP00000319635; ENSG00000180871
GeneIDi3579
KEGGihsa:3579

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CXC chemokine receptors entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73969 mRNA Translation: AAA83148.1
M94582 mRNA Translation: AAA36108.1
M99412 Genomic DNA Translation: AAC14460.1
L19593 mRNA Translation: AAB59437.1
U11869 Genomic DNA Translation: AAB60656.1
AY714242 Genomic DNA Translation: AAT97985.1
BC037961 mRNA Translation: AAH37961.2
AB032733 Genomic DNA Translation: BAA92295.1
AB032734 Genomic DNA Translation: BAA92296.1
CCDSiCCDS2408.1
PIRiI37898 A53611
RefSeqiNP_001161770.1, NM_001168298.1
NP_001548.1, NM_001557.3
XP_005246587.1, XM_005246530.3
XP_016859479.1, XM_017003990.1
XP_016859480.1, XM_017003991.1
XP_016859481.1, XM_017003992.1
UniGeneiHs.846

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q3HX-ray1.44A/B356-360[»]
5TYTX-ray2.40A/B/C/D356-360[»]
ProteinModelPortaliP25025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109793, 8 interactors
CORUMiP25025
DIPiDIP-3782N
IntActiP25025, 17 interactors
MINTiP25025
STRINGi9606.ENSP00000319635

Chemistry databases

BindingDBiP25025
ChEMBLiCHEMBL2434
GuidetoPHARMACOLOGYi69

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP25025
PhosphoSitePlusiP25025

Polymorphism and mutation databases

BioMutaiCXCR2
DMDMi1352454

Proteomic databases

PaxDbiP25025
PeptideAtlasiP25025
PRIDEiP25025
ProteomicsDBi54246

Protocols and materials databases

DNASUi3579
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318507; ENSP00000319635; ENSG00000180871
GeneIDi3579
KEGGihsa:3579

Organism-specific databases

CTDi3579
DisGeNETi3579
EuPathDBiHostDB:ENSG00000180871.7
GeneCardsiCXCR2
HGNCiHGNC:6027 CXCR2
HPAiCAB016268
HPA031999
HPA032017
MalaCardsiCXCR2
MIMi146928 gene
neXtProtiNX_P25025
OpenTargetsiENSG00000180871
Orphaneti420699 Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency
PharmGKBiPA29843
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEHI Eukaryota
ENOG410Y9Y6 LUCA
GeneTreeiENSGT00930000150843
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP25025
KOiK05050
OMAiINKHAVV
OrthoDBiEOG091G0C7W
PhylomeDBiP25025
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP25025
SIGNORiP25025

Miscellaneous databases

GenomeRNAii3579
PROiPR:P25025
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180871 Expressed in 159 organ(s), highest expression level in blood
CleanExiHS_IL8RB
ExpressionAtlasiP25025 baseline and differential
GenevisibleiP25025 HS

Family and domain databases

CDDicd15178 7tmA_CXCR1_2, 1 hit
InterProiView protein in InterPro
IPR000057 Chemokine_CXCR2
IPR000174 Chemokine_CXCR_1/2
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00427 INTRLEUKIN8R
PR00573 INTRLEUKN8BR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR2_HUMAN
AccessioniPrimary (citable) accession number: P25025
Secondary accession number(s): Q8IUZ1, Q9P2T6, Q9P2T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  8. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again