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Protein

C-X-C chemokine receptor type 2

Gene

CXCR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

GO - Molecular functioni

  • C-X-C chemokine receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB
  • interleukin-8 binding Source: UniProtKB
  • interleukin-8 receptor activity Source: UniProtKB

GO - Biological processi

  • acute inflammatory response to antigenic stimulus Source: Ensembl
  • cell surface receptor signaling pathway Source: UniProtKB
  • cellular defense response Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • dendritic cell chemotaxis Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: Reactome
  • inflammatory response Source: ProtInc
  • interleukin-8-mediated signaling pathway Source: UniProtKB
  • metanephric tubule morphogenesis Source: Ensembl
  • midbrain development Source: Ensembl
  • negative regulation of neutrophil apoptotic process Source: Ensembl
  • neutrophil activation Source: UniProtKB
  • neutrophil chemotaxis Source: UniProtKB
  • neutrophil degranulation Source: Reactome
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • positive regulation of neutrophil chemotaxis Source: Ensembl
  • positive regulation of vascular permeability Source: Ensembl
  • receptor internalization Source: UniProtKB
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP25025
SIGNORiP25025

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
CDw128b
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name:
IL-8R B
IL-8 receptor type 2
CD_antigen: CD182
Gene namesi
Name:CXCR2
Synonyms:IL8RB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000180871.7
HGNCiHGNC:6027 CXCR2
MIMi146928 gene
neXtProtiNX_P25025

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 75Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini76 – 84CytoplasmicSequence analysis9
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini106 – 120ExtracellularSequence analysisAdd BLAST15
Transmembranei121 – 142Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini143 – 163CytoplasmicSequence analysisAdd BLAST21
Transmembranei164 – 183Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini184 – 208ExtracellularSequence analysisAdd BLAST25
Transmembranei209 – 231Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini232 – 251CytoplasmicSequence analysisAdd BLAST20
Transmembranei252 – 273Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini274 – 294ExtracellularSequence analysisAdd BLAST21
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 360CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3579
MalaCardsiCXCR2
OpenTargetsiENSG00000180871
PharmGKBiPA29843

Chemistry databases

ChEMBLiCHEMBL2434
GuidetoPHARMACOLOGYi69

Polymorphism and mutation databases

BioMutaiCXCR2
DMDMi1352454

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693371 – 360C-X-C chemokine receptor type 2Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 196PROSITE-ProRule annotation
Modified residuei347Phosphoserine1 Publication1
Modified residuei351Phosphoserine1 Publication1
Modified residuei352Phosphoserine1 Publication1
Modified residuei353Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP25025
PeptideAtlasiP25025
PRIDEiP25025
ProteomicsDBi54246

PTM databases

iPTMnetiP25025
PhosphoSitePlusiP25025

Expressioni

Gene expression databases

BgeeiENSG00000180871
CleanExiHS_IL8RB
ExpressionAtlasiP25025 baseline and differential
GenevisibleiP25025 HS

Organism-specific databases

HPAiCAB016268
HPA031999
HPA032017

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CXCL8P101453EBI-2835281,EBI-3917999

GO - Molecular functioni

  • interleukin-8 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109793, 8 interactors
CORUMiP25025
DIPiDIP-3782N
IntActiP25025, 18 interactors
MINTiP25025
STRINGi9606.ENSP00000319635

Chemistry databases

BindingDBiP25025

Structurei

Secondary structure

1360
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi356 – 359Combined sources4

3D structure databases

ProteinModelPortaliP25025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHI Eukaryota
ENOG410Y9Y6 LUCA
GeneTreeiENSGT00760000118785
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP25025
KOiK05050
OMAiINKHAVV
OrthoDBiEOG091G0C7W
PhylomeDBiP25025
TreeFamiTF330966

Family and domain databases

CDDicd15178 7tmA_CXCR1_2, 1 hit
InterProiView protein in InterPro
IPR000057 Chemokine_CXCR2
IPR000174 Chemokine_CXCR_1/2
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00427 INTRLEUKIN8R
PR00573 INTRLEUKN8BR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF
60 70 80 90 100
VVIIYALVFL LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT
110 120 130 140 150
LPIWAASKVN GWIFGTFLCK VVSLLKEVNF YSGILLLACI SVDRYLAIVH
160 170 180 190 200
ATRTLTQKRY LVKFICLSIW GLSLLLALPV LLFRRTVYSS NVSPACYEDM
210 220 230 240 250
GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK AHMGQKHRAM
260 270 280 290 300
RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE
310 320 330 340 350
ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG
360
SSSGHTSTTL
Length:360
Mass (Da):40,759
Last modified:February 1, 1996 - v2
Checksum:i564F04A8BCC0A197
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01467980R → C1 PublicationCorresponds to variant dbSNP:rs1805038Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73969 mRNA Translation: AAA83148.1
M94582 mRNA Translation: AAA36108.1
M99412 Genomic DNA Translation: AAC14460.1
L19593 mRNA Translation: AAB59437.1
U11869 Genomic DNA Translation: AAB60656.1
AY714242 Genomic DNA Translation: AAT97985.1
BC037961 mRNA Translation: AAH37961.2
AB032733 Genomic DNA Translation: BAA92295.1
AB032734 Genomic DNA Translation: BAA92296.1
CCDSiCCDS2408.1
PIRiI37898 A53611
RefSeqiNP_001161770.1, NM_001168298.1
NP_001548.1, NM_001557.3
XP_005246587.1, XM_005246530.3
XP_016859479.1, XM_017003990.1
XP_016859480.1, XM_017003991.1
XP_016859481.1, XM_017003992.1
UniGeneiHs.846

Genome annotation databases

EnsembliENST00000318507; ENSP00000319635; ENSG00000180871
GeneIDi3579
KEGGihsa:3579

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCXCR2_HUMAN
AccessioniPrimary (citable) accession number: P25025
Secondary accession number(s): Q8IUZ1, Q9P2T6, Q9P2T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1996
Last modified: July 18, 2018
This is version 187 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

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