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UniProtKB - P25024 (CXCR1_HUMAN)

Entry version 197 (10 Feb 2021)
Sequence version 2 (30 May 2006)
Previous versions | rss
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Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P25024

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-380108, Chemokine receptors bind chemokines
R-HSA-418594, G alpha (i) signalling events
R-HSA-6798695, Neutrophil degranulation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P25024

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
CDw128a
High affinity interleukin-8 receptor A
Short name:
IL-8R A
IL-8 receptor type 1
CD_antigen: CD181
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CXCR1
Synonyms:CMKAR1, IL8RA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6026, CXCR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		146929, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P25024

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163464.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 66Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini67 – 75CytoplasmicSequence analysis9
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 111ExtracellularSequence analysisAdd BLAST15
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 154CytoplasmicSequence analysisAdd BLAST21
Transmembranei155 – 174Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini175 – 199ExtracellularSequence analysisAdd BLAST25
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 242CytoplasmicSequence analysisAdd BLAST22
Transmembranei243 – 264Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini265 – 285ExtracellularSequence analysisAdd BLAST21
Transmembranei286 – 308Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini309 – 350CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3577

MalaCards human disease database

More...MalaCardsi		CXCR1

Open Targets

More...OpenTargetsi		ENSG00000163464

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29842

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P25024, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4029

Drug and drug target database

More...DrugBanki		DB01009, Ketoprofen

DrugCentral

More...DrugCentrali		P25024

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		68

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CXCR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		108936015

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000693301 – 350C-X-C chemokine receptor type 1Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P25024

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P25024

PeptideAtlas

More...PeptideAtlasi		P25024

PRoteomics IDEntifications database

More...PRIDEi		P25024

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54245

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P25024, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P25024

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P25024

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163464, Expressed in blood and 114 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P25024, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163464, Tissue enriched (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109791, 9 interactors

Database of interacting proteins

More...DIPi		DIP-3779N

Protein interaction database and analysis system

More...IntActi		P25024, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295683

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P25024

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P25024, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P25024

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P25024

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P25024

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214381

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_8_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P25024

Identification of Orthologs from Complete Genome Data

More...OMAi		NDTAKWR

Database of Orthologous Groups

More...OrthoDBi		865441at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P25024

TreeFam database of animal gene trees

More...TreeFami		TF330966

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001355, Chemokine_CXCR1
IPR000174, Chemokine_CXCR_1/2
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR00427, INTRLEUKIN8R
PR00572, INTRLEUKN8AR

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P25024-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF 
        60         70         80         90        100
LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV 
       110        120        130        140        150
NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR 
       160        170        180        190        200
HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM 
       210        220        230        240        250
VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI 
       260        270        280        290        300
FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL 
       310        320        330        340        350
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL
Length:350
Mass (Da):39,791
Last modified:May 30, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2463E868C0EB0DE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti154K → N in AAH72397 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02106131M → R3 PublicationsCorresponds to variant dbSNP:rs16858811Ensembl.1
Natural variantiVAR_01623671R → C. Corresponds to variant dbSNP:rs1805038Ensembl.1
Natural variantiVAR_026525268M → L. Corresponds to variant dbSNP:rs9282752Ensembl.1
Natural variantiVAR_003479276S → T4 PublicationsCorresponds to variant dbSNP:rs2234671Ensembl.1
Natural variantiVAR_016237306A → T1 PublicationCorresponds to variant dbSNP:rs201583693Ensembl.1
Natural variantiVAR_016238335R → C4 PublicationsCorresponds to variant dbSNP:rs16858808Ensembl.1
Natural variantiVAR_021062342S → L1 PublicationCorresponds to variant dbSNP:rs16858806EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L19591 mRNA Translation: AAB59436.1
L19592 Genomic DNA Translation: AAA59160.1
M68932 mRNA Translation: AAA59159.1
X65858 Genomic DNA Translation: CAA46688.1
U11870 Genomic DNA Translation: AAA64378.1
AY916762 Genomic DNA Translation: AAY21512.1
AY916763 Genomic DNA Translation: AAY21513.1
AY916764 Genomic DNA Translation: AAY21514.1
AY916765 Genomic DNA Translation: AAY21515.1
AY916766 Genomic DNA Translation: AAY21516.1
AY916769 Genomic DNA Translation: AAY21519.1
AY916772 Genomic DNA Translation: AAY21522.1
AY916773 Genomic DNA Translation: AAY21523.1
CR541994 mRNA Translation: CAG46791.1
CR542029 mRNA Translation: CAG46826.1
AK312668 mRNA Translation: BAG35550.1
AY651785 Genomic DNA Translation: AAT46689.1
AC097483 Genomic DNA Translation: AAX93212.1
CH471063 Genomic DNA Translation: EAW70590.1
BC028221 mRNA Translation: AAH28221.1
BC072397 mRNA Translation: AAH72397.1
AB032728 Genomic DNA Translation: BAA92290.1
AB032729 Genomic DNA Translation: BAA92291.1
AB032730 Genomic DNA Translation: BAA92292.1
AB032731 Genomic DNA Translation: BAA92293.1
AB032732 Genomic DNA Translation: BAA92294.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2409.1

Protein sequence database of the Protein Information Resource

More...PIRi		I37449, A39445

NCBI Reference Sequences

More...RefSeqi		NP_000625.1, NM_000634.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295683; ENSP00000295683; ENSG00000163464

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3577

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3577

UCSC genome browser

More...UCSCi		uc002vhc.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CXC chemokine receptors entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19591 mRNA Translation: AAB59436.1
L19592 Genomic DNA Translation: AAA59160.1
M68932 mRNA Translation: AAA59159.1
X65858 Genomic DNA Translation: CAA46688.1
U11870 Genomic DNA Translation: AAA64378.1
AY916762 Genomic DNA Translation: AAY21512.1
AY916763 Genomic DNA Translation: AAY21513.1
AY916764 Genomic DNA Translation: AAY21514.1
AY916765 Genomic DNA Translation: AAY21515.1
AY916766 Genomic DNA Translation: AAY21516.1
AY916769 Genomic DNA Translation: AAY21519.1
AY916772 Genomic DNA Translation: AAY21522.1
AY916773 Genomic DNA Translation: AAY21523.1
CR541994 mRNA Translation: CAG46791.1
CR542029 mRNA Translation: CAG46826.1
AK312668 mRNA Translation: BAG35550.1
AY651785 Genomic DNA Translation: AAT46689.1
AC097483 Genomic DNA Translation: AAX93212.1
CH471063 Genomic DNA Translation: EAW70590.1
BC028221 mRNA Translation: AAH28221.1
BC072397 mRNA Translation: AAH72397.1
AB032728 Genomic DNA Translation: BAA92290.1
AB032729 Genomic DNA Translation: BAA92291.1
AB032730 Genomic DNA Translation: BAA92292.1
AB032731 Genomic DNA Translation: BAA92293.1
AB032732 Genomic DNA Translation: BAA92294.1
CCDSiCCDS2409.1
PIRiI37449, A39445
RefSeqiNP_000625.1, NM_000634.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILPNMR-C9-29[»]
1ILQNMR-C9-29[»]
2LNLNMR-A20-328[»]
BMRBiP25024
SMRiP25024
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109791, 9 interactors
DIPiDIP-3779N
IntActiP25024, 8 interactors
STRINGi9606.ENSP00000295683

Chemistry databases

BindingDBiP25024
ChEMBLiCHEMBL4029
DrugBankiDB01009, Ketoprofen
DrugCentraliP25024
GuidetoPHARMACOLOGYi68

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP25024, 2 sites
iPTMnetiP25024
PhosphoSitePlusiP25024

Genetic variation databases

BioMutaiCXCR1
DMDMi108936015

Proteomic databases

MassIVEiP25024
PaxDbiP25024
PeptideAtlasiP25024
PRIDEiP25024
ProteomicsDBi54245

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4267, 599 antibodies

The DNASU plasmid repository

More...DNASUi		3577

Genome annotation databases

EnsembliENST00000295683; ENSP00000295683; ENSG00000163464
GeneIDi3577
KEGGihsa:3577
UCSCiuc002vhc.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3577
DisGeNETi3577

GeneCards: human genes, protein and diseases

More...GeneCardsi		CXCR1
HGNCiHGNC:6026, CXCR1
HPAiENSG00000163464, Tissue enriched (blood)
MalaCardsiCXCR1
MIMi146929, gene
neXtProtiNX_P25024
OpenTargetsiENSG00000163464
PharmGKBiPA29842
VEuPathDBiHostDB:ENSG00000163464.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT01000000214381
HOGENOMiCLU_009579_8_3_1
InParanoidiP25024
OMAiNDTAKWR
OrthoDBi865441at2759
PhylomeDBiP25024
TreeFamiTF330966

Enzyme and pathway databases

PathwayCommonsiP25024
ReactomeiR-HSA-380108, Chemokine receptors bind chemokines
R-HSA-418594, G alpha (i) signalling events
R-HSA-6798695, Neutrophil degranulation
SIGNORiP25024

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3577, 4 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CXCR1, human
EvolutionaryTraceiP25024

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Interleukin_8_receptor,_alpha

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3577
PharosiP25024, Tchem

Protein Ontology

More...PROi		PR:P25024
RNActiP25024, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163464, Expressed in blood and 114 other tissues
GenevisibleiP25024, HS

Family and domain databases

InterProiView protein in InterPro
IPR001355, Chemokine_CXCR1
IPR000174, Chemokine_CXCR_1/2
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR00427, INTRLEUKIN8R
PR00572, INTRLEUKN8AR
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCXCR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25024
Secondary accession number(s): B2R6Q3
, Q2YEF8, Q2YEG4, Q2YEG5, Q2YEG7, Q2YEG8, Q53R18, Q6IN95, Q8N6T6, Q9P2T8, Q9P2T9, Q9P2U0, Q9P2U1, Q9P2U2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 30, 2006
Last modified: February 10, 2021
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  7. Human entries with genetic variants
    List of human entries with genetic variants
  8. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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