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UniProtKB - P25024 (CXCR1_HUMAN)

Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • C-C chemokine binding Source: GO_Central
  • C-C chemokine receptor activity Source: GO_Central
  • chemokine binding Source: GO_Central
  • chemokine receptor activity Source: ProtInc
  • G protein-coupled receptor activity Source: ProtInc
  • interleukin-8 binding Source: UniProtKB
  • interleukin-8 receptor activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P25024

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
CDw128a
High affinity interleukin-8 receptor A
Short name:
IL-8R A
IL-8 receptor type 1
CD_antigen: CD181
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CXCR1
Synonyms:CMKAR1, IL8RA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000163464.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:6026 CXCR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		146929 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P25024

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 66Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini67 – 75CytoplasmicSequence analysis9
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 111ExtracellularSequence analysisAdd BLAST15
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 154CytoplasmicSequence analysisAdd BLAST21
Transmembranei155 – 174Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini175 – 199ExtracellularSequence analysisAdd BLAST25
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 242CytoplasmicSequence analysisAdd BLAST22
Transmembranei243 – 264Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini265 – 285ExtracellularSequence analysisAdd BLAST21
Transmembranei286 – 308Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini309 – 350CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3577

MalaCards human disease database

More...MalaCardsi		CXCR1

Open Targets

More...OpenTargetsi		ENSG00000163464

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29842

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4029

Drug and drug target database

More...DrugBanki		DB01009 Ketoprofen

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		68

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CXCR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		108936015

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000693301 – 350C-X-C chemokine receptor type 1Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P25024

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P25024

PeptideAtlas

More...PeptideAtlasi		P25024

PRoteomics IDEntifications database

More...PRIDEi		P25024

ProteomicsDB human proteome resource

More...ProteomicsDBi		54245

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P25024

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P25024

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163464 Expressed in 93 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P25024 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA031991

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109791, 5 interactors

Database of interacting proteins

More...DIPi		DIP-3779N

Protein interaction database and analysis system

More...IntActi		P25024, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295683

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P25024

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILPNMR-C9-29[»]
1ILQNMR-C9-29[»]
2LNLNMR-A20-328[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P25024

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P25024

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P25024

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IEHI Eukaryota
ENOG410Y9Y6 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154636

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG106917

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P25024

KEGG Orthology (KO)

More...KOi		K04175

Identification of Orthologs from Complete Genome Data

More...OMAi		NDTAKWR

Database of Orthologous Groups

More...OrthoDBi		865441at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P25024

TreeFam database of animal gene trees

More...TreeFami		TF330966

Family and domain databases

Conserved Domains Database

More...CDDi		cd15178 7tmA_CXCR1_2, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001355 Chemokine_CXCR1
IPR000174 Chemokine_CXCR_1/2
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237 GPCRRHODOPSN
PR00427 INTRLEUKIN8R
PR00572 INTRLEUKN8AR

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P25024-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF 
        60         70         80         90        100
LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV 
       110        120        130        140        150
NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR 
       160        170        180        190        200
HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM 
       210        220        230        240        250
VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI 
       260        270        280        290        300
FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL 
       310        320        330        340        350
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL
Length:350
Mass (Da):39,791
Last modified:May 30, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2463E868C0EB0DE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti154K → N in AAH72397 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02106131M → R3 PublicationsCorresponds to variant dbSNP:rs16858811Ensembl.1
Natural variantiVAR_01623671R → C. Corresponds to variant dbSNP:rs1805038Ensembl.1
Natural variantiVAR_026525268M → L. Corresponds to variant dbSNP:rs9282752Ensembl.1
Natural variantiVAR_003479276S → T Common polymorphism. 4 PublicationsCorresponds to variant dbSNP:rs2234671Ensembl.1
Natural variantiVAR_016237306A → T1 PublicationCorresponds to variant dbSNP:rs201583693Ensembl.1
Natural variantiVAR_016238335R → C4 PublicationsCorresponds to variant dbSNP:rs16858808Ensembl.1
Natural variantiVAR_021062342S → L1 PublicationCorresponds to variant dbSNP:rs16858806Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L19591 mRNA Translation: AAB59436.1
L19592 Genomic DNA Translation: AAA59160.1
M68932 mRNA Translation: AAA59159.1
X65858 Genomic DNA Translation: CAA46688.1
U11870 Genomic DNA Translation: AAA64378.1
AY916762 Genomic DNA Translation: AAY21512.1
AY916763 Genomic DNA Translation: AAY21513.1
AY916764 Genomic DNA Translation: AAY21514.1
AY916765 Genomic DNA Translation: AAY21515.1
AY916766 Genomic DNA Translation: AAY21516.1
AY916769 Genomic DNA Translation: AAY21519.1
AY916772 Genomic DNA Translation: AAY21522.1
AY916773 Genomic DNA Translation: AAY21523.1
CR541994 mRNA Translation: CAG46791.1
CR542029 mRNA Translation: CAG46826.1
AK312668 mRNA Translation: BAG35550.1
AY651785 Genomic DNA Translation: AAT46689.1
AC097483 Genomic DNA Translation: AAX93212.1
CH471063 Genomic DNA Translation: EAW70590.1
BC028221 mRNA Translation: AAH28221.1
BC072397 mRNA Translation: AAH72397.1
AB032728 Genomic DNA Translation: BAA92290.1
AB032729 Genomic DNA Translation: BAA92291.1
AB032730 Genomic DNA Translation: BAA92292.1
AB032731 Genomic DNA Translation: BAA92293.1
AB032732 Genomic DNA Translation: BAA92294.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2409.1

Protein sequence database of the Protein Information Resource

More...PIRi		I37449 A39445

NCBI Reference Sequences

More...RefSeqi		NP_000625.1, NM_000634.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.194778

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295683; ENSP00000295683; ENSG00000163464

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3577

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3577

UCSC genome browser

More...UCSCi		uc002vhc.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CXC chemokine receptors entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19591 mRNA Translation: AAB59436.1
L19592 Genomic DNA Translation: AAA59160.1
M68932 mRNA Translation: AAA59159.1
X65858 Genomic DNA Translation: CAA46688.1
U11870 Genomic DNA Translation: AAA64378.1
AY916762 Genomic DNA Translation: AAY21512.1
AY916763 Genomic DNA Translation: AAY21513.1
AY916764 Genomic DNA Translation: AAY21514.1
AY916765 Genomic DNA Translation: AAY21515.1
AY916766 Genomic DNA Translation: AAY21516.1
AY916769 Genomic DNA Translation: AAY21519.1
AY916772 Genomic DNA Translation: AAY21522.1
AY916773 Genomic DNA Translation: AAY21523.1
CR541994 mRNA Translation: CAG46791.1
CR542029 mRNA Translation: CAG46826.1
AK312668 mRNA Translation: BAG35550.1
AY651785 Genomic DNA Translation: AAT46689.1
AC097483 Genomic DNA Translation: AAX93212.1
CH471063 Genomic DNA Translation: EAW70590.1
BC028221 mRNA Translation: AAH28221.1
BC072397 mRNA Translation: AAH72397.1
AB032728 Genomic DNA Translation: BAA92290.1
AB032729 Genomic DNA Translation: BAA92291.1
AB032730 Genomic DNA Translation: BAA92292.1
AB032731 Genomic DNA Translation: BAA92293.1
AB032732 Genomic DNA Translation: BAA92294.1
CCDSiCCDS2409.1
PIRiI37449 A39445
RefSeqiNP_000625.1, NM_000634.2
UniGeneiHs.194778

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILPNMR-C9-29[»]
1ILQNMR-C9-29[»]
2LNLNMR-A20-328[»]
ProteinModelPortaliP25024
SMRiP25024
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109791, 5 interactors
DIPiDIP-3779N
IntActiP25024, 9 interactors
STRINGi9606.ENSP00000295683

Chemistry databases

BindingDBiP25024
ChEMBLiCHEMBL4029
DrugBankiDB01009 Ketoprofen
GuidetoPHARMACOLOGYi68

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiP25024
PhosphoSitePlusiP25024

Polymorphism and mutation databases

BioMutaiCXCR1
DMDMi108936015

Proteomic databases

jPOSTiP25024
PaxDbiP25024
PeptideAtlasiP25024
PRIDEiP25024
ProteomicsDBi54245

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3577
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295683; ENSP00000295683; ENSG00000163464
GeneIDi3577
KEGGihsa:3577
UCSCiuc002vhc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3577
DisGeNETi3577
EuPathDBiHostDB:ENSG00000163464.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		CXCR1

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0203926
HGNCiHGNC:6026 CXCR1
HPAiHPA031991
MalaCardsiCXCR1
MIMi146929 gene
neXtProtiNX_P25024
OpenTargetsiENSG00000163464
PharmGKBiPA29842

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IEHI Eukaryota
ENOG410Y9Y6 LUCA
GeneTreeiENSGT00940000154636
HOVERGENiHBG106917
InParanoidiP25024
KOiK04175
OMAiNDTAKWR
OrthoDBi865441at2759
PhylomeDBiP25024
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation
SIGNORiP25024

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CXCR1 human
EvolutionaryTraceiP25024

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Interleukin_8_receptor,_alpha

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3577

Protein Ontology

More...PROi		PR:P25024

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163464 Expressed in 93 organ(s), highest expression level in blood
GenevisibleiP25024 HS

Family and domain databases

CDDicd15178 7tmA_CXCR1_2, 1 hit
InterProiView protein in InterPro
IPR001355 Chemokine_CXCR1
IPR000174 Chemokine_CXCR_1/2
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00427 INTRLEUKIN8R
PR00572 INTRLEUKN8AR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCXCR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P25024
Secondary accession number(s): B2R6Q3
, Q2YEF8, Q2YEG4, Q2YEG5, Q2YEG7, Q2YEG8, Q53R18, Q6IN95, Q8N6T6, Q9P2T8, Q9P2T9, Q9P2U0, Q9P2U1, Q9P2U2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 30, 2006
Last modified: January 16, 2019
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  8. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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