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Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

GO - Molecular functioni

  • chemokine receptor activity Source: ProtInc
  • G-protein coupled receptor activity Source: ProtInc
  • interleukin-8 binding Source: UniProtKB
  • interleukin-8 receptor activity Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: UniProtKB
  • dendritic cell chemotaxis Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: Reactome
  • neutrophil degranulation Source: Reactome
  • receptor internalization Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation
SIGNORiP25024

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
CDw128a
High affinity interleukin-8 receptor A
Short name:
IL-8R A
IL-8 receptor type 1
CD_antigen: CD181
Gene namesi
Name:CXCR1
Synonyms:CMKAR1, IL8RA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163464.7
HGNCiHGNC:6026 CXCR1
MIMi146929 gene
neXtProtiNX_P25024

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 66Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini67 – 75CytoplasmicSequence analysis9
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 111ExtracellularSequence analysisAdd BLAST15
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 154CytoplasmicSequence analysisAdd BLAST21
Transmembranei155 – 174Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini175 – 199ExtracellularSequence analysisAdd BLAST25
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 242CytoplasmicSequence analysisAdd BLAST22
Transmembranei243 – 264Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini265 – 285ExtracellularSequence analysisAdd BLAST21
Transmembranei286 – 308Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini309 – 350CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3577
MalaCardsiCXCR1
OpenTargetsiENSG00000163464
PharmGKBiPA29842

Chemistry databases

ChEMBLiCHEMBL4029
DrugBankiDB01009 Ketoprofen
GuidetoPHARMACOLOGYi68

Polymorphism and mutation databases

BioMutaiCXCR1
DMDMi108936015

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693301 – 350C-X-C chemokine receptor type 1Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25024
PeptideAtlasiP25024
PRIDEiP25024
ProteomicsDBi54245

PTM databases

iPTMnetiP25024
PhosphoSitePlusiP25024

Expressioni

Gene expression databases

BgeeiENSG00000163464
GenevisibleiP25024 HS

Organism-specific databases

HPAiHPA031991

Interactioni

GO - Molecular functioni

  • interleukin-8 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109791, 5 interactors
DIPiDIP-3779N
IntActiP25024, 9 interactors
STRINGi9606.ENSP00000295683

Chemistry databases

BindingDBiP25024

Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi38 – 66Combined sources29
Helixi75 – 100Combined sources26
Beta strandi101 – 103Combined sources3
Helixi108 – 138Combined sources31
Beta strandi139 – 141Combined sources3
Beta strandi143 – 146Combined sources4
Helixi149 – 173Combined sources25
Turni195 – 197Combined sources3
Helixi201 – 204Combined sources4
Turni205 – 207Combined sources3
Helixi208 – 225Combined sources18
Turni226 – 228Combined sources3
Beta strandi229 – 231Combined sources3
Helixi235 – 238Combined sources4
Helixi240 – 267Combined sources28
Beta strandi270 – 272Combined sources3
Helixi276 – 282Combined sources7
Helixi285 – 293Combined sources9
Helixi294 – 298Combined sources5
Helixi300 – 308Combined sources9
Helixi311 – 322Combined sources12

3D structure databases

ProteinModelPortaliP25024
SMRiP25024
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25024

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHI Eukaryota
ENOG410Y9Y6 LUCA
GeneTreeiENSGT00760000118785
HOVERGENiHBG106917
InParanoidiP25024
KOiK04175
OMAiYAFIGQN
OrthoDBiEOG091G0C7W
PhylomeDBiP25024
TreeFamiTF330966

Family and domain databases

CDDicd15178 7tmA_CXCR1_2, 1 hit
InterProiView protein in InterPro
IPR001355 Chemokine_CXCR1
IPR000174 Chemokine_CXCR_1/2
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00427 INTRLEUKIN8R
PR00572 INTRLEUKN8AR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF
60 70 80 90 100
LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV
110 120 130 140 150
NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR
160 170 180 190 200
HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM
210 220 230 240 250
VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI
260 270 280 290 300
FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL
310 320 330 340 350
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL
Length:350
Mass (Da):39,791
Last modified:May 30, 2006 - v2
Checksum:i2463E868C0EB0DE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154K → N in AAH72397 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02106131M → R3 PublicationsCorresponds to variant dbSNP:rs16858811Ensembl.1
Natural variantiVAR_01623671R → C. Corresponds to variant dbSNP:rs1805038Ensembl.1
Natural variantiVAR_026525268M → L. Corresponds to variant dbSNP:rs9282752Ensembl.1
Natural variantiVAR_003479276S → T Common polymorphism. 4 PublicationsCorresponds to variant dbSNP:rs2234671Ensembl.1
Natural variantiVAR_016237306A → T1 PublicationCorresponds to variant dbSNP:rs201583693Ensembl.1
Natural variantiVAR_016238335R → C4 PublicationsCorresponds to variant dbSNP:rs16858808Ensembl.1
Natural variantiVAR_021062342S → L1 PublicationCorresponds to variant dbSNP:rs16858806Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19591 mRNA Translation: AAB59436.1
L19592 Genomic DNA Translation: AAA59160.1
M68932 mRNA Translation: AAA59159.1
X65858 Genomic DNA Translation: CAA46688.1
U11870 Genomic DNA Translation: AAA64378.1
AY916762 Genomic DNA Translation: AAY21512.1
AY916763 Genomic DNA Translation: AAY21513.1
AY916764 Genomic DNA Translation: AAY21514.1
AY916765 Genomic DNA Translation: AAY21515.1
AY916766 Genomic DNA Translation: AAY21516.1
AY916769 Genomic DNA Translation: AAY21519.1
AY916772 Genomic DNA Translation: AAY21522.1
AY916773 Genomic DNA Translation: AAY21523.1
CR541994 mRNA Translation: CAG46791.1
CR542029 mRNA Translation: CAG46826.1
AK312668 mRNA Translation: BAG35550.1
AY651785 Genomic DNA Translation: AAT46689.1
AC097483 Genomic DNA Translation: AAX93212.1
CH471063 Genomic DNA Translation: EAW70590.1
BC028221 mRNA Translation: AAH28221.1
BC072397 mRNA Translation: AAH72397.1
AB032728 Genomic DNA Translation: BAA92290.1
AB032729 Genomic DNA Translation: BAA92291.1
AB032730 Genomic DNA Translation: BAA92292.1
AB032731 Genomic DNA Translation: BAA92293.1
AB032732 Genomic DNA Translation: BAA92294.1
CCDSiCCDS2409.1
PIRiI37449 A39445
RefSeqiNP_000625.1, NM_000634.2
UniGeneiHs.194778

Genome annotation databases

EnsembliENST00000295683; ENSP00000295683; ENSG00000163464
GeneIDi3577
KEGGihsa:3577
UCSCiuc002vhc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCXCR1_HUMAN
AccessioniPrimary (citable) accession number: P25024
Secondary accession number(s): B2R6Q3
, Q2YEF8, Q2YEG4, Q2YEG5, Q2YEG7, Q2YEG8, Q53R18, Q6IN95, Q8N6T6, Q9P2T8, Q9P2T9, Q9P2U0, Q9P2U1, Q9P2U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 30, 2006
Last modified: June 20, 2018
This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

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