UniProtKB - P25024 (CXCR1_HUMAN)
Protein
C-X-C chemokine receptor type 1
Gene
CXCR1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- C-C chemokine receptor activity Source: GO_Central
- chemokine binding Source: GO_Central
- chemokine receptor activity Source: ProtInc
- G protein-coupled receptor activity Source: ProtInc
- interleukin-8 binding Source: UniProtKB
- interleukin-8 receptor activity Source: UniProtKB
GO - Biological processi
- calcium-mediated signaling Source: GO_Central
- cell chemotaxis Source: GO_Central
- cell surface receptor signaling pathway Source: UniProtKB
- chemotaxis Source: GO_Central
- dendritic cell chemotaxis Source: BHF-UCL
- G protein-coupled receptor signaling pathway Source: Reactome
- immune response Source: GO_Central
- neutrophil chemotaxis Source: GO_Central
- neutrophil degranulation Source: Reactome
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- receptor internalization Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Chemotaxis |
Enzyme and pathway databases
PathwayCommonsi | P25024 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events R-HSA-6798695, Neutrophil degranulation |
SIGNORi | P25024 |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C chemokine receptor type 1Short name: CXC-R1 Short name: CXCR-1 Alternative name(s): CDw128a High affinity interleukin-8 receptor A Short name: IL-8R A IL-8 receptor type 1 CD_antigen: CD181 |
Gene namesi | Name:CXCR1 Synonyms:CMKAR1, IL8RA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6026, CXCR1 |
MIMi | 146929, gene |
neXtProti | NX_P25024 |
VEuPathDBi | HostDB:ENSG00000163464.7 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- secretory granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 39 | ExtracellularSequence analysisAdd BLAST | 39 | |
Transmembranei | 40 – 66 | Helical; Name=1Sequence analysisAdd BLAST | 27 | |
Topological domaini | 67 – 75 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 76 – 96 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 97 – 111 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 112 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 134 – 154 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 174 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 175 – 199 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 200 – 220 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 221 – 242 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 243 – 264 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 265 – 285 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 286 – 308 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 309 – 350 | CytoplasmicSequence analysisAdd BLAST | 42 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3577 |
MalaCardsi | CXCR1 |
OpenTargetsi | ENSG00000163464 |
PharmGKBi | PA29842 |
Miscellaneous databases
Pharosi | P25024, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4029 |
DrugBanki | DB01009, Ketoprofen |
DrugCentrali | P25024 |
GuidetoPHARMACOLOGYi | 68 |
Genetic variation databases
BioMutai | CXCR1 |
DMDMi | 108936015 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069330 | 1 – 350 | C-X-C chemokine receptor type 1Add BLAST | 350 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 16 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 110 ↔ 187 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P25024 |
PaxDbi | P25024 |
PeptideAtlasi | P25024 |
PRIDEi | P25024 |
ProteomicsDBi | 54245 |
PTM databases
GlyGeni | P25024, 2 sites |
iPTMneti | P25024 |
PhosphoSitePlusi | P25024 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163464, Expressed in blood and 114 other tissues |
Genevisiblei | P25024, HS |
Organism-specific databases
HPAi | ENSG00000163464, Tissue enriched (blood) |
Interactioni
Binary interactionsi
Hide detailsP25024
With | #Exp. | IntAct |
---|---|---|
CLDND1 [Q9NY35] | 3 | EBI-3905522,EBI-4319704 |
FATE1 [Q969F0] | 3 | EBI-3905522,EBI-743099 |
IGFBP5 [P24593] | 3 | EBI-3905522,EBI-720480 |
TUSC5 [A5PKU2] | 3 | EBI-3905522,EBI-11988865 |
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- chemokine binding Source: GO_Central
- interleukin-8 binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109791, 9 interactors |
DIPi | DIP-3779N |
IntActi | P25024, 8 interactors |
STRINGi | 9606.ENSP00000295683 |
Chemistry databases
BindingDBi | P25024 |
Miscellaneous databases
RNActi | P25024, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P25024 |
SMRi | P25024 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P25024 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214381 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P25024 |
OMAi | NDTAKWR |
OrthoDBi | 865441at2759 |
PhylomeDBi | P25024 |
TreeFami | TF330966 |
Family and domain databases
InterProi | View protein in InterPro IPR001355, Chemokine_CXCR1 IPR000174, Chemokine_CXCR_1/2 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00427, INTRLEUKIN8R PR00572, INTRLEUKN8AR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P25024-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF
60 70 80 90 100
LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV
110 120 130 140 150
NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR
160 170 180 190 200
HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM
210 220 230 240 250
VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI
260 270 280 290 300
FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL
310 320 330 340 350
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 154 | K → N in AAH72397 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021061 | 31 | M → R3 PublicationsCorresponds to variant dbSNP:rs16858811Ensembl. | 1 | |
Natural variantiVAR_016236 | 71 | R → C. Corresponds to variant dbSNP:rs1805038Ensembl. | 1 | |
Natural variantiVAR_026525 | 268 | M → L. Corresponds to variant dbSNP:rs9282752Ensembl. | 1 | |
Natural variantiVAR_003479 | 276 | S → T4 PublicationsCorresponds to variant dbSNP:rs2234671Ensembl. | 1 | |
Natural variantiVAR_016237 | 306 | A → T1 PublicationCorresponds to variant dbSNP:rs201583693Ensembl. | 1 | |
Natural variantiVAR_016238 | 335 | R → C4 PublicationsCorresponds to variant dbSNP:rs16858808Ensembl. | 1 | |
Natural variantiVAR_021062 | 342 | S → L1 PublicationCorresponds to variant dbSNP:rs16858806EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19591 mRNA Translation: AAB59436.1 L19592 Genomic DNA Translation: AAA59160.1 M68932 mRNA Translation: AAA59159.1 X65858 Genomic DNA Translation: CAA46688.1 U11870 Genomic DNA Translation: AAA64378.1 AY916762 Genomic DNA Translation: AAY21512.1 AY916763 Genomic DNA Translation: AAY21513.1 AY916764 Genomic DNA Translation: AAY21514.1 AY916765 Genomic DNA Translation: AAY21515.1 AY916766 Genomic DNA Translation: AAY21516.1 AY916769 Genomic DNA Translation: AAY21519.1 AY916772 Genomic DNA Translation: AAY21522.1 AY916773 Genomic DNA Translation: AAY21523.1 CR541994 mRNA Translation: CAG46791.1 CR542029 mRNA Translation: CAG46826.1 AK312668 mRNA Translation: BAG35550.1 AY651785 Genomic DNA Translation: AAT46689.1 AC097483 Genomic DNA Translation: AAX93212.1 CH471063 Genomic DNA Translation: EAW70590.1 BC028221 mRNA Translation: AAH28221.1 BC072397 mRNA Translation: AAH72397.1 AB032728 Genomic DNA Translation: BAA92290.1 AB032729 Genomic DNA Translation: BAA92291.1 AB032730 Genomic DNA Translation: BAA92292.1 AB032731 Genomic DNA Translation: BAA92293.1 AB032732 Genomic DNA Translation: BAA92294.1 |
CCDSi | CCDS2409.1 |
PIRi | I37449, A39445 |
RefSeqi | NP_000625.1, NM_000634.2 |
Genome annotation databases
Ensembli | ENST00000295683; ENSP00000295683; ENSG00000163464 |
GeneIDi | 3577 |
KEGGi | hsa:3577 |
UCSCi | uc002vhc.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CXC chemokine receptors entry |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19591 mRNA Translation: AAB59436.1 L19592 Genomic DNA Translation: AAA59160.1 M68932 mRNA Translation: AAA59159.1 X65858 Genomic DNA Translation: CAA46688.1 U11870 Genomic DNA Translation: AAA64378.1 AY916762 Genomic DNA Translation: AAY21512.1 AY916763 Genomic DNA Translation: AAY21513.1 AY916764 Genomic DNA Translation: AAY21514.1 AY916765 Genomic DNA Translation: AAY21515.1 AY916766 Genomic DNA Translation: AAY21516.1 AY916769 Genomic DNA Translation: AAY21519.1 AY916772 Genomic DNA Translation: AAY21522.1 AY916773 Genomic DNA Translation: AAY21523.1 CR541994 mRNA Translation: CAG46791.1 CR542029 mRNA Translation: CAG46826.1 AK312668 mRNA Translation: BAG35550.1 AY651785 Genomic DNA Translation: AAT46689.1 AC097483 Genomic DNA Translation: AAX93212.1 CH471063 Genomic DNA Translation: EAW70590.1 BC028221 mRNA Translation: AAH28221.1 BC072397 mRNA Translation: AAH72397.1 AB032728 Genomic DNA Translation: BAA92290.1 AB032729 Genomic DNA Translation: BAA92291.1 AB032730 Genomic DNA Translation: BAA92292.1 AB032731 Genomic DNA Translation: BAA92293.1 AB032732 Genomic DNA Translation: BAA92294.1 |
CCDSi | CCDS2409.1 |
PIRi | I37449, A39445 |
RefSeqi | NP_000625.1, NM_000634.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ILP | NMR | - | C | 9-29 | [»] | |
1ILQ | NMR | - | C | 9-29 | [»] | |
2LNL | NMR | - | A | 20-328 | [»] | |
BMRBi | P25024 | |||||
SMRi | P25024 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109791, 9 interactors |
DIPi | DIP-3779N |
IntActi | P25024, 8 interactors |
STRINGi | 9606.ENSP00000295683 |
Chemistry databases
BindingDBi | P25024 |
ChEMBLi | CHEMBL4029 |
DrugBanki | DB01009, Ketoprofen |
DrugCentrali | P25024 |
GuidetoPHARMACOLOGYi | 68 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P25024, 2 sites |
iPTMneti | P25024 |
PhosphoSitePlusi | P25024 |
Genetic variation databases
BioMutai | CXCR1 |
DMDMi | 108936015 |
Proteomic databases
MassIVEi | P25024 |
PaxDbi | P25024 |
PeptideAtlasi | P25024 |
PRIDEi | P25024 |
ProteomicsDBi | 54245 |
Protocols and materials databases
Antibodypediai | 4267, 599 antibodies |
DNASUi | 3577 |
Genome annotation databases
Ensembli | ENST00000295683; ENSP00000295683; ENSG00000163464 |
GeneIDi | 3577 |
KEGGi | hsa:3577 |
UCSCi | uc002vhc.4, human |
Organism-specific databases
CTDi | 3577 |
DisGeNETi | 3577 |
GeneCardsi | CXCR1 |
HGNCi | HGNC:6026, CXCR1 |
HPAi | ENSG00000163464, Tissue enriched (blood) |
MalaCardsi | CXCR1 |
MIMi | 146929, gene |
neXtProti | NX_P25024 |
OpenTargetsi | ENSG00000163464 |
PharmGKBi | PA29842 |
VEuPathDBi | HostDB:ENSG00000163464.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214381 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P25024 |
OMAi | NDTAKWR |
OrthoDBi | 865441at2759 |
PhylomeDBi | P25024 |
TreeFami | TF330966 |
Enzyme and pathway databases
PathwayCommonsi | P25024 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events R-HSA-6798695, Neutrophil degranulation |
SIGNORi | P25024 |
Miscellaneous databases
BioGRID-ORCSi | 3577, 4 hits in 873 CRISPR screens |
ChiTaRSi | CXCR1, human |
EvolutionaryTracei | P25024 |
GeneWikii | Interleukin_8_receptor,_alpha |
GenomeRNAii | 3577 |
Pharosi | P25024, Tchem |
PROi | PR:P25024 |
RNActi | P25024, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163464, Expressed in blood and 114 other tissues |
Genevisiblei | P25024, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001355, Chemokine_CXCR1 IPR000174, Chemokine_CXCR_1/2 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00427, INTRLEUKIN8R PR00572, INTRLEUKN8AR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXCR1_HUMAN | |
Accessioni | P25024Primary (citable) accession number: P25024 Secondary accession number(s): B2R6Q3 Q9P2U2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 30, 2006 | |
Last modified: | February 10, 2021 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries