CXCR1

Functionⁱ

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

GO - Molecular functionⁱ

C-C chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
C-C chemokine receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine receptor activity
Source: ProtInc
Traceable author statementⁱ
- 1840701
G protein-coupled receptor activity
Source: ProtInc
Traceable author statementⁱ
- 8381837
interleukin-8 binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11564821
interleukin-8 receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10734056

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-mediated signaling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell surface receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 10734056
chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
dendritic cell chemotaxis
Source: BHF-UCL
Traceable author statementⁱ
- 16621978
G protein-coupled receptor signaling pathway Source: Reactome
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neutrophil chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neutrophil degranulation Source: Reactome
positive regulation of cytosolic calcium ion concentration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
receptor internalization
Source: UniProtKB
Inferred from direct assayⁱ
- 10734056

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Chemotaxis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events R-HSA-6798695 Neutrophil degranulation
SIGNORⁱ	P25024

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-X-C chemokine receptor type 1 Short name: CXC-R1 Short name: CXCR-1 Alternative name(s): CDw128a High affinity interleukin-8 receptor A Short name: IL-8R A IL-8 receptor type 1 CD_antigen: CD181
Gene namesⁱ	Name:CXCR1 Synonyms:CMKAR1, IL8RA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163464.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6026 CXCR1
MIMⁱ	146929 gene
neXtProtⁱ	NX_P25024

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 39	ExtracellularSequence analysisAdd BLAST	39
Transmembraneⁱ	40 – 66	Helical; Name=1Sequence analysisAdd BLAST	27
Topological domainⁱ	67 – 75	CytoplasmicSequence analysis	9
Transmembraneⁱ	76 – 96	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	97 – 111	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	112 – 133	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	134 – 154	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	155 – 174	Helical; Name=4Sequence analysisAdd BLAST	20
Topological domainⁱ	175 – 199	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	200 – 220	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	221 – 242	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	243 – 264	Helical; Name=6Sequence analysisAdd BLAST	22
Topological domainⁱ	265 – 285	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	286 – 308	Helical; Name=7Sequence analysisAdd BLAST	23
Topological domainⁱ	309 – 350	CytoplasmicSequence analysisAdd BLAST	42

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3577
MalaCards human disease database More...MalaCardsⁱ	CXCR1
Open Targets More...OpenTargetsⁱ	ENSG00000163464
PharmGKBⁱ	PA29842

Chemistry databases

ChEMBLⁱ	CHEMBL4029
Drug and drug target database More...DrugBankⁱ	DB01009 Ketoprofen
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	68

Polymorphism and mutation databases

BioMutaⁱ	CXCR1
DMDMⁱ	108936015

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069330	1 – 350	C-X-C chemokine receptor type 1Add BLAST		350

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	3	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	16	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	110 ↔ 187	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P25024
PeptideAtlas More...PeptideAtlasⁱ	P25024
PRIDEⁱ	P25024
ProteomicsDBⁱ	54245

PTM databases

iPTMnetⁱ	P25024
PhosphoSitePlusⁱ	P25024

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163464 Expressed in 93 organ(s), highest expression level in blood
Genevisibleⁱ	P25024 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031991

HPAⁱ

HPA031991

Interactionⁱ

GO - Molecular functionⁱ

C-C chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-8 binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11564821

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109791, 5 interactors
Database of interacting proteins More...DIPⁱ	DIP-3779N
IntActⁱ	P25024, 9 interactors
STRINGⁱ	9606.ENSP00000295683

Chemistry databases

BindingDBⁱ

P25024

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	38 – 66	Combined sources	29
Helixⁱ	75 – 100	Combined sources	26
Beta strandⁱ	101 – 103	Combined sources	3
Helixⁱ	108 – 138	Combined sources	31
Beta strandⁱ	139 – 141	Combined sources	3
Beta strandⁱ	143 – 146	Combined sources	4
Helixⁱ	149 – 173	Combined sources	25
Turnⁱ	195 – 197	Combined sources	3
Helixⁱ	201 – 204	Combined sources	4
Turnⁱ	205 – 207	Combined sources	3
Helixⁱ	208 – 225	Combined sources	18
Turnⁱ	226 – 228	Combined sources	3
Beta strandⁱ	229 – 231	Combined sources	3
Helixⁱ	235 – 238	Combined sources	4
Helixⁱ	240 – 267	Combined sources	28
Beta strandⁱ	270 – 272	Combined sources	3
Helixⁱ	276 – 282	Combined sources	7
Helixⁱ	285 – 293	Combined sources	9
Helixⁱ	294 – 298	Combined sources	5
Helixⁱ	300 – 308	Combined sources	9
Helixⁱ	311 – 322	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	P25024
SMRⁱ	P25024
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P25024

EvolutionaryTraceⁱ

P25024

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEHI Eukaryota ENOG410Y9Y6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150843
HOVERGENⁱ	HBG106917
InParanoidⁱ	P25024
KEGG Orthology (KO) More...KOⁱ	K04175
OMAⁱ	NDTAKWR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C7W
PhylomeDBⁱ	P25024
TreeFamⁱ	TF330966

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15178 7tmA_CXCR1_2, 1 hit
InterProⁱ	View protein in InterPro IPR001355 Chemokine_CXCR1 IPR000174 Chemokine_CXCR_1/2 IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00427 INTRLEUKIN8R PR00572 INTRLEUKN8AR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P25024-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF 
        60         70         80         90        100
LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV 
       110        120        130        140        150
NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR 
       160        170        180        190        200
HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM 
       210        220        230        240        250
VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI 
       260        270        280        290        300
FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL 
       310        320        330        340        350
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL

Length:350

Mass (Da):39,791

Last modified:May 30, 2006 - v2

Checksum:ⁱ2463E868C0EB0DE2

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	154	K → N in AAH72397 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021061	31	M → R3 PublicationsCorresponds to variant dbSNP:rs16858811Ensembl.	1
Natural variantⁱVAR_016236	71	R → C. Corresponds to variant dbSNP:rs1805038Ensembl.	1
Natural variantⁱVAR_026525	268	M → L. Corresponds to variant dbSNP:rs9282752Ensembl.	1
Natural variantⁱVAR_003479	276	S → T Common polymorphism. 4 PublicationsCorresponds to variant dbSNP:rs2234671Ensembl.	1
Natural variantⁱVAR_016237	306	A → T1 PublicationCorresponds to variant dbSNP:rs201583693Ensembl.	1
Natural variantⁱVAR_016238	335	R → C4 PublicationsCorresponds to variant dbSNP:rs16858808Ensembl.	1
Natural variantⁱVAR_021062	342	S → L1 PublicationCorresponds to variant dbSNP:rs16858806Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L19591 mRNA Translation: AAB59436.1 L19592 Genomic DNA Translation: AAA59160.1 M68932 mRNA Translation: AAA59159.1 X65858 Genomic DNA Translation: CAA46688.1 U11870 Genomic DNA Translation: AAA64378.1 AY916762 Genomic DNA Translation: AAY21512.1 AY916763 Genomic DNA Translation: AAY21513.1 AY916764 Genomic DNA Translation: AAY21514.1 AY916765 Genomic DNA Translation: AAY21515.1 AY916766 Genomic DNA Translation: AAY21516.1 AY916769 Genomic DNA Translation: AAY21519.1 AY916772 Genomic DNA Translation: AAY21522.1 AY916773 Genomic DNA Translation: AAY21523.1 CR541994 mRNA Translation: CAG46791.1 CR542029 mRNA Translation: CAG46826.1 AK312668 mRNA Translation: BAG35550.1 AY651785 Genomic DNA Translation: AAT46689.1 AC097483 Genomic DNA Translation: AAX93212.1 CH471063 Genomic DNA Translation: EAW70590.1 BC028221 mRNA Translation: AAH28221.1 BC072397 mRNA Translation: AAH72397.1 AB032728 Genomic DNA Translation: BAA92290.1 AB032729 Genomic DNA Translation: BAA92291.1 AB032730 Genomic DNA Translation: BAA92292.1 AB032731 Genomic DNA Translation: BAA92293.1 AB032732 Genomic DNA Translation: BAA92294.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2409.1
PIRⁱ	I37449 A39445
NCBI Reference Sequences More...RefSeqⁱ	NP_000625.1, NM_000634.2
UniGeneⁱ	Hs.194778

Genome annotation databases

Ensemblⁱ	ENST00000295683; ENSP00000295683; ENSG00000163464
GeneIDⁱ	3577
KEGGⁱ	hsa:3577
UCSC genome browser More...UCSCⁱ	uc002vhc.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P25024	C-X-C chemokine receptor type 1		HOOHO		351	UniRef90_P25024
C-X-C chemokine receptor type 1		PONPY		351
C-X-C chemokine receptor type 1		GORGO		350
C-X-C chemokine receptor type 1		PANTR		350
Uncharacterized protein		AOTNA		358
+13

Protein	Similar proteins		Species	Score	Length	Source
P25024	C-X-C chemokine receptor type 2	)	HUMAN		360	UniRef50_P25025
C-X-C chemokine receptor type 2 (Fragment)		PANTR		357
C-X-C chemokine receptor type 2 (Fragment)		GORGO		353
C-X-C chemokine receptor type 2 (Fragment)		MACMU		353
C-X-C chemokine receptor type 2		RAT		359
+385

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CXC chemokine receptors entry

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L19591 mRNA Translation: AAB59436.1 L19592 Genomic DNA Translation: AAA59160.1 M68932 mRNA Translation: AAA59159.1 X65858 Genomic DNA Translation: CAA46688.1 U11870 Genomic DNA Translation: AAA64378.1 AY916762 Genomic DNA Translation: AAY21512.1 AY916763 Genomic DNA Translation: AAY21513.1 AY916764 Genomic DNA Translation: AAY21514.1 AY916765 Genomic DNA Translation: AAY21515.1 AY916766 Genomic DNA Translation: AAY21516.1 AY916769 Genomic DNA Translation: AAY21519.1 AY916772 Genomic DNA Translation: AAY21522.1 AY916773 Genomic DNA Translation: AAY21523.1 CR541994 mRNA Translation: CAG46791.1 CR542029 mRNA Translation: CAG46826.1 AK312668 mRNA Translation: BAG35550.1 AY651785 Genomic DNA Translation: AAT46689.1 AC097483 Genomic DNA Translation: AAX93212.1 CH471063 Genomic DNA Translation: EAW70590.1 BC028221 mRNA Translation: AAH28221.1 BC072397 mRNA Translation: AAH72397.1 AB032728 Genomic DNA Translation: BAA92290.1 AB032729 Genomic DNA Translation: BAA92291.1 AB032730 Genomic DNA Translation: BAA92292.1 AB032731 Genomic DNA Translation: BAA92293.1 AB032732 Genomic DNA Translation: BAA92294.1
CCDSⁱ	CCDS2409.1
PIRⁱ	I37449 A39445
RefSeqⁱ	NP_000625.1, NM_000634.2
UniGeneⁱ	Hs.194778

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ILP	NMR	-	C	9-29	[»]
	1ILQ	NMR	-	C	9-29	[»]
	2LNL	NMR	-	A	20-328	[»]
ProteinModelPortalⁱ	P25024
SMRⁱ	P25024
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109791, 5 interactors
DIPⁱ	DIP-3779N
IntActⁱ	P25024, 9 interactors
STRINGⁱ	9606.ENSP00000295683

Chemistry databases

BindingDBⁱ	P25024
ChEMBLⁱ	CHEMBL4029
DrugBankⁱ	DB01009 Ketoprofen
GuidetoPHARMACOLOGYⁱ	68

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P25024
PhosphoSitePlusⁱ	P25024

Polymorphism and mutation databases

BioMutaⁱ	CXCR1
DMDMⁱ	108936015

Proteomic databases

PaxDbⁱ	P25024
PeptideAtlasⁱ	P25024
PRIDEⁱ	P25024
ProteomicsDBⁱ	54245

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3577
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000295683; ENSP00000295683; ENSG00000163464
GeneIDⁱ	3577
KEGGⁱ	hsa:3577
UCSCⁱ	uc002vhc.4 human

Organism-specific databases

CTDⁱ	3577
DisGeNETⁱ	3577
EuPathDBⁱ	HostDB:ENSG00000163464.7
GeneCardsⁱ	CXCR1
H-InvDBⁱ	HIX0203926
HGNCⁱ	HGNC:6026 CXCR1
HPAⁱ	HPA031991
MalaCardsⁱ	CXCR1
MIMⁱ	146929 gene
neXtProtⁱ	NX_P25024
OpenTargetsⁱ	ENSG00000163464
PharmGKBⁱ	PA29842
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEHI Eukaryota ENOG410Y9Y6 LUCA
GeneTreeⁱ	ENSGT00930000150843
HOVERGENⁱ	HBG106917
InParanoidⁱ	P25024
KOⁱ	K04175
OMAⁱ	NDTAKWR
OrthoDBⁱ	EOG091G0C7W
PhylomeDBⁱ	P25024
TreeFamⁱ	TF330966

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events R-HSA-6798695 Neutrophil degranulation
SIGNORⁱ	P25024

Miscellaneous databases

ChiTaRSⁱ	CXCR1 human
EvolutionaryTraceⁱ	P25024
GeneWikiⁱ	Interleukin_8_receptor,_alpha
GenomeRNAiⁱ	3577
Protein Ontology More...PROⁱ	PR:P25024
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163464 Expressed in 93 organ(s), highest expression level in blood
Genevisibleⁱ	P25024 HS

Family and domain databases

CDDⁱ	cd15178 7tmA_CXCR1_2, 1 hit
InterProⁱ	View protein in InterPro IPR001355 Chemokine_CXCR1 IPR000174 Chemokine_CXCR_1/2 IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00427 INTRLEUKIN8R PR00572 INTRLEUKN8AR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXCR1_HUMAN
Accessionⁱ	P25024Primary (citable) accession number: P25024 Secondary accession number(s): B2R6Q3 Q9P2U2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	May 30, 2006
	Last modified:	November 7, 2018
	This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P25024 (CXCR1_HUMAN)

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C-X-C chemokine receptor type 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Plasma Membrane

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Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ