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Protein

Cyclin-dependent kinase 2

Gene

CDK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431).By similarity19 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.3 Publications

Cofactori

Mg2+1 PublicationNote: Binds 2 Mg2+ ions.1 Publication

Activity regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it (PubMed:1396589). Inhibited by 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), AG-024322, N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), R547 (Ro-4584820), purine, pyrimidine and pyridine derivatives, 2-aminopyrimidines, paullones, thiazo derivatives, macrocyclic quinoxalin-2-one, pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine, 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine, seliciclib and CYC202), SNS-032 (BMS-387032), triazolo[1,5-a]pyrimidines, staurosporine and olomoucine. Stimulated by MYC. Inactivated by CDKN1A (p21).5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei9CDK7 binding1
Binding sitei33ATPPROSITE-ProRule annotation2 Publications1
Binding sitei86ATPPROSITE-ProRule annotation2 Publications1
Sitei88 – 89CDK7 binding2
Active sitei127Proton acceptor1
Metal bindingi132Magnesium1 Publication1
Metal bindingi145Magnesium1 Publication1
Binding sitei145ATPPROSITE-ProRule annotation2 Publications1
Sitei166CDK7 binding1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation2 Publications9
Nucleotide bindingi81 – 83ATPPROSITE-ProRule annotation2 Publications3
Nucleotide bindingi129 – 132ATPPROSITE-ProRule annotation2 Publications4

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin binding Source: UniProtKB
  • cyclin-dependent protein kinase activity Source: UniProtKB
  • cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
  • magnesium ion binding Source: Ensembl
  • protein domain specific binding Source: CAFA
  • protein serine/threonine kinase activity Source: ARUK-UCL

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, DNA damage, DNA repair, Meiosis, Mitosis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
ReactomeiR-HSA-1538133 G0 and Early G1
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-68911 G2 Phase
R-HSA-68949 Orc1 removal from chromatin
R-HSA-68962 Activation of the pre-replicative complex
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69563 p53-Dependent G1 DNA Damage Response
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-8849470 PTK6 Regulates Cell Cycle
R-HSA-912446 Meiotic recombination
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP24941
SIGNORiP24941

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2 (EC:2.7.11.223 Publications)
Alternative name(s):
Cell division protein kinase 2
p33 protein kinase
Gene namesi
Name:CDK2
Synonyms:CDKN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000123374.10
HGNCiHGNC:1771 CDK2
MIMi116953 gene
neXtProtiNX_P24941

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi9K → F: Reduced phosphorylation by CAK. 1 Publication1
Mutagenesisi14T → A: 2-fold increase in activity. 1 Publication1
Mutagenesisi15Y → F: 2-fold increase in activity. 1 Publication1
Mutagenesisi88 – 89KK → EV: Reduced phosphorylation by CAK. 1 Publication2
Mutagenesisi160T → A: Abolishes activity. 1 Publication1
Mutagenesisi166L → R: Reduced phosphorylation by CAK and reduced kinase activity. 1 Publication1

Organism-specific databases

DisGeNETi1017
OpenTargetsiENSG00000123374
PharmGKBiPA101

Chemistry databases

ChEMBLiCHEMBL301
DrugBankiDB07054 (2R)-1-(DIMETHYLAMINO)-3-{4-[(6-{[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENOXY}PROPAN-2-OL
DB07504 (2R)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL
DB08463 (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol
DB07501 (2S)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL
DB07137 (2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE
DB08137 (4E)-N-(4-fluorophenyl)-4-[(phenylcarbonyl)imino]-4H-pyrazole-3-carboxamide
DB02603 1-Amino-6-Cyclohex-3-Enylmethyloxypurine
DB04288 2-[Trans-(4-Aminocyclohexyl)Amino]-6-(Benzyl-Amino)-9-Cyclopentylpurine
DB02297 2-Amino-6-Chloropyrazine
DB06948 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE
DB07982 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol
DB08248 3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE
DB08309 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL
DB02973 4-(5-Bromo-2-Oxo-2h-Indol-3-Ylazo)-Benzenesulfonamide
DB08241 4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE
DB08136 4-(acetylamino)-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide
DB03307 4-[(6-Amino-4-Pyrimidinyl)Amino]Benzenesulfonamide
DB08134 4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide
DB04407 4-[4-(4-Methyl-2-Methylamino-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol
DB07791 4-{[4-(1-CYCLOPROPYL-2-METHYL-1H-IMIDAZOL-5-YL)PYRIMIDIN-2-YL]AMINO}-N-METHYLBENZENESULFONAMIDE
DB08572 4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE
DB07163 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE
DB08132 5-hydroxynaphthalene-1-sulfonamide
DB02898 5-{[(2-Amino-9h-Purin-6-Yl)Oxy]Methyl}-2-Pyrrolidinone
DB07612 6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE
DB08247 6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE
DB07203 6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE
DB08233 6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE
DB02407 6-O-Cyclohexylmethyl Guanine
DB02833 [4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amine
DB05037 AT7519
DB06616 Bosutinib
DB03496 Flavopiridol
DB02950 Hymenialdisine
DB02052 Indirubin-3'-Monoxime
DB03801 Lysine Nz-Carboxylic Acid
DB07790 N-(2-METHOXYETHYL)-4-({4-[2-METHYL-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE
DB06944 N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide
DB08768 N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE
DB08133 N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide
DB07936 N-(4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-amine
DB02647 N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide
DB08677 N-(5-ISOPROPYL-THIAZOL-2-YL)-2-PYRIDIN-3-YL-ACETAMIDE
DB08066 N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
DB08135 N-phenyl-1H-pyrazole-3-carboxamide
DB07126 O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE
DB02116 Olomoucine
DB04662 OLOMOUCINE II
DB02733 Purvalanol
DB02010 Staurosporine
DB03428 SU9516
DB04669 TRIAZOLOPYRIMIDINE
GuidetoPHARMACOLOGYi1973

Polymorphism and mutation databases

BioMutaiCDK2
DMDMi116051

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857691 – 298Cyclin-dependent kinase 2Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei6N6-acetyllysineCombined sources1
Modified residuei14Phosphothreonine2 Publications1
Modified residuei15Phosphotyrosine; by WEE1Combined sources2 Publications1
Modified residuei19PhosphotyrosineCombined sources1
Modified residuei160Phosphothreonine; by CAK and CCRK1 Publication8 Publications1

Post-translational modificationi

Phosphorylated at Thr-160 by CDK7 in a CAK complex (PubMed:28666995). Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A.1 Publication11 Publications
Nitrosylated after treatment with nitric oxide (DETA-NO).1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

EPDiP24941
MaxQBiP24941
PaxDbiP24941
PeptideAtlasiP24941
PRIDEiP24941
ProteomicsDBi54241
54242 [P24941-2]

PTM databases

iPTMnetiP24941
PhosphoSitePlusiP24941
SwissPalmiP24941

Expressioni

Inductioni

Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis.

Gene expression databases

BgeeiENSG00000123374 Expressed in 200 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_CDK2
ExpressionAtlasiP24941 baseline and differential
GenevisibleiP24941 HS

Organism-specific databases

HPAiCAB013115
HPA066915

Interactioni

Subunit structurei

Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC (PubMed:15611625). Interaction with SPDYA promotes kinase activation via a conformation change that alleviates obstruction of the substrate-binding cleft by the T-loop (PubMed:28666995). Found in a complex with both SPDYA and CDKN1B/KIP1 (PubMed:12972555, PubMed:28666995). Binds to RB1 and CDK7. Binding to CDKN1A (p21) leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Associated with PTPN6 and beta-catenin/CTNNB1. Interacts with CACUL1. May interact with CEP63. Interacts with ANKRD17. Interacts with CEBPA (when phosphorylated) (PubMed:15107404). Forms a ternary complex with CCNA2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements (PubMed:8684460). Interacts with cyclins A, B1, B3, D, or E (PubMed:10499802, PubMed:10884347, PubMed:12185076, PubMed:23781148). Interacts with CDK2AP2 (PubMed:23781148).By similarity29 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107452, 685 interactors
ComplexPortaliCPX-2005 Cyclin A1-CDK2 complex
CPX-2006 Cyclin A2-CDK2 complex
CPX-2009 Cyclin B3-CDK2 complex
CPX-2015 Cyclin E1-CDK2 complex
CPX-2016 Cyclin E2-CDK2 complex
CORUMiP24941
DIPiDIP-161N
ELMiP24941
IntActiP24941, 157 interactors
MINTiP24941
STRINGi9606.ENSP00000266970

Chemistry databases

BindingDBiP24941

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP24941
SMRiP24941
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24941

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00910000144030
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiP24941
KOiK02206
PhylomeDBiP24941
TreeFamiTF101021

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P24941-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR
60 70 80 90 100
EISLLKELNH PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP
110 120 130 140 150
LPLIKSYLFQ LLQGLAFCHS HRVLHRDLKP QNLLINTEGA IKLADFGLAR
160 170 180 190 200
AFGVPVRTYT HEVVTLWYRA PEILLGCKYY STAVDIWSLG CIFAEMVTRR
210 220 230 240 250
ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF PKWARQDFSK
260 270 280 290
VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL
Length:298
Mass (Da):33,930
Last modified:August 1, 1992 - v2
Checksum:iF90A0F4E70910B51
GO
Isoform 2 (identifier: P24941-2) [UniParc]FASTAAdd to basket
Also known as: CDK2deltaT

The sequence of this isoform differs from the canonical sequence as follows:
     163-196: Missing.

Show »
Length:264
Mass (Da):30,035
Checksum:i50CE890992AC71EE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ESI2E7ESI2_HUMAN
Cyclin-dependent kinase 2
CDK2
238Annotation score:
G3V5T9G3V5T9_HUMAN
Cyclin-dependent kinase 2
CDK2 hCG_24992
346Annotation score:
G3V317G3V317_HUMAN
Cyclin-dependent kinase 2
CDK2
39Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8 – 12EKIGE → AQIGQ in BAA32794 (Ref. 5) Curated5
Sequence conflicti25 – 29LTGEV → STGQM in BAA32794 (Ref. 5) Curated5
Sequence conflicti272 – 277NKRISA → YKRFST in BAA32794 (Ref. 5) Curated6
Sequence conflicti286 – 287FQ → LE in BAA32794 (Ref. 5) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01615715Y → S. Corresponds to variant dbSNP:rs3087335Ensembl.1
Natural variantiVAR_05392718V → L. Corresponds to variant dbSNP:rs11554376Ensembl.1
Natural variantiVAR_04197245P → L in a glioblastoma multiforme sample; somatic mutation. 1 Publication1
Natural variantiVAR_019988290T → S2 PublicationsCorresponds to variant dbSNP:rs2069413Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041998163 – 196Missing in isoform 2. CuratedAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61622 mRNA Translation: CAA43807.1
X62071 mRNA Translation: CAA43985.1
M68520 mRNA Translation: AAA35667.1
AB012305 mRNA Translation: BAA32794.1
BT006821 mRNA Translation: AAP35467.1
AF512553 Genomic DNA Translation: AAM34794.1
AK291941 mRNA Translation: BAF84630.1
AC025162 Genomic DNA No translation available.
AC034102 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96858.1
BC003065 mRNA Translation: AAH03065.1
CCDSiCCDS8898.1 [P24941-1]
CCDS8899.1 [P24941-2]
PIRiA41227
RefSeqiNP_001277159.1, NM_001290230.1
NP_001789.2, NM_001798.4 [P24941-1]
NP_439892.2, NM_052827.3 [P24941-2]
UniGeneiHs.19192
Hs.689624

Genome annotation databases

EnsembliENST00000266970; ENSP00000266970; ENSG00000123374 [P24941-1]
ENST00000354056; ENSP00000243067; ENSG00000123374 [P24941-2]
GeneIDi1017
KEGGihsa:1017
UCSCiuc001sit.5 human [P24941-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61622 mRNA Translation: CAA43807.1
X62071 mRNA Translation: CAA43985.1
M68520 mRNA Translation: AAA35667.1
AB012305 mRNA Translation: BAA32794.1
BT006821 mRNA Translation: AAP35467.1
AF512553 Genomic DNA Translation: AAM34794.1
AK291941 mRNA Translation: BAF84630.1
AC025162 Genomic DNA No translation available.
AC034102 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96858.1
BC003065 mRNA Translation: AAH03065.1
CCDSiCCDS8898.1 [P24941-1]
CCDS8899.1 [P24941-2]
PIRiA41227
RefSeqiNP_001277159.1, NM_001290230.1
NP_001789.2, NM_001798.4 [P24941-1]
NP_439892.2, NM_052827.3 [P24941-2]
UniGeneiHs.19192
Hs.689624

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AQ1X-ray2.00A1-298[»]
1B38X-ray2.00A1-298[»]
1B39X-ray2.10A1-298[»]
1BUHX-ray2.60A1-298[»]
1CKPX-ray2.05A1-298[»]
1DI8X-ray2.20A1-298[»]
1DM2X-ray2.10A1-298[»]
1E1VX-ray1.95A1-298[»]
1E1XX-ray1.85A1-298[»]
1E9HX-ray2.50A/C1-296[»]
1F5QX-ray2.50A/C1-298[»]
1FINX-ray2.30A/C1-298[»]
1FQ1X-ray3.00B1-298[»]
1FVTX-ray2.20A1-298[»]
1FVVX-ray2.80A/C1-298[»]
1G5SX-ray2.61A1-298[»]
1GIHX-ray2.80A1-298[»]
1GIIX-ray2.00A1-298[»]
1GIJX-ray2.20A1-298[»]
1GY3X-ray2.70A/C1-296[»]
1GZ8X-ray1.30A1-298[»]
1H00X-ray1.60A1-298[»]
1H01X-ray1.79A1-298[»]
1H07X-ray1.85A1-298[»]
1H08X-ray1.80A1-298[»]
1H0VX-ray1.90A1-298[»]
1H0WX-ray2.10A1-298[»]
1H1PX-ray2.10A/C1-298[»]
1H1QX-ray2.50A/C1-298[»]
1H1RX-ray2.00A/C1-298[»]
1H1SX-ray2.00A/C1-298[»]
1H24X-ray2.50A/C1-298[»]
1H25X-ray2.50A/C1-298[»]
1H26X-ray2.24A/C1-298[»]
1H27X-ray2.20A/C1-298[»]
1H28X-ray2.80A/C1-298[»]
1HCKX-ray1.90A1-298[»]
1HCLX-ray1.80A1-298[»]
1JSTX-ray2.60A/C1-298[»]
1JSUX-ray2.30A1-298[»]
1JSVX-ray1.96A1-298[»]
1JVPX-ray1.53P1-298[»]
1KE5X-ray2.20A1-298[»]
1KE6X-ray2.00A1-298[»]
1KE7X-ray2.00A1-298[»]
1KE8X-ray2.00A1-298[»]
1KE9X-ray2.00A1-298[»]
1OGUX-ray2.60A/C1-298[»]
1OI9X-ray2.10A/C1-298[»]
1OIQX-ray2.31A1-298[»]
1OIRX-ray1.91A1-298[»]
1OITX-ray1.60A1-298[»]
1OIUX-ray2.00A/C1-298[»]
1OIYX-ray2.40A/C1-298[»]
1OKVX-ray2.40A/C1-298[»]
1OKWX-ray2.50A/C1-298[»]
1OL1X-ray2.90A/C1-298[»]
1OL2X-ray2.60A/C1-298[»]
1P2AX-ray2.50A1-298[»]
1P5EX-ray2.22A/C1-298[»]
1PF8X-ray2.51A1-298[»]
1PKDX-ray2.30A/C1-296[»]
1PW2X-ray1.95A1-298[»]
1PXIX-ray1.95A1-298[»]
1PXJX-ray2.30A1-298[»]
1PXKX-ray2.80A1-298[»]
1PXLX-ray2.50A1-298[»]
1PXMX-ray2.53A1-298[»]
1PXNX-ray2.50A1-298[»]
1PXOX-ray1.96A1-298[»]
1PXPX-ray2.30A1-298[»]
1PYEX-ray2.00A1-298[»]
1QMZX-ray2.20A/C1-298[»]
1R78X-ray2.00A1-298[»]
1URCX-ray2.60A/C1-298[»]
1URWX-ray1.60A1-298[»]
1V1KX-ray2.31A1-298[»]
1VYWX-ray2.30A/C1-298[»]
1VYZX-ray2.21A1-298[»]
1W0XX-ray2.20C1-298[»]
1W8CX-ray2.05A1-298[»]
1W98X-ray2.15A1-297[»]
1WCCX-ray2.20A1-298[»]
1Y8YX-ray2.00A1-298[»]
1Y91X-ray2.15A1-298[»]
1YKRX-ray1.80A1-298[»]
2A0CX-ray1.95X1-298[»]
2A4LX-ray2.40A1-298[»]
2B52X-ray1.88A1-298[»]
2B53X-ray2.00A1-298[»]
2B54X-ray1.85A1-298[»]
2B55X-ray1.85A1-298[»]
2BHEX-ray1.90A1-298[»]
2BHHX-ray2.60A1-298[»]
2BKZX-ray2.60A/C1-298[»]
2BPMX-ray2.40A/C1-298[»]
2BTRX-ray1.85A1-298[»]
2BTSX-ray1.99A1-298[»]
2C4GX-ray2.70A/C1-298[»]
2C5NX-ray2.10A/C1-298[»]
2C5OX-ray2.10A/C1-298[»]
2C5VX-ray2.90A/C1-298[»]
2C5XX-ray2.90A/C1-298[»]
2C5YX-ray2.25A1-298[»]
2C68X-ray1.95A1-298[»]
2C69X-ray2.10A1-298[»]
2C6IX-ray1.80A1-298[»]
2C6KX-ray1.90A1-298[»]
2C6LX-ray2.30A1-298[»]
2C6MX-ray1.90A1-298[»]
2C6OX-ray2.10A1-298[»]
2C6TX-ray2.61A/C1-298[»]
2CCHX-ray1.70A/C1-298[»]
2CCIX-ray2.70A/C1-298[»]
2CJMX-ray2.30A/C1-298[»]
2CLXX-ray1.80A1-298[»]
2DS1X-ray2.00A1-298[»]
2DUVX-ray2.20A1-298[»]
2EXMX-ray1.80A1-298[»]
2FVDX-ray1.85A1-298[»]
2G9XX-ray2.50A/C1-298[»]
2HICmodel-A1-298[»]
2I40X-ray2.80A/C1-298[»]
2IW6X-ray2.30A/C1-298[»]
2IW8X-ray2.30A/C1-298[»]
2IW9X-ray2.00A/C1-298[»]
2J9MX-ray2.50A1-298[»]
2JGZX-ray2.90A1-288[»]
2R3FX-ray1.50A1-298[»]
2R3GX-ray1.55A1-298[»]
2R3HX-ray1.50A1-298[»]
2R3IX-ray1.28A1-298[»]
2R3JX-ray1.65A1-298[»]
2R3KX-ray1.70A1-298[»]
2R3LX-ray1.65A1-298[»]
2R3MX-ray1.70A1-298[»]
2R3NX-ray1.63A1-298[»]
2R3OX-ray1.80A1-298[»]
2R3PX-ray1.66A1-298[»]
2R3QX-ray1.35A1-298[»]
2R3RX-ray1.47A1-298[»]
2R64X-ray2.30A1-298[»]
2UUEX-ray2.06A/C1-298[»]
2UZBX-ray2.70A/C1-298[»]
2UZDX-ray2.72A/C1-298[»]
2UZEX-ray2.40A/C1-298[»]
2UZLX-ray2.40A/C1-298[»]
2UZNX-ray2.30A1-298[»]
2UZOX-ray2.30A1-298[»]
2V0DX-ray2.20A1-298[»]
2V22X-ray2.60A/C1-298[»]
2VTAX-ray2.00A1-298[»]
2VTHX-ray1.90A1-298[»]
2VTIX-ray2.00A1-298[»]
2VTJX-ray2.20A1-298[»]
2VTLX-ray2.00A1-298[»]
2VTMX-ray2.25A1-298[»]
2VTNX-ray2.20A1-298[»]
2VTOX-ray2.19A1-298[»]
2VTPX-ray2.15A1-298[»]
2VTQX-ray1.90A1-298[»]
2VTRX-ray1.90A1-298[»]
2VTSX-ray1.90A1-298[»]
2VTTX-ray1.68A1-298[»]
2VU3X-ray1.85A1-298[»]
2VV9X-ray1.90A1-298[»]
2W05X-ray1.90A1-298[»]
2W06X-ray2.04A1-298[»]
2W17X-ray2.15A1-298[»]
2W1HX-ray2.15A1-298[»]
2WEVX-ray2.30A/C1-298[»]
2WFYX-ray2.53A/C1-298[»]
2WHBX-ray2.90A/C1-298[»]
2WIHX-ray2.50A/C1-298[»]
2WIPX-ray2.80A/C1-298[»]
2WMAX-ray2.80A/C1-298[»]
2WMBX-ray2.60A/C1-298[»]
2WPAX-ray2.51A/C1-298[»]
2WXVX-ray2.60A/C1-298[»]
2X1NX-ray2.75A/C1-298[»]
2XMYX-ray1.90A1-298[»]
2XNBX-ray1.85A1-298[»]
3BHTX-ray2.00A/C1-298[»]
3BHUX-ray2.30A/C1-298[»]
3BHVX-ray2.10A/C1-298[»]
3DDPX-ray2.70A/C1-298[»]
3DDQX-ray1.80A/C1-298[»]
3DOGX-ray2.70A/C1-298[»]
3EIDX-ray3.15A/C1-298[»]
3EJ1X-ray3.22A/C1-298[»]
3EOCX-ray3.20A/C1-298[»]
3EZRX-ray1.90A1-298[»]
3EZVX-ray1.99A1-298[»]
3F5XX-ray2.40A/C1-298[»]
3FZ1X-ray1.90A1-298[»]
3IG7X-ray1.80A1-298[»]
3IGGX-ray1.80A1-298[»]
3LE6X-ray2.00A1-298[»]
3LFNX-ray2.28A1-298[»]
3LFQX-ray2.03A1-298[»]
3LFSX-ray2.40A1-298[»]
3MY5X-ray2.10A/C1-298[»]
3NS9X-ray1.78A1-298[»]
3PJ8X-ray1.96A1-298[»]
3PXFX-ray1.80A1-298[»]
3PXQX-ray1.90A1-298[»]
3PXRX-ray2.00A1-298[»]
3PXYX-ray1.80A1-298[»]
3PXZX-ray1.70A1-298[»]
3PY0X-ray1.75A1-298[»]
3PY1X-ray2.05A1-298[»]
3QHRX-ray2.17A/C1-296[»]
3QHWX-ray1.91A/C1-296[»]
3QL8X-ray1.90A1-298[»]
3QQFX-ray1.75A1-298[»]
3QQGX-ray1.90A1-298[»]
3QQHX-ray1.87A1-298[»]
3QQJX-ray1.70A1-298[»]
3QQKX-ray1.86A1-298[»]
3QQLX-ray1.85A1-298[»]
3QRTX-ray1.75A1-298[»]
3QRUX-ray1.95A1-298[»]
3QTQX-ray1.80A1-298[»]
3QTRX-ray1.85A1-298[»]
3QTSX-ray1.90A1-298[»]
3QTUX-ray1.82A1-298[»]
3QTWX-ray1.85A1-298[»]
3QTXX-ray1.95A1-298[»]
3QTZX-ray2.00A1-298[»]
3QU0X-ray1.95A1-298[»]
3QWJX-ray1.75A1-298[»]
3QWKX-ray1.85A1-298[»]
3QX2X-ray1.75A1-298[»]
3QX4X-ray1.92A1-298[»]
3QXOX-ray1.75A1-298[»]
3QXPX-ray1.75A1-298[»]
3QZFX-ray2.00A1-298[»]
3QZGX-ray1.75A1-298[»]
3QZHX-ray1.95A1-298[»]
3QZIX-ray1.75A1-298[»]
3R1QX-ray1.85A1-298[»]
3R1SX-ray1.80A1-298[»]
3R1YX-ray1.80A1-298[»]
3R28X-ray1.75A1-298[»]
3R6XX-ray1.75A1-298[»]
3R71X-ray1.75A1-298[»]
3R73X-ray1.70A1-298[»]
3R7EX-ray1.90A1-298[»]
3R7IX-ray1.85A1-298[»]
3R7UX-ray1.75A1-298[»]
3R7VX-ray1.95A1-298[»]
3R7YX-ray1.90A1-298[»]
3R83X-ray1.75A1-298[»]
3R8LX-ray1.90A1-298[»]
3R8MX-ray1.80A1-298[»]
3R8PX-ray1.80A1-298[»]
3R8UX-ray2.00A1-298[»]
3R8VX-ray1.90A1-298[»]
3R8ZX-ray1.85A1-298[»]
3R9DX-ray1.95A1-298[»]
3R9HX-ray2.10A1-298[»]
3R9NX-ray1.75A1-298[»]
3R9OX-ray1.90A1-298[»]
3RAHX-ray1.75A1-298[»]
3RAIX-ray1.70A1-298[»]
3RAKX-ray1.75A1-298[»]
3RALX-ray1.75A1-298[»]
3RJCX-ray1.85A1-298[»]
3RK5X-ray2.00A1-298[»]
3RK7X-ray1.80A1-298[»]
3RK9X-ray1.85A1-298[»]
3RKBX-ray2.00A1-298[»]
3RM6X-ray1.60A1-298[»]
3RM7X-ray1.85A1-298[»]
3RMFX-ray1.75A1-298[»]
3RNIX-ray1.95A1-298[»]
3ROYX-ray1.75A1-298[»]
3RPOX-ray1.75A1-298[»]
3RPRX-ray1.75A1-298[»]
3RPVX-ray1.80A1-298[»]
3RPYX-ray1.90A1-298[»]
3RZBX-ray1.90A1-298[»]
3S00X-ray1.80A1-298[»]
3S0OX-ray2.00A1-298[»]
3S1HX-ray1.75A1-298[»]
3S2PX-ray2.30A1-298[»]
3SQQX-ray1.85A1-298[»]
3SW4X-ray1.70A1-298[»]
3SW7X-ray1.80A1-298[»]
3TI1X-ray1.99A1-298[»]
3TIYX-ray1.84A1-298[»]
3TIZX-ray2.02A1-298[»]
3TNWX-ray2.00A/C1-298[»]
3ULIX-ray2.00A1-298[»]
3UNJX-ray1.90A1-298[»]
3UNKX-ray2.10A1-298[»]
3WBLX-ray2.00A1-298[»]
4ACMX-ray1.63A1-298[»]
4BCKX-ray2.05A/C1-298[»]
4BCMX-ray2.45A/C1-298[»]
4BCNX-ray2.10A/C1-298[»]
4BCOX-ray2.05A/C1-298[»]
4BCPX-ray2.26A/C1-298[»]
4BCQX-ray2.40A/C1-298[»]
4BGHX-ray1.95A1-298[»]
4BZDX-ray1.83A1-298[»]
4CFMX-ray2.85A/C1-298[»]
4CFNX-ray2.20A/C1-298[»]
4CFUX-ray2.20A/C1-298[»]
4CFVX-ray2.00A/C1-298[»]
4CFWX-ray2.45A/C1-298[»]
4CFXX-ray3.50A/C1-298[»]
4D1XX-ray2.10A1-298[»]
4D1ZX-ray1.85A1-298[»]
4EK3X-ray1.34A1-298[»]
4EK4X-ray1.26A1-298[»]
4EK5X-ray1.60A1-298[»]
4EK6X-ray1.52A1-298[»]
4EK8X-ray1.70A1-298[»]
4EOIX-ray2.00A/C1-298[»]
4EOJX-ray1.65A/C1-298[»]
4EOKX-ray2.57A/C1-297[»]
4EOLX-ray2.40A/C1-297[»]
4EOMX-ray2.10A/C1-297[»]
4EONX-ray2.40A/C1-298[»]
4EOOX-ray2.10A/C1-297[»]
4EOPX-ray1.99A/C1-297[»]
4EOQX-ray2.15A/C1-297[»]
4EORX-ray2.20A/C1-297[»]
4EOSX-ray2.57A/C1-297[»]
4ERWX-ray2.00A1-298[»]
4EZ3X-ray2.00A1-298[»]
4EZ7X-ray2.49A1-298[»]
4FKGX-ray1.51A1-298[»]
4FKIX-ray1.60A1-298[»]
4FKJX-ray1.63A1-298[»]
4FKLX-ray1.26A1-298[»]
4FKOX-ray1.55A1-298[»]
4FKPX-ray1.60A1-298[»]
4FKQX-ray1.75A1-298[»]
4FKRX-ray1.90A1-298[»]
4FKSX-ray1.55A1-298[»]
4FKTX-ray1.60A1-298[»]
4FKUX-ray1.47A1-298[»]
4FKVX-ray1.70A1-298[»]
4FKWX-ray1.80A1-298[»]
4FX3X-ray2.75A/C1-298[»]
4GCJX-ray1.42A1-298[»]
4I3ZX-ray2.05A/C1-296[»]
4II5X-ray2.15A/C1-298[»]
4KD1X-ray1.70A1-298[»]
4LYNX-ray2.00A1-298[»]
4NJ3X-ray1.85A1-298[»]
4RJ3X-ray1.63A1-298[»]
5A14X-ray2.00A1-298[»]
5ANDX-ray2.30A1-298[»]
5ANEX-ray1.70A1-298[»]
5ANGX-ray1.90A1-298[»]
5ANIX-ray1.90A1-298[»]
5ANJX-ray1.60A1-298[»]
5ANKX-ray1.90A1-298[»]
5ANOX-ray1.70A1-298[»]
5CYIX-ray2.00A/C1-298[»]
5D1JX-ray1.80A1-298[»]
5FP5X-ray2.16A1-298[»]
5FP6X-ray1.85A1-298[»]
5IEVX-ray2.03A1-298[»]
5IEXX-ray2.03A1-298[»]
5IEYX-ray1.66A1-298[»]
5IF1X-ray2.61A/C1-298[»]
5JQ5X-ray1.94A1-298[»]
5JQ8X-ray1.94A1-298[»]
5K4JX-ray1.60A1-298[»]
5L2WX-ray2.80A1-298[»]
5LMKX-ray2.40A1-298[»]
C1-296[»]
5MHQX-ray1.30A1-298[»]
5NEVX-ray2.97A/C1-298[»]
5OO0X-ray1.60A1-298[»]
5OO1X-ray2.00A1-298[»]
5OO3X-ray1.73A1-298[»]
5OSJX-ray1.83A1-298[»]
5OSMX-ray1.77A1-298[»]
5UQ1X-ray3.20A/C1-298[»]
5UQ2X-ray2.70A1-298[»]
5UQ3X-ray3.60A1-298[»]
ProteinModelPortaliP24941
SMRiP24941
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107452, 685 interactors
ComplexPortaliCPX-2005 Cyclin A1-CDK2 complex
CPX-2006 Cyclin A2-CDK2 complex
CPX-2009 Cyclin B3-CDK2 complex
CPX-2015 Cyclin E1-CDK2 complex
CPX-2016 Cyclin E2-CDK2 complex
CORUMiP24941
DIPiDIP-161N
ELMiP24941
IntActiP24941, 157 interactors
MINTiP24941
STRINGi9606.ENSP00000266970

Chemistry databases

BindingDBiP24941
ChEMBLiCHEMBL301
DrugBankiDB07054 (2R)-1-(DIMETHYLAMINO)-3-{4-[(6-{[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENOXY}PROPAN-2-OL
DB07504 (2R)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL
DB08463 (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol
DB07501 (2S)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL
DB07137 (2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE
DB08137 (4E)-N-(4-fluorophenyl)-4-[(phenylcarbonyl)imino]-4H-pyrazole-3-carboxamide
DB02603 1-Amino-6-Cyclohex-3-Enylmethyloxypurine
DB04288 2-[Trans-(4-Aminocyclohexyl)Amino]-6-(Benzyl-Amino)-9-Cyclopentylpurine
DB02297 2-Amino-6-Chloropyrazine
DB06948 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE
DB07982 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol
DB08248 3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE
DB08309 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL
DB02973 4-(5-Bromo-2-Oxo-2h-Indol-3-Ylazo)-Benzenesulfonamide
DB08241 4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE
DB08136 4-(acetylamino)-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide
DB03307 4-[(6-Amino-4-Pyrimidinyl)Amino]Benzenesulfonamide
DB08134 4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide
DB04407 4-[4-(4-Methyl-2-Methylamino-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol
DB07791 4-{[4-(1-CYCLOPROPYL-2-METHYL-1H-IMIDAZOL-5-YL)PYRIMIDIN-2-YL]AMINO}-N-METHYLBENZENESULFONAMIDE
DB08572 4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE
DB07163 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE
DB08132 5-hydroxynaphthalene-1-sulfonamide
DB02898 5-{[(2-Amino-9h-Purin-6-Yl)Oxy]Methyl}-2-Pyrrolidinone
DB07612 6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE
DB08247 6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE
DB07203 6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE
DB08233 6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE
DB02407 6-O-Cyclohexylmethyl Guanine
DB02833 [4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amine
DB05037 AT7519
DB06616 Bosutinib
DB03496 Flavopiridol
DB02950 Hymenialdisine
DB02052 Indirubin-3'-Monoxime
DB03801 Lysine Nz-Carboxylic Acid
DB07790 N-(2-METHOXYETHYL)-4-({4-[2-METHYL-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE
DB06944 N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide
DB08768 N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE
DB08133 N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide
DB07936 N-(4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-amine
DB02647 N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide
DB08677 N-(5-ISOPROPYL-THIAZOL-2-YL)-2-PYRIDIN-3-YL-ACETAMIDE
DB08066 N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
DB08135 N-phenyl-1H-pyrazole-3-carboxamide
DB07126 O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE
DB02116 Olomoucine
DB04662 OLOMOUCINE II
DB02733 Purvalanol
DB02010 Staurosporine
DB03428 SU9516
DB04669 TRIAZOLOPYRIMIDINE
GuidetoPHARMACOLOGYi1973

PTM databases

iPTMnetiP24941
PhosphoSitePlusiP24941
SwissPalmiP24941

Polymorphism and mutation databases

BioMutaiCDK2
DMDMi116051

Proteomic databases

EPDiP24941
MaxQBiP24941
PaxDbiP24941
PeptideAtlasiP24941
PRIDEiP24941
ProteomicsDBi54241
54242 [P24941-2]

Protocols and materials databases

DNASUi1017
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266970; ENSP00000266970; ENSG00000123374 [P24941-1]
ENST00000354056; ENSP00000243067; ENSG00000123374 [P24941-2]
GeneIDi1017
KEGGihsa:1017
UCSCiuc001sit.5 human [P24941-1]

Organism-specific databases

CTDi1017
DisGeNETi1017
EuPathDBiHostDB:ENSG00000123374.10
GeneCardsiCDK2
HGNCiHGNC:1771 CDK2
HPAiCAB013115
HPA066915
MIMi116953 gene
neXtProtiNX_P24941
OpenTargetsiENSG00000123374
PharmGKBiPA101
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00910000144030
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiP24941
KOiK02206
PhylomeDBiP24941
TreeFamiTF101021

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
ReactomeiR-HSA-1538133 G0 and Early G1
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-68911 G2 Phase
R-HSA-68949 Orc1 removal from chromatin
R-HSA-68962 Activation of the pre-replicative complex
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69563 p53-Dependent G1 DNA Damage Response
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-8849470 PTK6 Regulates Cell Cycle
R-HSA-912446 Meiotic recombination
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP24941
SIGNORiP24941

Miscellaneous databases

ChiTaRSiCDK2 human
EvolutionaryTraceiP24941
GeneWikiiCyclin-dependent_kinase_2
GenomeRNAii1017
PROiPR:P24941
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123374 Expressed in 200 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_CDK2
ExpressionAtlasiP24941 baseline and differential
GenevisibleiP24941 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDK2_HUMAN
AccessioniPrimary (citable) accession number: P24941
Secondary accession number(s): A8K7C6, O75100
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: August 1, 1992
Last modified: October 10, 2018
This is version 234 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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