Transcription factor JunB

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers."
    Bergman M.R., Cheng S., Honbo N., Piacentini L., Karliner J.S., Lovett D.H.
    Biochem J 369:485-496(2003) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription factor activity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site."
    Varghese S., Rydziel S., Canalis E.
    Endocrinology 141:2185-2191(2000) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• double-stranded DNA binding Source: RGDInferred from direct assayⁱ
  • "Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site."
    Varghese S., Rydziel S., Canalis E.
    Endocrinology 141:2185-2191(2000) [PubMed] [Europe PMC] [Abstract]
  • "Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation."
    Williams J.M., Beckmann A.M., Mason-Parker S.E., Abraham W.C., Wilce P.A., Tate W.P.
    Brain Res Mol Brain Res 77:258-266(2000) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
• sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • "Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site."
    Varghese S., Rydziel S., Canalis E.
    Endocrinology 141:2185-2191(2000) [PubMed] [Europe PMC] [Abstract]
  • "Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation."
    Williams J.M., Beckmann A.M., Mason-Parker S.E., Abraham W.C., Wilce P.A., Tate W.P.
    Brain Res Mol Brain Res 77:258-266(2000) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: RGD

GO - Biological processⁱ

• cellular response to calcium ion Source: RGD
• cellular response to hormone stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Rapid effects of triiodothyronine on immediate-early gene expression in Schwann cells."
    Mercier G., Turque N., Schumacher M.
    Glia 35:81-89(2001) [PubMed] [Europe PMC] [Abstract]
• decidualization Source: RGD
• embryonic process involved in female pregnancy Source: RGD
• female pregnancy Source: RGDInferred from expression patternⁱ
  • "Differential expression of activator protein-1 transcription factors in pregnant rat myometrium."
    Mitchell J.A., Lye S.J.
    Biol Reprod 67:240-246(2002) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: RGD
• labyrinthine layer blood vessel development Source: RGD
• osteoblast differentiation Source: RGD
• osteoblast proliferation Source: RGD
• osteoclast differentiation Source: RGD
• positive regulation of cell differentiation Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGD
• regulation of cell cycle Source: RGD
• regulation of cell population proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGD
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to cAMP Source: RGDInferred from expression patternⁱ
  • "Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors."
    Szabo-Fresnais N., Blondeau J.P., Pomerance M.
    Mol Cell Endocrinol 284:28-37(2008) [PubMed] [Europe PMC] [Abstract]
• response to corticosterone Source: RGDInferred from expression patternⁱ
  • "Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge."
    Hansson A.C., Fuxe K.
    Brain Res 1215:1-10(2008) [PubMed] [Europe PMC] [Abstract]
• response to cytokine Source: RGDInferred from expression patternⁱ
  • "Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors."
    Szabo-Fresnais N., Blondeau J.P., Pomerance M.
    Mol Cell Endocrinol 284:28-37(2008) [PubMed] [Europe PMC] [Abstract]
• response to light stimulus Source: RGDInferred from expression patternⁱ
  • "Is light-regulated AP-1 binding in the rat suprachiasmatic nucleus gated by the circadian clock?"
    Francois-Bellan A.M., Guillaumond F., Bosler O., Becquet D.
    Brain Res Mol Brain Res 85:161-170(2000) [PubMed] [Europe PMC] [Abstract]
• response to mechanical stimulus Source: RGDInferred from expression patternⁱ
  • "Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells."
    Mitchell J.A., Shynlova O., Langille B.L., Lye S.J.
    Am J Physiol Endocrinol Metab 287:E439-45(2004) [PubMed] [Europe PMC] [Abstract]
  • "Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes."
    Papachristou D., Pirttiniemi P., Kantomaa T., Agnantis N., Basdra E.K.
    Eur J Orthod 28:20-26(2006) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation."
    Sharma S.C., Richards J.S.
    J Biol Chem 275:33718-33728(2000) [PubMed] [Europe PMC] [Abstract]
  • "The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes."
    Won J.S., Suh H.W.
    Brain Res Mol Brain Res 84:41-51(2000) [PubMed] [Europe PMC] [Abstract]
• response to peptide hormone Source: RGDInferred from expression patternⁱ
  • "Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation."
    Sharma S.C., Richards J.S.
    J Biol Chem 275:33718-33728(2000) [PubMed] [Europe PMC] [Abstract]
• response to progesterone Source: RGDInferred from expression patternⁱ
  • "Differential expression of activator protein-1 transcription factors in pregnant rat myometrium."
    Mitchell J.A., Lye S.J.
    Biol Reprod 67:240-246(2002) [PubMed] [Europe PMC] [Abstract]
• response to xenobiotic stimulus Source: RGDInferred from expression patternⁱ
  • "Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex."
    Kontkanen O., Lakso M., Wong G., Castren E.
    Neuropsychopharmacology 27:152-162(2002) [PubMed] [Europe PMC] [Abstract]
• transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site."
    Varghese S., Rydziel S., Canalis E.
    Endocrinology 141:2185-2191(2000) [PubMed] [Europe PMC] [Abstract]
• trophectodermal cell differentiation Source: RGD
• vasculogenesis Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MCTKMEQPFY HDDSYAAAGY GRSPGSLSLH DYKLLKPTLA LNLADPYRGL 
        60         70         80         90        100
KGPGARGPGP EGSGAGSYFS GQGSDTGASL KLASTELERL IVPNSNGVIT 
       110        120        130        140        150
TTPTPPGQYF YPRGGGSGGG TGGGVTEEQE GFADGFVKAL DDLHKMNHVT 
       160        170        180        190        200
PPNVSLGASG GPQAGPGGVY AGPEPPPVYT NLSSYSPASA PSGGSGTAVG 
       210        220        230        240        250
TGSSYPTATI SYLPHAPPFA GGHPAQLGLS RGASAFKEEP QTVPEARSRD 
       260        270        280        290        300
ATPPVSPINM EDQERIKVER KRLRNRLAAT KCRKRKLERI ARLEDKVKTL 
       310        320        330        340 
KAENAGLSSA AGLLREQVAQ LKQKVMTHVS NGCQLLLGVK GHAF       

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families