Junb

Functionⁱ

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

GO - Molecular functionⁱ

DNA binding
Source: RGD
Inferred from direct assayⁱ
- 12371906
DNA-binding transcription factor activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 10830307
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
double-stranded DNA binding
Source: RGD
Inferred from direct assayⁱ
- 10830307
- 10837920
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: RGD
Inferred from direct assayⁱ
- 10830307
- 10837920
transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to hormone stimulus
Source: RGD
Inferred from expression patternⁱ
- 11460264
female pregnancy
Source: RGD
Inferred from expression patternⁱ
- 12080023
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to cAMP
Source: RGD
Inferred from expression patternⁱ
- 18280640
response to corticosterone
Source: RGD
Inferred from expression patternⁱ
- 18485334
response to cytokine
Source: RGD
Inferred from expression patternⁱ
- 18280640
response to drug
Source: RGD
Inferred from expression patternⁱ
- 12093589
response to light stimulus
Source: RGD
Inferred from expression patternⁱ
- 11146118
response to lipopolysaccharide
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to mechanical stimulus
Source: RGD
Inferred from expression patternⁱ
- 15126239
- 16373449
response to organic cyclic compound
Source: RGD
Inferred from expression patternⁱ
- 10934195
- 11113530
response to organic substance
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to peptide hormone
Source: RGD
Inferred from expression patternⁱ
- 10934195
response to progesterone
Source: RGD
Inferred from expression patternⁱ
- 12080023
response to radiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription by RNA polymerase II
Source: RGD
Inferred from mutant phenotypeⁱ
- 10830307

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor jun-B
Gene namesⁱ	Name:Junb Synonyms:Jun-b
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	2944 Junb

RGDⁱ

2944 Junb

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076440	1 – 344	Transcription factor jun-BAdd BLAST		344

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	4	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	33	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	36	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	81	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	102	PhosphothreonineBy similarity	1
Modified residueⁱ	104	PhosphothreonineBy similarity	1
Modified residueⁱ	117	PhosphoserineBy similarity	1
Cross-linkⁱ	138	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	237	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	237	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linkⁱ	237	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	248	PhosphoserineBy similarity	1
Modified residueⁱ	252	PhosphothreonineCombined sources	1
Modified residueⁱ	256	PhosphoserineCombined sources	1
Cross-linkⁱ	340	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationⁱ

Ubiquitinated by ITCH, leading to its degradation.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	P24898
PRIDEⁱ	P24898

PTM databases

iPTMnetⁱ	P24898
PhosphoSitePlusⁱ	P24898

Expressionⁱ

Inductionⁱ

By growth factors.

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with NFE2 (via its WW domains).By similarity

GO - Molecular functionⁱ

transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	246672, 1 interactor
CORUMⁱ	P24898
STRINGⁱ	10116.ENSRNOP00000061729

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P24898
SMRⁱ	P24898
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	265 – 328	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	265 – 292	Basic motifPROSITE-ProRule annotationAdd BLAST		28
Regionⁱ	293 – 321	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the bZIP family. Jun subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0837 Eukaryota ENOG410XRWH LUCA
HOGENOMⁱ	HOG000006648
HOVERGENⁱ	HBG001722
InParanoidⁱ	P24898
KEGG Orthology (KO) More...KOⁱ	K09028
PhylomeDBⁱ	P24898

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR005643 JNK IPR029822 JunB IPR002112 Leuzip_Jun IPR008917 TF_DNA-bd_sf
PANTHERⁱ	PTHR11462:SF37 PTHR11462:SF37, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit PF03957 Jun, 1 hit
PRINTSⁱ	PR00043 LEUZIPPRJUN
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
SUPFAMⁱ	SSF47454 SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P24898-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCTKMEQPFY HDDSYAAAGY GRSPGSLSLH DYKLLKPTLA LNLADPYRGL 
        60         70         80         90        100
KGPGARGPGP EGSGAGSYFS GQGSDTGASL KLASTELERL IVPNSNGVIT 
       110        120        130        140        150
TTPTPPGQYF YPRGGGSGGG TGGGVTEEQE GFADGFVKAL DDLHKMNHVT 
       160        170        180        190        200
PPNVSLGASG GPQAGPGGVY AGPEPPPVYT NLSSYSPASA PSGGSGTAVG 
       210        220        230        240        250
TGSSYPTATI SYLPHAPPFA GGHPAQLGLS RGASAFKEEP QTVPEARSRD 
       260        270        280        290        300
ATPPVSPINM EDQERIKVER KRLRNRLAAT KCRKRKLERI ARLEDKVKTL 
       310        320        330        340 
KAENAGLSSA AGLLREQVAQ LKQKVMTHVS NGCQLLLGVK GHAF

Length:344

Mass (Da):35,765

Last modified:September 27, 2004 - v2

Checksum:ⁱ6F52D4FECC32E234

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2JSY8	A0A0G2JSY8_RAT		RCG51087 RCG51087 (Transcription factor jun-B)	Junb rCG_51087	344	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	8	P → A in CAA38500 (PubMed:1542584).Curated	1
Sequence conflictⁱ	144	H → Q in CAA38500 (PubMed:1542584).Curated	1
Sequence conflictⁱ	310	A → T in AAH61862 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54686 Genomic DNA Translation: CAA38500.1 BC061862 mRNA Translation: AAH61862.1
PIRⁱ	S21063
NCBI Reference Sequences More...RefSeqⁱ	NP_068608.2, NM_021836.2
UniGeneⁱ	Rn.15806

Genome annotation databases

GeneIDⁱ	24517
KEGGⁱ	rno:24517

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24898	Transcription factor jun-B		MOUSE		344	UniRef100_P09450
Jun-B oncogene		MOUSE		344
Uncharacterized protein (Fragment)		MOUSE		180

Protein	Similar proteins		Species	Score	Length	Source
P24898	Transcription factor jun-B		HUMAN		347	UniRef90_P17275
Transcription factor jun-B		BOVIN		347
Transcription factor jun-B		MOUSE		344
Uncharacterized protein		PANPA		347
transcription factor jun-B		Florida manatee		348
+101

Protein	Similar proteins		Species	Score	Length	Source
P24898	Transcription factor jun-B		HUMAN		347	UniRef50_P17275
Transcription factor jun-B		BOVIN		347
Transcription factor jun-B		MOUSE		344
Uncharacterized protein		PANPA		347
transcription factor jun-B		Florida manatee		348
+109

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54686 Genomic DNA Translation: CAA38500.1 BC061862 mRNA Translation: AAH61862.1
PIRⁱ	S21063
RefSeqⁱ	NP_068608.2, NM_021836.2
UniGeneⁱ	Rn.15806

3D structure databases

ProteinModelPortalⁱ	P24898
SMRⁱ	P24898
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	246672, 1 interactor
CORUMⁱ	P24898
STRINGⁱ	10116.ENSRNOP00000061729

PTM databases

iPTMnetⁱ	P24898
PhosphoSitePlusⁱ	P24898

Proteomic databases

PaxDbⁱ	P24898
PRIDEⁱ	P24898

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	24517
KEGGⁱ	rno:24517

Organism-specific databases

CTDⁱ	3726
RGDⁱ	2944 Junb

Phylogenomic databases

eggNOGⁱ	KOG0837 Eukaryota ENOG410XRWH LUCA
HOGENOMⁱ	HOG000006648
HOVERGENⁱ	HBG001722
InParanoidⁱ	P24898
KOⁱ	K09028
PhylomeDBⁱ	P24898

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P24898

PROⁱ

PR:P24898

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR005643 JNK IPR029822 JunB IPR002112 Leuzip_Jun IPR008917 TF_DNA-bd_sf
PANTHERⁱ	PTHR11462:SF37 PTHR11462:SF37, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit PF03957 Jun, 1 hit
PRINTSⁱ	PR00043 LEUZIPPRJUN
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
SUPFAMⁱ	SSF47454 SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	JUNB_RAT
Accessionⁱ	P24898Primary (citable) accession number: P24898 Secondary accession number(s): Q6P733
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	September 27, 2004
	Last modified:	November 7, 2018
	This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniParc

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Supporting data

UniProtKB - P24898 (JUNB_RAT)

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Transcription factor jun-B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ