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Entry version 121 (10 Feb 2021)
Sequence version 2 (11 Apr 2003)
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Protein

NADH-ubiquinone oxidoreductase chain 1

Gene

nduo-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 1 (EC:7.1.1.2By similarity)
Alternative name(s):
NADH dehydrogenase subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nduo-1Imported
Synonyms:nd1Imported
ORF Names:MTCE.11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrion
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Mitochondrion

Organism-specific databases

WormBase

More...
WormBasei
MTCE.11 ; CE34065 ; WBGene00010959 ; nduo-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001173611 – 291NADH-ubiquinone oxidoreductase chain 1Add BLAST291

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P24887

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24887

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00010959, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.MTCE.11

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I subunit 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4770, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015134_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24887

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24887

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001694, NADH_UbQ_OxRdtase_su1/FPO
IPR018086, NADH_UbQ_OxRdtase_su1_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11432, PTHR11432, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00146, NADHdh, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00667, COMPLEX1_ND1_1, 1 hit
PS00668, COMPLEX1_ND1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24887-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILVLLMVIL MMIFIVQSIA FITLYERHLL GSSQNRLGPT KVTFMGLAQA
60 70 80 90 100
LLDGVKLLKK EQMTPLNSSE VSFLLVPGIS FVVMYLEWFT LPYFFDFISF
110 120 130 140 150
EYSVLFFLCL IGFSVYTTLI SGIVSKSKYG MIGAIRASSQ SISYEIAFSL
160 170 180 190 200
YVLCIIIHNN VFNFVSKFNL SLLIIYIPFL IMVIAELNRA PFDFSEGERE
210 220 230 240 250
LVRGFNVEFA RVAFVLLFLS EYGSLIFFSV LSSAMFFKFS IFMAFSIFSL
260 270 280 290
LIFIRSSYPR YRYDLMMSLF WFKLLPISLI MLCFYAVIFY Y
Length:291
Mass (Da):33,667
Last modified:April 11, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8E73DC8BA4A628D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence X54252 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti181I → M in strain: CB4853 and CB4858. 1 Publication1
Natural varianti238K → N in strain: Bristol N2, CB4855, CB4857, CB4858 and KR314. 1 Publication1
Natural varianti246S → I in strain: CB4854. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54252 Genomic DNA No translation available.
AY171133 Genomic DNA Translation: AAO16387.1
AY171134 Genomic DNA Translation: AAO16390.1
AY171135 Genomic DNA Translation: AAO16393.1
AY171136 Genomic DNA Translation: AAO16396.1
AY171137 Genomic DNA Translation: AAO16399.1
AY171138 Genomic DNA Translation: AAO16402.1
AY171139 Genomic DNA Translation: AAO16405.1
AY171140 Genomic DNA Translation: AAO16408.1
AY171141 Genomic DNA Translation: AAO16411.1
AY171142 Genomic DNA Translation: AAO16414.1
AY171143 Genomic DNA Translation: AAO16417.1
AY171144 Genomic DNA Translation: AAO16420.1
AY171145 Genomic DNA Translation: AAO16423.1
AY171146 Genomic DNA Translation: AAO16426.1
AY171147 Genomic DNA Translation: AAO16429.1
AY171148 Genomic DNA Translation: AAO16310.1
AY171149 Genomic DNA Translation: AAO16312.1
AY171150 Genomic DNA Translation: AAO16314.1
AY171151 Genomic DNA Translation: AAO16316.1
AY171152 Genomic DNA Translation: AAO16318.1
AY171153 Genomic DNA Translation: AAO16320.1
AY171154 Genomic DNA Translation: AAO16322.1
AY171155 Genomic DNA Translation: AAO16324.1
AY171156 Genomic DNA Translation: AAO16326.1
AY171157 Genomic DNA Translation: AAO16328.1
AY171158 Genomic DNA Translation: AAO16330.1
AY171159 Genomic DNA Translation: AAO16332.1
AY171160 Genomic DNA Translation: AAO16334.1
AY171161 Genomic DNA Translation: AAO16336.1
AY171162 Genomic DNA Translation: AAO16338.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S26028

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54252 Genomic DNA No translation available.
AY171133 Genomic DNA Translation: AAO16387.1
AY171134 Genomic DNA Translation: AAO16390.1
AY171135 Genomic DNA Translation: AAO16393.1
AY171136 Genomic DNA Translation: AAO16396.1
AY171137 Genomic DNA Translation: AAO16399.1
AY171138 Genomic DNA Translation: AAO16402.1
AY171139 Genomic DNA Translation: AAO16405.1
AY171140 Genomic DNA Translation: AAO16408.1
AY171141 Genomic DNA Translation: AAO16411.1
AY171142 Genomic DNA Translation: AAO16414.1
AY171143 Genomic DNA Translation: AAO16417.1
AY171144 Genomic DNA Translation: AAO16420.1
AY171145 Genomic DNA Translation: AAO16423.1
AY171146 Genomic DNA Translation: AAO16426.1
AY171147 Genomic DNA Translation: AAO16429.1
AY171148 Genomic DNA Translation: AAO16310.1
AY171149 Genomic DNA Translation: AAO16312.1
AY171150 Genomic DNA Translation: AAO16314.1
AY171151 Genomic DNA Translation: AAO16316.1
AY171152 Genomic DNA Translation: AAO16318.1
AY171153 Genomic DNA Translation: AAO16320.1
AY171154 Genomic DNA Translation: AAO16322.1
AY171155 Genomic DNA Translation: AAO16324.1
AY171156 Genomic DNA Translation: AAO16326.1
AY171157 Genomic DNA Translation: AAO16328.1
AY171158 Genomic DNA Translation: AAO16330.1
AY171159 Genomic DNA Translation: AAO16332.1
AY171160 Genomic DNA Translation: AAO16334.1
AY171161 Genomic DNA Translation: AAO16336.1
AY171162 Genomic DNA Translation: AAO16338.1
PIRiS26028

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.MTCE.11

Proteomic databases

EPDiP24887
PaxDbiP24887

Organism-specific databases

WormBaseiMTCE.11 ; CE34065 ; WBGene00010959 ; nduo-1

Phylogenomic databases

eggNOGiKOG4770, Eukaryota
HOGENOMiCLU_015134_0_1_1
InParanoidiP24887
PhylomeDBiP24887

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P24887

Gene expression databases

BgeeiWBGene00010959, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR001694, NADH_UbQ_OxRdtase_su1/FPO
IPR018086, NADH_UbQ_OxRdtase_su1_CS
PANTHERiPTHR11432, PTHR11432, 1 hit
PfamiView protein in Pfam
PF00146, NADHdh, 1 hit
PROSITEiView protein in PROSITE
PS00667, COMPLEX1_ND1_1, 1 hit
PS00668, COMPLEX1_ND1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU1M_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24887
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: April 11, 2003
Last modified: February 10, 2021
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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