UniProtKB - P24877 (NU2M_ASCSU)
Protein
NADH-ubiquinone oxidoreductase chain 2
Gene
ND2
Organism
Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Status
Functioni
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity
Catalytic activityi
- EC:7.1.1.2
GO - Molecular functioni
- NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Keywordsi
Molecular function | Translocase |
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | NAD, Ubiquinone |
Names & Taxonomyi
Protein namesi | Recommended name: NADH-ubiquinone oxidoreductase chain 2 (EC:7.1.1.2)Alternative name(s): NADH dehydrogenase subunit 2 |
Gene namesi | Name:ND2 |
Encoded oni | Mitochondrion |
Organismi | Ascaris suum (Pig roundworm) (Ascaris lumbricoides) |
Taxonomic identifieri | 6253 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Spirurina › Ascaridomorpha › Ascaridoidea › Ascarididae › Ascaris |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- respirasome Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 29 – 49 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 58 – 78 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 122 – 142 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 165 – 185 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 267 – 287 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000117554 | 1 – 300 | NADH-ubiquinone oxidoreductase chain 2Add BLAST | 300 |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I subunit 2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixi Sequence
Sequence statusi: Complete.
P24877-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLFFCIFVV FLCVLNFFTS NVLVWWSVFL LMTVVFVCLS KGSGSYVGIL
60 70 80 90 100
NYFVIQESLG LFFLVFNVFL LQFFIVMMKV GVAPFHFWVF SVTGSLYDWL
110 120 130 140 150
LMWFLTFQKL PFLPVLVQLF DFSAFFIFLF GICVCYFQLF VLKGYKSMMV
160 170 180 190 200
ISSTESFNWV VLTCFLSVVN VIYLFFYYVV LMAFLMPNFN VKDFNFVNWE
210 220 230 240 250
VLLVFLNVPF SVSFFIKIFV LSEVFKLDGL FLLFLLLMMF LSMLCFSLWL
260 270 280 290 300
VNMSVKNMKM LGDNFKVLFF LVFPMMVFSV IYYFSKILLC RLDKAEFFLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54253 Genomic DNA Translation: CAA38167.1 |
PIRi | S26018 |
RefSeqi | NP_006945.2, NC_001327.1 |
Genome annotation databases
GeneIDi | 807674 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54253 Genomic DNA Translation: CAA38167.1 |
PIRi | S26018 |
RefSeqi | NP_006945.2, NC_001327.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 807674 |
Organism-specific databases
CTDi | 4536 |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NU2M_ASCSU | |
Accessioni | P24877Primary (citable) accession number: P24877 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 11, 2019 | |
This is version 66 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |