CCNE1

Functionⁱ

Essential for the control of the cell cycle at the G1/S (start) transition.1 Publication

GO - Molecular functionⁱ

androgen receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 15572661
cyclin-dependent protein serine/threonine kinase activity Source: Reactome
cyclin-dependent protein serine/threonine kinase regulator activity Source: Ensembl
protein kinase binding Source: Ensembl
transcription coactivator activity
Source: UniProtKB
Non-traceable author statementⁱ
- 15572661

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

androgen receptor signaling pathway
Source: UniProtKB
Non-traceable author statementⁱ
- 15572661
cell division Source: UniProtKB-KW
DNA replication initiation Source: Ensembl
G1/S transition of mitotic cell cycle Source: Reactome
negative regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 15572661
protein phosphorylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 10500095
regulation of cellular protein localization Source: Ensembl
regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
synapsis Source: Ensembl
telomere maintenance Source: Ensembl
Wnt signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cyclin
Biological process	Cell cycle, Cell division

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1538133 G0 and Early G1 R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69563 p53-Dependent G1 DNA Damage Response R-HSA-8849470 PTK6 Regulates Cell Cycle
SignaLinkⁱ	P24864
SIGNORⁱ	P24864

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G1/S-specific cyclin-E1
Gene namesⁱ	Name:CCNE1 Synonyms:CCNE
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105173.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1589 CCNE1
MIMⁱ	123837 gene
neXtProtⁱ	NX_P24864

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	898
Open Targets More...OpenTargetsⁱ	ENSG00000105173
PharmGKBⁱ	PA96

Chemistry databases

ChEMBLⁱ	CHEMBL3617

ChEMBLⁱ

CHEMBL3617

Polymorphism and mutation databases

BioMutaⁱ	CCNE1
DMDMⁱ	3041657

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080449	1 – 410	G1/S-specific cyclin-E1Add BLAST		410

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	77	Phosphothreonine2 Publications	1
Modified residueⁱ	103	PhosphoserineCombined sources	1
Modified residueⁱ	387	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	395	Phosphothreonine; by GSK3Combined sources3 Publications	1
Modified residueⁱ	399	Phosphoserine; by CDK22 Publications	1

Post-translational modificationⁱ

Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.4 Publications

Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P24864
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P24864
PaxDbⁱ	P24864
PeptideAtlas More...PeptideAtlasⁱ	P24864
PRIDEⁱ	P24864
ProteomicsDBⁱ	54236 54237 [P24864-2] 54238 [P24864-3]

PTM databases

iPTMnetⁱ	P24864
PhosphoSitePlusⁱ	P24864

Miscellaneous databases

PMAP-CutDBⁱ	P24864

PMAP-CutDBⁱ

P24864

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000105173 Expressed in 152 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_CCNE1
ExpressionAtlasⁱ	P24864 baseline and differential
Genevisibleⁱ	P24864 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000308 CAB016682 HPA018169

HPAⁱ

CAB000308
CAB016682
HPA018169

Interactionⁱ

Subunit structureⁱ

Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (PubMed:15660127). Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1 (PubMed:15178429). Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (PubMed:21952639). Interacts with INCA1 (PubMed:21540187).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AKAP8	Q5VK71	2	EBI-519526,EBI-11601938	From Canis lupus familiaris.
BRCA1	P38398	2	EBI-519526,EBI-349905
CDK2	P24941	18	EBI-519526,EBI-375096
CDKN1A	P38936	9	EBI-519526,EBI-375077
CDKN1B	P46527	8	EBI-519526,EBI-519280
FOXM1	Q08050	2	EBI-519526,EBI-866480
UHRF2	Q96PU4	4	EBI-519526,EBI-625304

GO - Molecular functionⁱ

androgen receptor binding
Source: UniProtKB
Non-traceable author statementⁱ
- 15572661
protein kinase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107338, 74 interactors
ComplexPortalⁱ	CPX-2015 Cyclin E1-CDK2 complex
CORUMⁱ	P24864
Database of interacting proteins More...DIPⁱ	DIP-149N
IntActⁱ	P24864, 20 interactors
Molecular INTeraction database More...MINTⁱ	P24864
STRINGⁱ	9606.ENSP00000262643

Chemistry databases

BindingDBⁱ

P24864

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	109 – 111	Combined sources	3
Helixⁱ	113 – 123	Combined sources	11
Turnⁱ	124 – 126	Combined sources	3
Helixⁱ	133 – 136	Combined sources	4
Helixⁱ	142 – 158	Combined sources	17
Helixⁱ	163 – 179	Combined sources	17
Helixⁱ	185 – 187	Combined sources	3
Helixⁱ	188 – 203	Combined sources	16
Helixⁱ	210 – 215	Combined sources	6
Turnⁱ	216 – 219	Combined sources	4
Helixⁱ	223 – 236	Combined sources	14
Turnⁱ	237 – 239	Combined sources	3
Helixⁱ	246 – 257	Combined sources	12
Beta strandⁱ	265 – 267	Combined sources	3
Helixⁱ	272 – 287	Combined sources	16
Helixⁱ	289 – 293	Combined sources	5
Helixⁱ	296 – 306	Combined sources	11
Helixⁱ	310 – 316	Combined sources	7
Helixⁱ	321 – 341	Combined sources	21
Helixⁱ	354 – 359	Combined sources	6
Helixⁱ	366 – 370	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P24864
SMRⁱ	P24864
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P24864

EvolutionaryTraceⁱ

P24864

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0655 Eukaryota ENOG410XS2J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118939
HOGENOMⁱ	HOG000231743
HOVERGENⁱ	HBG050834
InParanoidⁱ	P24864
KEGG Orthology (KO) More...KOⁱ	K06626
OMAⁱ	KLHQFAY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DAW
PhylomeDBⁱ	P24864
TreeFamⁱ	TF101005

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR028858 Cyclin_E IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF71 PTHR10177:SF71, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform E1L (identifier: P24864-1) [UniParc]FASTA Add to basket

Also known as: E-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRERRERDA KERDTMKEDG GAEFSARSRK RKANVTVFLQ DPDEEMAKID 
        60         70         80         90        100
RTARDQCGSQ PWDNNAVCAD PCSLIPTPDK EDDDRVYPNS TCKPRIIAPS 
       110        120        130        140        150
RGSPLPVLSW ANREEVWKIM LNKEKTYLRD QHFLEQHPLL QPKMRAILLD 
       160        170        180        190        200
WLMEVCEVYK LHRETFYLAQ DFFDRYMATQ ENVVKTLLQL IGISSLFIAA 
       210        220        230        240        250
KLEEIYPPKL HQFAYVTDGA CSGDEILTME LMIMKALKWR LSPLTIVSWL 
       260        270        280        290        300
NVYMQVAYLN DLHEVLLPQY PQQIFIQIAE LLDLCVLDVD CLEFPYGILA 
       310        320        330        340        350
ASALYHFSSS ELMQKVSGYQ WCDIENCVKW MVPFAMVIRE TGSSKLKHFR 
       360        370        380        390        400
GVADEDAHNI QTHRDSLDLL DKARAKKAML SEQNRASPLP SGLLTPPQSG 
       410
KKQSSGPEMA

Length:410

Mass (Da):47,077

Last modified:July 15, 1998 - v2

Checksum:ⁱ424DF0B253B7047E

GO

Isoform E1S (identifier: P24864-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
154-196: Missing.

« Hide

        10         20         30         40         50
MPRERRERDA KERDTMKEDG GAEFSARSRK RKANVTVFLQ DPDEEMAKID 
        60         70         80         90        100
RTARDQCGSQ PWDNNAVCAD PCSLIPTPDK EDDDRVYPNS TCKPRIIAPS 
       110        120        130        140        150
RGSPLPVLSW ANREEVWKIM LNKEKTYLRD QHFLEQHPLL QPKMRAILLD 
       160        170        180        190        200
WLMFIAAKLE EIYPPKLHQF AYVTDGACSG DEILTMELMI MKALKWRLSP 
       210        220        230        240        250
LTIVSWLNVY MQVAYLNDLH EVLLPQYPQQ IFIQIAELLD LCVLDVDCLE 
       260        270        280        290        300
FPYGILAASA LYHFSSSELM QKVSGYQWCD IENCVKWMVP FAMVIRETGS 
       310        320        330        340        350
SKLKHFRGVA DEDAHNIQTH RDSLDLLDKA RAKKAMLSEQ NRASPLPSGL 
       360 
LTPPQSGKKQ SSGPEMA

Note: Lacks 49 residues within the cyclin box and cannot complex with CDK2.

Show »

Length:367

Mass (Da):41,982

Checksum:ⁱ526E59736D99D3C6

GO

Isoform 3 (identifier: P24864-3) [UniParc]FASTA Add to basket

Also known as: E-S

The sequence of this isoform differs from the canonical sequence as follows:
1-15: Missing.

« Hide

        10         20         30         40         50
MKEDGGAEFS ARSRKRKANV TVFLQDPDEE MAKIDRTARD QCGSQPWDNN 
        60         70         80         90        100
AVCADPCSLI PTPDKEDDDR VYPNSTCKPR IIAPSRGSPL PVLSWANREE 
       110        120        130        140        150
VWKIMLNKEK TYLRDQHFLE QHPLLQPKMR AILLDWLMEV CEVYKLHRET 
       160        170        180        190        200
FYLAQDFFDR YMATQENVVK TLLQLIGISS LFIAAKLEEI YPPKLHQFAY 
       210        220        230        240        250
VTDGACSGDE ILTMELMIMK ALKWRLSPLT IVSWLNVYMQ VAYLNDLHEV 
       260        270        280        290        300
LLPQYPQQIF IQIAELLDLC VLDVDCLEFP YGILAASALY HFSSSELMQK 
       310        320        330        340        350
VSGYQWCDIE NCVKWMVPFA MVIRETGSSK LKHFRGVADE DAHNIQTHRD 
       360        370        380        390 
SLDLLDKARA KKAMLSEQNR ASPLPSGLLT PPQSGKKQSS GPEMA

Show »

Length:395

Mass (Da):45,150

Checksum:ⁱ4E55D1F80BCFB3EB

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9J2U0	C9J2U0_HUMAN	Cyclin E variant ex7del Cyclin E variant ex7del (G1/S-specific cyclin-E1)	CCNE1	350	Annotation score:
I3L1Q9	I3L1Q9_HUMAN	G1/S-specific cyclin-E1 G1/S-specific cyclin-E1	CCNE1	215	Annotation score:
I3L413	I3L413_HUMAN	G1/S-specific cyclin-E1 G1/S-specific cyclin-E1	CCNE1	283	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	9	D → K no nucleotide entry (PubMed:7739542).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037381	1 – 15	Missing in isoform 3. 3 PublicationsAdd BLAST		15
Alternative sequenceⁱVSP_001253	154 – 196	Missing in isoform E1S. CuratedAdd BLAST		43

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74093 mRNA No translation available. M73812 mRNA No translation available. AK291549 mRNA Translation: BAF84238.1 AF518727 Genomic DNA Translation: AAM54043.1 BC035498 mRNA Translation: AAH35498.1 X95406 Genomic DNA Translation: CAA64687.1 X95406 Genomic DNA Translation: CAA64688.1 AH003247 Genomic DNA Translation: AAA83269.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12419.1 [P24864-1] CCDS46035.1 [P24864-3]
PIRⁱ	A40270
NCBI Reference Sequences More...RefSeqⁱ	NP_001229.1, NM_001238.3 [P24864-1] NP_001309191.1, NM_001322262.1 [P24864-3]
UniGeneⁱ	Hs.244723

Genome annotation databases

Ensemblⁱ	ENST00000262643; ENSP00000262643; ENSG00000105173 [P24864-1] ENST00000444983; ENSP00000410179; ENSG00000105173 [P24864-3]
GeneIDⁱ	898
KEGGⁱ	hsa:898
UCSC genome browser More...UCSCⁱ	uc002nsn.4 human [P24864-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24864	Isoform 3 of G1/S-specific cyclin-E1		HUMAN		395	UniRef100_P24864
Cyclin E1 (Fragment)		HUMAN		20

Protein	Similar proteins		Species	Score	Length	Source
P24864	Isoform 3 of G1/S-specific cyclin-E1		HUMAN		395	UniRef90_P24864
CCNE1 isoform 1		PANTR		411
Uncharacterized protein		PANPA		396
Cyclin E1		CALJA		410
CCNE1 isoform 1		PONAB		410
+54
P24864-2	Cyclin E1		PANTR		362	UniRef90_P24864-2
Cyclin E variant ex5del		HUMAN		361
Uncharacterized protein		MACMU		361
Uncharacterized protein		MACFA		361
Uncharacterized protein		CERAT		361
+13

Protein	Similar proteins		Species	Score	Length	Source
P24864	G1/S-specific cyclin-E1		RAT		411	UniRef50_P24864
G1/S-specific cyclin-E1		MOUSE		408
G1/S-specific cyclin-E1		DANRE		410
G1/S-specific cyclin-E3		XENLA		408
Isoform 3 of G1/S-specific cyclin-E1		HUMAN		395
+207
P24864-2	Cyclin E1		PANTR		362	UniRef50_P24864-2
Uncharacterized protein		RHIBE		361
Cyclin E1		GORGO		361
Uncharacterized protein		MACMU		361
Uncharacterized protein		MACFA		361
+22

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74093 mRNA No translation available. M73812 mRNA No translation available. AK291549 mRNA Translation: BAF84238.1 AF518727 Genomic DNA Translation: AAM54043.1 BC035498 mRNA Translation: AAH35498.1 X95406 Genomic DNA Translation: CAA64687.1 X95406 Genomic DNA Translation: CAA64688.1 AH003247 Genomic DNA Translation: AAA83269.1
CCDSⁱ	CCDS12419.1 [P24864-1] CCDS46035.1 [P24864-3]
PIRⁱ	A40270
RefSeqⁱ	NP_001229.1, NM_001238.3 [P24864-1] NP_001309191.1, NM_001322262.1 [P24864-3]
UniGeneⁱ	Hs.244723

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1W98	X-ray	2.15	B	96-378	[»]
	5L2W	X-ray	2.80	B	96-378	[»]
ProteinModelPortalⁱ	P24864
SMRⁱ	P24864
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107338, 74 interactors
ComplexPortalⁱ	CPX-2015 Cyclin E1-CDK2 complex
CORUMⁱ	P24864
DIPⁱ	DIP-149N
IntActⁱ	P24864, 20 interactors
MINTⁱ	P24864
STRINGⁱ	9606.ENSP00000262643

Chemistry databases

BindingDBⁱ	P24864
ChEMBLⁱ	CHEMBL3617

PTM databases

iPTMnetⁱ	P24864
PhosphoSitePlusⁱ	P24864

Polymorphism and mutation databases

BioMutaⁱ	CCNE1
DMDMⁱ	3041657

Proteomic databases

EPDⁱ	P24864
MaxQBⁱ	P24864
PaxDbⁱ	P24864
PeptideAtlasⁱ	P24864
PRIDEⁱ	P24864
ProteomicsDBⁱ	54236 54237 [P24864-2] 54238 [P24864-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	898
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262643; ENSP00000262643; ENSG00000105173 [P24864-1] ENST00000444983; ENSP00000410179; ENSG00000105173 [P24864-3]
GeneIDⁱ	898
KEGGⁱ	hsa:898
UCSCⁱ	uc002nsn.4 human [P24864-1]

Organism-specific databases

CTDⁱ	898
DisGeNETⁱ	898
EuPathDBⁱ	HostDB:ENSG00000105173.13
GeneCardsⁱ	CCNE1
HGNCⁱ	HGNC:1589 CCNE1
HPAⁱ	CAB000308 CAB016682 HPA018169
MIMⁱ	123837 gene
neXtProtⁱ	NX_P24864
OpenTargetsⁱ	ENSG00000105173
PharmGKBⁱ	PA96
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0655 Eukaryota ENOG410XS2J LUCA
GeneTreeⁱ	ENSGT00760000118939
HOGENOMⁱ	HOG000231743
HOVERGENⁱ	HBG050834
InParanoidⁱ	P24864
KOⁱ	K06626
OMAⁱ	KLHQFAY
OrthoDBⁱ	EOG091G0DAW
PhylomeDBⁱ	P24864
TreeFamⁱ	TF101005

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1538133 G0 and Early G1 R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69563 p53-Dependent G1 DNA Damage Response R-HSA-8849470 PTK6 Regulates Cell Cycle
SignaLinkⁱ	P24864
SIGNORⁱ	P24864

Miscellaneous databases

ChiTaRSⁱ	CCNE1 human
EvolutionaryTraceⁱ	P24864
GeneWikiⁱ	Cyclin_E1
GenomeRNAiⁱ	898
PMAP-CutDBⁱ	P24864
Protein Ontology More...PROⁱ	PR:P24864
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105173 Expressed in 152 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_CCNE1
ExpressionAtlasⁱ	P24864 baseline and differential
Genevisibleⁱ	P24864 HS

Family and domain databases

CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR028858 Cyclin_E IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF71 PTHR10177:SF71, 1 hit
Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCNE1_HUMAN
Accessionⁱ	P24864Primary (citable) accession number: P24864 Secondary accession number(s): A8K684 , Q14091, Q8NFG1, Q92501, Q9UD21
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	July 15, 1998
	Last modified:	October 10, 2018
	This is version 195 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

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Supporting data

UniProtKB - P24864 (CCNE1_HUMAN)

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G1/S-specific cyclin-E1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ