Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G1/S-specific cyclin-E1

Gene

CCNE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-HSA-1538133 G0 and Early G1
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69563 p53-Dependent G1 DNA Damage Response
R-HSA-8849470 PTK6 Regulates Cell Cycle
SignaLinkiP24864
SIGNORiP24864

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-E1
Gene namesi
Name:CCNE1
Synonyms:CCNE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105173.13
HGNCiHGNC:1589 CCNE1
MIMi123837 gene
neXtProtiNX_P24864

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi898
OpenTargetsiENSG00000105173
PharmGKBiPA96

Chemistry databases

ChEMBLiCHEMBL3617

Polymorphism and mutation databases

BioMutaiCCNE1
DMDMi3041657

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804491 – 410G1/S-specific cyclin-E1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77Phosphothreonine2 Publications1
Modified residuei103PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1 Publication1
Modified residuei395Phosphothreonine; by GSK3Combined sources3 Publications1
Modified residuei399Phosphoserine; by CDK22 Publications1

Post-translational modificationi

Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.4 Publications
Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP24864
MaxQBiP24864
PaxDbiP24864
PeptideAtlasiP24864
PRIDEiP24864
ProteomicsDBi54236
54237 [P24864-2]
54238 [P24864-3]

PTM databases

iPTMnetiP24864
PhosphoSitePlusiP24864

Miscellaneous databases

PMAP-CutDBiP24864

Expressioni

Tissue specificityi

Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.1 Publication

Gene expression databases

BgeeiENSG00000105173 Expressed in 152 organ(s), highest expression level in secondary oocyte
CleanExiHS_CCNE1
ExpressionAtlasiP24864 baseline and differential
GenevisibleiP24864 HS

Organism-specific databases

HPAiCAB000308
CAB016682
HPA018169

Interactioni

Subunit structurei

Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (PubMed:15660127). Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1 (PubMed:15178429). Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (PubMed:21952639). Interacts with INCA1 (PubMed:21540187).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107338, 74 interactors
ComplexPortaliCPX-2015 Cyclin E1-CDK2 complex
CORUMiP24864
DIPiDIP-149N
IntActiP24864, 20 interactors
MINTiP24864
STRINGi9606.ENSP00000262643

Chemistry databases

BindingDBiP24864

Structurei

Secondary structure

1410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP24864
SMRiP24864
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24864

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

eggNOGiKOG0655 Eukaryota
ENOG410XS2J LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000231743
HOVERGENiHBG050834
InParanoidiP24864
KOiK06626
OMAiKLHQFAY
OrthoDBiEOG091G0DAW
PhylomeDBiP24864
TreeFamiTF101005

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR028858 Cyclin_E
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF71 PTHR10177:SF71, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform E1L (identifier: P24864-1) [UniParc]FASTAAdd to basket
Also known as: E-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRERRERDA KERDTMKEDG GAEFSARSRK RKANVTVFLQ DPDEEMAKID
60 70 80 90 100
RTARDQCGSQ PWDNNAVCAD PCSLIPTPDK EDDDRVYPNS TCKPRIIAPS
110 120 130 140 150
RGSPLPVLSW ANREEVWKIM LNKEKTYLRD QHFLEQHPLL QPKMRAILLD
160 170 180 190 200
WLMEVCEVYK LHRETFYLAQ DFFDRYMATQ ENVVKTLLQL IGISSLFIAA
210 220 230 240 250
KLEEIYPPKL HQFAYVTDGA CSGDEILTME LMIMKALKWR LSPLTIVSWL
260 270 280 290 300
NVYMQVAYLN DLHEVLLPQY PQQIFIQIAE LLDLCVLDVD CLEFPYGILA
310 320 330 340 350
ASALYHFSSS ELMQKVSGYQ WCDIENCVKW MVPFAMVIRE TGSSKLKHFR
360 370 380 390 400
GVADEDAHNI QTHRDSLDLL DKARAKKAML SEQNRASPLP SGLLTPPQSG
410
KKQSSGPEMA
Length:410
Mass (Da):47,077
Last modified:July 15, 1998 - v2
Checksum:i424DF0B253B7047E
GO
Isoform E1S (identifier: P24864-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-196: Missing.

Note: Lacks 49 residues within the cyclin box and cannot complex with CDK2.
Show »
Length:367
Mass (Da):41,982
Checksum:i526E59736D99D3C6
GO
Isoform 3 (identifier: P24864-3) [UniParc]FASTAAdd to basket
Also known as: E-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.

Show »
Length:395
Mass (Da):45,150
Checksum:i4E55D1F80BCFB3EB
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J2U0C9J2U0_HUMAN
Cyclin E variant ex7del
CCNE1
350Annotation score:
I3L1Q9I3L1Q9_HUMAN
G1/S-specific cyclin-E1
CCNE1
215Annotation score:
I3L413I3L413_HUMAN
G1/S-specific cyclin-E1
CCNE1
283Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9D → K no nucleotide entry (PubMed:7739542).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0373811 – 15Missing in isoform 3. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_001253154 – 196Missing in isoform E1S. CuratedAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74093 mRNA No translation available.
M73812 mRNA No translation available.
AK291549 mRNA Translation: BAF84238.1
AF518727 Genomic DNA Translation: AAM54043.1
BC035498 mRNA Translation: AAH35498.1
X95406 Genomic DNA Translation: CAA64687.1
X95406 Genomic DNA Translation: CAA64688.1
AH003247 Genomic DNA Translation: AAA83269.1
CCDSiCCDS12419.1 [P24864-1]
CCDS46035.1 [P24864-3]
PIRiA40270
RefSeqiNP_001229.1, NM_001238.3 [P24864-1]
NP_001309191.1, NM_001322262.1 [P24864-3]
UniGeneiHs.244723

Genome annotation databases

EnsembliENST00000262643; ENSP00000262643; ENSG00000105173 [P24864-1]
ENST00000444983; ENSP00000410179; ENSG00000105173 [P24864-3]
GeneIDi898
KEGGihsa:898
UCSCiuc002nsn.4 human [P24864-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74093 mRNA No translation available.
M73812 mRNA No translation available.
AK291549 mRNA Translation: BAF84238.1
AF518727 Genomic DNA Translation: AAM54043.1
BC035498 mRNA Translation: AAH35498.1
X95406 Genomic DNA Translation: CAA64687.1
X95406 Genomic DNA Translation: CAA64688.1
AH003247 Genomic DNA Translation: AAA83269.1
CCDSiCCDS12419.1 [P24864-1]
CCDS46035.1 [P24864-3]
PIRiA40270
RefSeqiNP_001229.1, NM_001238.3 [P24864-1]
NP_001309191.1, NM_001322262.1 [P24864-3]
UniGeneiHs.244723

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W98X-ray2.15B96-378[»]
5L2WX-ray2.80B96-378[»]
ProteinModelPortaliP24864
SMRiP24864
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107338, 74 interactors
ComplexPortaliCPX-2015 Cyclin E1-CDK2 complex
CORUMiP24864
DIPiDIP-149N
IntActiP24864, 20 interactors
MINTiP24864
STRINGi9606.ENSP00000262643

Chemistry databases

BindingDBiP24864
ChEMBLiCHEMBL3617

PTM databases

iPTMnetiP24864
PhosphoSitePlusiP24864

Polymorphism and mutation databases

BioMutaiCCNE1
DMDMi3041657

Proteomic databases

EPDiP24864
MaxQBiP24864
PaxDbiP24864
PeptideAtlasiP24864
PRIDEiP24864
ProteomicsDBi54236
54237 [P24864-2]
54238 [P24864-3]

Protocols and materials databases

DNASUi898
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262643; ENSP00000262643; ENSG00000105173 [P24864-1]
ENST00000444983; ENSP00000410179; ENSG00000105173 [P24864-3]
GeneIDi898
KEGGihsa:898
UCSCiuc002nsn.4 human [P24864-1]

Organism-specific databases

CTDi898
DisGeNETi898
EuPathDBiHostDB:ENSG00000105173.13
GeneCardsiCCNE1
HGNCiHGNC:1589 CCNE1
HPAiCAB000308
CAB016682
HPA018169
MIMi123837 gene
neXtProtiNX_P24864
OpenTargetsiENSG00000105173
PharmGKBiPA96
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0655 Eukaryota
ENOG410XS2J LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000231743
HOVERGENiHBG050834
InParanoidiP24864
KOiK06626
OMAiKLHQFAY
OrthoDBiEOG091G0DAW
PhylomeDBiP24864
TreeFamiTF101005

Enzyme and pathway databases

ReactomeiR-HSA-1538133 G0 and Early G1
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69563 p53-Dependent G1 DNA Damage Response
R-HSA-8849470 PTK6 Regulates Cell Cycle
SignaLinkiP24864
SIGNORiP24864

Miscellaneous databases

ChiTaRSiCCNE1 human
EvolutionaryTraceiP24864
GeneWikiiCyclin_E1
GenomeRNAii898
PMAP-CutDBiP24864
PROiPR:P24864
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105173 Expressed in 152 organ(s), highest expression level in secondary oocyte
CleanExiHS_CCNE1
ExpressionAtlasiP24864 baseline and differential
GenevisibleiP24864 HS

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR028858 Cyclin_E
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF71 PTHR10177:SF71, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCNE1_HUMAN
AccessioniPrimary (citable) accession number: P24864
Secondary accession number(s): A8K684
, Q14091, Q8NFG1, Q92501, Q9UD21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 15, 1998
Last modified: October 10, 2018
This is version 195 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again