UniProtKB - P24864 (CCNE1_HUMAN)
G1/S-specific cyclin-E1
CCNE1
Functioni
Essential for the control of the cell cycle at the G1/S (start) transition.
1 PublicationGO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
- kinase activity Source: Ensembl
- protein kinase binding Source: Ensembl
GO - Biological processi
- cell division Source: UniProtKB-KW
- DNA replication initiation Source: Ensembl
- G1/S transition of mitotic cell cycle Source: BHF-UCL
- homologous chromosome pairing at meiosis Source: Ensembl
- mitotic cell cycle phase transition Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of mesenchymal stem cell proliferation Source: BHF-UCL
- protein phosphorylation Source: MGI
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- regulation of protein localization Source: Ensembl
- telomere maintenance Source: Ensembl
- Wnt signaling pathway Source: Ensembl
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
PathwayCommonsi | P24864 |
Reactomei | R-HSA-1538133, G0 and Early G1 R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69205, G1/S-Specific Transcription R-HSA-69231, Cyclin D associated events in G1 R-HSA-69563, p53-Dependent G1 DNA Damage Response R-HSA-8849470, PTK6 Regulates Cell Cycle R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9706019, RHOBTB3 ATPase cycle |
SignaLinki | P24864 |
SIGNORi | P24864 |
Names & Taxonomyi
Protein namesi | Recommended name: G1/S-specific cyclin-E1 |
Gene namesi | Name:CCNE1 Synonyms:CCNE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1589, CCNE1 |
MIMi | 123837, gene |
neXtProti | NX_P24864 |
VEuPathDBi | HostDB:ENSG00000105173 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- centrosome Source: GO_Central
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cyclin E1-CDK2 complex Source: GO_Central
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 898 |
OpenTargetsi | ENSG00000105173 |
PharmGKBi | PA96 |
Miscellaneous databases
Pharosi | P24864, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3617 |
Genetic variation databases
BioMutai | CCNE1 |
DMDMi | 3041657 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080449 | 1 – 410 | G1/S-specific cyclin-E1Add BLAST | 410 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 77 | Phosphothreonine2 Publications | 1 | |
Modified residuei | 103 | PhosphoserineCombined sources | 1 | |
Modified residuei | 387 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 395 | Phosphothreonine; by GSK3Combined sources3 Publications | 1 | |
Modified residuei | 399 | Phosphoserine; by CDK22 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P24864 |
jPOSTi | P24864 |
MassIVEi | P24864 |
MaxQBi | P24864 |
PaxDbi | P24864 |
PeptideAtlasi | P24864 |
PRIDEi | P24864 |
ProteomicsDBi | 54236 [P24864-1] 54237 [P24864-2] 54238 [P24864-3] |
PTM databases
iPTMneti | P24864 |
PhosphoSitePlusi | P24864 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000105173, Expressed in secondary oocyte and 165 other tissues |
ExpressionAtlasi | P24864, baseline and differential |
Genevisiblei | P24864, HS |
Organism-specific databases
HPAi | ENSG00000105173, Tissue enhanced (bone marrow, placenta) |
Interactioni
Subunit structurei
Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (PubMed:15660127).
Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity).
Part of a complex consisting of UHRF2, CDK2 and CCNE1 (PubMed:15178429).
Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (PubMed:21952639).
Interacts with INCA1 (PubMed:21540187).
By similarity4 PublicationsBinary interactionsi
P24864
GO - Molecular functioni
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107338, 105 interactors |
ComplexPortali | CPX-2015, Cyclin E1-CDK2 complex |
CORUMi | P24864 |
DIPi | DIP-149N |
IntActi | P24864, 26 interactors |
MINTi | P24864 |
STRINGi | 9606.ENSP00000262643 |
Chemistry databases
BindingDBi | P24864 |
Miscellaneous databases
RNActi | P24864, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P24864 |
SMRi | P24864 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P24864 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 378 – 410 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 384 – 410 | Polar residuesSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0655, Eukaryota |
GeneTreei | ENSGT00940000156256 |
InParanoidi | P24864 |
OMAi | HRIQTHV |
OrthoDBi | 993640at2759 |
PhylomeDBi | P24864 |
TreeFami | TF101005 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
DisProti | DP01120 |
IDEALi | IID00603 |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR028858, Cyclin_E IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF71, PTHR10177:SF71, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPRERRERDA KERDTMKEDG GAEFSARSRK RKANVTVFLQ DPDEEMAKID
60 70 80 90 100
RTARDQCGSQ PWDNNAVCAD PCSLIPTPDK EDDDRVYPNS TCKPRIIAPS
110 120 130 140 150
RGSPLPVLSW ANREEVWKIM LNKEKTYLRD QHFLEQHPLL QPKMRAILLD
160 170 180 190 200
WLMEVCEVYK LHRETFYLAQ DFFDRYMATQ ENVVKTLLQL IGISSLFIAA
210 220 230 240 250
KLEEIYPPKL HQFAYVTDGA CSGDEILTME LMIMKALKWR LSPLTIVSWL
260 270 280 290 300
NVYMQVAYLN DLHEVLLPQY PQQIFIQIAE LLDLCVLDVD CLEFPYGILA
310 320 330 340 350
ASALYHFSSS ELMQKVSGYQ WCDIENCVKW MVPFAMVIRE TGSSKLKHFR
360 370 380 390 400
GVADEDAHNI QTHRDSLDLL DKARAKKAML SEQNRASPLP SGLLTPPQSG
410
KKQSSGPEMA
The sequence of this isoform differs from the canonical sequence as follows:
154-196: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J2U0 | C9J2U0_HUMAN | Cyclin E variant ex7del | CCNE1 | 350 | Annotation score: | ||
I3L1Q9 | I3L1Q9_HUMAN | G1/S-specific cyclin-E1 | CCNE1 | 215 | Annotation score: | ||
I3L413 | I3L413_HUMAN | G1/S-specific cyclin-E1 | CCNE1 | 283 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | D → K no nucleotide entry (PubMed:7739542).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037381 | 1 – 15 | Missing in isoform 3. 3 PublicationsAdd BLAST | 15 | |
Alternative sequenceiVSP_001253 | 154 – 196 | Missing in isoform E1S. CuratedAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74093 mRNA No translation available. M73812 mRNA No translation available. AK291549 mRNA Translation: BAF84238.1 AF518727 Genomic DNA Translation: AAM54043.1 BC035498 mRNA Translation: AAH35498.1 X95406 Genomic DNA Translation: CAA64687.1 X95406 Genomic DNA Translation: CAA64688.1 AH003247 Genomic DNA Translation: AAA83269.1 |
CCDSi | CCDS12419.1 [P24864-1] CCDS46035.1 [P24864-3] |
PIRi | A40270 |
RefSeqi | NP_001229.1, NM_001238.3 [P24864-1] NP_001309191.1, NM_001322262.1 [P24864-3] |
Genome annotation databases
Ensembli | ENST00000262643.8; ENSP00000262643.3; ENSG00000105173.14 ENST00000444983.6; ENSP00000410179.2; ENSG00000105173.14 [P24864-3] |
GeneIDi | 898 |
KEGGi | hsa:898 |
MANE-Selecti | ENST00000262643.8; ENSP00000262643.3; NM_001238.4; NP_001229.1 |
UCSCi | uc002nsn.4, human [P24864-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74093 mRNA No translation available. M73812 mRNA No translation available. AK291549 mRNA Translation: BAF84238.1 AF518727 Genomic DNA Translation: AAM54043.1 BC035498 mRNA Translation: AAH35498.1 X95406 Genomic DNA Translation: CAA64687.1 X95406 Genomic DNA Translation: CAA64688.1 AH003247 Genomic DNA Translation: AAA83269.1 |
CCDSi | CCDS12419.1 [P24864-1] CCDS46035.1 [P24864-3] |
PIRi | A40270 |
RefSeqi | NP_001229.1, NM_001238.3 [P24864-1] NP_001309191.1, NM_001322262.1 [P24864-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1W98 | X-ray | 2.15 | B | 96-378 | [»] | |
5L2W | X-ray | 2.80 | B | 96-378 | [»] | |
7KJS | X-ray | 2.19 | B | 96-378 | [»] | |
AlphaFoldDBi | P24864 | |||||
SMRi | P24864 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107338, 105 interactors |
ComplexPortali | CPX-2015, Cyclin E1-CDK2 complex |
CORUMi | P24864 |
DIPi | DIP-149N |
IntActi | P24864, 26 interactors |
MINTi | P24864 |
STRINGi | 9606.ENSP00000262643 |
Chemistry databases
BindingDBi | P24864 |
ChEMBLi | CHEMBL3617 |
PTM databases
iPTMneti | P24864 |
PhosphoSitePlusi | P24864 |
Genetic variation databases
BioMutai | CCNE1 |
DMDMi | 3041657 |
Proteomic databases
EPDi | P24864 |
jPOSTi | P24864 |
MassIVEi | P24864 |
MaxQBi | P24864 |
PaxDbi | P24864 |
PeptideAtlasi | P24864 |
PRIDEi | P24864 |
ProteomicsDBi | 54236 [P24864-1] 54237 [P24864-2] 54238 [P24864-3] |
Protocols and materials databases
Antibodypediai | 3286, 1191 antibodies from 47 providers |
DNASUi | 898 |
Genome annotation databases
Ensembli | ENST00000262643.8; ENSP00000262643.3; ENSG00000105173.14 ENST00000444983.6; ENSP00000410179.2; ENSG00000105173.14 [P24864-3] |
GeneIDi | 898 |
KEGGi | hsa:898 |
MANE-Selecti | ENST00000262643.8; ENSP00000262643.3; NM_001238.4; NP_001229.1 |
UCSCi | uc002nsn.4, human [P24864-1] |
Organism-specific databases
CTDi | 898 |
DisGeNETi | 898 |
GeneCardsi | CCNE1 |
HGNCi | HGNC:1589, CCNE1 |
HPAi | ENSG00000105173, Tissue enhanced (bone marrow, placenta) |
MIMi | 123837, gene |
neXtProti | NX_P24864 |
OpenTargetsi | ENSG00000105173 |
PharmGKBi | PA96 |
VEuPathDBi | HostDB:ENSG00000105173 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0655, Eukaryota |
GeneTreei | ENSGT00940000156256 |
InParanoidi | P24864 |
OMAi | HRIQTHV |
OrthoDBi | 993640at2759 |
PhylomeDBi | P24864 |
TreeFami | TF101005 |
Enzyme and pathway databases
PathwayCommonsi | P24864 |
Reactomei | R-HSA-1538133, G0 and Early G1 R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69205, G1/S-Specific Transcription R-HSA-69231, Cyclin D associated events in G1 R-HSA-69563, p53-Dependent G1 DNA Damage Response R-HSA-8849470, PTK6 Regulates Cell Cycle R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9706019, RHOBTB3 ATPase cycle |
SignaLinki | P24864 |
SIGNORi | P24864 |
Miscellaneous databases
BioGRID-ORCSi | 898, 64 hits in 1086 CRISPR screens |
ChiTaRSi | CCNE1, human |
EvolutionaryTracei | P24864 |
GeneWikii | Cyclin_E1 |
GenomeRNAii | 898 |
Pharosi | P24864, Tchem |
PROi | PR:P24864 |
RNActi | P24864, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105173, Expressed in secondary oocyte and 165 other tissues |
ExpressionAtlasi | P24864, baseline and differential |
Genevisiblei | P24864, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
DisProti | DP01120 |
IDEALi | IID00603 |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR028858, Cyclin_E IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF71, PTHR10177:SF71, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNE1_HUMAN | |
Accessioni | P24864Primary (citable) accession number: P24864 Secondary accession number(s): A8K684 Q9UD21 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | July 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 218 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families