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UniProtKB - P24864 (CCNE1_HUMAN)

Entry version 218 (25 May 2022)
Sequence version 2 (15 Jul 1998)
Previous versions | rss
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Protein

G1/S-specific cyclin-E1

Gene

CCNE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the control of the cell cycle at the G1/S (start) transition.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P24864

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1538133, G0 and Early G1
R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21
R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence
R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis
R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-HSA-69202, Cyclin E associated events during G1/S transition
R-HSA-69205, G1/S-Specific Transcription
R-HSA-69231, Cyclin D associated events in G1
R-HSA-69563, p53-Dependent G1 DNA Damage Response
R-HSA-8849470, PTK6 Regulates Cell Cycle
R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
R-HSA-9706019, RHOBTB3 ATPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P24864

SIGNOR Signaling Network Open Resource

More...SIGNORi		P24864

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G1/S-specific cyclin-E1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNE1
Synonyms:CCNE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1589, CCNE1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		123837, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P24864

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105173

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		898

Open Targets

More...OpenTargetsi		ENSG00000105173

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA96

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P24864, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3617

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCNE1

Domain mapping of disease mutations (DMDM)

More...DMDMi		3041657

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000804491 – 410G1/S-specific cyclin-E1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei77Phosphothreonine2 Publications1
Modified residuei103PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1 Publication1
Modified residuei395Phosphothreonine; by GSK3Combined sources3 Publications1
Modified residuei399Phosphoserine; by CDK22 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.4 Publications
Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P24864

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P24864

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P24864

MaxQB - The MaxQuant DataBase

More...MaxQBi		P24864

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P24864

PeptideAtlas

More...PeptideAtlasi		P24864

PRoteomics IDEntifications database

More...PRIDEi		P24864

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54236 [P24864-1]
54237 [P24864-2]
54238 [P24864-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P24864

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P24864

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105173, Expressed in secondary oocyte and 165 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P24864, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P24864, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105173, Tissue enhanced (bone marrow, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (PubMed:15660127).

Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity).

Part of a complex consisting of UHRF2, CDK2 and CCNE1 (PubMed:15178429).

Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (PubMed:21952639).

Interacts with INCA1 (PubMed:21540187).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107338, 105 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2015, Cyclin E1-CDK2 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P24864

Database of interacting proteins

More...DIPi		DIP-149N

Protein interaction database and analysis system

More...IntActi		P24864, 26 interactors

Molecular INTeraction database

More...MINTi		P24864

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262643

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P24864

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P24864, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P24864

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24864

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P24864

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni378 – 410DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi384 – 410Polar residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0655, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156256

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24864

Identification of Orthologs from Complete Genome Data

More...OMAi		HRIQTHV

Database of Orthologous Groups

More...OrthoDBi		993640at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24864

TreeFam database of animal gene trees

More...TreeFami		TF101005

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 1 hit

Database of protein disorder

More...DisProti		DP01120

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00603

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR028858, Cyclin_E
IPR006671, Cyclin_N

The PANTHER Classification System

More...PANTHERi		PTHR10177, PTHR10177, 1 hit
PTHR10177:SF71, PTHR10177:SF71, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 1 hit
SM01332, Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00292, CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform E1L (identifier: P24864-1) [UniParc]FASTAAdd to basket
Also known as: E-L

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRERRERDA KERDTMKEDG GAEFSARSRK RKANVTVFLQ DPDEEMAKID 
        60         70         80         90        100
RTARDQCGSQ PWDNNAVCAD PCSLIPTPDK EDDDRVYPNS TCKPRIIAPS 
       110        120        130        140        150
RGSPLPVLSW ANREEVWKIM LNKEKTYLRD QHFLEQHPLL QPKMRAILLD 
       160        170        180        190        200
WLMEVCEVYK LHRETFYLAQ DFFDRYMATQ ENVVKTLLQL IGISSLFIAA 
       210        220        230        240        250
KLEEIYPPKL HQFAYVTDGA CSGDEILTME LMIMKALKWR LSPLTIVSWL 
       260        270        280        290        300
NVYMQVAYLN DLHEVLLPQY PQQIFIQIAE LLDLCVLDVD CLEFPYGILA 
       310        320        330        340        350
ASALYHFSSS ELMQKVSGYQ WCDIENCVKW MVPFAMVIRE TGSSKLKHFR 
       360        370        380        390        400
GVADEDAHNI QTHRDSLDLL DKARAKKAML SEQNRASPLP SGLLTPPQSG 
       410
KKQSSGPEMA
Length:410
Mass (Da):47,077
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i424DF0B253B7047E
GO
Isoform E1S (identifier: P24864-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-196: Missing.

Note: Lacks 49 residues within the cyclin box and cannot complex with CDK2.Curated
Show »
Length:367
Mass (Da):41,982
Checksum:i526E59736D99D3C6
GO
Isoform 3 (identifier: P24864-3) [UniParc]FASTAAdd to basket
Also known as: E-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.

Show »
Length:395
Mass (Da):45,150
Checksum:i4E55D1F80BCFB3EB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J2U0C9J2U0_HUMAN
Cyclin E variant ex7del
CCNE1
350Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1Q9I3L1Q9_HUMAN
G1/S-specific cyclin-E1
CCNE1
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L413I3L413_HUMAN
G1/S-specific cyclin-E1
CCNE1
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9D → K no nucleotide entry (PubMed:7739542).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0373811 – 15Missing in isoform 3. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_001253154 – 196Missing in isoform E1S. CuratedAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M74093 mRNA No translation available.
M73812 mRNA No translation available.
AK291549 mRNA Translation: BAF84238.1
AF518727 Genomic DNA Translation: AAM54043.1
BC035498 mRNA Translation: AAH35498.1
X95406 Genomic DNA Translation: CAA64687.1
X95406 Genomic DNA Translation: CAA64688.1
AH003247 Genomic DNA Translation: AAA83269.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12419.1 [P24864-1]
CCDS46035.1 [P24864-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A40270

NCBI Reference Sequences

More...RefSeqi		NP_001229.1, NM_001238.3 [P24864-1]
NP_001309191.1, NM_001322262.1 [P24864-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262643.8; ENSP00000262643.3; ENSG00000105173.14
ENST00000444983.6; ENSP00000410179.2; ENSG00000105173.14 [P24864-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:898

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000262643.8; ENSP00000262643.3; NM_001238.4; NP_001229.1

UCSC genome browser

More...UCSCi		uc002nsn.4, human [P24864-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74093 mRNA No translation available.
M73812 mRNA No translation available.
AK291549 mRNA Translation: BAF84238.1
AF518727 Genomic DNA Translation: AAM54043.1
BC035498 mRNA Translation: AAH35498.1
X95406 Genomic DNA Translation: CAA64687.1
X95406 Genomic DNA Translation: CAA64688.1
AH003247 Genomic DNA Translation: AAA83269.1
CCDSiCCDS12419.1 [P24864-1]
CCDS46035.1 [P24864-3]
PIRiA40270
RefSeqiNP_001229.1, NM_001238.3 [P24864-1]
NP_001309191.1, NM_001322262.1 [P24864-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W98X-ray2.15B96-378[»]
5L2WX-ray2.80B96-378[»]
7KJSX-ray2.19B96-378[»]
AlphaFoldDBiP24864
SMRiP24864
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107338, 105 interactors
ComplexPortaliCPX-2015, Cyclin E1-CDK2 complex
CORUMiP24864
DIPiDIP-149N
IntActiP24864, 26 interactors
MINTiP24864
STRINGi9606.ENSP00000262643

Chemistry databases

BindingDBiP24864
ChEMBLiCHEMBL3617

PTM databases

iPTMnetiP24864
PhosphoSitePlusiP24864

Genetic variation databases

BioMutaiCCNE1
DMDMi3041657

Proteomic databases

EPDiP24864
jPOSTiP24864
MassIVEiP24864
MaxQBiP24864
PaxDbiP24864
PeptideAtlasiP24864
PRIDEiP24864
ProteomicsDBi54236 [P24864-1]
54237 [P24864-2]
54238 [P24864-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3286, 1191 antibodies from 47 providers

The DNASU plasmid repository

More...DNASUi		898

Genome annotation databases

EnsembliENST00000262643.8; ENSP00000262643.3; ENSG00000105173.14
ENST00000444983.6; ENSP00000410179.2; ENSG00000105173.14 [P24864-3]
GeneIDi898
KEGGihsa:898
MANE-SelectiENST00000262643.8; ENSP00000262643.3; NM_001238.4; NP_001229.1
UCSCiuc002nsn.4, human [P24864-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		898
DisGeNETi898

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCNE1
HGNCiHGNC:1589, CCNE1
HPAiENSG00000105173, Tissue enhanced (bone marrow, placenta)
MIMi123837, gene
neXtProtiNX_P24864
OpenTargetsiENSG00000105173
PharmGKBiPA96
VEuPathDBiHostDB:ENSG00000105173

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0655, Eukaryota
GeneTreeiENSGT00940000156256
InParanoidiP24864
OMAiHRIQTHV
OrthoDBi993640at2759
PhylomeDBiP24864
TreeFamiTF101005

Enzyme and pathway databases

PathwayCommonsiP24864
ReactomeiR-HSA-1538133, G0 and Early G1
R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21
R-HSA-2559586, DNA Damage/Telomere Stress Induced Senescence
R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis
R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-HSA-69202, Cyclin E associated events during G1/S transition
R-HSA-69205, G1/S-Specific Transcription
R-HSA-69231, Cyclin D associated events in G1
R-HSA-69563, p53-Dependent G1 DNA Damage Response
R-HSA-8849470, PTK6 Regulates Cell Cycle
R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
R-HSA-9706019, RHOBTB3 ATPase cycle
SignaLinkiP24864
SIGNORiP24864

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		898, 64 hits in 1086 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCNE1, human
EvolutionaryTraceiP24864

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Cyclin_E1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		898
PharosiP24864, Tchem

Protein Ontology

More...PROi		PR:P24864
RNActiP24864, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105173, Expressed in secondary oocyte and 165 other tissues
ExpressionAtlasiP24864, baseline and differential
GenevisibleiP24864, HS

Family and domain databases

CDDicd00043, CYCLIN, 1 hit
DisProtiDP01120
IDEALiIID00603
InterProiView protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR028858, Cyclin_E
IPR006671, Cyclin_N
PANTHERiPTHR10177, PTHR10177, 1 hit
PTHR10177:SF71, PTHR10177:SF71, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 1 hit
SM01332, Cyclin_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292, CYCLINS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNE1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24864
Secondary accession number(s): A8K684
, Q14091, Q8NFG1, Q92501, Q9UD21
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 15, 1998
Last modified: May 25, 2022
This is version 218 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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