CCNC

Functionⁱ

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.2 Publications

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase regulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein serine/threonine kinase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of cyclin-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of phosphorylation of RNA polymerase II C-terminal domain
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Cyclin, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-212436 Generic Transcription Pathway R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkⁱ	P24863
SIGNORⁱ	P24863

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-C Alternative name(s): SRB11 homolog Short name: hSRB11
Gene namesⁱ	Name:CCNC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112237.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1581 CCNC
MIMⁱ	123838 gene
neXtProtⁱ	NX_P24863

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	892
Open Targets More...OpenTargetsⁱ	ENSG00000112237
PharmGKBⁱ	PA26149

Chemistry databases

ChEMBLⁱ	CHEMBL3883323

ChEMBLⁱ

CHEMBL3883323

Polymorphism and mutation databases

BioMutaⁱ	CCNC
DMDMⁱ	166214910

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080420	1 – 283	Cyclin-CAdd BLAST		283

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	275	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P24863
PaxDbⁱ	P24863
PeptideAtlas More...PeptideAtlasⁱ	P24863
PRIDEⁱ	P24863
ProteomicsDBⁱ	54234 54235 [P24863-2]

PTM databases

iPTMnetⁱ	P24863
PhosphoSitePlusⁱ	P24863

Expressionⁱ

Tissue specificityⁱ

Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.

Gene expression databases

Bgeeⁱ	ENSG00000112237 Expressed in 236 organ(s), highest expression level in nasal cavity mucosa
CleanExⁱ	HS_CCNC
ExpressionAtlasⁱ	P24863 baseline and differential
Genevisibleⁱ	P24863 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010499 HPA069322

HPAⁱ

CAB010499
HPA069322

Interactionⁱ

Subunit structureⁱ

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CDK3	Q00526	6	EBI-395261,EBI-1245761
CDK5	Q00535	2	EBI-395261,EBI-1041567
CDK8	P49336	32	EBI-395261,EBI-394377
CRX	O43186	3	EBI-395261,EBI-748171
DYDC1	Q8WWB3	3	EBI-395261,EBI-740680
FOXP2	O15409	3	EBI-395261,EBI-983612
GLYR1	Q49A26	3	EBI-395261,EBI-2804292
GOLGA2	Q08379	3	EBI-395261,EBI-618309
KRT13	A1A4E9	3	EBI-395261,EBI-10171552
KRT15	P19012	3	EBI-395261,EBI-739566
KRT31	Q15323	5	EBI-395261,EBI-948001
LZTS2	Q9BRK4	3	EBI-395261,EBI-741037
MBIP	Q9NS73-5	3	EBI-395261,EBI-10182361
MEOX2	P50222	3	EBI-395261,EBI-748397
MGST3	O14880	3	EBI-395261,EBI-724754
NEFL	I6L9F6	3	EBI-395261,EBI-10178578
NMNAT1	Q9HAN9	3	EBI-395261,EBI-3917542
PBXIP1	Q96AQ6	3	EBI-395261,EBI-740845
PNMA5	Q96PV4	3	EBI-395261,EBI-10171633
PUF60	Q9UHX1	3	EBI-395261,EBI-1053259
RB1	P06400	4	EBI-395261,EBI-491274
TADA3	O75528	3	EBI-395261,EBI-473249
TRIM39	Q9HCM9	3	EBI-395261,EBI-739510
ZNF18	P17022	4	EBI-395261,EBI-8648067

Protein-protein interaction databases

BioGridⁱ	107333, 74 interactors
ComplexPortalⁱ	CPX-1969 Cyclin C-CDK8 complex CPX-3232 CKM complex variant 1 CPX-3263 CKM complex variant 2 CPX-330 Cyclin C-CDK3 complex
CORUMⁱ	P24863
Database of interacting proteins More...DIPⁱ	DIP-32920N
IntActⁱ	P24863, 102 interactors
Molecular INTeraction database More...MINTⁱ	P24863
STRINGⁱ	9606.ENSP00000428982

Chemistry databases

BindingDBⁱ

P24863

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	1 – 3	Combined sources	3
Helixⁱ	5 – 7	Combined sources	3
Helixⁱ	9 – 13	Combined sources	5
Helixⁱ	18 – 25	Combined sources	8
Turnⁱ	26 – 31	Combined sources	6
Helixⁱ	34 – 54	Combined sources	21
Helixⁱ	59 – 75	Combined sources	17
Turnⁱ	78 – 80	Combined sources	3
Helixⁱ	83 – 97	Combined sources	15
Beta strandⁱ	98 – 100	Combined sources	3
Helixⁱ	105 – 119	Combined sources	15
Turnⁱ	121 – 123	Combined sources	3
Helixⁱ	132 – 145	Combined sources	14
Turnⁱ	146 – 148	Combined sources	3
Helixⁱ	156 – 166	Combined sources	11
Helixⁱ	169 – 183	Combined sources	15
Turnⁱ	184 – 187	Combined sources	4
Helixⁱ	188 – 191	Combined sources	4
Helixⁱ	194 – 208	Combined sources	15
Helixⁱ	214 – 218	Combined sources	5
Helixⁱ	224 – 243	Combined sources	20
Helixⁱ	246 – 256	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P24863
SMRⁱ	P24863
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	46 – 144	Cyclin N-terminalAdd BLAST		99

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0794 Eukaryota COG5333 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119191
HOGENOMⁱ	HOG000008007
HOVERGENⁱ	HBG050836
InParanoidⁱ	P24863
KEGG Orthology (KO) More...KOⁱ	K15161
OMAⁱ	SSHHQQW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FSG
PhylomeDBⁱ	P24863

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 2 hits
InterProⁱ	View protein in InterPro IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR031658 Cyclin_C_2 IPR006671 Cyclin_N IPR028367 CyclinC/Ssn8
PANTHERⁱ	PTHR10026:SF7 PTHR10026:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16899 Cyclin_C_2, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits
SUPFAMⁱ	SSF47954 SSF47954, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P24863-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA 
        60         70         80         90        100
LGEHLKLRQQ VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF 
       110        120        130        140        150
GVVSNTRLIA AATSVLKTRF SYAFPKEFPY RMNHILECEF YLLELMDCCL 
       160        170        180        190        200
IVYHPYRPLL QYVQDMGQED MLLPLAWRIV NDTYRTDLCL LYPPFMIALA 
       210        220        230        240        250
CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ WKNFDERKEM 
       260        270        280 
ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS

Length:283

Mass (Da):33,243

Last modified:January 15, 2008 - v2

Checksum:ⁱCF8AC5E94E621F4C

GO

Isoform 2 (identifier: P24863-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-85: Missing.

« Hide

        10         20         30         40         50
MAPTCVFLAS KVEEFGVVSN TRLIAAATSV LKTRFSYAFP KEFPYRMNHI 
        60         70         80         90        100
LECEFYLLEL MDCCLIVYHP YRPLLQYVQD MGQEDMLLPL AWRIVNDTYR 
       110        120        130        140        150
TDLCLLYPPF MIALACLHVA CVVQQKDARQ WFAELSVDME KILEIIRVIL 
       160        170        180        190 
KLYEQWKNFD ERKEMATILS KMPKPKPPPN SEGEQGPNGS QNSSYSQS

Note: No experimental confirmation available.

Show »

Length:198

Mass (Da):22,945

Checksum:ⁱ1A22C22167A775E7

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RFK5	E5RFK5_HUMAN	Cyclin-C Cyclin-C	CCNC	282	Annotation score:
Q5JV82	Q5JV82_HUMAN	Cyclin-C Cyclin-C	CCNC	143	Annotation score:
G5E954	G5E954_HUMAN	Cyclin C, isoform CRA_c Cyclin C, isoform CRA_c (Cyclin-C)	CCNC hCG_1757197	202	Annotation score:
E5RI39	E5RI39_HUMAN	Cyclin-C Cyclin-C	CCNC	192	Annotation score:
H0YBQ5	H0YBQ5_HUMAN	Cyclin-C Cyclin-C	CCNC	228	Annotation score:
J3KP90	J3KP90_HUMAN	Cyclin-C Cyclin-C	CCNC	282	Annotation score:
E5RIH8	E5RIH8_HUMAN	Cyclin-C Cyclin-C	CCNC	114	Annotation score:
E5RFX8	E5RFX8_HUMAN	Cyclin-C Cyclin-C	CCNC	162	Annotation score:
E5RHL8	E5RHL8_HUMAN	Cyclin-C Cyclin-C	CCNC	49	Annotation score:

Sequence cautionⁱ

The sequence AAC50825 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043075	1 – 85	Missing in isoform 2. 1 PublicationAdd BLAST		85

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74091 mRNA No translation available. U40739 U40738 Genomic DNA Translation: AAC50825.1 Different initiation. AK298558 mRNA Translation: BAG60753.1 AL137784 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34502.1 [P24863-1] CCDS47461.1 [P24863-2]
PIRⁱ	A40268
NCBI Reference Sequences More...RefSeqⁱ	NP_001013417.1, NM_001013399.1 [P24863-2] NP_005181.2, NM_005190.3 [P24863-1]
UniGeneⁱ	Hs.430646 Hs.633351

Genome annotation databases

Ensemblⁱ	ENST00000520429; ENSP00000428982; ENSG00000112237 [P24863-1] ENST00000523799; ENSP00000430014; ENSG00000112237 [P24863-2] ENST00000523985; ENSP00000430119; ENSG00000112237 [P24863-2]
GeneIDⁱ	892
KEGGⁱ	hsa:892
UCSC genome browser More...UCSCⁱ	uc003pqd.4 human [P24863-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24863	Cyclin C		HUMAN		283	UniRef100_P24863
Cyclin-C isoform a		MACMU		283
CCNC isoform 1		PANTR		283
Cyclin C		MACFA		283
CCNC isoform 1		PONAB		283
+15
P24863-2	CCNC isoform 2		PANTR		198	UniRef100_A0A2J8PUY8
CCNC isoform 6		PONAB		198
UPI00064306E0		MICMU		310

Protein	Similar proteins		Species	Score	Length	Source
P24863	Cyclin-C		XENLA		283	UniRef90_P24863
Cyclin-C		BOVIN		283
Cyclin-C		CHICK		283
Cyclin C		HUMAN		283
Cyclin-C isoform a		MACMU		283
+144

Protein	Similar proteins		Species	Score	Length	Source
P24863	Cyclin-C		XENLA		283	UniRef50_P24863
Cyclin-C		CHICK		283
Cyclin-C		BOVIN		283
Cyclin-C		MOUSE		283
Cyclin-C		XENTR		283
+354

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74091 mRNA No translation available. U40739 U40738 Genomic DNA Translation: AAC50825.1 Different initiation. AK298558 mRNA Translation: BAG60753.1 AL137784 Genomic DNA No translation available.
CCDSⁱ	CCDS34502.1 [P24863-1] CCDS47461.1 [P24863-2]
PIRⁱ	A40268
RefSeqⁱ	NP_001013417.1, NM_001013399.1 [P24863-2] NP_005181.2, NM_005190.3 [P24863-1]
UniGeneⁱ	Hs.430646 Hs.633351

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3RGF	X-ray	2.20	B	1-283	[»]
	4CRL	X-ray	2.40	B	1-283	[»]
	4F6S	X-ray	2.60	B	1-283	[»]
	4F6U	X-ray	2.10	B	1-283	[»]
	4F6W	X-ray	2.39	B	1-283	[»]
	4F70	X-ray	3.00	B	1-283	[»]
	4F7J	X-ray	2.60	B	1-283	[»]
	4F7L	X-ray	2.90	B	1-283	[»]
	4F7N	X-ray	2.65	B	1-283	[»]
	4F7S	X-ray	2.20	B	1-283	[»]
	4G6L	X-ray	2.70	B	1-283	[»]
	5BNJ	X-ray	2.64	B	1-283	[»]
	5CEI	X-ray	2.24	B	1-283	[»]
	5FGK	X-ray	2.36	B	1-264	[»]
	5HBE	X-ray	2.38	B	1-264	[»]
	5HBH	X-ray	2.50	B	1-264	[»]
	5HBJ	X-ray	3.00	B	1-264	[»]
	5HNB	X-ray	2.35	B	1-264	[»]
	5HVY	X-ray	2.39	B	1-283	[»]
	5I5Z	X-ray	2.60	B	1-264	[»]
	5ICP	X-ray	2.18	B	1-264	[»]
	5IDN	X-ray	2.26	B	1-264	[»]
	5IDP	X-ray	2.65	B	1-264	[»]
	5XQX	X-ray	2.30	B	2-264	[»]
	5XS2	X-ray	2.04	B	2-264	[»]
ProteinModelPortalⁱ	P24863
SMRⁱ	P24863
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107333, 74 interactors
ComplexPortalⁱ	CPX-1969 Cyclin C-CDK8 complex CPX-3232 CKM complex variant 1 CPX-3263 CKM complex variant 2 CPX-330 Cyclin C-CDK3 complex
CORUMⁱ	P24863
DIPⁱ	DIP-32920N
IntActⁱ	P24863, 102 interactors
MINTⁱ	P24863
STRINGⁱ	9606.ENSP00000428982

Chemistry databases

BindingDBⁱ	P24863
ChEMBLⁱ	CHEMBL3883323

PTM databases

iPTMnetⁱ	P24863
PhosphoSitePlusⁱ	P24863

Polymorphism and mutation databases

BioMutaⁱ	CCNC
DMDMⁱ	166214910

Proteomic databases

EPDⁱ	P24863
PaxDbⁱ	P24863
PeptideAtlasⁱ	P24863
PRIDEⁱ	P24863
ProteomicsDBⁱ	54234 54235 [P24863-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	892
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000520429; ENSP00000428982; ENSG00000112237 [P24863-1] ENST00000523799; ENSP00000430014; ENSG00000112237 [P24863-2] ENST00000523985; ENSP00000430119; ENSG00000112237 [P24863-2]
GeneIDⁱ	892
KEGGⁱ	hsa:892
UCSCⁱ	uc003pqd.4 human [P24863-1]

Organism-specific databases

CTDⁱ	892
DisGeNETⁱ	892
EuPathDBⁱ	HostDB:ENSG00000112237.12
GeneCardsⁱ	CCNC
HGNCⁱ	HGNC:1581 CCNC
HPAⁱ	CAB010499 HPA069322
MIMⁱ	123838 gene
neXtProtⁱ	NX_P24863
OpenTargetsⁱ	ENSG00000112237
PharmGKBⁱ	PA26149
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0794 Eukaryota COG5333 LUCA
GeneTreeⁱ	ENSGT00760000119191
HOGENOMⁱ	HOG000008007
HOVERGENⁱ	HBG050836
InParanoidⁱ	P24863
KOⁱ	K15161
OMAⁱ	SSHHQQW
OrthoDBⁱ	EOG091G0FSG
PhylomeDBⁱ	P24863

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-212436 Generic Transcription Pathway R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkⁱ	P24863
SIGNORⁱ	P24863

Miscellaneous databases

ChiTaRSⁱ	CCNC human
GeneWikiⁱ	CCNC_(gene)
GenomeRNAiⁱ	892
Protein Ontology More...PROⁱ	PR:P24863
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112237 Expressed in 236 organ(s), highest expression level in nasal cavity mucosa
CleanExⁱ	HS_CCNC
ExpressionAtlasⁱ	P24863 baseline and differential
Genevisibleⁱ	P24863 HS

Family and domain databases

CDDⁱ	cd00043 CYCLIN, 2 hits
InterProⁱ	View protein in InterPro IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR031658 Cyclin_C_2 IPR006671 Cyclin_N IPR028367 CyclinC/Ssn8
PANTHERⁱ	PTHR10026:SF7 PTHR10026:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF16899 Cyclin_C_2, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCNC_HUMAN
Accessionⁱ	P24863Primary (citable) accession number: P24863 Secondary accession number(s): B4DPZ1, Q9H543
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	January 15, 2008
	Last modified:	September 12, 2018
	This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P24863 (CCNC_HUMAN)

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Cyclin-C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ