Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P24863 (CCNC_HUMAN)

Entry version 204 (02 Jun 2021)
Sequence version 2 (15 Jan 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Cyclin-C

Gene

CCNC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Cyclin, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P24863

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1989781, PPARA activates gene expression
R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-212436, Generic Transcription Pathway
R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P24863

SIGNOR Signaling Network Open Resource

More...SIGNORi		P24863

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-C
Alternative name(s):
SRB11 homolog
Short name:
hSRB11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCNC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1581, CCNC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		123838, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P24863

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000112237.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		892

Open Targets

More...OpenTargetsi		ENSG00000112237

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26149

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P24863, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3038474
CHEMBL3883323

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCNC

Domain mapping of disease mutations (DMDM)

More...DMDMi		166214910

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000804201 – 283Cyclin-CAdd BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei275PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P24863

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P24863

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P24863

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P24863

PeptideAtlas

More...PeptideAtlasi		P24863

PRoteomics IDEntifications database

More...PRIDEi		P24863

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54234 [P24863-1]
54235 [P24863-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P24863

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P24863

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P24863

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112237, Expressed in nasal cavity mucosa and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P24863, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P24863, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000112237, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P24863
With#Exp.IntAct
APBB2 - isoform 2 [Q92870-2]3EBI-395261,EBI-21535880
ASH2L [Q9UBL3]3EBI-395261,EBI-540797
BLOC1S2 [Q6QNY1]3EBI-395261,EBI-465872
BTBD2 [Q9BX70]3EBI-395261,EBI-710091
CASP6 [P55212]3EBI-395261,EBI-718729
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-395261,EBI-10175300
itself3EBI-395261,EBI-395261
CDK3 [Q00526]7EBI-395261,EBI-1245761
CDK5 [Q00535]2EBI-395261,EBI-1041567
CDK8 [P49336]36EBI-395261,EBI-394377
CDKN2B [P42772]3EBI-395261,EBI-711280
CFAP53 [Q96M91]3EBI-395261,EBI-742422
CKS1B [P61024]3EBI-395261,EBI-456371
CRX [O43186]4EBI-395261,EBI-748171
DYDC1 [Q8WWB3]3EBI-395261,EBI-740680
FAM161A [Q3B820]3EBI-395261,EBI-719941
FAM50B [Q9Y247]3EBI-395261,EBI-742802
FAM90A1 [Q86YD7]3EBI-395261,EBI-6658203
FOXP2 [O15409]3EBI-395261,EBI-983612
FOXR2 [Q6PJQ5]3EBI-395261,EBI-8468543
GADD45GIP1 [Q8TAE8]3EBI-395261,EBI-372506
GFAP [P14136]3EBI-395261,EBI-744302
GLE1 [Q53GS7]3EBI-395261,EBI-1955541
GLYR1 [Q49A26]3EBI-395261,EBI-2804292
GOLGA2 [Q08379]3EBI-395261,EBI-618309
hCG_1987119 [A0A024R8L2]3EBI-395261,EBI-14103818
HTT [P42858]9EBI-395261,EBI-466029
ISY1 [Q9ULR0]3EBI-395261,EBI-2557660
KRT13 [A1A4E9]3EBI-395261,EBI-10171552
KRT15 [P19012]3EBI-395261,EBI-739566
KRT16 [P08779]3EBI-395261,EBI-356410
KRT27 [Q7Z3Y8]3EBI-395261,EBI-3044087
KRT31 [Q15323]6EBI-395261,EBI-948001
KRT34 [O76011]3EBI-395261,EBI-1047093
LAMP2 - isoform LAMP-2B [P13473-2]3EBI-395261,EBI-21591415
LCN2 [P80188]3EBI-395261,EBI-11911016
LZTS2 [Q9BRK4]3EBI-395261,EBI-741037
MBD3 - isoform 2 [O95983-2]3EBI-395261,EBI-11978579
MBIP - isoform 4 [Q9NS73-5]3EBI-395261,EBI-10182361
MEOX2 [P50222]3EBI-395261,EBI-748397
MEOX2 [Q6FHY5]3EBI-395261,EBI-16439278
MGST3 [O14880]3EBI-395261,EBI-724754
NDUFB7 [P17568]3EBI-395261,EBI-1246238
NDUFV2 [P19404]6EBI-395261,EBI-713665
NEFL [I6L9F6]3EBI-395261,EBI-10178578
NMNAT1 [Q9HAN9]4EBI-395261,EBI-3917542
NRBF2 [Q96F24]3EBI-395261,EBI-2362014
PAX5 [Q02548]3EBI-395261,EBI-296331
PBXIP1 [Q96AQ6]3EBI-395261,EBI-740845
PLEKHO2 - isoform 2 [Q8TD55-2]3EBI-395261,EBI-12905986
PLIN3 [O60664]3EBI-395261,EBI-725795
PMP22 [D3DTS7]3EBI-395261,EBI-25882629
PNMA5 [Q96PV4]4EBI-395261,EBI-10171633
POU6F2 [P78424]3EBI-395261,EBI-12029004
PRPF18 [Q99633]3EBI-395261,EBI-2798416
PRPF40A - isoform 2 [O75400-2]3EBI-395261,EBI-5280197
PUF60 [Q9UHX1]3EBI-395261,EBI-1053259
RB1 [P06400]4EBI-395261,EBI-491274
RBM41 [Q96IZ5]3EBI-395261,EBI-740773
REL - isoform 2 [Q04864-2]3EBI-395261,EBI-10829018
RFC5 [P40937]5EBI-395261,EBI-712376
RIBC1 [Q8N443]5EBI-395261,EBI-10265323
RPA2 [P15927]3EBI-395261,EBI-621404
RUSC1 [Q9BVN2]3EBI-395261,EBI-6257312
SERTAD3 [Q9UJW9]3EBI-395261,EBI-748621
SH3GLB1 [Q9Y371]3EBI-395261,EBI-2623095
SHC3 [Q92529]3EBI-395261,EBI-79084
SPAG8 - isoform 2 [Q99932-2]3EBI-395261,EBI-11959123
SPRED1 [Q7Z699]3EBI-395261,EBI-5235340
SRCAP - isoform 3 [Q6ZRS2-3]3EBI-395261,EBI-12029182
TADA3 [O75528]3EBI-395261,EBI-473249
TCEANC - isoform 2 [Q8N8B7-2]3EBI-395261,EBI-11955057
TEPSIN [Q96N21]3EBI-395261,EBI-11139477
TEX12 [Q9BXU0]3EBI-395261,EBI-12090309
TRAF3IP3 [Q9Y228]3EBI-395261,EBI-765817
TRIM39 [Q9HCM9]4EBI-395261,EBI-739510
UBE2K [P61086]3EBI-395261,EBI-473850
VHL - isoform 2 [P40337-2]3EBI-395261,EBI-12157263
VTA1 [Q9NP79]3EBI-395261,EBI-740160
ZFP90 [Q8TF47]3EBI-395261,EBI-11419867
ZNF18 [P17022]4EBI-395261,EBI-8648067
ZNF426 [Q9BUY5]3EBI-395261,EBI-743265
ZNF620 [Q6ZNG0]3EBI-395261,EBI-4395669
ZNF688 [P0C7X2]3EBI-395261,EBI-4395732
ZNF792 [Q3KQV3]3EBI-395261,EBI-10240849

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107333, 129 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1969, Cyclin C-CDK8 complex
CPX-3232, CKM complex variant 1
CPX-3263, CKM complex variant 2
CPX-330, Cyclin C-CDK3 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P24863

Database of interacting proteins

More...DIPi		DIP-32920N

Protein interaction database and analysis system

More...IntActi		P24863, 124 interactors

Molecular INTeraction database

More...MINTi		P24863

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000428982

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P24863

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P24863, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1283
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24863

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 144Cyclin N-terminalAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni252 – 283DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi268 – 283Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0794, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155625

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24863

Identification of Orthologs from Complete Genome Data

More...OMAi		ANYWEST

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24863

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR043198, Cyclin/Ssn8
IPR006671, Cyclin_N
IPR028367, CyclinC/Ssn8

The PANTHER Classification System

More...PANTHERi		PTHR10026, PTHR10026, 1 hit
PTHR10026:SF7, PTHR10026:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00134, Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P24863-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA 
        60         70         80         90        100
LGEHLKLRQQ VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF 
       110        120        130        140        150
GVVSNTRLIA AATSVLKTRF SYAFPKEFPY RMNHILECEF YLLELMDCCL 
       160        170        180        190        200
IVYHPYRPLL QYVQDMGQED MLLPLAWRIV NDTYRTDLCL LYPPFMIALA 
       210        220        230        240        250
CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ WKNFDERKEM 
       260        270        280 
ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS
Length:283
Mass (Da):33,243
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF8AC5E94E621F4C
GO
Isoform 2 (identifier: P24863-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:198
Mass (Da):22,945
Checksum:i1A22C22167A775E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KP90J3KP90_HUMAN
Cyclin-C
CCNC
282Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFK5E5RFK5_HUMAN
Cyclin-C
CCNC
282Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBQ5H0YBQ5_HUMAN
Cyclin-C
CCNC
228Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E954G5E954_HUMAN
Cyclin-C
CCNC hCG_1757197
202Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI39E5RI39_HUMAN
Cyclin-C
CCNC
192Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JV82Q5JV82_HUMAN
Cyclin-C
CCNC
143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIH8E5RIH8_HUMAN
Cyclin-C
CCNC
114Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFX8E5RFX8_HUMAN
Cyclin-C
CCNC
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHL8E5RHL8_HUMAN
Cyclin-C
CCNC
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50825 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430751 – 85Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M74091 mRNA No translation available.
U40739 U40738 Genomic DNA Translation: AAC50825.1 Different initiation.
AK298558 mRNA Translation: BAG60753.1
AL137784 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34502.1 [P24863-1]
CCDS47461.1 [P24863-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A40268

NCBI Reference Sequences

More...RefSeqi		NP_001013417.1, NM_001013399.1 [P24863-2]
NP_005181.2, NM_005190.3 [P24863-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000520429; ENSP00000428982; ENSG00000112237 [P24863-1]
ENST00000523799; ENSP00000430014; ENSG00000112237 [P24863-2]
ENST00000523985; ENSP00000430119; ENSG00000112237 [P24863-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		892

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:892

UCSC genome browser

More...UCSCi		uc003pqd.4, human [P24863-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74091 mRNA No translation available.
U40739 U40738 Genomic DNA Translation: AAC50825.1 Different initiation.
AK298558 mRNA Translation: BAG60753.1
AL137784 Genomic DNA No translation available.
CCDSiCCDS34502.1 [P24863-1]
CCDS47461.1 [P24863-2]
PIRiA40268
RefSeqiNP_001013417.1, NM_001013399.1 [P24863-2]
NP_005181.2, NM_005190.3 [P24863-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RGFX-ray2.20B1-283[»]
4CRLX-ray2.40B1-283[»]
4F6SX-ray2.60B1-283[»]
4F6UX-ray2.10B1-283[»]
4F6WX-ray2.39B1-283[»]
4F70X-ray3.00B1-283[»]
4F7JX-ray2.60B1-283[»]
4F7LX-ray2.90B1-283[»]
4F7NX-ray2.65B1-283[»]
4F7SX-ray2.20B1-283[»]
4G6LX-ray2.70B1-283[»]
5BNJX-ray2.64B1-283[»]
5CEIX-ray2.24B1-283[»]
5FGKX-ray2.36B1-264[»]
5HBEX-ray2.38B1-264[»]
5HBHX-ray2.50B1-264[»]
5HBJX-ray3.00B1-264[»]
5HNBX-ray2.35B1-264[»]
5HVYX-ray2.39B1-283[»]
5I5ZX-ray2.60B1-264[»]
5ICPX-ray2.18B1-264[»]
5IDNX-ray2.26B1-264[»]
5IDPX-ray2.65B1-264[»]
5XQXX-ray2.30B2-264[»]
5XS2X-ray2.04B2-264[»]
6QTGX-ray2.70B1-283[»]
6QTJX-ray2.48B1-283[»]
6R3SX-ray2.19B1-283[»]
6T41X-ray2.45B1-283[»]
6TPAX-ray2.80B1-283[»]
6Y0AX-ray2.19B1-280[»]
SMRiP24863
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107333, 129 interactors
ComplexPortaliCPX-1969, Cyclin C-CDK8 complex
CPX-3232, CKM complex variant 1
CPX-3263, CKM complex variant 2
CPX-330, Cyclin C-CDK3 complex
CORUMiP24863
DIPiDIP-32920N
IntActiP24863, 124 interactors
MINTiP24863
STRINGi9606.ENSP00000428982

Chemistry databases

BindingDBiP24863
ChEMBLiCHEMBL3038474
CHEMBL3883323

PTM databases

iPTMnetiP24863
PhosphoSitePlusiP24863
SwissPalmiP24863

Genetic variation databases

BioMutaiCCNC
DMDMi166214910

Proteomic databases

EPDiP24863
jPOSTiP24863
MassIVEiP24863
PaxDbiP24863
PeptideAtlasiP24863
PRIDEiP24863
ProteomicsDBi54234 [P24863-1]
54235 [P24863-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4188, 338 antibodies

The DNASU plasmid repository

More...DNASUi		892

Genome annotation databases

EnsembliENST00000520429; ENSP00000428982; ENSG00000112237 [P24863-1]
ENST00000523799; ENSP00000430014; ENSG00000112237 [P24863-2]
ENST00000523985; ENSP00000430119; ENSG00000112237 [P24863-2]
GeneIDi892
KEGGihsa:892
UCSCiuc003pqd.4, human [P24863-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		892
DisGeNETi892

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCNC
HGNCiHGNC:1581, CCNC
HPAiENSG00000112237, Low tissue specificity
MIMi123838, gene
neXtProtiNX_P24863
OpenTargetsiENSG00000112237
PharmGKBiPA26149
VEuPathDBiHostDB:ENSG00000112237.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0794, Eukaryota
GeneTreeiENSGT00940000155625
InParanoidiP24863
OMAiANYWEST
PhylomeDBiP24863

Enzyme and pathway databases

PathwayCommonsiP24863
ReactomeiR-HSA-1989781, PPARA activates gene expression
R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-212436, Generic Transcription Pathway
R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-381340, Transcriptional regulation of white adipocyte differentiation
SignaLinkiP24863
SIGNORiP24863

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		892, 270 hits in 1022 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCNC, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CCNC_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		892
PharosiP24863, Tbio

Protein Ontology

More...PROi		PR:P24863
RNActiP24863, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112237, Expressed in nasal cavity mucosa and 249 other tissues
ExpressionAtlasiP24863, baseline and differential
GenevisibleiP24863, HS

Family and domain databases

CDDicd00043, CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR043198, Cyclin/Ssn8
IPR006671, Cyclin_N
IPR028367, CyclinC/Ssn8
PANTHERiPTHR10026, PTHR10026, 1 hit
PTHR10026:SF7, PTHR10026:SF7, 1 hit
PfamiView protein in Pfam
PF00134, Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 2 hits
SUPFAMiSSF47954, SSF47954, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24863
Secondary accession number(s): B4DPZ1, Q9H543
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 15, 2008
Last modified: June 2, 2021
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again