UniProtKB - P24863 (CCNC_HUMAN)
Cyclin-C
CCNC
Functioni
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
- identical protein binding Source: IntAct
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription initiation from RNA polymerase II promoter Source: Reactome
Keywordsi
Molecular function | Activator, Cyclin, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P24863 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-HSA-212436, Generic Transcription Pathway R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
SignaLinki | P24863 |
SIGNORi | P24863 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-CAlternative name(s): SRB11 homolog Short name: hSRB11 |
Gene namesi | Name:CCNC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1581, CCNC |
MIMi | 123838, gene |
neXtProti | NX_P24863 |
VEuPathDBi | HostDB:ENSG00000112237.12 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- mediator complex Source: GO_Central
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 892 |
OpenTargetsi | ENSG00000112237 |
PharmGKBi | PA26149 |
Miscellaneous databases
Pharosi | P24863, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3038474 CHEMBL3883323 |
Genetic variation databases
BioMutai | CCNC |
DMDMi | 166214910 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080420 | 1 – 283 | Cyclin-CAdd BLAST | 283 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 275 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P24863 |
jPOSTi | P24863 |
MassIVEi | P24863 |
PaxDbi | P24863 |
PeptideAtlasi | P24863 |
PRIDEi | P24863 |
ProteomicsDBi | 54234 [P24863-1] 54235 [P24863-2] |
PTM databases
iPTMneti | P24863 |
PhosphoSitePlusi | P24863 |
SwissPalmi | P24863 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000112237, Expressed in nasal cavity mucosa and 248 other tissues |
ExpressionAtlasi | P24863, baseline and differential |
Genevisiblei | P24863, HS |
Organism-specific databases
HPAi | ENSG00000112237, Low tissue specificity |
Interactioni
Subunit structurei
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II.
4 PublicationsBinary interactionsi
P24863
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 107333, 126 interactors |
ComplexPortali | CPX-1969, Cyclin C-CDK8 complex CPX-3232, CKM complex variant 1 CPX-3263, CKM complex variant 2 CPX-330, Cyclin C-CDK3 complex |
CORUMi | P24863 |
DIPi | DIP-32920N |
IntActi | P24863, 122 interactors |
MINTi | P24863 |
STRINGi | 9606.ENSP00000428982 |
Chemistry databases
BindingDBi | P24863 |
Miscellaneous databases
RNActi | P24863, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P24863 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 144 | Cyclin N-terminalAdd BLAST | 99 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0794, Eukaryota |
GeneTreei | ENSGT00940000155625 |
InParanoidi | P24863 |
OMAi | ANYWEST |
PhylomeDBi | P24863 |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR043198, Cyclin/Ssn8 IPR006671, Cyclin_N IPR028367, CyclinC/Ssn8 |
PANTHERi | PTHR10026, PTHR10026, 1 hit PTHR10026:SF7, PTHR10026:SF7, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits |
SUPFAMi | SSF47954, SSF47954, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA
60 70 80 90 100
LGEHLKLRQQ VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF
110 120 130 140 150
GVVSNTRLIA AATSVLKTRF SYAFPKEFPY RMNHILECEF YLLELMDCCL
160 170 180 190 200
IVYHPYRPLL QYVQDMGQED MLLPLAWRIV NDTYRTDLCL LYPPFMIALA
210 220 230 240 250
CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ WKNFDERKEM
260 270 280
ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KP90 | J3KP90_HUMAN | Cyclin-C | CCNC | 282 | Annotation score: | ||
E5RFK5 | E5RFK5_HUMAN | Cyclin-C | CCNC | 282 | Annotation score: | ||
H0YBQ5 | H0YBQ5_HUMAN | Cyclin-C | CCNC | 228 | Annotation score: | ||
E5RI39 | E5RI39_HUMAN | Cyclin-C | CCNC | 192 | Annotation score: | ||
G5E954 | G5E954_HUMAN | Cyclin-C | CCNC hCG_1757197 | 202 | Annotation score: | ||
Q5JV82 | Q5JV82_HUMAN | Cyclin-C | CCNC | 143 | Annotation score: | ||
E5RIH8 | E5RIH8_HUMAN | Cyclin-C | CCNC | 114 | Annotation score: | ||
E5RFX8 | E5RFX8_HUMAN | Cyclin-C | CCNC | 162 | Annotation score: | ||
E5RHL8 | E5RHL8_HUMAN | Cyclin-C | CCNC | 49 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043075 | 1 – 85 | Missing in isoform 2. 1 PublicationAdd BLAST | 85 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74091 mRNA No translation available. U40739 , U40728, U40729, U40730, U40731, U40732, U40733, U40734, U40735, U40736, U40737, U40738 Genomic DNA Translation: AAC50825.1 Different initiation. AK298558 mRNA Translation: BAG60753.1 AL137784 Genomic DNA No translation available. |
CCDSi | CCDS34502.1 [P24863-1] CCDS47461.1 [P24863-2] |
PIRi | A40268 |
RefSeqi | NP_001013417.1, NM_001013399.1 [P24863-2] NP_005181.2, NM_005190.3 [P24863-1] |
Genome annotation databases
Ensembli | ENST00000520429; ENSP00000428982; ENSG00000112237 [P24863-1] ENST00000523799; ENSP00000430014; ENSG00000112237 [P24863-2] ENST00000523985; ENSP00000430119; ENSG00000112237 [P24863-2] |
GeneIDi | 892 |
KEGGi | hsa:892 |
UCSCi | uc003pqd.4, human [P24863-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74091 mRNA No translation available. U40739 , U40728, U40729, U40730, U40731, U40732, U40733, U40734, U40735, U40736, U40737, U40738 Genomic DNA Translation: AAC50825.1 Different initiation. AK298558 mRNA Translation: BAG60753.1 AL137784 Genomic DNA No translation available. |
CCDSi | CCDS34502.1 [P24863-1] CCDS47461.1 [P24863-2] |
PIRi | A40268 |
RefSeqi | NP_001013417.1, NM_001013399.1 [P24863-2] NP_005181.2, NM_005190.3 [P24863-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3RGF | X-ray | 2.20 | B | 1-283 | [»] | |
4CRL | X-ray | 2.40 | B | 1-283 | [»] | |
4F6S | X-ray | 2.60 | B | 1-283 | [»] | |
4F6U | X-ray | 2.10 | B | 1-283 | [»] | |
4F6W | X-ray | 2.39 | B | 1-283 | [»] | |
4F70 | X-ray | 3.00 | B | 1-283 | [»] | |
4F7J | X-ray | 2.60 | B | 1-283 | [»] | |
4F7L | X-ray | 2.90 | B | 1-283 | [»] | |
4F7N | X-ray | 2.65 | B | 1-283 | [»] | |
4F7S | X-ray | 2.20 | B | 1-283 | [»] | |
4G6L | X-ray | 2.70 | B | 1-283 | [»] | |
5BNJ | X-ray | 2.64 | B | 1-283 | [»] | |
5CEI | X-ray | 2.24 | B | 1-283 | [»] | |
5FGK | X-ray | 2.36 | B | 1-264 | [»] | |
5HBE | X-ray | 2.38 | B | 1-264 | [»] | |
5HBH | X-ray | 2.50 | B | 1-264 | [»] | |
5HBJ | X-ray | 3.00 | B | 1-264 | [»] | |
5HNB | X-ray | 2.35 | B | 1-264 | [»] | |
5HVY | X-ray | 2.39 | B | 1-283 | [»] | |
5I5Z | X-ray | 2.60 | B | 1-264 | [»] | |
5ICP | X-ray | 2.18 | B | 1-264 | [»] | |
5IDN | X-ray | 2.26 | B | 1-264 | [»] | |
5IDP | X-ray | 2.65 | B | 1-264 | [»] | |
5XQX | X-ray | 2.30 | B | 2-264 | [»] | |
5XS2 | X-ray | 2.04 | B | 2-264 | [»] | |
6QTG | X-ray | 2.70 | B | 1-283 | [»] | |
6QTJ | X-ray | 2.48 | B | 1-283 | [»] | |
6R3S | X-ray | 2.19 | B | 1-283 | [»] | |
6T41 | X-ray | 2.45 | B | 1-283 | [»] | |
SMRi | P24863 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107333, 126 interactors |
ComplexPortali | CPX-1969, Cyclin C-CDK8 complex CPX-3232, CKM complex variant 1 CPX-3263, CKM complex variant 2 CPX-330, Cyclin C-CDK3 complex |
CORUMi | P24863 |
DIPi | DIP-32920N |
IntActi | P24863, 122 interactors |
MINTi | P24863 |
STRINGi | 9606.ENSP00000428982 |
Chemistry databases
BindingDBi | P24863 |
ChEMBLi | CHEMBL3038474 CHEMBL3883323 |
PTM databases
iPTMneti | P24863 |
PhosphoSitePlusi | P24863 |
SwissPalmi | P24863 |
Genetic variation databases
BioMutai | CCNC |
DMDMi | 166214910 |
Proteomic databases
EPDi | P24863 |
jPOSTi | P24863 |
MassIVEi | P24863 |
PaxDbi | P24863 |
PeptideAtlasi | P24863 |
PRIDEi | P24863 |
ProteomicsDBi | 54234 [P24863-1] 54235 [P24863-2] |
Protocols and materials databases
Antibodypediai | 4188, 325 antibodies |
DNASUi | 892 |
Genome annotation databases
Ensembli | ENST00000520429; ENSP00000428982; ENSG00000112237 [P24863-1] ENST00000523799; ENSP00000430014; ENSG00000112237 [P24863-2] ENST00000523985; ENSP00000430119; ENSG00000112237 [P24863-2] |
GeneIDi | 892 |
KEGGi | hsa:892 |
UCSCi | uc003pqd.4, human [P24863-1] |
Organism-specific databases
CTDi | 892 |
DisGeNETi | 892 |
GeneCardsi | CCNC |
HGNCi | HGNC:1581, CCNC |
HPAi | ENSG00000112237, Low tissue specificity |
MIMi | 123838, gene |
neXtProti | NX_P24863 |
OpenTargetsi | ENSG00000112237 |
PharmGKBi | PA26149 |
VEuPathDBi | HostDB:ENSG00000112237.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0794, Eukaryota |
GeneTreei | ENSGT00940000155625 |
InParanoidi | P24863 |
OMAi | ANYWEST |
PhylomeDBi | P24863 |
Enzyme and pathway databases
PathwayCommonsi | P24863 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription R-HSA-212436, Generic Transcription Pathway R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2644606, Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-381340, Transcriptional regulation of white adipocyte differentiation |
SignaLinki | P24863 |
SIGNORi | P24863 |
Miscellaneous databases
BioGRID-ORCSi | 892, 244 hits in 902 CRISPR screens |
ChiTaRSi | CCNC, human |
GeneWikii | CCNC_(gene) |
GenomeRNAii | 892 |
Pharosi | P24863, Tbio |
PROi | PR:P24863 |
RNActi | P24863, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112237, Expressed in nasal cavity mucosa and 248 other tissues |
ExpressionAtlasi | P24863, baseline and differential |
Genevisiblei | P24863, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR043198, Cyclin/Ssn8 IPR006671, Cyclin_N IPR028367, CyclinC/Ssn8 |
PANTHERi | PTHR10026, PTHR10026, 1 hit PTHR10026:SF7, PTHR10026:SF7, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits |
SUPFAMi | SSF47954, SSF47954, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNC_HUMAN | |
Accessioni | P24863Primary (citable) accession number: P24863 Secondary accession number(s): B4DPZ1, Q9H543 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | January 15, 2008 | |
Last modified: | February 10, 2021 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM