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UniProtKB - P24860 (CCNB1_MOUSE)

Entry version 191 (02 Dec 2020)
Sequence version 3 (01 Oct 1996)
Previous versions | rss
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Protein

G2/mitotic-specific cyclin-B1

Gene

Ccnb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-MMU-176408, Regulation of APC/C activators between G1/S and early anaphase
R-MMU-176412, Phosphorylation of the APC/C
R-MMU-176417, Phosphorylation of Emi1
R-MMU-2299718, Condensation of Prophase Chromosomes
R-MMU-2500257, Resolution of Sister Chromatid Cohesion
R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition
R-MMU-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7
R-MMU-2995383, Initiation of Nuclear Envelope (NE) Reformation
R-MMU-3301854, Nuclear Pore Complex (NPC) Disassembly
R-MMU-4419969, Depolymerisation of the Nuclear Lamina
R-MMU-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-MMU-68875, Mitotic Prophase
R-MMU-69273, Cyclin A/B1/B2 associated events during G2/M transition
R-MMU-69478, G2/M DNA replication checkpoint
R-MMU-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8878166, Transcriptional regulation by RUNX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccnb1
Synonyms:Ccn-2, Ccnb1-rs13, Cycb, Cycb1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:88302, Ccnb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000803521 – 430G2/mitotic-specific cyclin-B1Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei73N6-acetyllysineBy similarity1
Modified residuei123Phosphoserine; by CDK1By similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei130Phosphoserine; by PLK1By similarity1
Modified residuei144PhosphoserineBy similarity1
Modified residuei318PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases (By similarity).By similarity
Phosphorylated by PLK1 at Ser-130 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-144 was also reported to be mediated by PLK1 but Ser-130 seems to be the primary phosphorylation site (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P24860

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P24860

PeptideAtlas

More...PeptideAtlasi		P24860

PRoteomics IDEntifications database

More...PRIDEi		P24860

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P24860

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P24860

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000041431, Expressed in embryo and 212 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P24860, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10.

Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase.

Interacts with CCNF; interaction is required for nuclear localization.

Interacts with CDK5RAP3 (By similarity).

Interacts with RFPL4A and UBE2A (PubMed:12525704).

Interacts with INCA1 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		234538, 11 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2069, Cyclin B1-CDK1 complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P24860

Protein interaction database and analysis system

More...IntActi		P24860, 2 interactors

Molecular INTeraction database

More...MINTi		P24860

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000071989

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P24860, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24860

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni166 – 174Interaction with CDK2By similarity9
Regioni255 – 258Interaction with CDK2By similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 85Lys-richAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0653, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154586

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24860

Identification of Orthologs from Complete Genome Data

More...OMAi		YLVGQEV

Database of Orthologous Groups

More...OrthoDBi		993640at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24860

TreeFam database of animal gene trees

More...TreeFami		TF101001

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N

The PANTHER Classification System

More...PANTHERi		PTHR10177, PTHR10177, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001771, Cyclin_A_B_D_E, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00292, CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P24860-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRVTRNTK INAENKAKVS MAGAKRVPVT VTAASKPGLR PRTALGDIGN 
        60         70         80         90        100
KVSEELQARV PLKREAKTLG TGKGTVKALP KPVEKVPVCE PEVELAEPEP 
       110        120        130        140        150
EPELEHVREE KLSPEPILVD NPSPSPMETS GCAPAEEYLC QAFSDVILAV 
       160        170        180        190        200
SDVDADDGAD PNLCSEYVKD IYAYLRQLEE EQSVRPKYLQ GREVTGNMRA 
       210        220        230        240        250
ILIDWLIQVQ MKFRLLQETM YMTVSIIDRF MQNSCVPKKM LQLVGVTAMF 
       260        270        280        290        300
IASKYEEMYP PEIGDFAFVT NNTYTKHQIR QMEMKILRVL NFSLGRPLPL 
       310        320        330        340        350
HFLRRASKVG EVDVEQHTLA KYLMELSMLD YDMVHFAPSQ IAAGAFCLAL 
       360        370        380        390        400
KILDNGEWTP TLQHYLSYSE DSLLPVMQHL AKNVVMVNCG LTKHMTVKNK 
       410        420        430
YAASKHAKIS TLAQLNCTLV QNLSKAVTKA
Length:430
Mass (Da):48,052
Last modified:October 1, 1996 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3BC9C856F66986E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UY65G3UY65_MOUSE
G2/mitotic-specific cyclin-B1
Ccnb1
393Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q68EM3Q68EM3_MOUSE
Ccnb1 protein
Ccnb1
369Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25K → M in CAA45968 (PubMed:1280449).Curated1
Sequence conflicti59R → T in CAA41545 (PubMed:1836195).Curated1
Sequence conflicti130S → C in CAA41545 (PubMed:1836195).Curated1
Sequence conflicti139L → P in CAA41545 (PubMed:1836195).Curated1
Sequence conflicti157D → S in CAA41545 (PubMed:1836195).Curated1
Sequence conflicti241L → I in CAA41545 (PubMed:1836195).Curated1
Sequence conflicti257E → D in CAA41545 (PubMed:1836195).Curated1
Sequence conflicti315E → R in CAA41545 (PubMed:1836195).Curated1
Sequence conflicti331Y → C in CAA45968 (PubMed:1280449).Curated1
Sequence conflicti340 – 343QIAA → RAFS in CAA41545 (PubMed:1836195).Curated4
Sequence conflicti351K → E in CAA41545 (PubMed:1836195).Curated1
Sequence conflicti419L → H in CAA41545 (PubMed:1836195).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X64713 mRNA Translation: CAA45968.1
X58708 mRNA Translation: CAA41545.1
S43105 mRNA Translation: AAB22970.1
BC011478 mRNA Translation: AAH11478.1
BC085238 mRNA Translation: AAH85238.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS36768.1

Protein sequence database of the Protein Information Resource

More...PIRi		A43285
I48316
JH0509

NCBI Reference Sequences

More...RefSeqi		NP_758505.2, NM_172301.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000072119; ENSMUSP00000071989; ENSMUSG00000041431

Database of genes from NCBI RefSeq genomes

More...GeneIDi		268697

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:268697

UCSC genome browser

More...UCSCi		uc007rro.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64713 mRNA Translation: CAA45968.1
X58708 mRNA Translation: CAA41545.1
S43105 mRNA Translation: AAB22970.1
BC011478 mRNA Translation: AAH11478.1
BC085238 mRNA Translation: AAH85238.1
CCDSiCCDS36768.1
PIRiA43285
I48316
JH0509
RefSeqiNP_758505.2, NM_172301.3

3D structure databases

SMRiP24860
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi234538, 11 interactors
ComplexPortaliCPX-2069, Cyclin B1-CDK1 complex
CORUMiP24860
IntActiP24860, 2 interactors
MINTiP24860
STRINGi10090.ENSMUSP00000071989

PTM databases

iPTMnetiP24860
PhosphoSitePlusiP24860

Proteomic databases

EPDiP24860
PaxDbiP24860
PeptideAtlasiP24860
PRIDEiP24860

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3537, 1825 antibodies

Genome annotation databases

EnsembliENSMUST00000072119; ENSMUSP00000071989; ENSMUSG00000041431
GeneIDi268697
KEGGimmu:268697
UCSCiuc007rro.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		891
MGIiMGI:88302, Ccnb1

Phylogenomic databases

eggNOGiKOG0653, Eukaryota
GeneTreeiENSGT00940000154586
InParanoidiP24860
OMAiYLVGQEV
OrthoDBi993640at2759
PhylomeDBiP24860
TreeFamiTF101001

Enzyme and pathway databases

ReactomeiR-MMU-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-MMU-176408, Regulation of APC/C activators between G1/S and early anaphase
R-MMU-176412, Phosphorylation of the APC/C
R-MMU-176417, Phosphorylation of Emi1
R-MMU-2299718, Condensation of Prophase Chromosomes
R-MMU-2500257, Resolution of Sister Chromatid Cohesion
R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition
R-MMU-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7
R-MMU-2995383, Initiation of Nuclear Envelope (NE) Reformation
R-MMU-3301854, Nuclear Pore Complex (NPC) Disassembly
R-MMU-4419969, Depolymerisation of the Nuclear Lamina
R-MMU-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-MMU-68875, Mitotic Prophase
R-MMU-69273, Cyclin A/B1/B2 associated events during G2/M transition
R-MMU-69478, G2/M DNA replication checkpoint
R-MMU-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8878166, Transcriptional regulation by RUNX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		268697, 7 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ccnb1, mouse

Protein Ontology

More...PROi		PR:P24860
RNActiP24860, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000041431, Expressed in embryo and 212 other tissues
GenevisibleiP24860, MM

Family and domain databases

CDDicd00043, CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N
PANTHERiPTHR10177, PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
PIRSFiPIRSF001771, Cyclin_A_B_D_E, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 2 hits
SM01332, Cyclin_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292, CYCLINS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNB1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24860
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 1, 1996
Last modified: December 2, 2020
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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