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Entry version 72 (08 May 2019)
Sequence version 2 (30 May 2000)
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Protein

Ice-structuring glycoprotein

Gene

afgp8

Organism
Notothenia neglecta (Yellowbelly rockcod) (Notothenia coriiceps neglecta)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antifreeze proteins lower the blood freezing point.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntifreeze protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ice-structuring glycoprotein
Short name:
ISGP
Alternative name(s):
Antifreeze glycopeptide polyprotein
Short name:
AFGP polyprotein
Cleaved into the following 8 chains:
Alternative name(s):
AFGP 7
Alternative name(s):
AFGP 7
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
Alternative name(s):
AFGP 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:afgp8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNotothenia neglecta (Yellowbelly rockcod) (Notothenia coriiceps neglecta)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri202063 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesNotothenioideiNototheniidaeNotothenia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000001634‹1 – 5›5
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000016356 – 790Ice-structuring glycoproteinAdd BLAST785
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_00000016366 – 19AFGP8-1Add BLAST14
PeptideiPRO_000000163723 – 36AFGP8-5Add BLAST14
PeptideiPRO_000000163840 – 53AFGP8-1Add BLAST14
PeptideiPRO_000000163957 – 70AFGP8-4Add BLAST14
PeptideiPRO_000000164074 – 87AFGP8-2Add BLAST14
PeptideiPRO_000000164191 – 104AFGP8-4Add BLAST14
PeptideiPRO_0000001642108 – 121AFGP8-3Add BLAST14
PeptideiPRO_0000001643125 – 138AFGP8-4Add BLAST14
PeptideiPRO_0000001644142 – 155AFGP8-3Add BLAST14
PeptideiPRO_0000001645159 – 172AFGP8-4Add BLAST14
PeptideiPRO_0000001646176 – 189AFGP8-1Add BLAST14
PeptideiPRO_0000001647193 – 206AFGP8-4Add BLAST14
PeptideiPRO_0000001648210 – 223AFGP8-1Add BLAST14
PeptideiPRO_0000001649227 – 240AFGP8-1Add BLAST14
PeptideiPRO_0000001650244 – 257AFGP8-4Add BLAST14
PeptideiPRO_0000001651261 – 274AFGP8-1Add BLAST14
PeptideiPRO_0000001652278 – 291AFGP8-4Add BLAST14
PeptideiPRO_0000001653295 – 308AFGP8-1Add BLAST14
PeptideiPRO_0000001654312 – 325AFGP8-4Add BLAST14
PeptideiPRO_0000001655329 – 342AFGP8-1Add BLAST14
PeptideiPRO_0000001656346 – 359AFGP8-4Add BLAST14
PeptideiPRO_0000001657363 – 376AFGP8-1Add BLAST14
PeptideiPRO_0000001658380 – 393AFGP8-3Add BLAST14
PeptideiPRO_0000001659397 – 410AFGP8-4Add BLAST14
PeptideiPRO_0000001660414 – 427AFGP8-1Add BLAST14
PeptideiPRO_0000001661431 – 444AFGP8-4Add BLAST14
PeptideiPRO_0000001662448 – 461AFGP8-1Add BLAST14
PeptideiPRO_0000001663465 – 478AFGP8-1Add BLAST14
PeptideiPRO_0000001664482 – 495AFGP8-4Add BLAST14
PeptideiPRO_0000001665499 – 512AFGP8-1Add BLAST14
PeptideiPRO_0000001666516 – 529AFGP8-1Add BLAST14
PeptideiPRO_0000001667533 – 546AFGP8-4Add BLAST14
PeptideiPRO_0000001668550 – 563AFGP8-1Add BLAST14
PeptideiPRO_0000001669567 – 580AFGP8-4Add BLAST14
PeptideiPRO_0000001670584 – 597AFGP8-3Add BLAST14
PeptideiPRO_0000001671601 – 614AFGP8-4Add BLAST14
PeptideiPRO_0000001672618 – 631AFGP8-1Add BLAST14
PeptideiPRO_0000001673635 – 648AFGP8-1Add BLAST14
PeptideiPRO_0000001674652 – 665AFGP8-4Add BLAST14
PeptideiPRO_0000001675669 – 682AFGP8-1Add BLAST14
PeptideiPRO_0000001676686 – 699AFGP8-4Add BLAST14
PeptideiPRO_0000001677703 – 716AFGP8-1Add BLAST14
PeptideiPRO_0000001678720 – 736AFGP7-1Add BLAST17
PeptideiPRO_0000001679740 – 756AFGP7-2Add BLAST17
PeptideiPRO_0000001680760 – 773AFGP8-3Add BLAST14
PeptideiPRO_0000001681777 – 790AFGP8-likeAdd BLAST14

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated; contains disaccharide galactose-N-acetylgalactosamine attached to threonines in AFGP8 and AFGP7.

Keywords - PTMi

Glycoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Synthesized by the liver and secreted into the blood from which they become distributed to almost the entire extracellular space.

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Keywords - Domaini

Repeat

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P24856-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VTAAPAATAA TAATPATAAL NFAATAATPA TPATPALIFA ATAATAATPA
60 70 80 90 100
TAALNFAATA ATPATAATPA LIFAAAAATA ATPATAALNF AATAATPATA
110 120 130 140 150
ATPALIFAAT AATAATPATP AFHFAATAAT PATAATPALI FAATAATAAT
160 170 180 190 200
PATPAFHFAA TAATPATAAT PALIFAATAA TAATPATAAL NFAATAATPA
210 220 230 240 250
TAATPALIFA ATAATAATPA TAALNFAATA ATAATPATAA CNFAATAATP
260 270 280 290 300
ATAATPALIF AATAATAATP ATAACNFAAT AATPATAATP ALIFAATAAT
310 320 330 340 350
AATPATAALN FAATAATPAT AATPALIFAA TAATAATPAT AALNFAATAA
360 370 380 390 400
TPATAATPAL IFAATAATAA TPATAALNFA ATAATAATPA TPAFNFAATA
410 420 430 440 450
ATPATAATPA LIFAATAATA ATPATAALNF AATAATPATA ATPALIFAAT
460 470 480 490 500
AATAATPATA ALHFAATAAT AATPATAALN FAATAATPAT AATPALIFAA
510 520 530 540 550
TAATAATPAT AAFNFAATAA TAATPATAAL NFAATAATPA TAATPALIFA
560 570 580 590 600
ATAATAATPA TAALNFAATA ATPATAATPA LIFAATAATA ATPATPAFHF
610 620 630 640 650
AATAATPATA ATPALIFAAT AATAATPATA ALNFAATAAT AATPATAALN
660 670 680 690 700
FAATAATPAT AATPALIFAA TAATAATPAT AALNFAATAA TPATAATPAL
710 720 730 740 750
IFAATAATAA TPATAAFNFA ATAATAATPA TAATPALIFA ATAATAATPA
760 770 780 790
TPATPALIFA ATAATAATPA TPALNFAATA ATAATTAARG
Length:790
Mass (Da):71,267
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C7CCCADC48FE902
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M55000 Genomic DNA Translation: AAA49392.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A38420

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Cool news - Issue 5 of December 2000

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55000 Genomic DNA Translation: AAA49392.2
PIRiA38420

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANP_NOTNE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24856
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 30, 2000
Last modified: May 8, 2019
This is version 72 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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