DNASE1

Functionⁱ

Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).By similarity3 Publications

Catalytic activityⁱ

Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products.3 Publications

Cofactorⁱ

Ca²⁺2 Publications, Mg²⁺2 PublicationsNote: Divalent metal cations. Prefers Ca²⁺ or Mg²⁺.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	35	Involved in actin-bindingBy similarity	1
Siteⁱ	87	Nitration by tetranitromethane destroys a Ca(2+) binding site and inactivates enzymeBy similarity	1
Siteⁱ	89	Involved in actin-bindingBy similarity	1
Active siteⁱ	100	By similarity	1
Active siteⁱ	156	By similarity	1

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
deoxyribonuclease activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
deoxyribonuclease I activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
DNA catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA catabolic process, endonucleolytic
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 29191910
neutrophil activation involved in immune response
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 29191910
regulation of acute inflammatory response
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 29191910
regulation of neutrophil mediated cytotoxicity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 29191910

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Endonuclease, Hydrolase, Nuclease
Biological process	Apoptosis
Ligand	Calcium

Enzyme and pathway databases

BRENDAⁱ	3.1.21.1 2681
SIGNORⁱ	P24855

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Deoxyribonuclease-1 (EC:3.1.21.13 Publications) Alternative name(s): Deoxyribonuclease I Short name: DNase I INN: Dornase alfa
Gene namesⁱ	Name:DNASE1Imported Synonyms:DNL1, DRNI
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000213918.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2956 DNASE1
MIMⁱ	125505 gene
neXtProtⁱ	NX_P24855

Keywords - Cellular componentⁱ

Nucleus, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Systemic lupus erythematosus (SLE)2 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry. Neutrophil extracellular traps (NETs) are impaired in patients suffering from SLE (PubMed:20439745). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:20439745).1 Publication

Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Pharmaceutical useⁱ

Available under the name Pulmozyme (Genentech). Used to reduce the viscosity of cystic fibrosis sputum by hydrolyzing the extracellular DNA released by degenerating leukocytes that accumulate in response to infection.1 Publication

Keywords - Diseaseⁱ

Systemic lupus erythematosus

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1773
MalaCards human disease database More...MalaCardsⁱ	DNASE1
MIMⁱ	152700 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000213918
Orphanetⁱ	300345 Autosomal systemic lupus erythematosus 536 NON RARE IN EUROPE: Systemic lupus erythematosus
PharmGKBⁱ	PA27427

Chemistry databases

ChEMBLⁱ	CHEMBL3351219

ChEMBLⁱ

CHEMBL3351219

Polymorphism and mutation databases

BioMutaⁱ	DNASE1
DMDMⁱ	118919

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	2 PublicationsAdd BLAST		22
ChainⁱPRO_0000007277	23 – 282	Deoxyribonuclease-1Add BLAST		260

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	40	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	123 ↔ 126	By similarity
Glycosylationⁱ	128	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	195 ↔ 231	Essential for enzymatic activityBy similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P24855
PeptideAtlas More...PeptideAtlasⁱ	P24855
PRIDEⁱ	P24855
ProteomicsDBⁱ	54233

PTM databases

iPTMnetⁱ	P24855
PhosphoSitePlusⁱ	P24855

Expressionⁱ

Tissue specificityⁱ

Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.

Gene expression databases

Bgeeⁱ	ENSG00000213918 Expressed in 174 organ(s), highest expression level in cortex of kidney
CleanExⁱ	HS_DNASE1
ExpressionAtlasⁱ	P24855 baseline and differential
Genevisibleⁱ	P24855 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA010703

HPAⁱ

HPA010703

Interactionⁱ

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108112, 2 interactors
STRINGⁱ	9606.ENSP00000246949

Chemistry databases

BindingDBⁱ

P24855

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	24 – 34	Combined sources	11
Helixⁱ	35 – 38	Combined sources	4
Helixⁱ	41 – 51	Combined sources	11
Beta strandⁱ	55 – 62	Combined sources	8
Helixⁱ	68 – 77	Combined sources	10
Turnⁱ	78 – 80	Combined sources	3
Beta strandⁱ	86 – 89	Combined sources	4
Beta strandⁱ	93 – 98	Combined sources	6
Beta strandⁱ	100 – 106	Combined sources	7
Turnⁱ	108 – 110	Combined sources	3
Beta strandⁱ	112 – 118	Combined sources	7
Turnⁱ	124 – 127	Combined sources	4
Beta strandⁱ	136 – 141	Combined sources	6
Beta strandⁱ	149 – 154	Combined sources	6
Helixⁱ	159 – 161	Combined sources	3
Helixⁱ	162 – 180	Combined sources	19
Beta strandⁱ	185 – 190	Combined sources	6
Turnⁱ	195 – 197	Combined sources	3
Helixⁱ	200 – 205	Combined sources	6
Helixⁱ	207 – 210	Combined sources	4
Beta strandⁱ	214 – 216	Combined sources	3
Beta strandⁱ	225 – 228	Combined sources	4
Beta strandⁱ	234 – 240	Combined sources	7
Helixⁱ	241 – 246	Combined sources	6
Helixⁱ	257 – 260	Combined sources	4
Helixⁱ	265 – 271	Combined sources	7
Beta strandⁱ	277 – 281	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P24855
SMRⁱ	P24855
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the DNase I family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IFZB Eukaryota ENOG410Z4MV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013146
HOGENOMⁱ	HOG000059570
HOVERGENⁱ	HBG051368
InParanoidⁱ	P24855
KEGG Orthology (KO) More...KOⁱ	K11994
OMAⁱ	SHWSSIR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I0B
PhylomeDBⁱ	P24855
TreeFamⁱ	TF329541

Family and domain databases

Gene3Dⁱ	3.60.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR018057 Deoxyribonuclease-1_AS IPR016202 DNase_I IPR033125 DNASE_I_2 IPR036691 Endo/exonu/phosph_ase_sf IPR005135 Endo/exonuclease/phosphatase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03372 Exo_endo_phos, 1 hit
PIRSFⁱ	PIRSF000988 DNase_I_euk, 1 hit
PRINTSⁱ	PR00130 DNASEI
SMARTⁱ	View protein in SMART SM00476 DNaseIc, 1 hit
SUPFAMⁱ	SSF56219 SSF56219, 1 hit
PROSITEⁱ	View protein in PROSITE PS00919 DNASE_I_1, 1 hit PS00918 DNASE_I_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P24855-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGMKLLGAL LALAALLQGA VSLKIAAFNI QTFGETKMSN ATLVSYIVQI 
        60         70         80         90        100
LSRYDIALVQ EVRDSHLTAV GKLLDNLNQD APDTYHYVVS EPLGRNSYKE 
       110        120        130        140        150
RYLFVYRPDQ VSAVDSYYYD DGCEPCGNDT FNREPAIVRF FSRFTEVREF 
       160        170        180        190        200
AIVPLHAAPG DAVAEIDALY DVYLDVQEKW GLEDVMLMGD FNAGCSYVRP 
       210        220        230        240        250
SQWSSIRLWT SPTFQWLIPD SADTTATPTH CAYDRIVVAG MLLRGAVVPD 
       260        270        280 
SALPFNFQAA YGLSDQLAQA ISDHYPVEVM LK

Length:282

Mass (Da):31,434

Last modified:March 1, 1992 - v1

Checksum:ⁱ040042E2D23555B6

GO

Isoform 2 (identifier: P24855-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MRGMKLLGAL...ALVQEVRDSH → MHQTPITTWS...PLSGSSPGSQ
     67-183: Missing.
     268-282: AQAISDHYPVEVMLK → FSVHTCSGAGLGERHGLPASAALPSNTCRAGTHRVST

« Hide

        10         20         30         40         50
MHQTPITTWS VSHWDGTAIR SATCSCTGLT RCLRWTATTT MMAASPAGTT 
        60         70         80         90        100
PSTESQPLSG SSPGSQDVML MGDFNAGCSY VRPSQWSSIR LWTSPTFQWL 
       110        120        130        140        150
IPDSADTTAT PTHCAYDRIV VAGMLLRGAV VPDSALPFNF QAAYGLSDQL 
       160        170        180 
FSVHTCSGAG LGERHGLPAS AALPSNTCRA GTHRVST

Note: No experimental confirmation available.

Show »

Length:187

Mass (Da):19,771

Checksum:ⁱC66A988635746FB9

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

I3L0Z9	I3L0Z9_HUMAN	Deoxyribonuclease-1 Deoxyribonuclease-1	DNASE1	86	Annotation score:
I3L298	I3L298_HUMAN	Deoxyribonuclease-1 Deoxyribonuclease-1	DNASE1	108	Annotation score:
I3L1N2	I3L1N2_HUMAN	Deoxyribonuclease-1 Deoxyribonuclease-1	DNASE1	90	Annotation score:
I3L4B8	I3L4B8_HUMAN	Deoxyribonuclease-1 Deoxyribonuclease-1	DNASE1	72	Annotation score:
I3L4C7	I3L4C7_HUMAN	Deoxyribonuclease-1 Deoxyribonuclease-1	DNASE1	65	Annotation score:
I3L530	I3L530_HUMAN	Deoxyribonuclease-1 Deoxyribonuclease-1	DNASE1	60	Annotation score:
I3L4U3	I3L4U3_HUMAN	Deoxyribonuclease-1 Deoxyribonuclease-1	DNASE1	75	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	143	R → Q in BAE96964 (PubMed:16771825).Curated		1

Polymorphismⁱ

At least 6 alleles of DNASE1 are known: DNASE1*1 to DNASE1*6. The sequence shown is that of DNASE1*2.4 Publications

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024434	2	R → S. Corresponds to variant dbSNP:rs8176927Ensembl.	1
Natural variantⁱVAR_002264	31	Q → E in allele DNASE1*4. Corresponds to variant dbSNP:rs77254040Ensembl.	1
Natural variantⁱVAR_029172	107	R → G. Corresponds to variant dbSNP:rs8176928Ensembl.	1
Natural variantⁱVAR_009300	114	V → M in allele DNASE1*5. Corresponds to variant dbSNP:rs530214101Ensembl.	1
Natural variantⁱVAR_024435	127	G → R. Corresponds to variant dbSNP:rs8176919Ensembl.	1
Natural variantⁱVAR_002265	154	P → A in allele DNASE1*3. Corresponds to variant dbSNP:rs1799891Ensembl.	1
Natural variantⁱVAR_009301	207	R → C in allele DNASE1*6. Corresponds to variant dbSNP:rs148373909EnsemblClinVar.	1
Natural variantⁱVAR_029173	231	C → Y. Corresponds to variant dbSNP:rs8176940Ensembl.	1
Natural variantⁱVAR_002266	244	R → Q in allele DNASE1*1. 1 PublicationCorresponds to variant dbSNP:rs1053874EnsemblClinVar.	1
Natural variantⁱVAR_029174	246	A → P. Corresponds to variant dbSNP:rs8176939Ensembl.	1
Natural variantⁱVAR_029175	262	G → D. Corresponds to variant dbSNP:rs8176924Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_056974	1 – 66	MRGMK…VRDSH → MHQTPITTWSVSHWDGTAIR SATCSCTGLTRCLRWTATTT MMAASPAGTTPSTESQPLSG SSPGSQ in isoform 2. 1 PublicationAdd BLAST	66
Alternative sequenceⁱVSP_056975	67 – 183	Missing in isoform 2. 1 PublicationAdd BLAST	117
Alternative sequenceⁱVSP_056976	268 – 282	AQAIS…EVMLK → FSVHTCSGAGLGERHGLPAS AALPSNTCRAGTHRVST in isoform 2. 1 PublicationAdd BLAST	15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55983 mRNA Translation: AAA63170.1 D83195 Genomic DNA Translation: BAA11841.1 AJ298844 mRNA Translation: CAC12813.1 AB188151 mRNA Translation: BAE96964.1 AB188152 mRNA Translation: BAE96965.1 AK300914 mRNA Translation: BAG62547.1 AC005203 Genomic DNA Translation: AAC24721.1 AC006111 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85344.1 BC029437 mRNA Translation: AAH29437.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10507.1 [P24855-1]
PIRⁱ	A38417 NDHU1
NCBI Reference Sequences More...RefSeqⁱ	NP_005214.2, NM_005223.3 [P24855-1] XP_011520695.1, XM_011522393.2 [P24855-1] XP_016878488.1, XM_017022999.1 XP_016878492.1, XM_017023003.1 [P24855-2] XP_016878493.1, XM_017023004.1 [P24855-2] XP_016878494.1, XM_017023005.1 [P24855-2] XP_016878495.1, XM_017023006.1 [P24855-2]
UniGeneⁱ	Hs.629638 Hs.733045

Genome annotation databases

Ensemblⁱ	ENST00000246949; ENSP00000246949; ENSG00000213918 [P24855-1] ENST00000407479; ENSP00000385905; ENSG00000213918 [P24855-1]
GeneIDⁱ	1773
KEGGⁱ	hsa:1773
UCSC genome browser More...UCSCⁱ	uc002cvr.4 human [P24855-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24855	Deoxyribonuclease		GORGO		282	UniRef90_P24855
Deoxyribonuclease		PANTR		282
Deoxyribonuclease		PANPA		282
Deoxyribonuclease		MACFA		282
Deoxyribonuclease		MACMU		282
+16

Protein	Similar proteins		Species	Score	Length	Source
P24855	Deoxyribonuclease-1		PIG		284	UniRef50_P24855
Deoxyribonuclease-1		CHICK		282
Deoxyribonuclease-1		CANLF		284
Deoxyribonuclease-1		OREMO		284
Deoxyribonuclease-1		HORSE		282
+276

Cross-referencesⁱ

Web resourcesⁱ

Pulmozyme

Clinical information on Pulmozyme

Wikipedia

Deoxyribonuclease entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M55983 mRNA Translation: AAA63170.1 D83195 Genomic DNA Translation: BAA11841.1 AJ298844 mRNA Translation: CAC12813.1 AB188151 mRNA Translation: BAE96964.1 AB188152 mRNA Translation: BAE96965.1 AK300914 mRNA Translation: BAG62547.1 AC005203 Genomic DNA Translation: AAC24721.1 AC006111 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85344.1 BC029437 mRNA Translation: AAH29437.1
CCDSⁱ	CCDS10507.1 [P24855-1]
PIRⁱ	A38417 NDHU1
RefSeqⁱ	NP_005214.2, NM_005223.3 [P24855-1] XP_011520695.1, XM_011522393.2 [P24855-1] XP_016878488.1, XM_017022999.1 XP_016878492.1, XM_017023003.1 [P24855-2] XP_016878493.1, XM_017023004.1 [P24855-2] XP_016878494.1, XM_017023005.1 [P24855-2] XP_016878495.1, XM_017023006.1 [P24855-2]
UniGeneⁱ	Hs.629638 Hs.733045

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4AWN	X-ray	1.95	A	23-282	[»]
ProteinModelPortalⁱ	P24855
SMRⁱ	P24855
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108112, 2 interactors
STRINGⁱ	9606.ENSP00000246949

Chemistry databases

BindingDBⁱ	P24855
ChEMBLⁱ	CHEMBL3351219

PTM databases

iPTMnetⁱ	P24855
PhosphoSitePlusⁱ	P24855

Polymorphism and mutation databases

BioMutaⁱ	DNASE1
DMDMⁱ	118919

Proteomic databases

PaxDbⁱ	P24855
PeptideAtlasⁱ	P24855
PRIDEⁱ	P24855
ProteomicsDBⁱ	54233

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1773
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000246949; ENSP00000246949; ENSG00000213918 [P24855-1] ENST00000407479; ENSP00000385905; ENSG00000213918 [P24855-1]
GeneIDⁱ	1773
KEGGⁱ	hsa:1773
UCSCⁱ	uc002cvr.4 human [P24855-1]

Organism-specific databases

CTDⁱ	1773
DisGeNETⁱ	1773
EuPathDBⁱ	HostDB:ENSG00000213918.10
GeneCardsⁱ	DNASE1
HGNCⁱ	HGNC:2956 DNASE1
HPAⁱ	HPA010703
MalaCardsⁱ	DNASE1
MIMⁱ	125505 gene 152700 phenotype
neXtProtⁱ	NX_P24855
OpenTargetsⁱ	ENSG00000213918
Orphanetⁱ	300345 Autosomal systemic lupus erythematosus 536 NON RARE IN EUROPE: Systemic lupus erythematosus
PharmGKBⁱ	PA27427
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFZB Eukaryota ENOG410Z4MV LUCA
GeneTreeⁱ	ENSGT00390000013146
HOGENOMⁱ	HOG000059570
HOVERGENⁱ	HBG051368
InParanoidⁱ	P24855
KOⁱ	K11994
OMAⁱ	SHWSSIR
OrthoDBⁱ	EOG091G0I0B
PhylomeDBⁱ	P24855
TreeFamⁱ	TF329541

Enzyme and pathway databases

BRENDAⁱ	3.1.21.1 2681
SIGNORⁱ	P24855

Miscellaneous databases

ChiTaRSⁱ	DNASE1 human
GeneWikiⁱ	Deoxyribonuclease_I
GenomeRNAiⁱ	1773
Protein Ontology More...PROⁱ	PR:P24855
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000213918 Expressed in 174 organ(s), highest expression level in cortex of kidney
CleanExⁱ	HS_DNASE1
ExpressionAtlasⁱ	P24855 baseline and differential
Genevisibleⁱ	P24855 HS

Family and domain databases

Gene3Dⁱ	3.60.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR018057 Deoxyribonuclease-1_AS IPR016202 DNase_I IPR033125 DNASE_I_2 IPR036691 Endo/exonu/phosph_ase_sf IPR005135 Endo/exonuclease/phosphatase
Pfamⁱ	View protein in Pfam PF03372 Exo_endo_phos, 1 hit
PIRSFⁱ	PIRSF000988 DNase_I_euk, 1 hit
PRINTSⁱ	PR00130 DNASEI
SMARTⁱ	View protein in SMART SM00476 DNaseIc, 1 hit
SUPFAMⁱ	SSF56219 SSF56219, 1 hit
PROSITEⁱ	View protein in PROSITE PS00919 DNASE_I_1, 1 hit PS00918 DNASE_I_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DNAS1_HUMAN
Accessionⁱ	P24855Primary (citable) accession number: P24855 Secondary accession number(s): B4DV35, Q14UU9, Q14UV0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	March 1, 1992
	Last modified:	November 7, 2018
	This is version 191 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniRef

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Supporting data

UniProtKB - P24855 (DNAS1_HUMAN)

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Deoxyribonuclease-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Extracellular region or secreted

Extracellular region or secreted

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ