UniProtKB - P24854 (IBP4_PIG)
Protein
Insulin-like growth factor-binding protein 4
Gene
IGFBP4
Organism
Sus scrofa (Pig)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GO - Molecular functioni
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
GO - Biological processi
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | Growth factor binding |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 4Short name: IBP-4 Short name: IGF-binding protein 4 Short name: IGFBP-4 |
Gene namesi | Name:IGFBP4 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 1 PublicationAdd BLAST | 22 | |
ChainiPRO_0000152773 | 23 – 259 | Insulin-like growth factor-binding protein 4Add BLAST | 237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 ↔ 54 | PROSITE-ProRule annotation | ||
Disulfide bondi | 31 ↔ 56 | PROSITE-ProRule annotation | ||
Disulfide bondi | 39 ↔ 60 | PROSITE-ProRule annotation | ||
Disulfide bondi | 45 ↔ 57 | PROSITE-ProRule annotation | ||
Disulfide bondi | 68 ↔ 81 | PROSITE-ProRule annotation | ||
Disulfide bondi | 75 ↔ 101 | PROSITE-ProRule annotation | ||
Glycosylationi | 126 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 132 ↔ 139 | PROSITE-ProRule annotation | ||
Disulfide bondi | 175 ↔ 205 | PROSITE-ProRule annotation | ||
Disulfide bondi | 216 ↔ 227 | PROSITE-ProRule annotation | ||
Disulfide bondi | 229 ↔ 250 | PROSITE-ProRule annotation | ||
Modified residuei | 256 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P24854 |
Interactioni
Subunit structurei
Binds IGF2 more than IGF1.
By similarityGO - Molecular functioni
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000018516 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 104 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 172 – 250 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 79 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
InParanoidi | P24854 |
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P24854-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPLCLVAAL LLSASGPRPS LGDEAIHCPP CSEEKLARCR PPVGCEELVR
60 70 80 90 100
EPGCGCCATC ALGKGMPCGV YTPRCGSGLR CYPPRGVEKP LHTLMHGQGL
110 120 130 140 150
CMELAEIEAI QESLQPSDKD EGDHPNNSFS PCSPQDRRCL QKHLAKIRDR
160 170 180 190 200
STSGGKMKVI GAPREEARPV PQGSCQSELH RALERLAASQ RRTHEDLYII
210 220 230 240 250
PIPNCDRNGN FHPKQCHPAL DGQRGKCWCV DRKTGVKLPG GLEPKGELDC
HQLADSFRE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 31 | C → P AA sequence (PubMed:1722398).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ917619 mRNA Translation: ABI97164.1 |
PIRi | JH0517 |
RefSeqi | NP_001116601.1, NM_001123129.1 |
Genome annotation databases
GeneIDi | 100144490 |
KEGGi | ssc:100144490 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ917619 mRNA Translation: ABI97164.1 |
PIRi | JH0517 |
RefSeqi | NP_001116601.1, NM_001123129.1 |
3D structure databases
SMRi | P24854 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000018516 |
Proteomic databases
PaxDbi | P24854 |
Genome annotation databases
GeneIDi | 100144490 |
KEGGi | ssc:100144490 |
Organism-specific databases
CTDi | 3487 |
Phylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
InParanoidi | P24854 |
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP4_PIG | |
Accessioni | P24854Primary (citable) accession number: P24854 Secondary accession number(s): Q06AV6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | May 29, 2007 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |