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Protein

Tenascin

Gene

TNC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).1 Publication

GO - Molecular functioni

  • extracellular matrix structural constituent Source: BHF-UCL
  • syndecan binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP24821

Names & Taxonomyi

Protein namesi
Recommended name:
Tenascin
Short name:
TN
Alternative name(s):
Cytotactin
GMEM
GP 150-225
Glioma-associated-extracellular matrix antigen
Hexabrachion
JI
Myotendinous antigen
Neuronectin
Tenascin-C
Short name:
TN-C
Gene namesi
Name:TNC
Synonyms:HXB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000041982.15
HGNCiHGNC:5318 TNC
MIMi187380 gene
neXtProtiNX_P24821

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal dominant, 56 (DFNA56)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with post-lingual onset.
See also OMIM:615629
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0709841773V → M in DFNA56. 1 PublicationCorresponds to variant dbSNP:rs137933052EnsemblClinVar.1
Natural variantiVAR_0709851796T → S in DFNA56. 1 PublicationCorresponds to variant dbSNP:rs431905513EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNETi3371
MalaCardsiTNC
MIMi615629 phenotype
OpenTargetsiENSG00000041982
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA35103

Chemistry databases

ChEMBLiCHEMBL3712856

Polymorphism and mutation databases

BioMutaiTNC
DMDMi281185495

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000000774123 – 2201TenascinAdd BLAST2179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei65PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei72Phosphoserine; by FAM20CCombined sources1 Publication1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi190 ↔ 200By similarity
Disulfide bondi194 ↔ 205By similarity
Disulfide bondi207 ↔ 216By similarity
Disulfide bondi221 ↔ 231By similarity
Disulfide bondi225 ↔ 236By similarity
Disulfide bondi238 ↔ 247By similarity
Disulfide bondi252 ↔ 263By similarity
Disulfide bondi256 ↔ 268By similarity
Disulfide bondi270 ↔ 279By similarity
Disulfide bondi284 ↔ 294By similarity
Disulfide bondi288 ↔ 299By similarity
Disulfide bondi301 ↔ 310By similarity
Disulfide bondi315 ↔ 325By similarity
Disulfide bondi319 ↔ 330By similarity
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi332 ↔ 341By similarity
Disulfide bondi346 ↔ 356By similarity
Disulfide bondi350 ↔ 361By similarity
Disulfide bondi363 ↔ 372By similarity
Disulfide bondi377 ↔ 387By similarity
Disulfide bondi381 ↔ 392By similarity
Disulfide bondi394 ↔ 403By similarity
Disulfide bondi408 ↔ 418By similarity
Disulfide bondi412 ↔ 423By similarity
Disulfide bondi425 ↔ 434By similarity
Disulfide bondi439 ↔ 449By similarity
Disulfide bondi443 ↔ 454By similarity
Disulfide bondi456 ↔ 465By similarity
Disulfide bondi470 ↔ 480By similarity
Disulfide bondi474 ↔ 485By similarity
Disulfide bondi487 ↔ 496By similarity
Disulfide bondi501 ↔ 511By similarity
Disulfide bondi505 ↔ 516By similarity
Disulfide bondi518 ↔ 527By similarity
Disulfide bondi532 ↔ 542By similarity
Disulfide bondi536 ↔ 547By similarity
Disulfide bondi549 ↔ 558By similarity
Disulfide bondi563 ↔ 573By similarity
Disulfide bondi567 ↔ 578By similarity
Disulfide bondi580 ↔ 589By similarity
Disulfide bondi594 ↔ 604By similarity
Disulfide bondi598 ↔ 609By similarity
Disulfide bondi611 ↔ 620By similarity
Glycosylationi788N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei905PhosphothreonineCombined sources1
Glycosylationi1018N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1034N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1079N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1093N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1184N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1261N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1275N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1301N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi1366N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1392N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1445N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1455N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1485N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi1534N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1809N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2162N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP24821
MaxQBiP24821
PaxDbiP24821
PeptideAtlasiP24821
PRIDEiP24821
ProteomicsDBi54225
54226 [P24821-2]
54227 [P24821-3]
54228 [P24821-4]
54229 [P24821-5]
54230 [P24821-6]

PTM databases

iPTMnetiP24821
PhosphoSitePlusiP24821

Expressioni

Inductioni

By TGFB1.

Gene expression databases

BgeeiENSG00000041982 Expressed in 213 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_TNC
ExpressionAtlasiP24821 baseline and differential
GenevisibleiP24821 HS

Organism-specific databases

HPAiCAB004592
HPA004823

Interactioni

Subunit structurei

Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109602, 3 interactors
ComplexPortaliCPX-466 Tenascin-C complex
CORUMiP24821
IntActiP24821, 2 interactors
STRINGi9606.ENSP00000265131

Structurei

Secondary structure

12201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP24821
SMRiP24821
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24821

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 186EGF-like 1; incompletePROSITE-ProRule annotationAdd BLAST13
Domaini186 – 217EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Domaini217 – 248EGF-like 3PROSITE-ProRule annotationAdd BLAST32
Domaini248 – 280EGF-like 4PROSITE-ProRule annotationAdd BLAST33
Domaini280 – 311EGF-like 5PROSITE-ProRule annotationAdd BLAST32
Domaini311 – 342EGF-like 6PROSITE-ProRule annotationAdd BLAST32
Domaini342 – 373EGF-like 7PROSITE-ProRule annotationAdd BLAST32
Domaini373 – 404EGF-like 8PROSITE-ProRule annotationAdd BLAST32
Domaini404 – 435EGF-like 9PROSITE-ProRule annotationAdd BLAST32
Domaini435 – 466EGF-like 10PROSITE-ProRule annotationAdd BLAST32
Domaini466 – 497EGF-like 11PROSITE-ProRule annotationAdd BLAST32
Domaini497 – 528EGF-like 12PROSITE-ProRule annotationAdd BLAST32
Domaini528 – 559EGF-like 13PROSITE-ProRule annotationAdd BLAST32
Domaini559 – 590EGF-like 14PROSITE-ProRule annotationAdd BLAST32
Domaini590 – 621EGF-like 15PROSITE-ProRule annotationAdd BLAST32
Domaini625 – 715Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini716 – 804Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST89
Domaini805 – 894Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini895 – 990Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini991 – 1075Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST85
Domaini1076 – 1165Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST90
Domaini1167 – 1256Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST90
Domaini1258 – 1350Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST93
Domaini1351 – 1439Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST89
Domaini1440 – 1531Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST92
Domaini1533 – 1621Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST89
Domaini1622 – 1711Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST90
Domaini1712 – 1801Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST90
Domaini1802 – 1888Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST87
Domaini1889 – 1977Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST89
Domaini1975 – 2190Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili118 – 145Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the tenascin family.Curated

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1225 Eukaryota
KOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00920000148942
HOVERGENiHBG008949
InParanoidiP24821
KOiK06252
OMAiHYTAKIQ
OrthoDBiEOG091G03M1
PhylomeDBiP24821
TreeFamiTF329915

Family and domain databases

CDDicd00063 FN3, 15 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 15 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC
PANTHERiPTHR19143:SF38 PTHR19143:SF38, 9 hits
PfamiView protein in Pfam
PF07974 EGF_2, 6 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 15 hits
SMARTiView protein in SMART
SM00181 EGF, 14 hits
SM00186 FBG, 1 hit
SM00060 FN3, 15 hits
SUPFAMiSSF49265 SSF49265, 12 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 15 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 15 hits

Sequences (6+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoforms are produced in a tissue- and time-specific manner during development.

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P24821-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF
60 70 80 90 100
NHVYNIKLPV GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF
110 120 130 140 150
THRINIPRRA CGCAAAPDVK ELLSRLEELE NLVSSLREQC TAGAGCCLQP
160 170 180 190 200
ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW KGPNCSEPEC PGNCHLRGRC
210 220 230 240 250
IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE GYAGADCSRE
260 270 280 290 300
ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV
310 320 330 340 350
CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC
360 370 380 390 400
HTQGRCEEGQ CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG
410 420 430 440 450
ADCGELKCPN GCSGHGRCVN GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV
460 470 480 490 500
EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC VNGMCVCDDG YTGEDCRDRQ
510 520 530 540 550
CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG RCVNGQCVCH
560 570 580 590 600
EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN
610 620 630 640 650
LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT
660 670 680 690 700
EYLVVYTPTH EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK
710 720 730 740 750
SIPVSARVAT YLPAPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN
760 770 780 790 800
KEDEGEITKS LRRPETSYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKRVTT
810 820 830 840 850
TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK DVPGDRTTID
860 870 880 890 900
LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR
910 920 930 940 950
RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT
960 970 980 990 1000
TLTGLRPGTE YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS
1010 1020 1030 1040 1050
LTLLWKTPLA KFDRYRLNYS LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN
1060 1070 1080 1090 1100
VLLTAEKGRH KSKPARVKAS TEQAPELENL TVTEVGWDGL RLNWTAADQA
1110 1120 1130 1140 1150
YEHFIIQVQE ANKVEAARNL TVPGSLRAVD IPGLKAATPY TVSIYGVIQG
1160 1170 1180 1190 1200
YRTPVLSAEA STGETPNLGE VVVAEVGWDA LKLNWTAPEG AYEYFFIQVQ
1210 1220 1230 1240 1250
EADTVEAAQN LTVPGGLRST DLPGLKAATH YTITIRGVTQ DFSTTPLSVE
1260 1270 1280 1290 1300
VLTEEVPDMG NLTVTEVSWD ALRLNWTTPD GTYDQFTIQV QEADQVEEAH
1310 1320 1330 1340 1350
NLTVPGSLRS MEIPGLRAGT PYTVTLHGEV RGHSTRPLAV EVVTEDLPQL
1360 1370 1380 1390 1400
GDLAVSEVGW DGLRLNWTAA DNAYEHFVIQ VQEVNKVEAA QNLTLPGSLR
1410 1420 1430 1440 1450
AVDIPGLEAA TPYRVSIYGV IRGYRTPVLS AEASTAKEPE IGNLNVSDIT
1460 1470 1480 1490 1500
PESFNLSWMA TDGIFETFTI EIIDSNRLLE TVEYNISGAE RTAHISGLPP
1510 1520 1530 1540 1550
STDFIVYLSG LAPSIRTKTI SATATTEALP LLENLTISDI NPYGFTVSWM
1560 1570 1580 1590 1600
ASENAFDSFL VTVVDSGKLL DPQEFTLSGT QRKLELRGLI TGIGYEVMVS
1610 1620 1630 1640 1650
GFTQGHQTKP LRAEIVTEAE PEVDNLLVSD ATPDGFRLSW TADEGVFDNF
1660 1670 1680 1690 1700
VLKIRDTKKQ SEPLEITLLA PERTRDITGL REATEYEIEL YGISKGRRSQ
1710 1720 1730 1740 1750
TVSAIATTAM GSPKEVIFSD ITENSATVSW RAPTAQVESF RITYVPITGG
1760 1770 1780 1790 1800
TPSMVTVDGT KTQTRLVKLI PGVEYLVSII AMKGFEESEP VSGSFTTALD
1810 1820 1830 1840 1850
GPSGLVTANI TDSEALARWQ PAIATVDSYV ISYTGEKVPE ITRTVSGNTV
1860 1870 1880 1890 1900
EYALTDLEPA TEYTLRIFAE KGPQKSSTIT AKFTTDLDSP RDLTATEVQS
1910 1920 1930 1940 1950
ETALLTWRPP RASVTGYLLV YESVDGTVKE VIVGPDTTSY SLADLSPSTH
1960 1970 1980 1990 2000
YTAKIQALNG PLRSNMIQTI FTTIGLLYPF PKDCSQAMLN GDTTSGLYTI
2010 2020 2030 2040 2050
YLNGDKAEAL EVFCDMTSDG GGWIVFLRRK NGRENFYQNW KAYAAGFGDR
2060 2070 2080 2090 2100
REEFWLGLDN LNKITAQGQY ELRVDLRDHG ETAFAVYDKF SVGDAKTRYK
2110 2120 2130 2140 2150
LKVEGYSGTA GDSMAYHNGR SFSTFDKDTD SAITNCALSY KGAFWYRNCH
2160 2170 2180 2190 2200
RVNLMGRYGD NNHSQGVNWF HWKGHEHSIQ FAEMKLRPSN FRNLEGRRKR

A
Length:2,201
Mass (Da):240,853
Last modified:December 15, 2009 - v3
Checksum:iB2BEF378AA6F1D85
GO
Isoform 2 (identifier: P24821-2) [UniParc]FASTAAdd to basket
Also known as: HT-5

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1435: Missing.
     1527-1617: Missing.

Show »
Length:1,746
Mass (Da):191,373
Checksum:i588B877CF66A227D
GO
Isoform 3 (identifier: P24821-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1435: Missing.

Show »
Length:1,837
Mass (Da):201,359
Checksum:i54B916A3A6664FDE
GO
Isoform 4 (identifier: P24821-4) [UniParc]FASTAAdd to basket
Also known as: HT-33

The sequence of this isoform differs from the canonical sequence as follows:
     1527-1617: Missing.

Show »
Length:2,110
Mass (Da):230,867
Checksum:i379795176A2B7252
GO
Isoform 5 (identifier: P24821-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1617: Missing.

Show »
Length:1,655
Mass (Da):181,528
Checksum:iFA3D6624965AE06A
GO
Isoform 6 (identifier: P24821-6) [UniParc]FASTAAdd to basket
Also known as: P31

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1708: Missing.

Show »
Length:1,564
Mass (Da):171,360
Checksum:iB240934A9414ABC4
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QSU6J3QSU6_HUMAN
Tenascin
TNC
2,019Annotation score:
E9PC84E9PC84_HUMAN
Tenascin
TNC
1,928Annotation score:
F5H7V9F5H7V9_HUMAN
Tenascin
TNC
1,838Annotation score:
H0YGZ3H0YGZ3_HUMAN
Tenascin
TNC
615Annotation score:
F5H5D6F5H5D6_HUMAN
Tenascin
TNC
92Annotation score:
A0A0U1RR80A0A0U1RR80_HUMAN
Tenascin
TNC
23Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244Missing in CAA39628 (PubMed:1707164).Curated1
Sequence conflicti370V → L no nucleotide entry (PubMed:1704365).Curated1
Sequence conflicti370V → L in AAA88083 (PubMed:1719530).Curated1
Sequence conflicti370V → L in CAA55309 (PubMed:7531707).Curated1
Sequence conflicti1066R → H no nucleotide entry (PubMed:1704365).Curated1
Sequence conflicti1066R → H in AAA88083 (PubMed:1719530).Curated1
Sequence conflicti1066R → H in AAA52703 (PubMed:2466295).Curated1
Sequence conflicti1600 – 1608SGFTQGHQT → LWLHPRASN no nucleotide entry (PubMed:1704365).Curated9
Sequence conflicti1600 – 1608SGFTQGHQT → LWLHPRASN in AAA88083 (PubMed:1719530).Curated9
Sequence conflicti1600 – 1608SGFTQGHQT → LWLHPRASN in AAA52703 (PubMed:2466295).Curated9
Sequence conflicti2054F → FLH no nucleotide entry (PubMed:1704365).Curated1
Sequence conflicti2054F → FLH in AAA88083 (PubMed:1719530).Curated1
Sequence conflicti2055W → L in AAA52703 (PubMed:2466295).Curated1
Sequence conflicti2140 – 2143YKGA → TRG in CAA39628 (PubMed:1707164).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055778213G → S. Corresponds to variant dbSNP:rs7020958Ensembl.1
Natural variantiVAR_024266539Q → R3 PublicationsCorresponds to variant dbSNP:rs1757095Ensembl.1
Natural variantiVAR_024267605V → I. Corresponds to variant dbSNP:rs3827816Ensembl.1
Natural variantiVAR_024268680Q → R1 PublicationCorresponds to variant dbSNP:rs1061494Ensembl.1
Natural variantiVAR_055779850D → H. Corresponds to variant dbSNP:rs3748169Ensembl.1
Natural variantiVAR_0607381677I → L4 PublicationsCorresponds to variant dbSNP:rs2104772Ensembl.1
Natural variantiVAR_0709841773V → M in DFNA56. 1 PublicationCorresponds to variant dbSNP:rs137933052EnsemblClinVar.1
Natural variantiVAR_0201691781A → T. Corresponds to variant dbSNP:rs2274750Ensembl.1
Natural variantiVAR_0709851796T → S in DFNA56. 1 PublicationCorresponds to variant dbSNP:rs431905513EnsemblClinVar.1
Natural variantiVAR_0146652008E → Q5 PublicationsCorresponds to variant dbSNP:rs13321Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0014151072 – 1708Missing in isoform 6. 1 PublicationAdd BLAST637
Alternative sequenceiVSP_0014141072 – 1617Missing in isoform 5. 1 PublicationAdd BLAST546
Alternative sequenceiVSP_0014121072 – 1435Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST364
Alternative sequenceiVSP_0014131527 – 1617Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55618 mRNA Translation: AAA88083.1
X56160 mRNA Translation: CAA39628.1
X78565 mRNA Translation: CAA55309.1
AL162425 Genomic DNA No translation available.
X80280 mRNA No translation available.
M24630 mRNA Translation: AAA52703.1
CCDSiCCDS6811.1 [P24821-1]
PIRiI38337 A32160
RefSeqiNP_002151.2, NM_002160.3 [P24821-1]
XP_005252029.1, XM_005251972.3 [P24821-4]
XP_005252031.1, XM_005251974.3 [P24821-5]
XP_005252032.1, XM_005251975.3 [P24821-6]
XP_011516931.1, XM_011518629.2 [P24821-2]
UniGeneiHs.143250
Hs.684865
Hs.734766

Genome annotation databases

EnsembliENST00000350763; ENSP00000265131; ENSG00000041982 [P24821-1]
ENST00000537320; ENSP00000443478; ENSG00000041982 [P24821-6]
GeneIDi3371
KEGGihsa:3371
UCSCiuc004bjj.6 human [P24821-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55618 mRNA Translation: AAA88083.1
X56160 mRNA Translation: CAA39628.1
X78565 mRNA Translation: CAA55309.1
AL162425 Genomic DNA No translation available.
X80280 mRNA No translation available.
M24630 mRNA Translation: AAA52703.1
CCDSiCCDS6811.1 [P24821-1]
PIRiI38337 A32160
RefSeqiNP_002151.2, NM_002160.3 [P24821-1]
XP_005252029.1, XM_005251972.3 [P24821-4]
XP_005252031.1, XM_005251974.3 [P24821-5]
XP_005252032.1, XM_005251975.3 [P24821-6]
XP_011516931.1, XM_011518629.2 [P24821-2]
UniGeneiHs.143250
Hs.684865
Hs.734766

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TENX-ray1.80A802-891[»]
2RB8X-ray1.45A802-893[»]
2RBLX-ray2.10A/B/M802-893[»]
ProteinModelPortaliP24821
SMRiP24821
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109602, 3 interactors
ComplexPortaliCPX-466 Tenascin-C complex
CORUMiP24821
IntActiP24821, 2 interactors
STRINGi9606.ENSP00000265131

Chemistry databases

ChEMBLiCHEMBL3712856

PTM databases

iPTMnetiP24821
PhosphoSitePlusiP24821

Polymorphism and mutation databases

BioMutaiTNC
DMDMi281185495

Proteomic databases

EPDiP24821
MaxQBiP24821
PaxDbiP24821
PeptideAtlasiP24821
PRIDEiP24821
ProteomicsDBi54225
54226 [P24821-2]
54227 [P24821-3]
54228 [P24821-4]
54229 [P24821-5]
54230 [P24821-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350763; ENSP00000265131; ENSG00000041982 [P24821-1]
ENST00000537320; ENSP00000443478; ENSG00000041982 [P24821-6]
GeneIDi3371
KEGGihsa:3371
UCSCiuc004bjj.6 human [P24821-1]

Organism-specific databases

CTDi3371
DisGeNETi3371
EuPathDBiHostDB:ENSG00000041982.15
GeneCardsiTNC
HGNCiHGNC:5318 TNC
HPAiCAB004592
HPA004823
MalaCardsiTNC
MIMi187380 gene
615629 phenotype
neXtProtiNX_P24821
OpenTargetsiENSG00000041982
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA35103
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1225 Eukaryota
KOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00920000148942
HOVERGENiHBG008949
InParanoidiP24821
KOiK06252
OMAiHYTAKIQ
OrthoDBiEOG091G03M1
PhylomeDBiP24821
TreeFamiTF329915

Enzyme and pathway databases

ReactomeiR-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP24821

Miscellaneous databases

ChiTaRSiTNC human
EvolutionaryTraceiP24821
GeneWikiiTenascin_C
GenomeRNAii3371
PROiPR:P24821
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000041982 Expressed in 213 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_TNC
ExpressionAtlasiP24821 baseline and differential
GenevisibleiP24821 HS

Family and domain databases

CDDicd00063 FN3, 15 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 15 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC
PANTHERiPTHR19143:SF38 PTHR19143:SF38, 9 hits
PfamiView protein in Pfam
PF07974 EGF_2, 6 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 15 hits
SMARTiView protein in SMART
SM00181 EGF, 14 hits
SM00186 FBG, 1 hit
SM00060 FN3, 15 hits
SUPFAMiSSF49265 SSF49265, 12 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 15 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 15 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTENA_HUMAN
AccessioniPrimary (citable) accession number: P24821
Secondary accession number(s): C9IYT7
, C9J575, C9J6D9, C9J848, Q14583, Q15567, Q5T7S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 15, 2009
Last modified: September 12, 2018
This is version 210 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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