UniProtKB - P24807 (CD24_MOUSE)
Signal transducer CD24
Cd24
Functioni
May have a pivotal role in cell differentiation of different cell types. May have a specific role in early thymocyte development. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses (By similarity).
In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (PubMed:19264983).
Plays a role in the control of autoimmunity (PubMed:20200274).
By similarity2 PublicationsGO - Molecular functioni
- carbohydrate binding Source: UniProtKB
- Hsp70 protein binding Source: UniProtKB
- Hsp90 protein binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein tyrosine kinase activator activity Source: UniProtKB
GO - Biological processi
- apoptotic mitochondrial changes Source: MGI
- apoptotic nuclear changes Source: MGI
- apoptotic signaling pathway Source: MGI
- B cell receptor transport into membrane raft Source: UniProtKB
- cell activation Source: UniProtKB
- cell migration Source: UniProtKB
- cell surface receptor signaling pathway Source: MGI
- chemokine receptor transport out of membrane raft Source: UniProtKB
- cholesterol homeostasis Source: UniProtKB
- glomerular parietal epithelial cell differentiation Source: UniProtKB
- glomerular visceral epithelial cell differentiation Source: UniProtKB
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
- homotypic cell-cell adhesion Source: MGI
- innate immune response Source: UniProtKB-KW
- leukocyte cell-cell adhesion Source: MGI
- leukocyte migration involved in inflammatory response Source: MGI
- negative regulation of B cell proliferation Source: MGI
- negative regulation of erythrocyte aggregation Source: MGI
- negative regulation of erythrocyte clearance Source: MGI
- negative regulation of inflammatory response to wounding Source: UniProtKB
- negative regulation of interleukin-6 production Source: UniProtKB
- negative regulation of monocyte chemotactic protein-1 production Source: UniProtKB
- negative regulation of neuroblast proliferation Source: MGI
- negative regulation of neurogenesis Source: MGI
- negative regulation of neuron differentiation Source: MGI
- negative regulation of T cell homeostatic proliferation Source: MGI
- negative regulation of transforming growth factor beta3 production Source: UniProtKB
- negative regulation of tumor necrosis factor production Source: UniProtKB
- neuromuscular synaptic transmission Source: MGI
- neuron projection development Source: MGI
- positive regulation of activated T cell proliferation Source: UniProtKB
- positive regulation of alpha-beta T cell proliferation Source: MGI
- positive regulation of B cell apoptotic process Source: MGI
- positive regulation of calcium-mediated signaling Source: MGI
- positive regulation of cell adhesion mediated by integrin Source: MGI
- positive regulation of cell-cell adhesion Source: MGI
- positive regulation of cell-cell adhesion mediated by integrin Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of inflammatory response to antigenic stimulus Source: MGI
- positive regulation of inflammatory response to wounding Source: UniProtKB
- positive regulation of integrin activation Source: MGI
- positive regulation of MAP kinase activity Source: UniProtKB
- positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
- positive regulation of neuron projection development Source: MGI
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- positive regulation of T cell homeostatic proliferation Source: MGI
- positive regulation of T cell mediated immune response to tumor cell Source: MGI
- pre-B cell differentiation Source: MGI
- regulation of B cell differentiation Source: MGI
- regulation of cell-cell adhesion Source: MGI
- regulation of cell-cell adhesion mediated by integrin Source: MGI
- regulation of cytokine-mediated signaling pathway Source: UniProtKB
- regulation of MAPK cascade Source: UniProtKB
- regulation of phosphorylation Source: UniProtKB
- respiratory burst Source: UniProtKB
- response to estrogen Source: UniProtKB
- response to hypoxia Source: UniProtKB
- response to molecule of bacterial origin Source: UniProtKB
- synaptic vesicle endocytosis Source: MGI
- T cell costimulation Source: UniProtKB
Keywordsi
Biological process | Immunity, Innate immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer CD24Alternative name(s): Lymphocyte antigen 52 Short name: Ly-52 M1/69-J11D heat stable antigen Short name: HSA Nectadrin R13-Ag X62 heat stable antigen CD_antigen: CD24 |
Gene namesi | Name:Cd24 Synonyms:Cd24a, Ly-52 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88323, Cd24a |
VEuPathDBi | HostDB:ENSMUSG00000047139 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- anchored component of external side of plasma membrane Source: MGI
- ciliary membrane Source: MGI
- external side of plasma membrane Source: MGI
- microvillus membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- membrane Source: MGI
- membrane raft Source: UniProtKB
- presynapse Source: GOC
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 1 PublicationAdd BLAST | 26 | |
PeptideiPRO_0000020895 | 27 – 53 | Signal transducer CD24Add BLAST | 27 | |
PropeptideiPRO_0000020896 | 54 – 76 | Removed in mature formSequence analysisAdd BLAST | 23 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 27 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 30 | O-linked (GalNAc...) serine1 Publication | 1 | |
Glycosylationi | 39 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 41 | O-linked (GalNAc...) serine; partial1 Publication | 1 | |
Glycosylationi | 43 | O-linked (GalNAc...) serine; partial1 Publication | 1 | |
Glycosylationi | 48 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 51 | O-linked (GalNAc...) threonine; partial1 Publication | 1 | |
Lipidationi | 53 | GPI-anchor amidated glycineSequence analysis | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 45 | Not glycosylated1 Publication | 1 |
Keywords - PTMi
Glycoprotein, GPI-anchor, LipoproteinProteomic databases
PaxDbi | P24807 |
PRIDEi | P24807 |
PTM databases
GlyGeni | P24807, 7 sites |
iPTMneti | P24807 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000047139, Expressed in blood and 378 other tissues |
Genevisiblei | P24807, MM |
Interactioni
Subunit structurei
Interacts with SIGLEC10; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response.
1 PublicationGO - Molecular functioni
- Hsp70 protein binding Source: UniProtKB
- Hsp90 protein binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000057983 |
Miscellaneous databases
RNActi | P24807, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 37 – 57 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RVSX, Eukaryota |
GeneTreei | ENSGT00390000018829 |
HOGENOMi | CLU_198463_1_0_1 |
InParanoidi | P24807 |
OMAi | QNTWTAT |
OrthoDBi | 1640445at2759 |
PhylomeDBi | P24807 |
TreeFami | TF338512 |
Family and domain databases
InterProi | View protein in InterPro IPR028029, CD24 |
PANTHERi | PTHR16676, PTHR16676, 1 hit |
Pfami | View protein in Pfam PF14984, CD24, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MGRAMVARLG LGLLLLALLL PTQIYCNQTS VAPFPGNQNI SASPNPSNAT
60 70
TRGGGSSLQS TAGLLALSLS LLHLYC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1SQ70 | A0A1L1SQ70_MOUSE | CD24a antigen | Cd24a | 98 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58661 mRNA Translation: AAA39481.1 X56469 Genomic DNA Translation: CAA39841.1 X72910 Genomic DNA Translation: CAA51415.1 X53825 mRNA Translation: CAA37822.1 BC075622 mRNA Translation: AAH75622.1 |
CCDSi | CCDS23821.1 |
PIRi | A43537 |
RefSeqi | NP_033976.1, NM_009846.2 |
Genome annotation databases
Ensembli | ENSMUST00000058714; ENSMUSP00000057983; ENSMUSG00000047139 |
GeneIDi | 12484 |
KEGGi | mmu:12484 |
UCSCi | uc007ezl.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58661 mRNA Translation: AAA39481.1 X56469 Genomic DNA Translation: CAA39841.1 X72910 Genomic DNA Translation: CAA51415.1 X53825 mRNA Translation: CAA37822.1 BC075622 mRNA Translation: AAH75622.1 |
CCDSi | CCDS23821.1 |
PIRi | A43537 |
RefSeqi | NP_033976.1, NM_009846.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000057983 |
PTM databases
GlyGeni | P24807, 7 sites |
iPTMneti | P24807 |
Proteomic databases
PaxDbi | P24807 |
PRIDEi | P24807 |
Protocols and materials databases
DNASUi | 12484 |
Genome annotation databases
Ensembli | ENSMUST00000058714; ENSMUSP00000057983; ENSMUSG00000047139 |
GeneIDi | 12484 |
KEGGi | mmu:12484 |
UCSCi | uc007ezl.1, mouse |
Organism-specific databases
CTDi | 12484 |
MGIi | MGI:88323, Cd24a |
VEuPathDBi | HostDB:ENSMUSG00000047139 |
Phylogenomic databases
eggNOGi | ENOG502RVSX, Eukaryota |
GeneTreei | ENSGT00390000018829 |
HOGENOMi | CLU_198463_1_0_1 |
InParanoidi | P24807 |
OMAi | QNTWTAT |
OrthoDBi | 1640445at2759 |
PhylomeDBi | P24807 |
TreeFami | TF338512 |
Miscellaneous databases
BioGRID-ORCSi | 12484, 0 hits in 65 CRISPR screens |
ChiTaRSi | Cd24a, mouse |
PROi | PR:P24807 |
RNActi | P24807, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000047139, Expressed in blood and 378 other tissues |
Genevisiblei | P24807, MM |
Family and domain databases
InterProi | View protein in InterPro IPR028029, CD24 |
PANTHERi | PTHR16676, PTHR16676, 1 hit |
Pfami | View protein in Pfam PF14984, CD24, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CD24_MOUSE | |
Accessioni | P24807Primary (citable) accession number: P24807 Secondary accession number(s): P26691 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families