Signal transducer CD24

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• carbohydrate binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Inhibition of human CD24 binding to platelet-bound P-selectin by monoclonal antibody."
    Chen C., He Z., Sai P., Faridi A., Aziz A., Kalavar M., Griciene P., Gintautas J., Steier W.
    Proc West Pharmacol Soc 47:28-29(2004) [PubMed] [Europe PMC] [Abstract]
• Hsp70 protein binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "CD24 and Siglec-10 selectively repress tissue damage-induced immune responses."
    Chen G.Y., Tang J., Zheng P., Liu Y.
    Science 323:1722-1725(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SIGLEC10 AND HMGB1.
• Hsp90 protein binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "CD24 and Siglec-10 selectively repress tissue damage-induced immune responses."
    Chen G.Y., Tang J., Zheng P., Liu Y.
    Science 323:1722-1725(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SIGLEC10 AND HMGB1.
• protein kinase binding Source: UniProtKB <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line."
    Zarn J.A., Zimmermann S.M., Pass M.K., Waibel R., Stahel R.A.
    Biochem. Biophys. Res. Commun. 225:384-391(1996) [PubMed] [Europe PMC] [Abstract]
• protein tyrosine kinase activator activity Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system."
    Suzuki T., Kiyokawa N., Taguchi T., Sekino T., Katagiri Y.U., Fujimoto J.
    J. Immunol. 166:5567-5577(2001) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• apoptotic mitochondrial changes Source: MGIInferred from direct assayⁱ
  • "TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking."
    Jung K.C., Park W.S., Kim H.J., Choi E.Y., Kook M.C., Lee H.W., Bae Y.
    J Immunol 172:795-802(2004) [PubMed] [Europe PMC] [Abstract]
• apoptotic nuclear changes Source: MGIInferred from direct assayⁱ
  • "TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking."
    Jung K.C., Park W.S., Kim H.J., Choi E.Y., Kook M.C., Lee H.W., Bae Y.
    J Immunol 172:795-802(2004) [PubMed] [Europe PMC] [Abstract]
• apoptotic signaling pathway Source: MGIInferred from direct assayⁱ
  • "TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking."
    Jung K.C., Park W.S., Kim H.J., Choi E.Y., Kook M.C., Lee H.W., Bae Y.
    J Immunol 172:795-802(2004) [PubMed] [Europe PMC] [Abstract]
  • "Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes."
    Chappel M.S., Hough M.R., Mittel A., Takei F., Kay R., Humphries R.K.
    J Exp Med 184:1639-1649(1996) [PubMed] [Europe PMC] [Abstract]
  • "Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen."
    Hitsumoto Y., Song D.S., Okada M., Hamada F., Saheki S., Takeuchi N.
    Immunology 89:200-204(1996) [PubMed] [Europe PMC] [Abstract]
• B cell receptor transport into membrane raft Source: UniProtKB
• cell activation Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens."
    Lund-Johansen F., Olweus J., Symington F.W., Arli A., Thompson J.S., Vilella R., Skubitz K., Horejsi V.
    Eur J Immunol 23:2782-2791(1993) [PubMed] [Europe PMC] [Abstract]
• cell migration Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells."
    Schabath H., Runz S., Joumaa S., Altevogt P.
    J Cell Sci 119:314-325(2006) [PubMed] [Europe PMC] [Abstract]
• cell surface receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • "Evidence for cis interaction and cooperative signalling by the heat-stable antigen nectadrin (murine CD24) and the cell adhesion molecule L1 in neurons."
    Kadmon G., von Bohlen und Halbach F., Horstkorte R., Eckert M., Altevogt P., Schachner M.
    Eur J Neurosci 7:993-1004(1995) [PubMed] [Europe PMC] [Abstract]
  • "Differential, LFA-1-sensitive effects of antibodies to nectadrin, the heat-stable antigen, on B lymphoblast aggregation and signal transduction."
    Kadmon G., von Bohlen und Halbach F., Schachner M., Altevogt P.
    Biochem Biophys Res Commun 198:1209-1215(1994) [PubMed] [Europe PMC] [Abstract]
  • "Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases."
    Sammar M., Gulbins E., Hilbert K., Lang F., Altevogt P.
    Biochem Biophys Res Commun 234:330-334(1997) [PubMed] [Europe PMC] [Abstract]
• chemokine receptor transport out of membrane raft Source: UniProtKBInferred from mutant phenotypeⁱ
  • "CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells."
    Schabath H., Runz S., Joumaa S., Altevogt P.
    J Cell Sci 119:314-325(2006) [PubMed] [Europe PMC] [Abstract]
• cholesterol homeostasis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells."
    Schabath H., Runz S., Joumaa S., Altevogt P.
    J Cell Sci 119:314-325(2006) [PubMed] [Europe PMC] [Abstract]
• glomerular parietal epithelial cell differentiation Source: UniProtKB
• glomerular visceral epithelial cell differentiation Source: UniProtKB
• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGIInferred from direct assayⁱ
  • "The heat-stable antigen can alter very late antigen 4-mediated adhesion."
    Hahne M., Wenger R.H., Vestweber D., Nielsen P.J.
    J Exp Med 179:1391-1395(1994) [PubMed] [Europe PMC] [Abstract]
  • "Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin."
    Aigner S., Ruppert M., Hubbe M., Sammar M., Sthoeger Z., Butcher E.C., Vestweber D., Altevogt P.
    Int Immunol 7:1557-1565(1995) [PubMed] [Europe PMC] [Abstract]
• homotypic cell-cell adhesion Source: MGIInferred from mutant phenotypeⁱ
  • "Evidence for cis interaction and cooperative signalling by the heat-stable antigen nectadrin (murine CD24) and the cell adhesion molecule L1 in neurons."
    Kadmon G., von Bohlen und Halbach F., Horstkorte R., Eckert M., Altevogt P., Schachner M.
    Eur J Neurosci 7:993-1004(1995) [PubMed] [Europe PMC] [Abstract]
• innate immune response Source: UniProtKB-KW
• leukocyte cell-cell adhesion Source: MGIInferred from direct assayⁱ
  • "Differential regulation of alpha 4 integrin-dependent binding to domains 1 and 4 of vascular cell adhesion molecule-1."
    Kilger G., Needham L.A., Nielsen P.J., Clements J., Vestweber D., Holzmann B.
    J Biol Chem 270:5979-5984(1995) [PubMed] [Europe PMC] [Abstract]
  • "Differential, LFA-1-sensitive effects of antibodies to nectadrin, the heat-stable antigen, on B lymphoblast aggregation and signal transduction."
    Kadmon G., von Bohlen und Halbach F., Schachner M., Altevogt P.
    Biochem Biophys Res Commun 198:1209-1215(1994) [PubMed] [Europe PMC] [Abstract]
  • "The L1 adhesion molecule is a cellular ligand for VLA-5."
    Ruppert M., Aigner S., Hubbe M., Yagita H., Altevogt P.
    J Cell Biol 131:1881-1891(1995) [PubMed] [Europe PMC] [Abstract]
  • "Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin."
    Aigner S., Ruppert M., Hubbe M., Sammar M., Sthoeger Z., Butcher E.C., Vestweber D., Altevogt P.
    Int Immunol 7:1557-1565(1995) [PubMed] [Europe PMC] [Abstract]
  • "Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases."
    Sammar M., Gulbins E., Hilbert K., Lang F., Altevogt P.
    Biochem Biophys Res Commun 234:330-334(1997) [PubMed] [Europe PMC] [Abstract]
• leukocyte migration involved in inflammatory response Source: MGIInferred from mutant phenotypeⁱ
  • "CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis."
    Bai X.F., Li O., Zhou Q., Zhang H., Joshi P.S., Zheng X., Liu Y., Wang Y., Zheng P., Liu Y.
    J Exp Med 200:447-458(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of B cell proliferation Source: MGIInferred from direct assayⁱ
  • "Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes."
    Chappel M.S., Hough M.R., Mittel A., Takei F., Kay R., Humphries R.K.
    J Exp Med 184:1639-1649(1996) [PubMed] [Europe PMC] [Abstract]
• negative regulation of erythrocyte aggregation Source: MGIInferred from mutant phenotypeⁱ
  • "Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice."
    Nielsen P.J., Lorenz B., Muller A.M., Wenger R.H., Brombacher F., Simon M., von der Weid T., Langhorne W.J., Mossmann H., Kohler G.
    Blood 89:1058-1067(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of erythrocyte clearance Source: MGIInferred from mutant phenotypeⁱ
  • "Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice."
    Nielsen P.J., Lorenz B., Muller A.M., Wenger R.H., Brombacher F., Simon M., von der Weid T., Langhorne W.J., Mossmann H., Kohler G.
    Blood 89:1058-1067(1997) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response to wounding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.7

    "CD24 and Siglec-10 selectively repress tissue damage-induced immune responses."
    Chen G.Y., Tang J., Zheng P., Liu Y.
    Science 323:1722-1725(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SIGLEC10 AND HMGB1.
• negative regulation of interleukin-6 production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.7

    "CD24 and Siglec-10 selectively repress tissue damage-induced immune responses."
    Chen G.Y., Tang J., Zheng P., Liu Y.
    Science 323:1722-1725(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SIGLEC10 AND HMGB1.
• negative regulation of monocyte chemotactic protein-1 production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.7

    "CD24 and Siglec-10 selectively repress tissue damage-induced immune responses."
    Chen G.Y., Tang J., Zheng P., Liu Y.
    Science 323:1722-1725(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SIGLEC10 AND HMGB1.
• negative regulation of neuroblast proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Increased neurogenesis in adult mCD24-deficient mice."
    Belvindrah R., Rougon G., Chazal G.
    J Neurosci 22:3594-3607(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neurogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "mCD24 regulates proliferation of neuronal committed precursors in the subventricular zone."
    Nieoullon V., Belvindrah R., Rougon G., Chazal G.
    Mol Cell Neurosci 28:462-474(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "mCD24 regulates proliferation of neuronal committed precursors in the subventricular zone."
    Nieoullon V., Belvindrah R., Rougon G., Chazal G.
    Mol Cell Neurosci 28:462-474(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of T cell homeostatic proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts."
    Li O., Chang X., Zhang H., Kocak E., Ding C., Zheng P., Liu Y.
    J Exp Med 203:1713-1720(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transforming growth factor beta3 production Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Regulation of E-cadherin and TGF-beta3 expression by CD24 in cultured oral epithelial cells."
    Ye P., Nadkarni M.A., Hunter N.
    Biochem Biophys Res Commun 349:229-235(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of tumor necrosis factor production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.7

    "CD24 and Siglec-10 selectively repress tissue damage-induced immune responses."
    Chen G.Y., Tang J., Zheng P., Liu Y.
    Science 323:1722-1725(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SIGLEC10 AND HMGB1.
• neuromuscular synaptic transmission Source: MGIInferred from mutant phenotypeⁱ
  • "CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission."
    Jevsek M., Jaworski A., Polo-Parada L., Kim N., Fan J., Landmesser L.T., Burden S.J.
    Proc Natl Acad Sci U S A 103:6374-6379(2006) [PubMed] [Europe PMC] [Abstract]
• neuron projection development Source: MGIInferred from direct assayⁱ
  • "The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth."
    Kleene R., Yang H., Kutsche M., Schachner M.
    J Biol Chem 276:21656-21663(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of activated T cell proliferation Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Antibodies recognizing CD24 LAP epitope on human T cells enhance CD28 and IL-2 T cell proliferation."
    Salamone M.C., Rosselot C., Salamone G.V., Barboza M., Kado M., Fainboim L.
    J Leukoc Biol 69:215-223(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of alpha-beta T cell proliferation Source: MGIInferred from direct assayⁱ
  • "Heat-stable antigen is a costimulatory molecule for CD4 T cell growth."
    Liu Y., Jones B., Aruffo A., Sullivan K.M., Linsley P.S., Janeway C.A. Jr.
    J Exp Med 175:437-445(1992) [PubMed] [Europe PMC] [Abstract]
  • "Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function."
    Hubbe M., Altevogt P.
    Eur J Immunol 24:731-737(1994) [PubMed] [Europe PMC] [Abstract]
  • "Homotypic interaction of the heat-stable antigen is not responsible for its co-stimulatory activity for T cell clonal expansion."
    Zhou Q., Wu Y., Nielsen P.J., Liu Y.
    Eur J Immunol 27:2524-2528(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of B cell apoptotic process Source: MGIInferred from direct assayⁱ
  • "Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes."
    Chappel M.S., Hough M.R., Mittel A., Takei F., Kay R., Humphries R.K.
    J Exp Med 184:1639-1649(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of calcium-mediated signaling Source: MGIInferred from direct assayⁱ
  • "Evidence for cis interaction and cooperative signalling by the heat-stable antigen nectadrin (murine CD24) and the cell adhesion molecule L1 in neurons."
    Kadmon G., von Bohlen und Halbach F., Horstkorte R., Eckert M., Altevogt P., Schachner M.
    Eur J Neurosci 7:993-1004(1995) [PubMed] [Europe PMC] [Abstract]
  • "Differential, LFA-1-sensitive effects of antibodies to nectadrin, the heat-stable antigen, on B lymphoblast aggregation and signal transduction."
    Kadmon G., von Bohlen und Halbach F., Schachner M., Altevogt P.
    Biochem Biophys Res Commun 198:1209-1215(1994) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell adhesion mediated by integrin Source: MGIInferred from direct assayⁱ
  • "Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts."
    Krauss K., Altevogt P.
    J Biol Chem 274:36921-36927(1999) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell-cell adhesion Source: MGIInferred from direct assayⁱ
  • "Adhesive hierarchy involving the cell adhesion molecules L1, CD24, and alpha 6 integrin in murine neuroblastoma N2A cells."
    Kadmon G., Imhof B.A., Altevogt P., Schachner M.
    Biochem Biophys Res Commun 214:94-101(1995) [PubMed] [Europe PMC] [Abstract]
  • "The L1 adhesion molecule is a cellular ligand for VLA-5."
    Ruppert M., Aigner S., Hubbe M., Yagita H., Altevogt P.
    J Cell Biol 131:1881-1891(1995) [PubMed] [Europe PMC] [Abstract]
  • "Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases."
    Sammar M., Gulbins E., Hilbert K., Lang F., Altevogt P.
    Biochem Biophys Res Commun 234:330-334(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell-cell adhesion mediated by integrin Source: MGIInferred from direct assayⁱ
  • "Differential regulation of alpha 4 integrin-dependent binding to domains 1 and 4 of vascular cell adhesion molecule-1."
    Kilger G., Needham L.A., Nielsen P.J., Clements J., Vestweber D., Holzmann B.
    J Biol Chem 270:5979-5984(1995) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules."
    Fischer G.F., Majdic O., Gadd S., Knapp W.
    J Immunol 144:638-641(1990) [PubMed] [Europe PMC] [Abstract]
  • "Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens."
    Lund-Johansen F., Olweus J., Symington F.W., Arli A., Thompson J.S., Vilella R., Skubitz K., Horejsi V.
    Eur J Immunol 23:2782-2791(1993) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inflammatory response to antigenic stimulus Source: MGIInferred from mutant phenotypeⁱ
  • "The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis."
    Bai X.F., Liu J.Q., Liu X., Guo Y., Cox K., Wen J., Zheng P., Liu Y.
    J Clin Invest 105:1227-1232(2000) [PubMed] [Europe PMC] [Abstract]
  • "CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis."
    Bai X.F., Li O., Zhou Q., Zhang H., Joshi P.S., Zheng X., Liu Y., Wang Y., Zheng P., Liu Y.
    J Exp Med 200:447-458(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inflammatory response to wounding Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.7

    "CD24 and Siglec-10 selectively repress tissue damage-induced immune responses."
    Chen G.Y., Tang J., Zheng P., Liu Y.
    Science 323:1722-1725(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SIGLEC10 AND HMGB1.
• positive regulation of integrin activation Source: MGIInferred from direct assayⁱ
  • "Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts."
    Krauss K., Altevogt P.
    J Biol Chem 274:36921-36927(1999) [PubMed] [Europe PMC] [Abstract]
  • "Differential regulation of alpha 4 integrin-dependent binding to domains 1 and 4 of vascular cell adhesion molecule-1."
    Kilger G., Needham L.A., Nielsen P.J., Clements J., Vestweber D., Holzmann B.
    J Biol Chem 270:5979-5984(1995) [PubMed] [Europe PMC] [Abstract]
• positive regulation of MAP kinase activity Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Pre-B cell antigen receptor-mediated signal inhibits CD24-induced apoptosis in human pre-B cells."
    Taguchi T., Kiyokawa N., Mimori K., Suzuki T., Sekino T., Nakajima H., Saito M., Katagiri Y.U., Matsuo N., Matsuo Y., Karasuyama H., Fujimoto J.
    J Immunol 170:252-260(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
• positive regulation of neuron projection development Source: MGIInferred from direct assayⁱ
  • "Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth."
    Lieberoth A., Splittstoesser F., Katagihallimath N., Jakovcevski I., Loers G., Ranscht B., Karagogeos D., Schachner M., Kleene R.
    J Neurosci 29:6677-6690(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-tyrosine phosphorylation Source: MGIInferred from direct assayⁱ
  • "Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts."
    Krauss K., Altevogt P.
    J Biol Chem 274:36921-36927(1999) [PubMed] [Europe PMC] [Abstract]
  • "Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases."
    Sammar M., Gulbins E., Hilbert K., Lang F., Altevogt P.
    Biochem Biophys Res Commun 234:330-334(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell homeostatic proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host."
    Li O., Zheng P., Liu Y.
    J Exp Med 200:1083-1089(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell mediated immune response to tumor cell Source: MGIInferred from direct assayⁱ
  • "Expression of heat-stable antigen on tumor cells provides co-stimulation for tumor-specific T cell proliferation and cytotoxicity in mice."
    Wang Y.C., Zhu L., McHugh R., Sell K.W., Selvaraj P.
    Eur J Immunol 25:1163-1167(1995) [PubMed] [Europe PMC] [Abstract]
• pre-B cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24)."
    Wenger R.H., Kopf M., Nitschke L., Lamers M.C., Kohler G., Nielsen P.J.
    Transgenic Res 4:173-183(1995) [PubMed] [Europe PMC] [Abstract]
  • "Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice."
    Nielsen P.J., Lorenz B., Muller A.M., Wenger R.H., Brombacher F., Simon M., von der Weid T., Langhorne W.J., Mossmann H., Kohler G.
    Blood 89:1058-1067(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of B cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24)."
    Wenger R.H., Kopf M., Nitschke L., Lamers M.C., Kohler G., Nielsen P.J.
    Transgenic Res 4:173-183(1995) [PubMed] [Europe PMC] [Abstract]
  • "Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice."
    Nielsen P.J., Lorenz B., Muller A.M., Wenger R.H., Brombacher F., Simon M., von der Weid T., Langhorne W.J., Mossmann H., Kohler G.
    Blood 89:1058-1067(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of cell-cell adhesion Source: MGIInferred from direct assayⁱ
  • "Differential, LFA-1-sensitive effects of antibodies to nectadrin, the heat-stable antigen, on B lymphoblast aggregation and signal transduction."
    Kadmon G., von Bohlen und Halbach F., Schachner M., Altevogt P.
    Biochem Biophys Res Commun 198:1209-1215(1994) [PubMed] [Europe PMC] [Abstract]
• regulation of cell-cell adhesion mediated by integrin Source: MGIInferred from direct assayⁱ
  • "The heat-stable antigen can alter very late antigen 4-mediated adhesion."
    Hahne M., Wenger R.H., Vestweber D., Nielsen P.J.
    J Exp Med 179:1391-1395(1994) [PubMed] [Europe PMC] [Abstract]
• regulation of cytokine-mediated signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • "CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells."
    Schabath H., Runz S., Joumaa S., Altevogt P.
    J Cell Sci 119:314-325(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of MAPK cascade Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system."
    Suzuki T., Kiyokawa N., Taguchi T., Sekino T., Katagiri Y.U., Fujimoto J.
    J. Immunol. 166:5567-5577(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of phosphorylation Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system."
    Suzuki T., Kiyokawa N., Taguchi T., Sekino T., Katagiri Y.U., Fujimoto J.
    J. Immunol. 166:5567-5577(2001) [PubMed] [Europe PMC] [Abstract]
• respiratory burst Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens."
    Lund-Johansen F., Olweus J., Symington F.W., Arli A., Thompson J.S., Vilella R., Skubitz K., Horejsi V.
    Eur J Immunol 23:2782-2791(1993) [PubMed] [Europe PMC] [Abstract]
• response to estrogen Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes."
    Yang G.P., Ross D.T., Kuang W.W., Brown P.O., Weigel R.J.
    Nucleic Acids Res 27:1517-1523(1999) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study."
    Scheurer S.B., Rybak J.N., Rosli C., Neri D., Elia G.
    Proteomics 4:1737-1760(2004) [PubMed] [Europe PMC] [Abstract]
• response to molecule of bacterial origin Source: UniProtKBInferred from direct assayⁱ
  • "Lipid rafts clustering and signalling by listeriolysin O."
    Gekara N.O., Weiss S.
    Biochem Soc Trans 32:712-714(2004) [PubMed] [Europe PMC] [Abstract]
• synaptic vesicle endocytosis Source: MGIInferred from mutant phenotypeⁱ
  • "CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission."
    Jevsek M., Jaworski A., Polo-Parada L., Kim N., Fan J., Landmesser L.T., Burden S.J.
    Proc Natl Acad Sci U S A 103:6374-6379(2006) [PubMed] [Europe PMC] [Abstract]
• T cell costimulation Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Antibodies recognizing CD24 LAP epitope on human T cells enhance CD28 and IL-2 T cell proliferation."
    Salamone M.C., Rosselot C., Salamone G.V., Barboza M., Kado M., Fainboim L.
    J Leukoc Biol 69:215-223(2001) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• Hsp70 protein binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "CD24 and Siglec-10 selectively repress tissue damage-induced immune responses."
    Chen G.Y., Tang J., Zheng P., Liu Y.
    Science 323:1722-1725(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SIGLEC10 AND HMGB1.
• Hsp90 protein binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "CD24 and Siglec-10 selectively repress tissue damage-induced immune responses."
    Chen G.Y., Tang J., Zheng P., Liu Y.
    Science 323:1722-1725(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH SIGLEC10 AND HMGB1.
• protein kinase binding Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line."
    Zarn J.A., Zimmermann S.M., Pass M.K., Waibel R., Stahel R.A.
    Biochem. Biophys. Res. Commun. 225:384-391(1996) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MGRAMVARLG LGLLLLALLL PTQIYCNQTS VAPFPGNQNI SASPNPSNAT 
        60         70 
TRGGGSSLQS TAGLLALSLS LLHLYC                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families