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UniProtKB - P24797 (AT1A2_CHICK)
Protein
Sodium/potassium-transporting ATPase subunit alpha-2
Gene
ATP1A2
Organism
Gallus gallus (Chicken)
Status
Functioni
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Catalytic activityi
- EC:7.2.2.13
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 371 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Binding sitei | 502 | ATPBy similarity | 1 | |
Metal bindingi | 711 | MagnesiumBy similarity | 1 | |
Metal bindingi | 715 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- P-type sodium:potassium-exchanging transporter activity Source: UniProtKB
GO - Biological processi
- cellular potassium ion homeostasis Source: GO_Central
- cellular sodium ion homeostasis Source: GO_Central
- neurotransmitter uptake Source: AgBase
- potassium ion import across plasma membrane Source: GO_Central
- proton transmembrane transport Source: GO_Central
- regulation of striated muscle contraction Source: AgBase
- sodium ion export across plasma membrane Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit alpha-2 (EC:7.2.2.13)Short name: Na(+)/K(+) ATPase alpha-2 subunit Alternative name(s): Sodium pump subunit alpha-2 |
Gene namesi | Name:ATP1A2 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 82 | CytoplasmicSequence analysisAdd BLAST | 82 | |
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 104 – 126 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 127 – 147 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 148 – 283 | CytoplasmicSequence analysisAdd BLAST | 136 | |
Transmembranei | 284 – 303 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 304 – 315 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 316 – 333 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 334 – 766 | CytoplasmicSequence analysisAdd BLAST | 433 | |
Transmembranei | 767 – 786 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 787 – 796 | ExtracellularSequence analysis | 10 | |
Transmembranei | 797 – 817 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 818 – 837 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 838 – 860 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 861 – 912 | ExtracellularSequence analysisAdd BLAST | 52 | |
Transmembranei | 913 – 932 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 933 – 945 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 946 – 964 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 965 – 979 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 980 – 1000 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1001 – 1017 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046297 | 1 – 1017 | Sodium/potassium-transporting ATPase subunit alpha-2Add BLAST | 1017 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 937 | Phosphoserine; by PKABy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PRIDEi | P24797 |
Interactioni
Subunit structurei
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
CuratedFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 31 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 77 – 79 | Interaction with phosphoinositide-3 kinaseBy similarity | 3 | |
Regioni | 207 – 228 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 31 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 207 – 227 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | P24797 |
OMAi | FINLVTD |
OrthoDBi | 388324at2759 |
PhylomeDBi | P24797 |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
P24797-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDGREYSPAA TTSENGGGRR KQKEKELDEL KKEVNLDDHK LSLDELGRKY
60 70 80 90 100
QVDLSRGLSN ARAAEVLAQD GPNALTPPPT TPEWVKFCRQ LFGGFSILLW
110 120 130 140 150
IGAILCFLAY GIQAAMEDEP SNDNLYLGVV LAAVVIVTGC FSYYQEAKSS
160 170 180 190 200
KIMDSFKNMV PQQALVIREG EKIQINAENV VVGDLVEVKG GDRVPADMRI
210 220 230 240 250
ISSHGCKVDN SSLTGESEPQ TRSPEFTHEN PLETRNICFF STNCVEGTAR
260 270 280 290 300
GIVISTGDRT VMGRIASLAS GLEVGRTPIA MEIEHFIRLI TGVAVFLGLS
310 320 330 340 350
FFILSLILGY TWLEAVIFLI GIIVANVPEG LLATVTVCLT LTAKRMARKN
360 370 380 390 400
CLVKNLEAVE TLGSTSTICS DKTGTLTQNR MTVAHMWFDN QIHEADTTED
410 420 430 440 450
QSGATFDKRS PTWAALSRIA GLCNRAVFKP GQENISISKR DTAGDASESA
460 470 480 490 500
LLKCIQLSCG SVKKMRDKNP KVTEIPFNST NKYQLSIHER EEDPQGHILV
510 520 530 540 550
MKGAPERILE RCSRILLQGQ EVPLDEEMKE AFQNAYLELG GLGERVLGFC
560 570 580 590 600
HLYLPPDKFP RGFRFDADEV NFPTSDLCFV GLMSMIDPPR AAVPDAVGKC
610 620 630 640 650
RSAGIKVIMV TGDHPITAKA IAKGVGIISE GNETVEDIAA RLNIPVSQVN
660 670 680 690 700
PREAKACVVH GSDLKDMTAE QLDEILRNHT EIVFARTSPQ QKLIIVEGCQ
710 720 730 740 750
RQGAIVAVTG DGVNDSPALK KADIGIAMGI AGSDVSKQAA DMILLDDNFA
760 770 780 790 800
SIVTGVEEGR LIFDNLKKSI AYTLTSNIPE ITPFLLFIIA NIPLPLGTVT
810 820 830 840 850
ILCIDLGTDM VPAISLAYEA AESDIMKRQP RNPRTDKLVN ERLISMAYGQ
860 870 880 890 900
IGMIQALGGF FTYFVILAEN GFLPARLLGV RLAWDDRSTN DLEDSYGQEW
910 920 930 940 950
TYEQRKVVEF TCHTAFFASI VVVQWADLII CKTRRNSVFQ QGMKNKILIF
960 970 980 990 1000
GLLEETALAA FLSYCPGMGV ALRMYPLKVT WWFCAFPYSL LIFAYDEVRK
1010
LILRRYPGGW VEKETYY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59959 mRNA Translation: AAA48981.1 |
PIRi | I50394, A37227 |
RefSeqi | NP_990807.1, NM_205476.1 |
Genome annotation databases
GeneIDi | 396468 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59959 mRNA Translation: AAA48981.1 |
PIRi | I50394, A37227 |
RefSeqi | NP_990807.1, NM_205476.1 |
3D structure databases
SMRi | P24797 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P24797 |
Genome annotation databases
GeneIDi | 396468 |
Organism-specific databases
CTDi | 477 |
Phylogenomic databases
InParanoidi | P24797 |
OMAi | FINLVTD |
OrthoDBi | 388324at2759 |
PhylomeDBi | P24797 |
Miscellaneous databases
PROi | PR:P24797 |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT1A2_CHICK | |
Accessioni | P24797Primary (citable) accession number: P24797 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | September 29, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families