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Protein

N-myc protein

Gene

mycn

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in CNS maturation.

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
N-myc protein
Gene namesi
Name:mycn
Synonyms:nmyc
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6464367 mycn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273301 – 437N-myc proteinAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231Phosphoserine; by CK2By similarity1
Modified residuei233Phosphoserine; by CK2By similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP24793
SMRiP24793
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini354 – 406bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni406 – 434Leucine-zipperAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi234 – 252Asp/Glu-rich (acidic)Add BLAST19

Phylogenomic databases

HOVERGENiHBG000472
KOiK09109

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR002418 Tscrpt_reg_Myc
IPR012682 Tscrpt_reg_Myc_N
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF01056 Myc_N, 1 hit
PIRSFiPIRSF001705 Myc_protein, 1 hit
PRINTSiPR00044 LEUZIPPRMYC
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P24793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLVSRNLD LEFDSLQPCF YPDEDDFYLC DPDSAPPGED IWKKFELLPT
60 70 80 90 100
PPLSPSRSGL HGDPLSPGLP GDYGDSVDWA SELLVLPPEA DLLGGSGWGE
110 120 130 140 150
LGLSPCNVKS IIIQDCMWSG FSAREKLERA VSEKLGKASC TPEPTIPHPP
160 170 180 190 200
SSTVGSSVSG RGVDMNNPAA HCVDPAVVFP FPFNKGESCR TAPSSANPPP
210 220 230 240 250
CTTTTVPTST TARNCTQPCT SSSSSGEESH SESDDDEDEE EEEEDDEEEE
260 270 280 290 300
IDVVTVEKRR NSSNKSVTSL TITVRPKNTI LVSSKTAQNE VILKRCAPVH
310 320 330 340 350
QQHNYAAPSP YVETEEVAPP QKKLRNELPR LVKNVVPTKP KSSSPRNYDS
360 370 380 390 400
EDSERRRNHN ILERQRRNDL RSSFLTLRDH VPELIKNEKA AKVVILKKAT
410 420 430
EYVHSLHADE QKLLLEKEKL QLRQQQLLKK IEHLRTC
Length:437
Mass (Da):48,406
Last modified:March 1, 1992 - v1
Checksum:iC4D6EEC0636E6F04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58670, X58671 Genomic DNA Translation: CAA41525.1
EF108321 mRNA Translation: ABL11345.1
PIRiS15704
RefSeqiNP_001165460.1, NM_001171989.1
XP_018117080.1, XM_018261591.1
UniGeneiXl.70037

Genome annotation databases

GeneIDi100337516
KEGGixla:100337516

Similar proteinsi

Entry informationi

Entry nameiMYCN_XENLA
AccessioniPrimary (citable) accession number: P24793
Secondary accession number(s): A1E5L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: January 31, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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