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UniProtKB - P24758 (A26_VACCW)
Protein
Protein A26
Gene
VACWR149
Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Functioni
Plays a role in bridging the mature virion with structural protein A25. Presence of protein A26 in the virion structurally prevents direct virus-cell fusion mechanism.
1 PublicationGO - Biological processi
- fusion of virus membrane with host plasma membrane Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Protein A26 |
Gene namesi | Ordered Locus Names:VACWR149 ORF Names:A26L |
Organismi | Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) |
Taxonomic identifieri | 10254 [NCBI] |
Taxonomic lineagei | Viruses › Varidnaviria › Bamfordvirae › Nucleocytoviricota › Pokkesviricetes › Chitovirales › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus |
Virus hosti | Bos taurus (Bovine) [TaxID: 9913] |
Proteomesi |
|
Subcellular locationi
- Virion membrane 1 Publication Note: A26 is anchored to the mature virion (MV) membrane through disulfide bonding with protein A27.
Keywords - Cellular componenti
Membrane, VirionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 441 | C → A: About 50% loss of interaction with A27. Complete loss of interaction with A2; when associated with A-442. 1 Publication | 1 | |
Mutagenesisi | 442 | C → A: About 60% loss of interaction with A27. Complete loss of interaction with A2; when associated with A-441. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000099278 | 1 – 500 | Protein A26Add BLAST | 500 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 43 ↔ 342 | |||
Disulfide bondi | 441 | Interchain (with C-71 in A27) | ||
Disulfide bondi | 442 | Interchain (with C-72 in A27) |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
Interacts with proteins A17, A25 and A27.
Interacts with host laminin.
4 PublicationsStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P24758 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the chordopoxvirinae A26 protein family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR003436, Chordopox_Fusion/A27 IPR009285, Orthopox_A30L/A26L |
Pfami | View protein in Pfam PF06086, Pox_A30L_A26L, 1 hit PF02346, Vac_Fusion, 1 hit |
i Sequence
Sequence statusi: Complete.
P24758-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANIINLWNG IVPTVQDVNV ASITAFKSMI DETWDKKIEA NTCISRKHRN
60 70 80 90 100
IIHEVIRDFM KAYPKMDENK KSPLGAPMQW LTQYYILKNE YHKTMLAYDN
110 120 130 140 150
GSLNTKFKTL NIYMITNVGQ YILYIVFCII SGKNHDGTPY IYDSEITSND
160 170 180 190 200
KNFINERIKY ACKQILHGQL TIALRIRNKF MFIGSPMYLW FNVNGSQVYH
210 220 230 240 250
DIYDRNAGFH NKEIGRLLYA FMYYLSISGR FLNDFALLKF TYLGESWTFS
260 270 280 290 300
LSVPEYILYG LGYSVFDTIE KFSNDAILVY IRTNNRNGYD YVEFNKKGIA
310 320 330 340 350
KVTEDKPDND KRIHAIRLIN DSTDVQHIHF GFRNMVIIDN ECANIQSSAE
360 370 380 390 400
NATDTGHHQD SKINIEVEDD VIDDDDYNPK PTPIPEPHPR PPFPRHEYHK
410 420 430 440 450
RPKLLPVEEP DPVKKDADRI RLDNHILNTL DHNLNFIGHY CCDTAAVDRL
460 470 480 490 500
EHHIETLGQY AVILARKINM QTLLFPWPLP TVHPHAIDGS IPPHGRSTIL
Sequence cautioni
The sequence AAA48323 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA40576 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M61187 Genomic DNA Translation: AAA48323.1 Sequence problems. X57318 Genomic DNA Translation: CAA40576.1 Sequence problems. AY243312 Genomic DNA Translation: AAO89428.1 |
PIRi | S29910 |
RefSeqi | YP_233031.1, NC_006998.1 |
Genome annotation databases
GeneIDi | 3707679 |
KEGGi | vg:3707679 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M61187 Genomic DNA Translation: AAA48323.1 Sequence problems. X57318 Genomic DNA Translation: CAA40576.1 Sequence problems. AY243312 Genomic DNA Translation: AAO89428.1 |
PIRi | S29910 |
RefSeqi | YP_233031.1, NC_006998.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6A9S | X-ray | 1.18 | A | 1-397 | [»] | |
SMRi | P24758 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protocols and materials databases
DNASUi | 3707679 |
Genome annotation databases
GeneIDi | 3707679 |
KEGGi | vg:3707679 |
Family and domain databases
InterProi | View protein in InterPro IPR003436, Chordopox_Fusion/A27 IPR009285, Orthopox_A30L/A26L |
Pfami | View protein in Pfam PF06086, Pox_A30L_A26L, 1 hit PF02346, Vac_Fusion, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A26_VACCW | |
Accessioni | P24758Primary (citable) accession number: P24758 Secondary accession number(s): Q80HU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 60 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families