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Protein

Acetyl-CoA acetyltransferase, mitochondrial

Gene

ACAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in ketone body metabolism.

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.PROSITE-ProRule annotation1 Publication

Activity regulationi

Activated by potassium ions, but not sodium ions.1 Publication

Kineticsi

  1. KM=4 µM for acetoacetyl coenzyme A1 Publication
  2. KM=20 µM for coenzyme A1 Publication
  3. KM=8 µM for 2-methylacetoacetyl coenzyme A1 Publication
  4. KM=508 µM for acetyl coenzyme A1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei126Acyl-thioester intermediateCurated1
    Metal bindingi219Potassium1 Publication1
    Binding sitei219Coenzyme A1 Publication1
    Binding sitei263Coenzyme A1 Publication1
    Metal bindingi280Potassium; via carbonyl oxygen1 Publication1
    Metal bindingi281Potassium; via carbonyl oxygen1 Publication1
    Metal bindingi283Potassium; via carbonyl oxygen1 Publication1
    Binding sitei284Coenzyme A1 Publication1
    Metal bindingi381Potassium; via carbonyl oxygen1 Publication1
    Active sitei385Proton acceptorCurated1
    Active sitei413Proton acceptorCurated1

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionAcyltransferase, Transferase
    LigandMetal-binding, Potassium

    Enzyme and pathway databases

    BioCyciMetaCyc:HS01167-MONOMER
    ReactomeiR-HSA-70895 Branched-chain amino acid catabolism
    R-HSA-77108 Utilization of Ketone Bodies
    R-HSA-77111 Synthesis of Ketone Bodies

    Chemistry databases

    SwissLipidsiSLP:000000701

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA acetyltransferase, mitochondrial (EC:2.3.1.9)
    Alternative name(s):
    Acetoacetyl-CoA thiolase
    T2
    Gene namesi
    Name:ACAT1
    Synonyms:ACAT, MAT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 11

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000075239.13
    HGNCiHGNC:93 ACAT1
    MIMi607809 gene
    neXtProtiNX_P24752

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    3-ketothiolase deficiency (3KTD)4 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn autosomal recessive inborn error of isoleucine catabolism characterized by intermittent ketoacidotic attacks associated with unconsciousness. Some patients die during an attack or are mentally retarded. Urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, triglylglycine, butanone is increased. It seems likely that the severity of this disease correlates better with the environmental or acquired factors than with the ACAT1 genotype.
    See also OMIM:203750
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_00749785Missing in 3KTD. 1
    Natural variantiVAR_00749893N → S in 3KTD; 10% activity. 1 PublicationCorresponds to variant dbSNP:rs120074145EnsemblClinVar.1
    Natural variantiVAR_007499152G → A in 3KTD. Corresponds to variant dbSNP:rs762991875EnsemblClinVar.1
    Natural variantiVAR_007500158N → D in 3KTD; no activity. 1 PublicationCorresponds to variant dbSNP:rs148639841EnsemblClinVar.1
    Natural variantiVAR_007501183G → R in 3KTD; no activity. 1 PublicationCorresponds to variant dbSNP:rs120074141EnsemblClinVar.1
    Natural variantiVAR_007502297T → M in 3KTD; 10% normal activity. 1 PublicationCorresponds to variant dbSNP:rs886041122EnsemblClinVar.1
    Natural variantiVAR_007503301A → P in 3KTD; 5% normal activity. 1 Publication1
    Natural variantiVAR_007504312I → T in 3KTD; 10% activity. 1 PublicationCorresponds to variant dbSNP:rs120074146EnsemblClinVar.1
    Natural variantiVAR_007505333A → P in 3KTD; no activity. 1 PublicationCorresponds to variant dbSNP:rs120074147EnsemblClinVar.1
    Natural variantiVAR_007506379G → V in 3KTD. Corresponds to variant dbSNP:rs120074143EnsemblClinVar.1
    Natural variantiVAR_007507380A → T in 3KTD; 7% normal activity. 1 PublicationCorresponds to variant dbSNP:rs120074140EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNETi38
    MalaCardsiACAT1
    MIMi203750 phenotype
    OpenTargetsiENSG00000075239
    Orphaneti134 Ketoacidosis due to beta-ketothiolase deficiency
    PharmGKBiPA24431

    Chemistry databases

    ChEMBLiCHEMBL2616
    DrugBankiDB00795 Sulfasalazine

    Polymorphism and mutation databases

    BioMutaiACAT1
    DMDMi135755

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transit peptidei1 – 33MitochondrionBy similarityAdd BLAST33
    ChainiPRO_000003408534 – 427Acetyl-CoA acetyltransferase, mitochondrialAdd BLAST394

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei66N6-acetyllysine; alternateBy similarity1
    Modified residuei66N6-succinyllysine; alternateBy similarity1
    Modified residuei78N6-succinyllysineBy similarity1
    Modified residuei174N6-acetyllysine; alternateCombined sources1
    Modified residuei174N6-succinyllysine; alternateBy similarity1
    Modified residuei181N6-acetyllysine; alternateCombined sources1
    Modified residuei181N6-succinyllysine; alternateBy similarity1
    Modified residuei190N6-acetyllysine; alternateBy similarity1
    Modified residuei190N6-succinyllysine; alternateBy similarity1
    Modified residuei202N6-acetyllysine; alternateBy similarity1
    Modified residuei202N6-succinyllysine; alternateBy similarity1
    Modified residuei223N6-acetyllysine; alternateBy similarity1
    Modified residuei223N6-succinyllysine; alternateBy similarity1
    Modified residuei230N6-acetyllysine; alternateBy similarity1
    Modified residuei230N6-succinyllysine; alternateBy similarity1
    Modified residuei243N6-succinyllysineBy similarity1
    Modified residuei251N6-acetyllysineCombined sources1
    Modified residuei257N6-acetyllysineBy similarity1
    Modified residuei263N6-acetyllysine; alternateCombined sources1
    Modified residuei263N6-succinyllysine; alternateBy similarity1
    Modified residuei266N6-succinyllysineBy similarity1
    Modified residuei268N6-succinyllysineBy similarity1
    Modified residuei273N6-acetyllysineBy similarity1
    Modified residuei338N6-acetyllysineBy similarity1

    Post-translational modificationi

    Succinylation at Lys-268, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity).By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    EPDiP24752
    MaxQBiP24752
    PaxDbiP24752
    PeptideAtlasiP24752
    PRIDEiP24752
    ProteomicsDBi54224
    TopDownProteomicsiP24752-1 [P24752-1]

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00030363
    UCD-2DPAGEiP24752

    PTM databases

    iPTMnetiP24752
    PhosphoSitePlusiP24752
    SwissPalmiP24752

    Expressioni

    Gene expression databases

    BgeeiENSG00000075239 Expressed in 233 organ(s), highest expression level in nephron tubule
    CleanExiHS_ACAT1
    ExpressionAtlasiP24752 baseline and differential
    GenevisibleiP24752 HS

    Organism-specific databases

    HPAiHPA004428
    HPA007569

    Interactioni

    Subunit structurei

    Homotetramer.1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    BioGridi106556, 69 interactors
    IntActiP24752, 17 interactors
    MINTiP24752
    STRINGi9606.ENSP00000265838

    Structurei

    Secondary structure

    1427
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliP24752
    SMRiP24752
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP24752

    Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni258 – 260Coenzyme A binding3

    Sequence similaritiesi

    Belongs to the thiolase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiKOG1390 Eukaryota
    COG0183 LUCA
    GeneTreeiENSGT00390000009412
    HOGENOMiHOG000012238
    HOVERGENiHBG003112
    InParanoidiP24752
    KOiK00626
    OMAiWDVYNKF
    OrthoDBiEOG091G09C6
    PhylomeDBiP24752
    TreeFamiTF300650

    Family and domain databases

    CDDicd00751 thiolase, 1 hit
    Gene3Di3.40.47.10, 4 hits
    InterProiView protein in InterPro
    IPR002155 Thiolase
    IPR016039 Thiolase-like
    IPR020615 Thiolase_acyl_enz_int_AS
    IPR020610 Thiolase_AS
    IPR020617 Thiolase_C
    IPR020613 Thiolase_CS
    IPR020616 Thiolase_N
    PfamiView protein in Pfam
    PF02803 Thiolase_C, 1 hit
    PF00108 Thiolase_N, 1 hit
    PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
    SUPFAMiSSF53901 SSF53901, 2 hits
    TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
    PROSITEiView protein in PROSITE
    PS00098 THIOLASE_1, 1 hit
    PS00737 THIOLASE_2, 1 hit
    PS00099 THIOLASE_3, 1 hit

    Sequences (2+)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P24752-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAVLAALLRS GARSRSPLLR RLVQEIRYVE RSYVSKPTLK EVVIVSATRT
    60 70 80 90 100
    PIGSFLGSLS LLPATKLGSI AIQGAIEKAG IPKEEVKEAY MGNVLQGGEG
    110 120 130 140 150
    QAPTRQAVLG AGLPISTPCT TINKVCASGM KAIMMASQSL MCGHQDVMVA
    160 170 180 190 200
    GGMESMSNVP YVMNRGSTPY GGVKLEDLIV KDGLTDVYNK IHMGSCAENT
    210 220 230 240 250
    AKKLNIARNE QDAYAINSYT RSKAAWEAGK FGNEVIPVTV TVKGQPDVVV
    260 270 280 290 300
    KEDEEYKRVD FSKVPKLKTV FQKENGTVTA ANASTLNDGA AALVLMTADA
    310 320 330 340 350
    AKRLNVTPLA RIVAFADAAV EPIDFPIAPV YAASMVLKDV GLKKEDIAMW
    360 370 380 390 400
    EVNEAFSLVV LANIKMLEID PQKVNINGGA VSLGHPIGMS GARIVGHLTH
    410 420
    ALKQGEYGLA SICNGGGGAS AMLIQKL
    Length:427
    Mass (Da):45,200
    Last modified:March 1, 1992 - v1
    Checksum:i2E81168EB39D0142
    GO
    Isoform 2 (identifier: P24752-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         146-162: DVMVAGGMESMSNVPYV → IKQETGSLAKICCHVRR
         163-427: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:162
    Mass (Da):17,175
    Checksum:iC76EA13AED1868FC
    GO

    Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H0YEL7H0YEL7_HUMAN
    Acetyl-CoA acetyltransferase, mitoc...
    ACAT1
    136Annotation score:
    E9PKF3E9PKF3_HUMAN
    Acetyl-CoA acetyltransferase, mitoc...
    ACAT1
    54Annotation score:
    E9PRQ6E9PRQ6_HUMAN
    Acetyl-CoA acetyltransferase, mitoc...
    ACAT1
    141Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti340V → M in BAA01387 (PubMed:1684944).Curated1
    Sequence conflicti346D → N in BAA01387 (PubMed:1684944).Curated1
    Sequence conflicti380A → S in BAA01387 (PubMed:1684944).Curated1
    Sequence conflicti412I → F in BAA01387 (PubMed:1684944).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_0074965A → P1 PublicationCorresponds to variant dbSNP:rs3741056EnsemblClinVar.1
    Natural variantiVAR_00749785Missing in 3KTD. 1
    Natural variantiVAR_00749893N → S in 3KTD; 10% activity. 1 PublicationCorresponds to variant dbSNP:rs120074145EnsemblClinVar.1
    Natural variantiVAR_007499152G → A in 3KTD. Corresponds to variant dbSNP:rs762991875EnsemblClinVar.1
    Natural variantiVAR_007500158N → D in 3KTD; no activity. 1 PublicationCorresponds to variant dbSNP:rs148639841EnsemblClinVar.1
    Natural variantiVAR_007501183G → R in 3KTD; no activity. 1 PublicationCorresponds to variant dbSNP:rs120074141EnsemblClinVar.1
    Natural variantiVAR_007502297T → M in 3KTD; 10% normal activity. 1 PublicationCorresponds to variant dbSNP:rs886041122EnsemblClinVar.1
    Natural variantiVAR_007503301A → P in 3KTD; 5% normal activity. 1 Publication1
    Natural variantiVAR_007504312I → T in 3KTD; 10% activity. 1 PublicationCorresponds to variant dbSNP:rs120074146EnsemblClinVar.1
    Natural variantiVAR_007505333A → P in 3KTD; no activity. 1 PublicationCorresponds to variant dbSNP:rs120074147EnsemblClinVar.1
    Natural variantiVAR_007506379G → V in 3KTD. Corresponds to variant dbSNP:rs120074143EnsemblClinVar.1
    Natural variantiVAR_007507380A → T in 3KTD; 7% normal activity. 1 PublicationCorresponds to variant dbSNP:rs120074140EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_056844146 – 162DVMVA…NVPYV → IKQETGSLAKICCHVRR in isoform 2. 1 PublicationAdd BLAST17
    Alternative sequenceiVSP_056845163 – 427Missing in isoform 2. 1 PublicationAdd BLAST265

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D90228 mRNA Translation: BAA14278.1
    D10511 Genomic DNA Translation: BAA01387.1
    AK312574 mRNA Translation: BAG35468.1
    AP002433 Genomic DNA No translation available.
    CH471065 Genomic DNA Translation: EAW67104.1
    CH471065 Genomic DNA Translation: EAW67105.1
    BC010942 mRNA Translation: AAH10942.1
    CCDSiCCDS8339.1 [P24752-1]
    PIRiJH0255
    RefSeqiNP_000010.1, NM_000019.3 [P24752-1]
    UniGeneiHs.232375

    Genome annotation databases

    EnsembliENST00000265838; ENSP00000265838; ENSG00000075239 [P24752-1]
    ENST00000299355; ENSP00000299355; ENSG00000075239 [P24752-2]
    GeneIDi38
    KEGGihsa:38
    UCSCiuc001pjw.2 human [P24752-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D90228 mRNA Translation: BAA14278.1
    D10511 Genomic DNA Translation: BAA01387.1
    AK312574 mRNA Translation: BAG35468.1
    AP002433 Genomic DNA No translation available.
    CH471065 Genomic DNA Translation: EAW67104.1
    CH471065 Genomic DNA Translation: EAW67105.1
    BC010942 mRNA Translation: AAH10942.1
    CCDSiCCDS8339.1 [P24752-1]
    PIRiJH0255
    RefSeqiNP_000010.1, NM_000019.3 [P24752-1]
    UniGeneiHs.232375

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2F2SX-ray2.00A/B/C/D41-427[»]
    2IB7X-ray2.05A/B/C/D34-427[»]
    2IB8X-ray1.85A/B/C/D34-427[»]
    2IB9X-ray2.05A/B/C/D34-427[»]
    2IBUX-ray1.90A/B/C/D34-427[»]
    2IBWX-ray1.90A/B/C/D34-427[»]
    2IBYX-ray1.85A/B/C/D34-427[»]
    ProteinModelPortaliP24752
    SMRiP24752
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi106556, 69 interactors
    IntActiP24752, 17 interactors
    MINTiP24752
    STRINGi9606.ENSP00000265838

    Chemistry databases

    ChEMBLiCHEMBL2616
    DrugBankiDB00795 Sulfasalazine
    SwissLipidsiSLP:000000701

    PTM databases

    iPTMnetiP24752
    PhosphoSitePlusiP24752
    SwissPalmiP24752

    Polymorphism and mutation databases

    BioMutaiACAT1
    DMDMi135755

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00030363
    UCD-2DPAGEiP24752

    Proteomic databases

    EPDiP24752
    MaxQBiP24752
    PaxDbiP24752
    PeptideAtlasiP24752
    PRIDEiP24752
    ProteomicsDBi54224
    TopDownProteomicsiP24752-1 [P24752-1]

    Protocols and materials databases

    DNASUi38
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000265838; ENSP00000265838; ENSG00000075239 [P24752-1]
    ENST00000299355; ENSP00000299355; ENSG00000075239 [P24752-2]
    GeneIDi38
    KEGGihsa:38
    UCSCiuc001pjw.2 human [P24752-1]

    Organism-specific databases

    CTDi38
    DisGeNETi38
    EuPathDBiHostDB:ENSG00000075239.13
    GeneCardsiACAT1
    HGNCiHGNC:93 ACAT1
    HPAiHPA004428
    HPA007569
    MalaCardsiACAT1
    MIMi203750 phenotype
    607809 gene
    neXtProtiNX_P24752
    OpenTargetsiENSG00000075239
    Orphaneti134 Ketoacidosis due to beta-ketothiolase deficiency
    PharmGKBiPA24431
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1390 Eukaryota
    COG0183 LUCA
    GeneTreeiENSGT00390000009412
    HOGENOMiHOG000012238
    HOVERGENiHBG003112
    InParanoidiP24752
    KOiK00626
    OMAiWDVYNKF
    OrthoDBiEOG091G09C6
    PhylomeDBiP24752
    TreeFamiTF300650

    Enzyme and pathway databases

    BioCyciMetaCyc:HS01167-MONOMER
    ReactomeiR-HSA-70895 Branched-chain amino acid catabolism
    R-HSA-77108 Utilization of Ketone Bodies
    R-HSA-77111 Synthesis of Ketone Bodies

    Miscellaneous databases

    ChiTaRSiACAT1 human
    EvolutionaryTraceiP24752
    GeneWikiiACAT1
    GenomeRNAii38
    PROiPR:P24752
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000075239 Expressed in 233 organ(s), highest expression level in nephron tubule
    CleanExiHS_ACAT1
    ExpressionAtlasiP24752 baseline and differential
    GenevisibleiP24752 HS

    Family and domain databases

    CDDicd00751 thiolase, 1 hit
    Gene3Di3.40.47.10, 4 hits
    InterProiView protein in InterPro
    IPR002155 Thiolase
    IPR016039 Thiolase-like
    IPR020615 Thiolase_acyl_enz_int_AS
    IPR020610 Thiolase_AS
    IPR020617 Thiolase_C
    IPR020613 Thiolase_CS
    IPR020616 Thiolase_N
    PfamiView protein in Pfam
    PF02803 Thiolase_C, 1 hit
    PF00108 Thiolase_N, 1 hit
    PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
    SUPFAMiSSF53901 SSF53901, 2 hits
    TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
    PROSITEiView protein in PROSITE
    PS00098 THIOLASE_1, 1 hit
    PS00737 THIOLASE_2, 1 hit
    PS00099 THIOLASE_3, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiTHIL_HUMAN
    AccessioniPrimary (citable) accession number: P24752
    Secondary accession number(s): B2R6H1, G3XAB4, Q96FG8
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: September 12, 2018
    This is version 198 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    2. SIMILARITY comments
      Index of protein domains and families
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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