UniProtKB - P24723 (KPCL_HUMAN)
Protein kinase C eta type
PRKCH
Functioni
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization.
10 PublicationsCatalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 384 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 479 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 171 – 222 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 52 | |
Zinc fingeri | 245 – 295 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 51 | |
Nucleotide bindingi | 361 – 369 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium-dependent protein kinase C activity Source: UniProtKB-EC
- enzyme binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- protein kinase C activity Source: ProtInc
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
GO - Biological processi
- intracellular signal transduction Source: GO_Central
- negative regulation of glial cell apoptotic process Source: UniProtKB
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of B cell receptor signaling pathway Source: UniProtKB
- positive regulation of glial cell proliferation Source: UniProtKB
- positive regulation of keratinocyte differentiation Source: UniProtKB
- positive regulation of macrophage derived foam cell differentiation Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of protein localization to plasma membrane Source: ParkinsonsUK-UCL
- protein phosphorylation Source: UniProtKB
- regulation of bicellular tight junction assembly Source: UniProtKB
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Differentiation |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.11.13, 2681 |
PathwayCommonsi | P24723 |
Reactomei | R-HSA-114508, Effects of PIP2 hydrolysis R-HSA-418597, G alpha (z) signalling events |
SABIO-RKi | P24723 |
SignaLinki | P24723 |
SIGNORi | P24723 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PRKCH Synonyms:PKCL, PRKCL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9403, PRKCH |
MIMi | 605437, gene |
neXtProti | NX_P24723 |
VEuPathDBi | HostDB:ENSG00000027075 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Ischemic stroke (ISCHSTR)1 Publication
Organism-specific databases
DisGeNETi | 5583 |
MalaCardsi | PRKCH |
MIMi | 601367, phenotype |
OpenTargetsi | ENSG00000027075 |
PharmGKBi | PA33767 |
Miscellaneous databases
Pharosi | P24723, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3616 |
DrugCentrali | P24723 |
GuidetoPHARMACOLOGYi | 1487 |
Genetic variation databases
BioMutai | PRKCH |
DMDMi | 281185512 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055705 | 1 – 683 | Protein kinase C eta typeAdd BLAST | 683 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 28 | Phosphoserine; by autocatalysisCombined sources1 Publication | 1 | |
Modified residuei | 32 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 317 | PhosphoserineBy similarity | 1 | |
Modified residuei | 513 | Phosphothreonine; by PDPK1Curated | 1 | |
Modified residuei | 656 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 675 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P24723 |
jPOSTi | P24723 |
MassIVEi | P24723 |
MaxQBi | P24723 |
PaxDbi | P24723 |
PeptideAtlasi | P24723 |
PRIDEi | P24723 |
ProteomicsDBi | 4395 54223 [P24723-1] |
PTM databases
iPTMneti | P24723 |
PhosphoSitePlusi | P24723 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000027075, Expressed in lung and 222 other tissues |
ExpressionAtlasi | P24723, baseline and differential |
Genevisiblei | P24723, HS |
Organism-specific databases
HPAi | ENSG00000027075, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with FYN and RALA (By similarity).
Interacts with DGKQ.
By similarity1 PublicationBinary interactionsi
P24723
With | #Exp. | IntAct |
---|---|---|
OCLN - isoform 1 [Q16625-1] | 2 | EBI-2865850,EBI-16115673 |
OCLN [Q28269] from Canis lupus familiaris. | 2 | EBI-2865850,EBI-16222162 |
GO - Molecular functioni
- enzyme binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111569, 23 interactors |
DIPi | DIP-44588N |
IntActi | P24723, 11 interactors |
MINTi | P24723 |
STRINGi | 9606.ENSP00000329127 |
Chemistry databases
BindingDBi | P24723 |
Miscellaneous databases
RNActi | P24723, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P24723 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P24723 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 118 | C2PROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 355 – 614 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 615 – 683 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 320 – 342 | DisorderedSequence analysisAdd BLAST | 23 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 171 – 222 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 52 | |
Zinc fingeri | 245 – 295 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0694, Eukaryota |
GeneTreei | ENSGT00940000158220 |
HOGENOMi | CLU_000288_54_4_1 |
InParanoidi | P24723 |
OMAi | RSHPFLT |
OrthoDBi | 222529at2759 |
PhylomeDBi | P24723 |
TreeFami | TF351133 |
Family and domain databases
CDDi | cd00029, C1, 2 hits cd05590, STKc_nPKC_eta, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR000008, C2_dom IPR035892, C2_domain_sf IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR034665, nPKC_eta IPR002219, PE/DAG-bd IPR027431, PKC_eta IPR017892, Pkinase_C IPR014376, Prot_kin_PKC_delta IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00168, C2, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000551, PKC_delta, 1 hit PIRSF501107, Protein_kin_C_eta, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00239, C2, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSGTMKFNG YLRVRIGEAV GLQPTRWSLR HSLFKKGHQL LDPYLTVSVD
60 70 80 90 100
QVRVGQTSTK QKTNKPTYNE EFCANVTDGG HLELAVFHET PLGYDHFVAN
110 120 130 140 150
CTLQFQELLR TTGASDTFEG WVDLEPEGKV FVVITLTGSF TEATLQRDRI
160 170 180 190 200
FKHFTRKRQR AMRRRVHQIN GHKFMATYLR QPTYCSHCRE FIWGVFGKQG
210 220 230 240 250
YQCQVCTCVV HKRCHHLIVT ACTCQNNINK VDSKIAEQRF GINIPHKFSI
260 270 280 290 300
HNYKVPTFCD HCGSLLWGIM RQGLQCKICK MNVHIRCQAN VAPNCGVNAV
310 320 330 340 350
ELAKTLAGMG LQPGNISPTS KLVSRSTLRR QGKESSKEGN GIGVNSSNRL
360 370 380 390 400
GIDNFEFIRV LGKGSFGKVM LARVKETGDL YAVKVLKKDV ILQDDDVECT
410 420 430 440 450
MTEKRILSLA RNHPFLTQLF CCFQTPDRLF FVMEFVNGGD LMFHIQKSRR
460 470 480 490 500
FDEARARFYA AEIISALMFL HDKGIIYRDL KLDNVLLDHE GHCKLADFGM
510 520 530 540 550
CKEGICNGVT TATFCGTPDY IAPEILQEML YGPAVDWWAM GVLLYEMLCG
560 570 580 590 600
HAPFEAENED DLFEAILNDE VVYPTWLHED ATGILKSFMT KNPTMRLGSL
610 620 630 640 650
TQGGEHAILR HPFFKEIDWA QLNHRQIEPP FRPRIKSRED VSNFDPDFIK
660 670 680
EEPVLTPIDE GHLPMINQDE FRNFSYVSPE LQP
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V4Q6 | G3V4Q6_HUMAN | Protein kinase C eta type | PRKCH | 224 | Annotation score: | ||
G3V5U5 | G3V5U5_HUMAN | Protein kinase C eta type | PRKCH | 106 | Annotation score: | ||
G3V304 | G3V304_HUMAN | Protein kinase C eta type | PRKCH | 83 | Annotation score: | ||
G3V4X4 | G3V4X4_HUMAN | Protein kinase C eta type | PRKCH | 129 | Annotation score: | ||
G3V3E7 | G3V3E7_HUMAN | Protein kinase C eta type | PRKCH | 73 | Annotation score: | ||
G3V4Q9 | G3V4Q9_HUMAN | Protein kinase C eta type | PRKCH | 87 | Annotation score: | ||
G3V5F8 | G3V5F8_HUMAN | Protein kinase C eta type | PRKCH | 71 | Annotation score: | ||
G3V4L3 | G3V4L3_HUMAN | Protein kinase C eta type | PRKCH | 151 | Annotation score: | ||
A0A1W2PPU0 | A0A1W2PPU0_HUMAN | Protein kinase C eta type | PRKCH | 95 | Annotation score: | ||
G3V4H0 | G3V4H0_HUMAN | Protein kinase C eta type | PRKCH | 53 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 96 | Missing in AAA60100 (PubMed:1986216).Curated | 1 | |
Sequence conflicti | 109 | L → R in AAA60100 (PubMed:1986216).Curated | 1 | |
Sequence conflicti | 110 | R → G in AAA60100 (PubMed:1986216).Curated | 1 | |
Sequence conflicti | 393 | Q → L in AAA60100 (PubMed:1986216).Curated | 1 | |
Sequence conflicti | 472 | D → E in AAB32724 (PubMed:7988719).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042312 | 19 | A → V1 PublicationCorresponds to variant dbSNP:rs55645551Ensembl. | 1 | |
Natural variantiVAR_042313 | 65 | K → R1 PublicationCorresponds to variant dbSNP:rs55737090Ensembl. | 1 | |
Natural variantiVAR_042314 | 149 | R → Q1 PublicationCorresponds to variant dbSNP:rs55848048Ensembl. | 1 | |
Natural variantiVAR_042315 | 359 | R → Q1 PublicationCorresponds to variant dbSNP:rs55818778Ensembl. | 1 | |
Natural variantiVAR_034604 | 374 | V → I Associated with susceptibility to ischemic stroke; increases autophosphorylation and kinase activity. 2 PublicationsCorresponds to variant dbSNP:rs2230500EnsemblClinVar. | 1 | |
Natural variantiVAR_060736 | 497 | D → Y. Corresponds to variant dbSNP:rs11846991Ensembl. | 1 | |
Natural variantiVAR_042316 | 575 | T → A in a aLL TEL/AML1+ sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1378993559Ensembl. | 1 | |
Natural variantiVAR_042317 | 594 | T → I in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042318 | 612 | P → S1 PublicationCorresponds to variant dbSNP:rs34159231Ensembl. | 1 | |
Natural variantiVAR_042438 | 645 | D → V. Corresponds to variant dbSNP:rs35561533Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056572 | 1 – 161 | Missing in isoform 2. 1 PublicationAdd BLAST | 161 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55284 mRNA Translation: AAA60100.1 AK290183 mRNA Translation: BAF82872.1 AK296158 mRNA Translation: BAG58897.1 AL138996 Genomic DNA No translation available. AL355916 Genomic DNA No translation available. AL359220 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW80800.1 CH471061 Genomic DNA Translation: EAW80801.1 BC037268 mRNA Translation: AAH37268.1 S74620 mRNA Translation: AAB32724.1 |
CCDSi | CCDS9752.1 [P24723-1] |
PIRi | A39666 |
RefSeqi | NP_006246.2, NM_006255.4 [P24723-1] XP_016876947.1, XM_017021458.1 [P24723-2] |
Genome annotation databases
Ensembli | ENST00000332981; ENSP00000329127; ENSG00000027075 ENST00000555082; ENSP00000450981; ENSG00000027075 [P24723-2] |
GeneIDi | 5583 |
KEGGi | hsa:5583 |
MANE-Selecti | ENST00000332981.11; ENSP00000329127.5; NM_006255.5; NP_006246.2 |
UCSCi | uc001xfn.4, human [P24723-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55284 mRNA Translation: AAA60100.1 AK290183 mRNA Translation: BAF82872.1 AK296158 mRNA Translation: BAG58897.1 AL138996 Genomic DNA No translation available. AL355916 Genomic DNA No translation available. AL359220 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW80800.1 CH471061 Genomic DNA Translation: EAW80801.1 BC037268 mRNA Translation: AAH37268.1 S74620 mRNA Translation: AAB32724.1 |
CCDSi | CCDS9752.1 [P24723-1] |
PIRi | A39666 |
RefSeqi | NP_006246.2, NM_006255.4 [P24723-1] XP_016876947.1, XM_017021458.1 [P24723-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FK9 | X-ray | 1.75 | A | 1-138 | [»] | |
3TXO | X-ray | 2.05 | A | 333-683 | [»] | |
SMRi | P24723 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111569, 23 interactors |
DIPi | DIP-44588N |
IntActi | P24723, 11 interactors |
MINTi | P24723 |
STRINGi | 9606.ENSP00000329127 |
Chemistry databases
BindingDBi | P24723 |
ChEMBLi | CHEMBL3616 |
DrugCentrali | P24723 |
GuidetoPHARMACOLOGYi | 1487 |
PTM databases
iPTMneti | P24723 |
PhosphoSitePlusi | P24723 |
Genetic variation databases
BioMutai | PRKCH |
DMDMi | 281185512 |
Proteomic databases
EPDi | P24723 |
jPOSTi | P24723 |
MassIVEi | P24723 |
MaxQBi | P24723 |
PaxDbi | P24723 |
PeptideAtlasi | P24723 |
PRIDEi | P24723 |
ProteomicsDBi | 4395 54223 [P24723-1] |
Protocols and materials databases
Antibodypediai | 24422, 263 antibodies from 33 providers |
DNASUi | 5583 |
Genome annotation databases
Ensembli | ENST00000332981; ENSP00000329127; ENSG00000027075 ENST00000555082; ENSP00000450981; ENSG00000027075 [P24723-2] |
GeneIDi | 5583 |
KEGGi | hsa:5583 |
MANE-Selecti | ENST00000332981.11; ENSP00000329127.5; NM_006255.5; NP_006246.2 |
UCSCi | uc001xfn.4, human [P24723-1] |
Organism-specific databases
CTDi | 5583 |
DisGeNETi | 5583 |
GeneCardsi | PRKCH |
HGNCi | HGNC:9403, PRKCH |
HPAi | ENSG00000027075, Low tissue specificity |
MalaCardsi | PRKCH |
MIMi | 601367, phenotype 605437, gene |
neXtProti | NX_P24723 |
OpenTargetsi | ENSG00000027075 |
PharmGKBi | PA33767 |
VEuPathDBi | HostDB:ENSG00000027075 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0694, Eukaryota |
GeneTreei | ENSGT00940000158220 |
HOGENOMi | CLU_000288_54_4_1 |
InParanoidi | P24723 |
OMAi | RSHPFLT |
OrthoDBi | 222529at2759 |
PhylomeDBi | P24723 |
TreeFami | TF351133 |
Enzyme and pathway databases
BRENDAi | 2.7.11.13, 2681 |
PathwayCommonsi | P24723 |
Reactomei | R-HSA-114508, Effects of PIP2 hydrolysis R-HSA-418597, G alpha (z) signalling events |
SABIO-RKi | P24723 |
SignaLinki | P24723 |
SIGNORi | P24723 |
Miscellaneous databases
BioGRID-ORCSi | 5583, 6 hits in 1079 CRISPR screens |
ChiTaRSi | PRKCH, human |
EvolutionaryTracei | P24723 |
GeneWikii | PRKCH |
GenomeRNAii | 5583 |
Pharosi | P24723, Tchem |
PROi | PR:P24723 |
RNActi | P24723, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000027075, Expressed in lung and 222 other tissues |
ExpressionAtlasi | P24723, baseline and differential |
Genevisiblei | P24723, HS |
Family and domain databases
CDDi | cd00029, C1, 2 hits cd05590, STKc_nPKC_eta, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR000008, C2_dom IPR035892, C2_domain_sf IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR034665, nPKC_eta IPR002219, PE/DAG-bd IPR027431, PKC_eta IPR017892, Pkinase_C IPR014376, Prot_kin_PKC_delta IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00168, C2, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000551, PKC_delta, 1 hit PIRSF501107, Protein_kin_C_eta, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00239, C2, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KPCL_HUMAN | |
Accessioni | P24723Primary (citable) accession number: P24723 Secondary accession number(s): B4DJN5, Q16246, Q8NE03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | December 15, 2009 | |
Last modified: | February 23, 2022 | |
This is version 213 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families