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Protein

Protein kinase C eta type

Gene

PRKCH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization.10 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei384ATPPROSITE-ProRule annotation1
Active sitei479Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 222Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri245 – 295Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51
Nucleotide bindingi361 – 369ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • enzyme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein kinase C activity Source: ProtInc
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.11.13 2681
ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-418597 G alpha (z) signalling events
SABIO-RKiP24723
SignaLinkiP24723
SIGNORiP24723

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C eta type (EC:2.7.11.13)
Alternative name(s):
PKC-L
nPKC-eta
Gene namesi
Name:PRKCH
Synonyms:PKCL, PRKCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000027075.13
HGNCiHGNC:9403 PRKCH
MIMi605437 gene
neXtProtiNX_P24723

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Ischemic stroke (ISCHSTR)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
See also OMIM:601367

Organism-specific databases

DisGeNETi5583
MalaCardsiPRKCH
MIMi601367 phenotype
OpenTargetsiENSG00000027075
PharmGKBiPA33767

Chemistry databases

ChEMBLiCHEMBL3616
GuidetoPHARMACOLOGYi1487

Polymorphism and mutation databases

BioMutaiPRKCH
DMDMi281185512

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000557051 – 683Protein kinase C eta typeAdd BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28Phosphoserine; by autocatalysisCombined sources1 Publication1
Modified residuei32Phosphoserine; by autocatalysis1 Publication1
Modified residuei317PhosphoserineBy similarity1
Modified residuei513Phosphothreonine; by PDPK1Curated1
Modified residuei656PhosphothreonineCombined sources1
Modified residuei675PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP24723
MaxQBiP24723
PaxDbiP24723
PeptideAtlasiP24723
PRIDEiP24723
ProteomicsDBi54223

PTM databases

iPTMnetiP24723
PhosphoSitePlusiP24723

Expressioni

Tissue specificityi

Most abundant in lung, less in heart and skin.1 Publication

Gene expression databases

BgeeiENSG00000027075 Expressed in 214 organ(s), highest expression level in amniotic fluid
CleanExiHS_PRKCH
ExpressionAtlasiP24723 baseline and differential
GenevisibleiP24723 HS

Organism-specific databases

HPAiHPA026294
HPA053709

Interactioni

Subunit structurei

Interacts with FYN and RALA (By similarity). Interacts with DGKQ.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111569, 13 interactors
DIPiDIP-44588N
IntActiP24723, 7 interactors
MINTiP24723
STRINGi9606.ENSP00000329127

Chemistry databases

BindingDBiP24723

Structurei

Secondary structure

1683
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP24723
SMRiP24723
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24723

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 113C2PROSITE-ProRule annotationAdd BLAST102
Domaini355 – 614Protein kinasePROSITE-ProRule annotationAdd BLAST260
Domaini615 – 683AGC-kinase C-terminalAdd BLAST69

Domaini

The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 222Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri245 – 295Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0694 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00930000150815
HOGENOMiHOG000233022
HOVERGENiHBG108317
InParanoidiP24723
KOiK18051
OMAiNHRQLEP
OrthoDBiEOG091G0QRS
PhylomeDBiP24723
TreeFamiTF351133

Family and domain databases

CDDicd00029 C1, 2 hits
cd05590 STKc_nPKC_eta, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR034665 nPKC_eta
IPR002219 PE/DAG-bd
IPR027431 PKC_eta
IPR017892 Pkinase_C
IPR014376 Prot_kin_PKC_delta
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00168 C2, 1 hit
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000551 PKC_delta, 1 hit
PIRSF501107 Protein_kin_C_eta, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00239 C2, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50004 C2, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P24723-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSGTMKFNG YLRVRIGEAV GLQPTRWSLR HSLFKKGHQL LDPYLTVSVD
60 70 80 90 100
QVRVGQTSTK QKTNKPTYNE EFCANVTDGG HLELAVFHET PLGYDHFVAN
110 120 130 140 150
CTLQFQELLR TTGASDTFEG WVDLEPEGKV FVVITLTGSF TEATLQRDRI
160 170 180 190 200
FKHFTRKRQR AMRRRVHQIN GHKFMATYLR QPTYCSHCRE FIWGVFGKQG
210 220 230 240 250
YQCQVCTCVV HKRCHHLIVT ACTCQNNINK VDSKIAEQRF GINIPHKFSI
260 270 280 290 300
HNYKVPTFCD HCGSLLWGIM RQGLQCKICK MNVHIRCQAN VAPNCGVNAV
310 320 330 340 350
ELAKTLAGMG LQPGNISPTS KLVSRSTLRR QGKESSKEGN GIGVNSSNRL
360 370 380 390 400
GIDNFEFIRV LGKGSFGKVM LARVKETGDL YAVKVLKKDV ILQDDDVECT
410 420 430 440 450
MTEKRILSLA RNHPFLTQLF CCFQTPDRLF FVMEFVNGGD LMFHIQKSRR
460 470 480 490 500
FDEARARFYA AEIISALMFL HDKGIIYRDL KLDNVLLDHE GHCKLADFGM
510 520 530 540 550
CKEGICNGVT TATFCGTPDY IAPEILQEML YGPAVDWWAM GVLLYEMLCG
560 570 580 590 600
HAPFEAENED DLFEAILNDE VVYPTWLHED ATGILKSFMT KNPTMRLGSL
610 620 630 640 650
TQGGEHAILR HPFFKEIDWA QLNHRQIEPP FRPRIKSRED VSNFDPDFIK
660 670 680
EEPVLTPIDE GHLPMINQDE FRNFSYVSPE LQP
Length:683
Mass (Da):77,828
Last modified:December 15, 2009 - v4
Checksum:i0A29806CE31912F2
GO
Isoform 2 (identifier: P24723-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.

Note: No experimental confirmation available.
Show »
Length:522
Mass (Da):59,521
Checksum:iD6852F6089A763E9
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4Q6G3V4Q6_HUMAN
Protein kinase C eta type
PRKCH
224Annotation score:
G3V4Q9G3V4Q9_HUMAN
Protein kinase C eta type
PRKCH
87Annotation score:
G3V5U5G3V5U5_HUMAN
Protein kinase C eta type
PRKCH
106Annotation score:
G3V4X4G3V4X4_HUMAN
Protein kinase C eta type
PRKCH
129Annotation score:
G3V304G3V304_HUMAN
Protein kinase C eta type
PRKCH
83Annotation score:
G3V4L3G3V4L3_HUMAN
Protein kinase C eta type
PRKCH
151Annotation score:
G3V3E7G3V3E7_HUMAN
Protein kinase C eta type
PRKCH
73Annotation score:
G3V5F8G3V5F8_HUMAN
Protein kinase C eta type
PRKCH
71Annotation score:
G3V5Y6G3V5Y6_HUMAN
Protein kinase C eta type
PRKCH
144Annotation score:
G3V4H0G3V4H0_HUMAN
Protein kinase C eta type
PRKCH
53Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96Missing in AAA60100 (PubMed:1986216).Curated1
Sequence conflicti109L → R in AAA60100 (PubMed:1986216).Curated1
Sequence conflicti110R → G in AAA60100 (PubMed:1986216).Curated1
Sequence conflicti393Q → L in AAA60100 (PubMed:1986216).Curated1
Sequence conflicti472D → E in AAB32724 (PubMed:7988719).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04231219A → V1 PublicationCorresponds to variant dbSNP:rs55645551Ensembl.1
Natural variantiVAR_04231365K → R1 PublicationCorresponds to variant dbSNP:rs55737090Ensembl.1
Natural variantiVAR_042314149R → Q1 PublicationCorresponds to variant dbSNP:rs55848048Ensembl.1
Natural variantiVAR_042315359R → Q1 PublicationCorresponds to variant dbSNP:rs55818778Ensembl.1
Natural variantiVAR_034604374V → I Associated with susceptibility to ischemic stroke; increases autophosphorylation and kinase activity. 2 PublicationsCorresponds to variant dbSNP:rs2230500EnsemblClinVar.1
Natural variantiVAR_060736497D → Y. Corresponds to variant dbSNP:rs11846991Ensembl.1
Natural variantiVAR_042316575T → A in a aLL TEL/AML1+ sample; somatic mutation. 1 Publication1
Natural variantiVAR_042317594T → I in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_042318612P → S1 PublicationCorresponds to variant dbSNP:rs34159231Ensembl.1
Natural variantiVAR_042438645D → V. Corresponds to variant dbSNP:rs35561533Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565721 – 161Missing in isoform 2. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55284 mRNA Translation: AAA60100.1
AK290183 mRNA Translation: BAF82872.1
AK296158 mRNA Translation: BAG58897.1
AL138996 Genomic DNA No translation available.
AL355916 Genomic DNA No translation available.
AL359220 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80800.1
CH471061 Genomic DNA Translation: EAW80801.1
BC037268 mRNA Translation: AAH37268.1
S74620 mRNA Translation: AAB32724.1
CCDSiCCDS9752.1 [P24723-1]
PIRiA39666
RefSeqiNP_006246.2, NM_006255.4 [P24723-1]
XP_016876947.1, XM_017021458.1 [P24723-2]
UniGeneiHs.333907
Hs.662187

Genome annotation databases

EnsembliENST00000332981; ENSP00000329127; ENSG00000027075 [P24723-1]
ENST00000555082; ENSP00000450981; ENSG00000027075 [P24723-2]
GeneIDi5583
KEGGihsa:5583
UCSCiuc001xfn.4 human [P24723-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55284 mRNA Translation: AAA60100.1
AK290183 mRNA Translation: BAF82872.1
AK296158 mRNA Translation: BAG58897.1
AL138996 Genomic DNA No translation available.
AL355916 Genomic DNA No translation available.
AL359220 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80800.1
CH471061 Genomic DNA Translation: EAW80801.1
BC037268 mRNA Translation: AAH37268.1
S74620 mRNA Translation: AAB32724.1
CCDSiCCDS9752.1 [P24723-1]
PIRiA39666
RefSeqiNP_006246.2, NM_006255.4 [P24723-1]
XP_016876947.1, XM_017021458.1 [P24723-2]
UniGeneiHs.333907
Hs.662187

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FK9X-ray1.75A1-138[»]
3TXOX-ray2.05A333-683[»]
ProteinModelPortaliP24723
SMRiP24723
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111569, 13 interactors
DIPiDIP-44588N
IntActiP24723, 7 interactors
MINTiP24723
STRINGi9606.ENSP00000329127

Chemistry databases

BindingDBiP24723
ChEMBLiCHEMBL3616
GuidetoPHARMACOLOGYi1487

PTM databases

iPTMnetiP24723
PhosphoSitePlusiP24723

Polymorphism and mutation databases

BioMutaiPRKCH
DMDMi281185512

Proteomic databases

EPDiP24723
MaxQBiP24723
PaxDbiP24723
PeptideAtlasiP24723
PRIDEiP24723
ProteomicsDBi54223

Protocols and materials databases

DNASUi5583
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332981; ENSP00000329127; ENSG00000027075 [P24723-1]
ENST00000555082; ENSP00000450981; ENSG00000027075 [P24723-2]
GeneIDi5583
KEGGihsa:5583
UCSCiuc001xfn.4 human [P24723-1]

Organism-specific databases

CTDi5583
DisGeNETi5583
EuPathDBiHostDB:ENSG00000027075.13
GeneCardsiPRKCH
HGNCiHGNC:9403 PRKCH
HPAiHPA026294
HPA053709
MalaCardsiPRKCH
MIMi601367 phenotype
605437 gene
neXtProtiNX_P24723
OpenTargetsiENSG00000027075
PharmGKBiPA33767
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0694 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00930000150815
HOGENOMiHOG000233022
HOVERGENiHBG108317
InParanoidiP24723
KOiK18051
OMAiNHRQLEP
OrthoDBiEOG091G0QRS
PhylomeDBiP24723
TreeFamiTF351133

Enzyme and pathway databases

BRENDAi2.7.11.13 2681
ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-418597 G alpha (z) signalling events
SABIO-RKiP24723
SignaLinkiP24723
SIGNORiP24723

Miscellaneous databases

ChiTaRSiPRKCH human
EvolutionaryTraceiP24723
GeneWikiiPRKCH
GenomeRNAii5583
PROiPR:P24723
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000027075 Expressed in 214 organ(s), highest expression level in amniotic fluid
CleanExiHS_PRKCH
ExpressionAtlasiP24723 baseline and differential
GenevisibleiP24723 HS

Family and domain databases

CDDicd00029 C1, 2 hits
cd05590 STKc_nPKC_eta, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR034665 nPKC_eta
IPR002219 PE/DAG-bd
IPR027431 PKC_eta
IPR017892 Pkinase_C
IPR014376 Prot_kin_PKC_delta
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00168 C2, 1 hit
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000551 PKC_delta, 1 hit
PIRSF501107 Protein_kin_C_eta, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00239 C2, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50004 C2, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKPCL_HUMAN
AccessioniPrimary (citable) accession number: P24723
Secondary accession number(s): B4DJN5, Q16246, Q8NE03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 15, 2009
Last modified: November 7, 2018
This is version 194 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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